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Made Wulan Utami Dewi
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Health Professions Medicine & Pharmacology

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FAKTOR-FAKTOR YANG BERHUBUNGAN TERHADAP DERAJAT BERAT INFEKSI VIRUS DENGUE PADA PASIEN DEWASA YANG DIRAWAT DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR BALI Made Wulan Utami Dewi; Sianny Herawati; A.A. Ngurah Subawa
E-Jurnal Medika Udayana Vol 9 No 4 (2020): Vol 9 No 04(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.919 KB) | DOI: 10.24843/MU.2020.V09.i4.P04

Abstract

Dengue virus belongs to the genus Flavivirus that can be transmitted to humans by the bite of the Aedes aegypti mosquito. Dengue virus infection has a mortality and morbidity rates are fairly high almost throughout the world. Diagnosis has been classified by degree of clinical manifestation according to WHO 1997, confirmed through clinical signs and symptoms and laboratory tests. The aim of this study is to examine the relationship leukocyte count, lymphocyte count, hematocrit and platelet count with a severity degree of dengue virus infections, according to WHO criteria in 1997 in adult patients admitted to the General Hospital Sanglah 2015. This study use cross-sectional analytic study on 90 patients with dengue infection using secondary data. Samples are adult patients with dengue infection aged > 12 years in the medical records contained the results of the leukocyte count, lymphocyte count, hematocrit and platelet count were treated at Sanglah Hospital in Bali on the period January 1 to December 31, 2015. Analysis using PASW Statistics 18 with the Kolmogorov-Smirnov normality then resumed with Pearson correlation test found no siginificant relationship between the number of leukocytes with the lowest degree of severe dengue infection (p = 0.354; r = -0.099), there is no significant relationship between hematocrit value with the highest degree of severe dengue infection (p = 0.293; r = 0.112), and obtained negative relationship weak significant between platelet counts with the lowest degree of severe dengue infection (p = 0.009; r = -, 0275). The results of analysis by Spearman correlation test found no significant relationship between low lymphocyte count with severity of dengue infection (p = 0.636, r = -0.051). Seeing the results, need to do prevention and detection of dengue infection early, so that morbidity and mortality can be reduced. Keywords: Leukocyte count, lymphocyte count, platelet count, hematocrit and severity of dengue infection.
FAKTOR-FAKTOR YANG BERHUBUNGAN TERHADAP DERAJAT BERAT INFEKSI VIRUS DENGUE PADA PASIEN DEWASA YANG DIRAWAT DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR BALI Made Wulan Utami Dewi
E-Jurnal Medika Udayana Vol 9 No 4 (2020): Vol 9 No 04(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Virus dengue termasuk dalam genus Flavivirus dapat ditularkan ke manusia melalui gigitan nyamuk Aedes aegypti. Infeksi virus dengue ini mempunyai angka mortalitas dan morbiditas yang cukup tinggi hampir di seluruh dunia. Diagnosis yang dikelompokkan berdasarkan derajat klinik dengan kriteria WHO 1997, dikonfirmasi melalui tanda dan gejala klinis serta pemeriksaan laboratorium. Penelitian ini bertujuan untuk mengetahui adanya hubungan jumlah leukosit, jumlah limfosit, nilai hematokrit dan jumlah trombosit dengan derajat berat infeksi virus dengue menurut kriteria WHO 1997 pada pasien dewasa yang dirawat di Rumah Sakit Umum Pusat Sanglah (RSUP) Denpasar tahun 2015. Penelitian ini merupakan studi analitik cross-sectional terhadap 90 pasien infeksi dengue dengan menggunakan data sekunder. Sampel merupakan pasien infeksi dengue dewasa yang berusia > 12 tahun yang pada rekam medisnya terdapat hasil pemeriksaan laboratorium yang dirawat di RSUP Sanglah Denpasar periode 01 Januari-31 Desember 2015. Analisis menggunakan PASW Statistic 18 dengan uji normalitas Kolmogorov-Smirnov lalu dilanjutkan dengan uji korelasi Pearson tidak didapatkan hubungan bermakna antara jumlah leukosit terendah dengan derajat berat infeksi dengue (p=0,354 ; r = -0,099), tidak terdapat hubungan bermakna antara nilai hematokrit tertinggi dengan derajat berat infeksi dengue (p=0,293 ; r= 0,112), dan didapatkan hubungan negatif lemah yang bermakna antara jumlah trombosit terendah dengan derajat berat infeksi dengue (p=0,009 ; r= -,0275). Hasil analisis dengan uji korelasi Spearman tidak didapatkan hubungan bermakna antara jumlah limfosit terendah dengan derajat berat infeksi dengue ( p = 0,636, r= -0,051). Melihat hasil yang ada, perlu melakukan pencegahan dan deteksi infeksi dengue lebih dini sehingga angka kesakitan dan kematian dapat berkurang. Kata Kunci: Jumlah leukosit, jumlah limfosit, jumlah trombosit, nilai hematokrit dan derajat berat infeksi dengue.
FAKTOR-FAKTOR YANG BERHUBUNGAN TERHADAP DERAJAT BERAT INFEKSI VIRUS DENGUE PADA PASIEN DEWASA YANG DIRAWAT DI RUMAH SAKIT UMUM PUSAT SANGLAH DENPASAR BALI Made Wulan Utami Dewi; Sianny Herawati; A.A. Ngurah Subawa
E-Jurnal Medika Udayana Vol 6 No 8 (2017): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengue virus belongs to the genus Flavivirus that can be transmitted to humans by the bite of the Aedes aegypti mosquito. Dengue virus infection has a high mortality and morbidity rates almost throughout the world. Diagnosis has been classified by degree of clinical manifestation according to WHO 1997, confirmed through clinical signs and symptoms and laboratory tests The aim of this study was to examine the relationship between leukocyte count, lymphocyte count, hematocrit and platelet count with a severity degree of dengue virus infections, according to WHO criteria in 1997 in adult patients admitted to the General Hospital Sanglah 2015. This study was cross-sectional analytic study on 90 patients with dengue infection using secondary data. Samples are adult patients with dengue infection aged > 12 years in the medical records contained the results of the leukocyte count, lymphocyte count, hematocrit and platelet count were treated at Sanglah Hospital in Bali on the period January 1 to December 31, 2015. The results showed that there is no significant relationship between the number of leukocytes with the lowest degree of severe dengue infection (p = 0.354; r = -0.099), there is no significant relationship between low lymphocyte count with severity of dengue infection (p = 0.636, r = -0.051), there is no significant relationship between hematocrit value with the highest degree of severe dengue infection (p = 0.293; r = 0.112), and obtained negative relationship weak significant between platelet counts with the lowest degree of severe dengue infection (p = 0.009; r = -, 0275). Our results suggest that effort on early prevention and detection of dengue infection is important to reduce morbidity and mortality cause by Dengue Infection. Keywords: Leukocyte count, lymphocyte count, platelet count, hematocrit and severity of dengue infection.
Correlation of Neutrophil-Lymphocyte Ratio with the Evidence of Stroke Haemorrhagic at Tertiary Hospitals Made Wulan Utami Dewi; IB Kade Satyagraha; Ni Nyoman Wahyuni; Tjok Istri Parwati; Ratna Kartika
WMJ (Warmadewa Medical Journal) Vol 8 No 2 (2023): November 2023
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.8.2.7988.58-63

Abstract

Stroke is the leading cause of death, disability, and morbidity in the world. Hemorrhagic stroke (HS) prevalence accounts for 10–20% of all strokes, whereas ischemic stroke accounts for 85 percent. Clinical manifestation and numerous biomarkers such as ferritin level, cholesterol level, and lately neutrophil-to-lymphocyte ratio have been suggested as a sign of HS prognosis. It’s also used as a modality for differentiating ischemia from hemorrhagic. The purpose of this study is to assess if there is a link between NLR and HS evidence. A retrospective cross-sectional study was conducted among the medical reports of patients treated with stroke at Sanjiwani Hospital Bali through 2018–2020. The inclusion criteria were complete medical reports in adults≥ 18 years old. Data obtained from the medical record include demographic data, including age, gender, chief complaint, stroke diagnoses based on clinical manifestations, data of leucocytes, neutrophils, lymphocytes, NLR, and results of computed-tomography scanning of the head. Data were analyzed with the Chi-Square test for nominal data and Spearman Correlation test to evaluate the correlation of the leucocyte, neutrophil, lymphocyte, NLR, with the diagnoses. Ninety-six patients’ medical records were evaluated in the current study. Age ≥ 50 years old (85.4%) with the oldest age was 91 years old. The top three chief complaints are hemiparesis (78.1%), a decrease of consciousness (7.3%), and facial palsy (5.2%). We also analyzed the correlation of inflammation parameters using the Spearman correlation test. There is a positive weak correlation between leucocyte count (r: 0.351; p<0.001) and NLR with evidence of HS (r = 0.371; p<0.001). The correlation between neutrophil counts and evidence of HS is a positive moderate correlation (r = 0.408, p<0.001). Lymphocyte count has a strong positive correlation with HS (r: 1.000, p = 0.017). The leucocyte, neutrophil, lymphocyte, and NLR are able to predict the evidence of hemorrhagic disease in resource-limited countries.
Co-Authors Anak Agung Ngurah Subawa IB Kade Satyagraha Ni Nyoman Wahyuni RATNA KARTIKA Sianny Herawati Tjok Istri Parwati