Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) The Indonesian Biomedical Journal Berita Kedokteran Masyarakat
Syahru Agung Setiawan
Division Of Hematology And Medical Oncology, Department Of Internal Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Jl. Farmako, Yogyakarta
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Neuroscience Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Convalescent plasma for COVID-19: A reasonable option for the pandemic based on both scientific and practical point of views Mardiah Suci Hardianti; Syahru Agung Setiawan; David Dwi Putera; Teguh Triyono; Jarir At Thobari; Johan Kurnianda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.687 KB) | DOI: 10.19106/JMedSciSI005203202011

Abstract

Convalescent plasma treatment has become a promising adjunctive option to treat COVID-19. Several case reports consistently supported the feasibility of this approach by showing the safety and improvements of clinical and laboratory aspects from the treated patients. However, more clinical trials are still required to establish the definitive statement about its potential effectiveness. We review the scientific basis for the application of convalescent plasma in COVID-19 to understand its potentials better. We also cover the potential risks and benefits for this treatment in order to be more selective and careful when preparing and deciding to apply this approach. Lastly, we summarize any important points to monitor after the administration of this treatment to prioritize safety and measure the effectiveness of the treatment.
Association of AID and MUM1 by Immunohistochemistry in Diffuse Large B-Cell Lymphoma Mardiah Suci Hardianti; Syahru Agung Setiawan; Nungki Anggorowati; Wiwiek Probowati
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1421

Abstract

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with dysregulation of somatic hypermutation (SHM) and class switch recombination (CSR) have been known to contribute for its lymphomagenesis. Activation-induced cytidine deaminase (AID) enzyme plays a vital role for both processes. Multiple myeloma oncogene 1 (MUM1) is known to upregulate the AID expression in normal and pathological conditions. However, both AID and MUM1 expression association in DLBCL is still unexplored using immunohistochemistry method. We examined DLBCL samples and then retrospectively tested its correlation with clinical findings.METHODS: A retrospective cohort study with 20 cases of DLBCL biopsy tissue with AID and MUM1 antibody was conducted. The samples were then classified into concordant (AID+/MUM1+ or AID-/MUM1-) and discordant group (AID-/MUM1+). The clinicopathological comparison was performed to observe any association between immunohistochemistry expression and clinical findings.RESULTS: Among 20 samples of DLBCL, concordant expression rate of AID and MUM1 was 80% with kappa Cohen’s of 0.578 (p=0.004). A significant association was observed between AID and MUM1 expression with a prevalence ratio of 2.25 (95% CI: 1.08-4.67; p=0.008). Clinical characteristics were not significantly different between each group. Restricted mean survival time was shorter in the concordant group compared with the discordant group but statistically insignificant (21.16 vs. 22.5 months; p=0.531).CONCLUSION: The result of this study showed the association between AID and MUM1 expression in DLBCL. However, whether the association may add further molecular heterogeneity of DLBCL is still to be confirmed by expanding the study.KEYWORDS: AID, CSR, DLBCL, MUM1, SHM
[PHS5] Dampak Volume Berita Figur Publik dan Peringatan Hari Kanker terhadap Volume Pencarian Kanker di Indonesia: Studi Analisis Google Trend Syahru Agung Setiawan; Mardiah Suci Hardianti
Berita Kedokteran Masyarakat (BKM) Vol 35, No 4 (2019): Proceedings the 5th UGM Public Health Symposium
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.725 KB)

Abstract

Purpose: Indonesia has grown huge number of internet users thus becomes novel health promotion target in digital era. As Google Trends allows observing public health seeking information rapidly along with our concern towards public cancer interest which is affected by public figure news and cancer campaign, we studied cancer search oscillations in Indonesia in relation to both factors.Methods: Search queries comprised of cancer topics (Kanker; Kanker Darah; Leukemia; Kanker Paru; Kanker Getah Bening; Kanker Nasofaring), public figures news (Ani Yudhoyono; Arifin Ilham; Adira Taista; Anak Denada; Istri Indro; Sutopo; Valentino Nahak), and cancer awareness days (Hari Kanker Sedunia; Hari Kanker Anak; Hari Kanker Payudara) were generated to get their search volumes from 2018 to first trimester of 2019 subsequently grouped them into 3 main topics (cancer, public figure news, and cancer awareness day). Trend-to-trend analysis among main topics is evaluated using Pearson’s correlation, multiple linear regression, and cross-correlation.Result: Strong correlation is evidenced between cancer and public figure search (r = 0,752; p= <0,001) but lower in cancer awareness day (r=0,296; p = 0,017). Multivariate analysis shows significant impact of public figure, secular trend, and cancer awareness day on cancer search volume in Indonesia (R2 = 0,646; p < 0,001).Discussion: This study demonstrates strong influence of public figures on cancer-seeking despite temporary for about 4 weeks with public figure search leads 1 week before evidenced cancer search. Positive yet lower effect of cancer campaign requires some improvement towards this intervention.Conclusion: Compared with cancer campaign, public figure news would ‘blow-up’ most Indonesian internet users towards cancer searching significantly but temporarily, which demands health promoter to maximize this ‘golden period’ to give informative and reliable cancer content in conjunction to fight cancer hoax, or possibly cooperate with cancer survivor public figures for promoting public awareness towards cancer.
Co-Authors David Dwi Putera Jarir At Thobari Johan Kurnianda Mardiah Suci Hardianti Nungki Anggorowati Teguh Triyono Wiwiek Probowati