Didik Indiarso
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Recurrent Severe Hypoglycemia in a 43 Year Old Extreme Obese Woman with Insulinoma: A Case Report Zaki Mita Kusumaadhi; Farah Hendara Ningrum; Bambang Satoto; Titik Yuliastuti; Y. F. Rahmat Sugianto; Etisa Adi Murbawani; Didik Indiarso; Erik Prabowo; Tania Tedjo Minuljo; Yohana Prima Ceria Anindita; K. Heri Nugroho HS; Meira Dewi Kusuma Astuti
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 2 (2025): InaJEMD Vol. 2, No. 2
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66266/inajemd.v2i2.66

Abstract

Insulinomas are very rare neuroendocrine tumors (4 cases per million individuals per year) leading to insulin hypersecretion and occurring more often in women at any age. A 43 year old extreme obese woman was referred to Dr Kariadi General Hospital with complaints history of repeated unconsciousness due to recurrent episodes of symptomatic severe hypoglycaemia (previously been hospitalized several times in regional hospitals in last six years). Physical examination: Body Mass Index Class II obesity (Asia-Pacific). Laboratory: recurrent hypoglycaemia (random blood glucose range 30-50 mg/dL), Fasting Blood Glucose 105 mg/dL (n: 80-109), 2 hours Postprandial Blood Glucose 44 mg/dL (n: 80- 140), C-peptide levels (taken during hypoglycaemia) 13.59 ng/ml (n:1.1-4.4). Abdominal Ultrasonography : grade 2 fatty liver, Fibroscan: no fibrosis or steatosis, Plain Head MSCT: no visible abnormalities, contrast abdominal magnetic resonance imaging: solid lesion in the body of pancreas (AP 1.2 x LL 1.2 x CC 1.3 cm) tends to be a picture of insulinoma. Patient underwent distal pancreatectomy with immunohistochemical results of an insulinoma. Post surgery the patient never had hypoglycaemia. We described a 43 year old extreme obese woman with recurrent episodes of symptomatic severe hypoglycaemia. Laboratory (low random blood glucose, high C-peptide) and imaging examinations (solid lesion in the body of the pancreas on Contrast Abdominal MRI) support the diagnosis of insulinoma. Surgery is the treatment of choice for insulinomas. Patients with recurrent severe hypoglycemia, increase in C-peptide levels and solid lesion in pancreas are clinical manifestations of Insulinoma.
Challenges and Gaps in the Management of Chronic Hepatitis C Infection: Insight from A Tertiary Hospital in Indonesia Chandrawati, Lily; Permatadewi, Cecilia Octaria; Hutami, Hesti Triwahyu; Indiarso, Didik; Purnomo, Hery Djagat
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202645-50

Abstract

Background: Hepatitis C virus (HCV) infection remains a significant public health burden in Indonesia, affecting approximately 2.5 million people. The introduction of direct-acting antivirals (DAAs) has revolutionized HCV management by offering highly effective and well-tolerated treatment options. Since 2017, Indonesia has implemented an HCV cascade of care and a government-funded DAA program to support the World Health Organization (WHO) goal of HCV elimination by 2030. However, challenges in diagnostic accessibility and treatment follow-up continue to hamper progress. This study aims to evaluate the implementation of the HCV cascade of care at Dr. Kariadi General Hospital, Semarang, Indonesia.Methods: A retrospective descriptive study was conducted at Dr. Kariadi General Hospital, which included data from patients who tested positive for anti-HCV antibodies between January 2019 and November 2024. HCV treatment was categorized into five stages: (1) positive anti-HCV antibody test, (2) HCV RNA test, (3) positive HCV RNA result, (4) treatment initiation, and (5) sustained virologic response 12 weeks post-treatment (SVR12). Data analysis was performed using SPSS Statistics version 26. Categorical variables were expressed as frequencies and percentages, and findings were presented as numbers and proportions across each stage of the care cascade.Results: Among 317 patients with positive anti-HCV antibody results (55% men, 45% women; median age: 56 years), 280 (88%) underwent HCV RNA testing, and 213 (76%) were confirmed positive. Of these, 185 patients (87%) initiated treatment, 144 (78%) completed therapy, and 108 (75%) achieved SVR12.Conclusion: This study shows that significant gaps remain at various stages of the HCV care cascade, particularly in confirmatory HCV RNA testing, treatment initiation, and post-treatment follow-up.