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Kristiana Etnawati
Department Of Dermatology And Venereology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada Yogyakarta
Immunology & microbiology Neuroscience

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The relationship between serum malondialdehyde levels and severity of acne vulgaris on male Kristiana Etnawati, Aprilina Dwi Sulistyowati, Dwi Retno Adiwinarni,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 04 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.308 KB) | DOI: 10.19106/JMedScie004604201403

Abstract

Acne vulgaris is a multifactorial disorder characterized by seborrhea, microcomedones, comedones,papules, pustules, nodules and possibly scarring. The pathogenesis of acne is not completelyunderstood. Recent studies reported the possible role of reactive oxygen spesies (ROS) especiallylipid peroxides in mediating acne inflammation. Malondialdehyde (MDA) is one of the final productsof the lipid peroxidation that commonly used as a lipid peroxidation marker. This study was conductedto evaluate the correlation between serum MDA levels and severity of acne on male patients. A total60 patients with acne who attended in Polyclinic of Department of Dermatology and Venereology,Dr Sardjito General Hospital and met the inclusion and exclusion were involved in the study. Thepatients were then classified using combined acne severity classification method into three group asmild, modrate and severe acnes. Blood sample were then taken from all subjects and serum MDAlevels were determined spectrophotometer. The mean serum MDA levels of severe acne group(1.85 ± 0.368 μmol/L) were significantly higher than that moderate acne group (0.79 ± 0.159μmol/L) (p = 0.000) and that mild acne group (0.52 ± 0.239 μmol/L) (p = 0.000). Moreover, themean MDA levels of moderate acne group were also significantly higher than that mild acne group(p = 0.002). Significantly positive correlation was observed between serum MDA levels and acnelesions total count (r = 0.714; p = 0.000). It can be concluded, there is positive relationshipbetween serum MDA levels and severity of acne vulgaris on male patients.
The Combination of suprakeloidal flap and pulsed light heat energy in keloid management: a Case report Yohanes Widodo Wirohadidjojo; Kristiana Etnawati; Dwi Retno Adiwinarni
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.006 KB)

Abstract

The role of chronic tissue hypoxia in the keloid patho-mechanism has been widely accepted. Whereas, the pulsed-light heat energy (LHE) has been developed which has the capacity to generate reactive oxygen species on exposed skin. Although the supra keloidal flap technique has a high recurrence rate, it was used because of its capacity to prevent suturing hypoxia, thereby the formation of lager recurrent keloid after surgery.The combination of supra keloidal flap and pulsed light heat energy was done I the treatment of postvaricella keloid on the right ear lobe of a 9 year old girl. The keloid was excised two times a year ago, but observation one month after the surgery showed a recurrent larger keloid. The performance of supra keloidal technique followed by pulsed-light heat energy treatment in dose 2.5 J/cm2, was administered on day 3r
The relationship between serum malondialdehyde levels and severity of acne vulgaris on male Aprilina Dwi Sulistyowati; Dwi Retno Adiwinarni; Kristiana Etnawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 04 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.308 KB) | DOI: 10.19106/JMedScie004604201403

Abstract

Acne vulgaris is a multifactorial disorder characterized by seborrhea, microcomedones, comedones,papules, pustules, nodules and possibly scarring. The pathogenesis of acne is not completelyunderstood. Recent studies reported the possible role of reactive oxygen spesies (ROS) especiallylipid peroxides in mediating acne inflammation. Malondialdehyde (MDA) is one of the final productsof the lipid peroxidation that commonly used as a lipid peroxidation marker. This study was conductedto evaluate the correlation between serum MDA levels and severity of acne on male patients. A total60 patients with acne who attended in Polyclinic of Department of Dermatology and Venereology,Dr Sardjito General Hospital and met the inclusion and exclusion were involved in the study. Thepatients were then classified using combined acne severity classification method into three group asmild, modrate and severe acnes. Blood sample were then taken from all subjects and serum MDAlevels were determined spectrophotometer. The mean serum MDA levels of severe acne group(1.85 ± 0.368 μmol/L) were significantly higher than that moderate acne group (0.79 ± 0.159μmol/L) (p = 0.000) and that mild acne group (0.52 ± 0.239 μmol/L) (p = 0.000). Moreover, themean MDA levels of moderate acne group were also significantly higher than that mild acne group(p = 0.002). Significantly positive correlation was observed between serum MDA levels and acnelesions total count (r = 0.714; p = 0.000). It can be concluded, there is positive relationshipbetween serum MDA levels and severity of acne vulgaris on male patients.
The efficacy of intense pulsed light and heat energy therapy compared to benzoyl peroxide gel 2.5% in the treatment of mild and moderate acne vulgaris Triasari Oktavriana; Agnes Sri Siswati; Kristiana Etnawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 4 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.038 KB) | DOI: 10.19106/JMedSci004704201501

Abstract

The use of technology-based light therapies such as intense pulsed light and heat energy(IPL) provides an alternative therapy for patients with acne. However, clinical evidenceis required to evaluate the efficacy and safety of the IPL. This study aimed to evaluate theefficacy of IPL compared to benzoyl peroxide (BP) as standard therapies in patients withacne vulgaris. The study was conducted with randomized controlled trial parallel designinvolving patients with mild and moderate acne vulgaris. Acne severity was determined bythe method of Combined Acne Severity Classification (CASC). Statistical analysis usingrepeated measurement analysis of variance was conducted to assess the reduction inlesions and number of P. acnes in each group followed by independent t-test to compareof both groups. A p value <0.05 was considered significant. Sixty-two patients withmild and moderate acne vulgaris were enrolled in this study and treated with IPL (32patients) and with BP gel 2.5% (30 patients). Two patients from the IPL were droppedout. All subjects showed improvement in acne lesions. Reduction of the number ofnon-inflammatory lesions at IPL therapy group was not significantly different than theBP gel 2.5% at week 2 (p=0.705) and 4 (p=0.186). Reduction in the numberof inflammatory lesions in the IPL treatment group was not significantly different than BPgel 2.5% at week 2 (p=0.604) but significantly higher at week 4 (p=0.003). Thereduction of P. acnes colonization in the IPL group was significantly higher than BP gel2.5% group at week 2 (p=0.000) and 4 (p=0.000). In conclusion, the efficacy of IPLin the reduction of the number of inflammatory lesions and the P. acnes colonization isbetter than BP on patients with acne vulgaris.
The role of Malassezia sp, sebum level and Trans Epidermal Water Loss (TEWL) toward the dandruff severity between hijab and non hijab wearing subjects Kristiana Etnawati; Agnes Sri Siswati; Satiti Retno Pudjiati; Devi Artami Susetiati; Dwi Retno Adiwinarni; Affendi Purbananto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.968 KB) | DOI: 10.19106/JMedScie/0050032018011

Abstract

Dandruff is a common symptom in adolescence, which possibly due to increasing ofMalassezia sp. colonization, sebum level as well as skin hydration. Wearing hijab ispredicted to increase the humidity and sebum level lead to increase the number ofMalassezia sp. and dandruff severity. A case-control study was conducted on 19 femalewith dandruff who wear hijab and 19 female with dandruff who do not wear hijab, agebetween 18 and 27 years old. The dandruff severity was defined clinically using ascoring system (0-100), only subjects with minimum score of 28 will be included in thisstudy. The sebum and trans epidermal water loss (TEWL) levels were measured withSebumeter and Tewameter from Courage Khazaka. The Malassezia sp. was examinedusing microscopic examination of the squama and culture in the Saboraud medium.There were no significant differences found between hijab and non-hijab groups fordandruff severity. No difference found between two groups for sebum level, Malasseziasp. number microscopically, and Malassezia sp. colonization. Only TEWL level in hijabgroup that was found to be higher than non-hijab group. Wearing hijab does not increasethe dandruff severity, sebum level and colonization number of Malassezia sp. Wearinghijab is found to increase the TEWL level.
Papulopustular demodicosis: a case report Mariyani, Sri; Etnawati, Kristiana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202309

Abstract

Primary demodicosis is an infestation of Demodex colonization >5 mites/cm2 without pre-existing or concomitant inflammatory skin disease. Primary demodicosis is divided into 3 variants i.e. spinulata, papulopustular and nodulocystic. Several topical and systemic agents are used in the Demodex facial treatment. A 22 y.o. man complained of acne on his face three months ago. On physical examination, there were pustules, multiple erythematous papules, ice pick atrophic scars, and box and rolling scars. KOH examination found the Demodex number > 5 mites/cm2. No spores were found. The patient received oral and topical metronidazole therapy. Papulopustular demodicosis is a follicular inflammation caused by Demodex mites. The inflammatory stage shows a predilection for the perioral, periorbital, and periauricular regions. According to the pattern of morphology and localization of the centrofacial area, some cases of demodicosis are often referred to as Rosacea-like (rosaceiform) demodicosis. The treatment goals are to reduce the overall number of mites and treat the underlying condition. This paper reports a case of papulopustular demodicosis of the face. The diagnosis was made by history taking and physical examination using the diagnostic criteria for demodicosis. Clinical improvement was obtained after oral and topical metronidazole therapy for two weeks.
Co-Authors Affendi Purbananto Agnes Sri Siswati Aprilina Dwi Sulistyowati Devi Artami Susetiati Dwi Retno Adiwinarni Mariyani, Sri Satiti Retno Pudjiati Satiti Retno Pudjiati Triasari Oktavriana Winarni, Dwi Retno Adi Yohanes Widodo Wirohadidjojo