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All Journal Majalah Patologi Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Jurnal RSMH Palembang Indonesian Journal of Cancer
Nora Ramkita
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Penyuluhan pentingnya fase pra-analitik di bidang Patologi Anatomi di Kota Prabumulih Murti, Krisna; Ramkita, Nora
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 2 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4l2.102

Abstract

The procedure for making preparations in the Anatomical Pathology Laboratory consists of three stages, including the pre-analytical process. The impact of pre-analytical process errors can lead to misdiagnosis and treatment. This community service is located at AR Bunda Hospital Prabumulih City, on Saturday, October 15, 2022 in the form of educational seminars, discussions and hands-on workshops to practice the correct tissue fixation and lamellation procedures. The activity was held in conjunction with the 60th Anniversary of the Faculty of Medicine, Sriwijaya University and the Prabumulih City Government. The seminar participants were active enough to ask questions and discuss. There were 51 participants, coming from 4 hospitals, namely Prabumulih Hospital (31.4%), AR Bunda Hospital (31.4%), Pertamina Prabumulih Hospital (19.6%), Fadillah Prabumulih Hospital (9.8%), and from other institutions around 7.8%, consisting of room nurses, general practitioners, dental nurses, operating room nurses, pharmacy, and laboratory workers. An increase in participants' knowledge by 15% was obtained based on pre-test and post-test results, so it is expected that the tissue processing process in the Anatomic Pathology Laboratory can produce paraffin blocks of good quality, immunohistochemical examinations to be accurate, and patient tissue diagnosis to be more precise.
Superior Vena Cava Syndrome in Men with Thymic Atypical Carcinoid (Neuroendocrine Tumor Grade 2) Ramkita, Nora; Suly Auline Rusminan; Ika Kartika; Krisna Murti; S. Nurul Amanah Ratna Sari; Devi Eqtriana Setyaningsih
Jurnal RSMH Palembang Vol. 3 No. 2 (2022): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v3i2.57

Abstract

Introduction: Cases of neuroendocrine tumors (NET) can occur in various organs, generally in the form of gastroenteropancreatic (GEP-NET) and pulmonary tract (PNET). The incidence of thymic neuroendocrine tumors (TNET) is rare, accounting for less than 5% of thymic and mediastinal malignancies, and 0.4% of all neuroendocrine tumors. Case presentation: A 57-year-old man came to RSUP Dr. Mohammad Hoesin Palembang with complaints of coughing, bluish and curved blood vessels in the chest, and shortness of breath during activities that have been getting worse for six months. CT scan showed a tumor measuring 18.6 x 11.7 x 11 cm in the anterior mediastinum and pressing on the superior vena cava and abdominal aorta. TTNA and core biopsy with CT guidance showed NET Grade 2, mitoses 6/2 mm2, positive tumor cells with immunohistochemistry for synaptophysin, chromogranin, CD 56, AE1/AE3, and Ki67 9%. The patient received paclitaxel and carboplatin chemotherapy for 6 cycles. Conclusion: The prognosis for atypical carcinoid patients is 20-80% for a 5-year survival rate. Appropriate patient management is needed to improve the outcome of patients with primary thymic atypical carcinoid (NET, grade 2).
Correlation between the Pre-Analytical Stage and Quality of Breast Histopathology Specimen Kurniawaty, Nyiayu Fauziah; Krisna Murti; Nora Ramkita; Sandria
Jurnal RSMH Palembang Vol. 5 No. 1 (2024): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jrp.v5i1.61

Abstract

The histopathology preparations procedure in the Anatomic Pathology Laboratory consists of three stages: pre-analytic, analytical and post-analytic. Errors in the pre-analytic process can affect the quality of histopathology preparations, thereby affecting diagnosis and patient management. The length of fixation and the large size of tissue lamellae are variables in the pre-analytic process that influence the quality of histopathological preparations. The aim of this study is to determine the relationship between the length of fixation and the size of large tissue lamellae on the quality of histopathological preparation. A cross-sectional study was conducted on medical record data of histopathological examination of breast tissue examined at the Barokah Palembang Anatomical Pathology Laboratory between January - December 2022. There were 37 cases of histopathological specimens that met the inclusion criteria, of which 3 cases were underfixed, 13 cases were overfixed and the rest were normal. One case from the underfixation, 20 cases from the normal fixation and 3 from the overfixation group were included in the good specimen quality category. The Spearman test showed that there was a significant relationship between normal fixation and good specimen quality (p=0.00217). Of the 37 research subjects, there were 18 subjects who were categorized as good lamellation. When related to specimen quality, good lamellation is associated with good specimen quality (p=0.02161). The correct fixation and lamellation during the pre-analytic phase are associated with good specimen quality.
Deteksi dini kanker serviks dengan metode pulasan papsmear pada wanita aktif secara seksual di Kecamatan Gandus Dewi, Citra; Kartika, Ika; Fauziah, Nyiayu; Ulfa, Maria; Desmaradd, Soraya Sagita; Ramkita, Nora; Sari, Pratia Mega; Suzena, Yayuk; Seda, Andi; Sandria, Sandria; Septa, Fadly; Libel, Eduwardo; Noprianti, Vivin; Fitri, Eka
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 3 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I3.142

Abstract

Cervical cancer is one of the most common cancers in women around the world after breast cancer. Persistent Human Papillomavirus (HPV) infections, especially types 16 and 18, are known to be the main cause of cervical cancer. Currently, preventive programs such as papsmear reviews are prioritized to reduce the incidence and mortality of cervical cancer. This community service activity aims to screen cervical cancer in sexually active women and increase public awareness about the importance of papsmear screening. This activity was located at Gandus Hospital, South Sumatra, involving as many as 31 participants, with the results of the examination obtained normal in 10 respondents (32.2%), atrophic smear in 2 respondents (6.4%), chronic cervicitis in 18 respondents (58.1%) and LGSIL in 1 respondent (3.2%). The characteristics of the respondents in this activity include, women under 40 years old with a general educational background of college or equivalent. The age of marriage or the age of the respondent's first sexual activity and the age of giving birth to the first child at the age of 16-25 years. The number of the most respondent children was less than or equal to 2 children. The use of contraceptives used by the most respondents was spiral contraception. The results of the screening examination found 1 respondent with LGSIL, so proper medical treatment was needed and the precancerous lesion did not continue to become cervical cancer.
Primary Bone Diffuse Large B-Cell Lymphoma: A Case Series and Review of Literature Ramkita, Nora; Murti, Krisna; Devi, SNA Ratna Sari; Dwiryanti, Rizky
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1272

Abstract

Introduction: Primary bone lymphoma (PBL) is an uncommon lymphoid cell neoplasm that appears as one or more bone lesions and does not appear in any lymph nodes or other places outside the lymph nodes. This type accounts for approximately 1% of all lymphomas and 7% of all cancerous primary bone tumors.Case Presentation: We collected two respective cases of primary bone lymphoma in the Department of Anatomic Pathology, Faculty of Medicine, Sriwijaya University, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Both cases were diffuse large B-cell lymphoma, non-germinal center subtype (DLBCL non-GCB), in individuals 48 and 18 years old, located in the right femur. The prognosis for both patients was poor due to the advanced stage, as well as the second patient's refusal of chemotherapy. Conclusion: These cases demonstrate the diagnostic and therapeutic challenges of primary bone diffuse large B-cell lymphoma, particularly the aggressive non-GCB subtype. Early recognition, accurate histopathological diagnosis, and prompt, multidisciplinary management are essential to improve prognosis, especially in advanced-stage presentations. Delay in treatment or refusal of therapy significantly worsens patient outcomes.
English: English Ramkita, Nora; Krisna Murti; Citra Dewi
Majalah Patologi Indonesia Vol. 34 No. 2 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Background: A frozen section or vries coupe (VC) is an examination procedure performed by a pathologist during a patient operation on the surgical table. VC provides immediate information to surgeons regarding the benign or malignant status of a tissue, as well as determines the incision margin free from tumor mass. Objective: This study aimed to evaluate diagnostic accuracy using the slide preparation archives of VC and histopathology at the Anatomic Pathology Department of Dr. Mohammad Hoesin Central General Hospital (RSUP), Palembang. Methods: Samples of patients were collected from 1 January 2021 to 1 October 2023, while sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for VC were assessed compared to the definitive diagnosis of histopathology. A reassessment was conducted by two pathologists on slide preparations with unmatched results between VC and histopathological diagnosis. Result: VC examination showed sensitivity, specificity, PPV, and NPV of 99.7%, 99.7%, 98.3%, and 98.3% for benign tumors as well as 98%, 99.6%, 98.3%, and 98.3% for malignant tumors, respectively. The reassessment of the inappropriate slide preparations obtained a weighted kappa value of 0.586, signifying moderate agreement. Diagnostic discordance is caused by the experience of pathologists, freezing artifacts, and challenges in obtaining precise samples under a limited timeframe. Conclusion: This study provided valuable insights into the effectiveness of VC procedure in intraoperative tissue diagnosis, showing the need for collaborative efforts and experienced pathologists to achieve improved accuracy.
Co-Authors Citra Dewi Citra Dewi Desmaradd, Soraya Sagita Devi Eqtriana Setyaningsih Devi, SNA Ratna Sari Dwiryanti, Rizky Fauziah, Nyiayu Fitri, Eka Ika Kartika Ika Kartika Krisna Murti Kurniawaty, Nyiayu Fauziah Libel, Eduwardo Maria Ulfa Noprianti, Vivin S. Nurul Amanah Ratna Sari Sandria Sandria, Sandria Sari, Pratia Mega Seda, Andi Septa, Fadly Suly Auline Rusminan Suzena, Yayuk