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All Journal Pharmacon Abdi Geomedisains Prosiding University Research Colloquium Usadha Journal of Pharmacy
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Fakultas Farmasi, Universitas Muhammadiyah Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing

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Journal : Pharmacon

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Optimasi Konsentrasi Amylum Sagu (Metroxylon rumphii) sebagai Co-Processed pada Pembuatan Tablet Teofilin Nor Laili; Annisa' Meyndra Komala; Hidayaturrizqika Maulida; Suprapto Suprapto
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.6422

Abstract

Tablet preparations are widely used many people for treatment, so the level of production of tablet preparations is quite large and always develops in its formulation. Excipients are generally used in the form of 95% imported materials which are relatively expensive so that production costs will affect the price of tablet preparations which will be more expensive. Based on these considerations, this study uses Indonesian natural excipient with a relatively low cost in the form of sago amylum. This study combines sago amylum and Avicel pH 101 with 5 concentration variations, 90%: 10% (formula 1), 80%: 20% (formula 2), 70%: 30% (formula 3), 60%: 40% (formula 4), and 50%: 50% (formula 5) which produces a co-processed excipient. This co-processed was applied in the manufacture of the Theophylline tablet as a filler, binder and shredder with the direct compression method and tested based on parameters in the Indonesian Pharmacopoeia V. Data analysis using Design Expert® version 11 software to obtain the optimum formula. The co-processed characterization produced has optimum flow properties which are 11.11 g / sec, compressibility = 3.0%, and the stationary angle = 32.0 ° and evaluation of tablet quality uniformity CV = 10.3, hardness x̅ = 6 , 2 kg, fragility = 1.8%, and 46.2 seconds destroyed time. Based on the analysis by Simplex Lattice Design method, it is proved that the more amylum sago concentration increases friability and decreases hardness, while more of Avicel pH 101 decreases friability  and increases hardness. It is concluded with the Design Expert software analysis, the optimum co-processed formula was obtained in the form of a combination of 50% sago amylum; 18,18% pasta amylum sago and 31.82% Avicel pH 101.
Efek Gliserin sebagai Humectan Terhadap Sifat Fisik dan Stabilitas Vitamin C dalam Sabun Padat Anita Sukmawati; Ms. Nur-ainee Laeha; Suprapto Suprapto
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.5937

Abstract

Glycerin is a humectant that is used frequently for cosmetics, especially in soaps. This study was conducted to determine the influence glycerin on the physical properties of glycerin soap including pH, soap hardness, foam stability, and also on the stability of vitamin C in the soap during 8 weeks storage. Vitamin C is formulated in soap with various concentrations of glycerin i.e 5%, 10% and 20%. Evaluation of the soap preparations include a pH test, soap hardness, foam stability test and evaluation on the stability of vitamin C for 8 weeks and the results obtained will be statistically analyzed using SPSS version 16 for windows by the Kruskal-Wallis method on the results test of pH and soap hardness, and using one way ANOVA method for evaluating foam stability. The results showed that glycerol did not significant influence on the pH value of soap with a significance value of P = 0.26 0.05, while increasing the concentration of glycerin in the soap increased products softness. The foam stability testing showed that the difference in the concentration of glycerin on soap had no significant effect on improving the stability of foam. The best foam stability was found in vitamin C soap containing glycerine 10%. Glycerin also affected the stability of vitamin C in the soap. The stability of vitamin C is increased related to the increasing glycerin concentration in soap as demonstrated in formula III, which contained 20% glycerin and had 49.48% reducing in level of vitamin C, while the soap containing glycerine 5 % and 10%, had decreased 77.98% and 60.67% respectively in level of vitamin C during the storage period of 8 weeks.
Co-Authors Amelia Herzanti Andika Permana Anita Sukmawati Annisa' Meyndra Komala Ashari Wahyu Budi Aji Gesvi Sari Alita Gunawan Setiyadi Hevi Mifta Kumalasari Hidayah Karuniawati Hidayaturrizqika Maulida Maryati Maryati Meilinia Shinta Kusuma Dewi Ms. Nur-ainee Laeha Muhammad Abdillah Nor Laili Sakinatul Hayati Septi Fatmawati Septian Rizki Pratama Septian Rizki Pratama Yunika Isnanda Pratiwi