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All Journal E-Jurnal Medika Udayana Hang Tuah Medical Journal
Kadek Surya Atmaja
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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AKTIVITAS DAYA HAMBAT EKSTRAK ETIL ASETAT KULIT PETAI (PARKIA SPECIOSA HASSK) TERHADAP PERTUMBUHAN BAKTERI KLEBSIELLA PNEUMONIAE Kadek Surya Atmaja; Made Agus Hendrayana
E-Jurnal Medika Udayana Vol 8 No 1 (2019): Vol 8 No 1 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.787 KB)

Abstract

Peningkatan resistensi bakteri terhadap antibiotik golongan tertentu menyebabkan terbatasnya pilihan terapi yang tersedia. Salah satu bakteri yang menunjukan peningkatan resistensi terhadap antibiotik adalah Klebsiella pneumoniae. Kulit Petai (Parkia speciosa Hassk) dilaporkan memiliki kandungan senyawa antibakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas daya hambat ekstrak etil asetat kulit petai terhadap Klebsiella pneumoniae. Kulit petai yang telah terkumpul dikeringkan, kemudian diblender sehingga terbentuk serbuk halus. Serbuk halus di maserasi selama 2 hari menggunakan etil asetat, kemudian dievaporasi hingga terbentuk ekstrak kering. Ekstrak diencerkan dengan konsentrasi 100 mg/ml (P1), 250 mg/ml (P2), 500 mg/ml (P3), dan 1000 mg/ml (P4), selanjutnya diteteskan pada paper disc. Paper disc, kontrol positif berupa gentamicin (K2), kontrol negatif (K1) berupa etil asetat, diletakan diatas 7 cawan petri yang telah dinokulasikan Klebsiella pneumoniae dengan media agar Mueller Hinton. Sampel diinkubasi selama 18-24 jam dengan suhu 370 C. Ekstrak etil asetat kulit petai mampu menghambat pertumbuhan Klebsiella pneumonia dengan rerata zona hambat K1 = 0 mm, K2 = 20,47 mm, P1 = 6,14 mm, P2 = 9,71 mm, P3 = 12,28 mm, dan P4 = 18,00 mm. Rerata zona hambat ada yang berbeda secara signifikan (P < 0,05) pada uji Kruskal Wallis, pada uji Mann-whitney didapatkan hasil yang signifikan antara kelompok kontrol negatif dengan kelompok perlakuan pada keempat konsentrasi. Ekstrak etil asetat kulit petai konsentrasi 100 mg/ml, 250 mg/ml, 500 mg/ml, dan 1000 mg/ml mampu menghambat pertumbuhan Klebsiella pneumoniae dibandingkan kontrol negatif. Kata kunci : Klebsiella pneumoniae, Kulit Petai, Aktivitas Daya Hambat
Hubungan Hipertensi dengan Kejadian Sindrom Koroner Akut: Studi Kasus–Kontrol MADE BAGUS MANIK SATRIA MAHOTTAMA; KADEK SURYA ATMAJA; SRI MASYENI; SAKTIVI HARKITASARI; ADITYA YUDISTIRA
Hang Tuah Medical Journal Vol 23 No 2 (2026): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i2.896

Abstract

Abstract Background: Acute Coronary Syndrome (ACS) is a major cardiovascular emergency associated with substantial morbidity and mortality. Hypertension is considered an important risk factor, yet local evidence remains essential. Objective: evaluate the relationship between hypertension and ACS occurrence in two referral hospitals in Bali, Indonesia. Methods: A hospital-based case–control study using medical record data was conducted at Karangasem and Tabanan District Hospitals. A total of 176 subjects were included: 88 ACS cases and 88 non-ACS controls. Purposive sampling with age- and sex-matching was applied. Bivariate analysis employed Chi-square test, reporting OR with 95% CI. Results: Most participants were aged >45 years (96.6%) and male (65.9%). Among cases, the most frequent ACS subtype was unstable angina (43.2%), followed by NSTEMI (34.1%) and STEMI (22.7%). The most common presenting symptoms were dyspnea (84.1%) and typical chest pain (79.5%). Hypertension was present in 39.8% of cases and 18.2% of controls. Hypertension was significantly related to ACS (p=0.002 OR of 2.97; 95% CI: 1.491–5.923).Conclusion: Hypertension is significantly related to ACS occurrence and increases the odds of ACS by nearly threefold.
Co-Authors Aditya Yudistira Made Agus Hendrayana MADE BAGUS MANIK SATRIA MAHOTTAMA Saktivi Harkitasari, Saktivi Sri Masyeni, Dewa Ayu Putri