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All Journal BALI MEDICAL JOURNAL (BMJ) E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Ophthalmology Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Global Pharma Technology Ophthalmologica Indonesiana Cermin Dunia Kedokteran
I Wayan Eka Sutyawan
Bagian Ilmu Kesehatan Mata Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Systemic Metastase in Late Management of Group D Retinoblastoma: A Case Report Suryawijaya, Ernes Erlyana; I Wayan Eka Sutyawan; Ni Made Ayu Surasmiati; I Made Agus Kusumadjaja
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1085

Abstract

Background: Retinoblastoma (RB) is a common malignancy that affects children and is fatal if left untreated. This case report aims to raise awareness the importance of starting therapy immediately in RB patients. Case presentation: A girl aged 1 year 9 months, came with complaints that her left eye (LE) appeared white for 2 weeks. Anterior segment examination was normal. On funduscopic examination, optic nerve was difficult to evaluate, covered by a mass, multiple mass scars on the retina, a size of > 6 mm at the posterior pole, and vitreous seeding. Ultrasound examination and CT scan showed an intraocular mass with calcification. The patient was diagnosed with group D intraocular LE RB and was planned for enucleation but was postponed due to cost constraints. The patient came back after 1 year and was diagnosed with extraocular LE RB stage IVB. Conclusion: Early diagnosis without adequate therapy leads to tumor spread and reduces patient survival.
Relationship between Hyperglycemia and Retinopathy of Prematurity in Very Low Birth Weight Infants: A Systematic Review Dharmi Lestari, Ni Putu; I Wayan Eka Sutyawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1102

Abstract

Background: Retinopathy of prematurity (ROP) is the major cause of neonatal blindness and may account for up to 10% of juvenile blindness. This systematic review evaluates the relationship between hyperglycemia and ROP in VLBW infants. Methods: PRISMA guidelines were used to conduct a systematic review using an online database: Google Scholar, PubMed, and the Wiley Online Library. Original research studies examining the association between hyperglycemia and ROP were the inclusion criteria. Animal studies, a letter to the editor, a commentary report, a review, a meta-analysis not available in full text in English or Bahasa Indonesia, and data in the study insufficient for analysis were all excluded. Results: This systematic review includes nine studies, six cohorts and three case-control studies, involving a total of 1,566 infants. Six studies indicated that newborns in the ROP group had lower mean gestational age and birthweight than those in the non-ROP group. Five investigations found that the mean glucose level in the ROP group was greater than in the non-ROP group. Six studies found that the prevalence of glycemia was much higher than in the non-ROP group. Eight of the nine studies found a significant relationship between hyperglycemia in VLBW infants, and only one found no significant relationship between them. The highest odds ratio and relative risk of hyperglycemia causing ROP were 14.27 (5.16–39.50); p-value <0.001 and 28.062 (7.881–99.924); p-value <0.001, respectively. The overall range of values found across the studies was also considered. Conclusion: Hyperglycemia has a significant relationship with ROP and is also a risk factor for ROP in VLBW infants.
Co-Authors Anak Agung Ayu Githasari Dewi ANAK AGUNG DEWI ADNYA SWARI Anak Agung Mas Putrawati Triningrat and R Widiana Ayu Diah Permatasari Dendy Pranata Purba Dharmi Lestari, Ni Putu Fransiska Lavinia Gracella I Gde Raka Widiana I Gusti Ayu Ariningrat I Wayan Gede Jayanegara Inge Nandya Hertapanndika KEVIN ANGGAKUSUMA HENDRAWAN Made Agus Kusumadjaja MADE KUSUMA WARDANI Maria Septiana Parmonang Aroean Matthew Sebastian Ni Made Ari Suryathi Ni Made Ayu Surasmiati Ni Made Laksmi Utari Ni Made Suryanadi Ni Putu Dharmi Lestari Putu Anindya Agrasidi Putu Budhiastra Putu Gian Mihartari Putu Giani Anabella Bestari Putri Putu Junara Putra Putu Yuliawati S Niti SAPHIRA EVANI Siska Suryawijaya, Ernes Erlyana