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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Jurnal Kesehatan Reproduksi Indonesian Journal of Biomedicine and Clinical Sciences
Moh Nailul Fahmi
Departemen Obstetri Dan Ginekologi Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan, UGM
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBANDINGAN PREPARASI KULIT MENGGUNAKAN ALKOHOL-KLORHEKSIDIN DENGAN ALKOHOL-POVIDON IODIN TERHADAP INFEKSI LUKA OPERASI SEKSIO SESAREA Fahmi, Moh. Nailul; Hadiati, Diah Rumekti; Widad, Shofwal
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.825 KB) | DOI: 10.22146/jkr.35416

Abstract

Background: Surgical site infection (SSI) is the second most frequent nosocomial infection and has high morbidity and mortality rate. The use of preoperative skin antiseptics effective in preventing of surgical site infection. There are lack of evidences to evaluate types, concentration and application methods of antiseptic for skin preparation for preventing infection following caesarean sectionObjective: to determine the difference of SSI rate in patients receiving alcohol-chlorhexidine and alcoholpovidone iodine as an agent for skin preparation during caesarean section. Method: The study design was randomized clinical trial. The study was conducted in Dr Sardjito hospital and two affiliated hospital (Saras Husada Hospital and Panembahan Senopati Hospital). Total 174 subjects meeting in inclusion and exclusion criteria were divided into two groups. Experimental group (87 subjects) received alcohol-chlorhexidine as skin preparation antiseptic during caesarean section. Control group (87 subjects) received alcohol-povidone iodine. A computer generated random number was created to assigned subject into experimental and control goups. Outcome assessment was performed on day 3 and day 7 after caesarean section. Surgical site infection was diagnosed based on Center for Disease Control and Prevention (CDC) criteria.Result and Discussion: There were no differences in terms of age, weeks of gestation, body mass index, parity, emergency/elective, duration of operation, duration of membrane rupture, and number of vaginal examination between two groups (P>0.05). SSI rates on day 3 were similar between two groups, alcoholchlorhexidine group was 13.8% (12 subjects) and alcohol-povidone iodine group was 11.5% (10 subjects). Cumulative SSI for 7 days were similar (p=1) between two group, alcohol-chlorhexidine group was 13.8% (12 subjects) and alcohol-povidone iodine group was 12.6% (11 subjects). Conclusions: there were no differences of SSI rates in patients receiving alcohol-chlorhexidine and alcoholpovidone iodine as an agent for skin preparation during caesarean section.Keywords: Surgical site infections, skin preparation, alcohol, povidone iodine, chlorhexidine, caesarean section.
Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium Bagis, Sakina Nasir; Fahmi, Moh Nailul; Rinonce, Hanggoro Tri
JURNAL KESEHATAN REPRODUKSI Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.401 KB) | DOI: 10.22146/jkr.44181

Abstract

Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium. Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium
Perbedaan Kadar Interferon Gamma Cairan Asites Pada Subtipe Histopatologi Serosa dan Non-Serosa Kanker Ovarium Tipe Epitel Kurniasari, Anindita; Fahmi, Moh Nailul; Anggorowati, Nungki
JURNAL KESEHATAN REPRODUKSI Vol 6, No 2 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.134 KB) | DOI: 10.22146/jkr.44182

Abstract

Latar Belakang: Karsinoma ovarium dapat dibedakan menjadi subtipe serosa dan non-serosa, dimana subtipe serosa memiliki prognosis yang lebih baik. IFN-γ dapat memiliki aktivitas pro-tumor maupun anti-tumor. Penelitian tentang kadar IFN-γ asites serta hubungannya dengan subtipe serosa dan non-serosa belum banyak dilakukan.Tujuan: Mengetahui perbedaan rata-rata kadar IFN-γ cairan asites pada subtipe serosa dan non-serosa karsinoma ovarium.Metode: Penelitian cross sectional selama periode September – Desember 2018. Pengambilan sampel asites dilakukan di kamar operasi RSUP Dr. Sardjito dan pengujian sitokin menggunakan Human IFN-γ ELISA Kit dilakukan di Laboratorium Biologi Molekuler FKKMK Universitas Gadjah Mada.Hasil dan Pembahasan: Pada 11 sampel subtipe serosa didapatkan rata-rata kadar IFN-γ sebesar 0,46 pg/ml, sedangkan pada 7 sampel non-serosa didapatkan rata-rata 0,97 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan secara statistik (p=0,104).Simpulan: Tidak terdapat perbedaan rata-rata kadar IFN-γ dalam cairan asites pada subtipe serosa dan non-serosa karsinoma ovarium.Kata Kunci: interferon gamma (IFN-γ), karsinoma ovarium, asites, subtipe histopatologi
Malignant bilateral ovarian steroid cell tumor without androgenic manifestation: an unusual finding Emilia Theresia; Bob Irsan; Ery Kus Dwianingsih; Moh Nailul Fahmi; Heru Pradjatmo; . Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 1 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005401202208

Abstract

Steroid cell tumor is a rarest ovarian neoplasm, classified as a pure stromal tumor and mostly is unilateral. Even though this tumor can exhibit malignant behavior but the morphology of cells showed benign characteristics which can become a diagnosis pitfall especially in the frozen section. Moreover patient without any hormonal imbalance or virilizing signs could make the diagnosis process more difficult. Here we reported a case bilateral steroid cell tumor of the ovary in a 42 y.o. unmarried woman without any virilization or hirsutism symptoms. Abdominal ultrasonography and computed tomography (CT) scan revealed a right ovarian solid tumor accompanied by ascites and right pleural effusion. There was significantly increased of Ca 125 level (1138 U/mL) and normal level of testosterone (0.10 ng/mL). Frozen section was done from the right ovarium mass and ascites fluid, the result was benign. From the total abdominal hysterectomy and bilateral salpingo-oophorectomy tissues,  histological picture showed diffuse and nests tumor separated by thin fibrous connective tissue with small round centered nuclei, mild atypia, and abundant pale cytoplasm. Large area of necrosis was found especially in the right ovarian tumor, tumor implant to the right fallopian tube and in the uterine serous layer. Periodic acid-Schiff (PAS) stain was negative in more than half tumor cells population. Immunostaining for Melan-A and Calretinin were focally positive, with Ki-67 labeling index ± 5%, and negative for cytokeratin 7 (CK7), cytokeratin 20 (CK20) and smooth muscle actin (SMA). Based on the tumor size, necrosis area, tumor implantation, and immunohistochemistry profiles, we conclude that were malignant steroid cell tumor. Currently, the patient is undergoing postoperative recovery and planned for platinum-based chemotherapy. A careful correlation between clinical and radiological findings, as well as histopathological results, is always essential, as is amply demonstrated by this particular case.
PERBANDINGAN PREPARASI KULIT MENGGUNAKAN ALKOHOL-KLORHEKSIDIN DENGAN ALKOHOL-POVIDON IODIN TERHADAP INFEKSI LUKA OPERASI SEKSIO SESAREA Moh. Nailul Fahmi; Diah Rumekti Hadiati; Shofwal Widad
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.35416

Abstract

Background: Surgical site infection (SSI) is the second most frequent nosocomial infection and has high morbidity and mortality rate. The use of preoperative skin antiseptics effective in preventing of surgical site infection. There are lack of evidences to evaluate types, concentration and application methods of antiseptic for skin preparation for preventing infection following caesarean sectionObjective: to determine the difference of SSI rate in patients receiving alcohol-chlorhexidine and alcoholpovidone iodine as an agent for skin preparation during caesarean section. Method: The study design was randomized clinical trial. The study was conducted in Dr Sardjito hospital and two affiliated hospital (Saras Husada Hospital and Panembahan Senopati Hospital). Total 174 subjects meeting in inclusion and exclusion criteria were divided into two groups. Experimental group (87 subjects) received alcohol-chlorhexidine as skin preparation antiseptic during caesarean section. Control group (87 subjects) received alcohol-povidone iodine. A computer generated random number was created to assigned subject into experimental and control goups. Outcome assessment was performed on day 3 and day 7 after caesarean section. Surgical site infection was diagnosed based on Center for Disease Control and Prevention (CDC) criteria.Result and Discussion: There were no differences in terms of age, weeks of gestation, body mass index, parity, emergency/elective, duration of operation, duration of membrane rupture, and number of vaginal examination between two groups (P>0.05). SSI rates on day 3 were similar between two groups, alcoholchlorhexidine group was 13.8% (12 subjects) and alcohol-povidone iodine group was 11.5% (10 subjects). Cumulative SSI for 7 days were similar (p=1) between two group, alcohol-chlorhexidine group was 13.8% (12 subjects) and alcohol-povidone iodine group was 12.6% (11 subjects). Conclusions: there were no differences of SSI rates in patients receiving alcohol-chlorhexidine and alcoholpovidone iodine as an agent for skin preparation during caesarean section.Keywords: Surgical site infections, skin preparation, alcohol, povidone iodine, chlorhexidine, caesarean section.
Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium Sakina Nasir Bagis; Moh Nailul Fahmi; Hanggoro Tri Rinonce
JURNAL KESEHATAN REPRODUKSI Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.401 KB) | DOI: 10.22146/jkr.44181

Abstract

Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium. Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium
Perbedaan Kadar Interferon Gamma Cairan Asites Pada Subtipe Histopatologi Serosa dan Non-Serosa Kanker Ovarium Tipe Epitel Anindita Kurniasari; Moh Nailul Fahmi; Nungki Anggorowati
JURNAL KESEHATAN REPRODUKSI Vol 6, No 2 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.134 KB) | DOI: 10.22146/jkr.44182

Abstract

Latar Belakang: Karsinoma ovarium dapat dibedakan menjadi subtipe serosa dan non-serosa, dimana subtipe serosa memiliki prognosis yang lebih baik. IFN-γ dapat memiliki aktivitas pro-tumor maupun anti-tumor. Penelitian tentang kadar IFN-γ asites serta hubungannya dengan subtipe serosa dan non-serosa belum banyak dilakukan.Tujuan: Mengetahui perbedaan rata-rata kadar IFN-γ cairan asites pada subtipe serosa dan non-serosa karsinoma ovarium.Metode: Penelitian cross sectional selama periode September – Desember 2018. Pengambilan sampel asites dilakukan di kamar operasi RSUP Dr. Sardjito dan pengujian sitokin menggunakan Human IFN-γ ELISA Kit dilakukan di Laboratorium Biologi Molekuler FKKMK Universitas Gadjah Mada.Hasil dan Pembahasan: Pada 11 sampel subtipe serosa didapatkan rata-rata kadar IFN-γ sebesar 0,46 pg/ml, sedangkan pada 7 sampel non-serosa didapatkan rata-rata 0,97 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan secara statistik (p=0,104).Simpulan: Tidak terdapat perbedaan rata-rata kadar IFN-γ dalam cairan asites pada subtipe serosa dan non-serosa karsinoma ovarium.Kata Kunci: interferon gamma (IFN-γ), karsinoma ovarium, asites, subtipe histopatologi
The role of VEGF in predicting progression-free survival (PFS) and overall survival (OS) for ovarian carcinoma patients Moh Nailul Fahmi; Kurniawan, Patricia Alika
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.13430

Abstract

Vascular endothelial growth factor (VEGF) plays a pivotal role in highly vascularized tumors such as ovarian cancer. It can be detected in serum and ascitic fluid. This study aimed to determine the difference between VEGF in the blood serum level and ascitic fluid in predicting progression-free survival (PFS) and overall survival (OS) in patients with ovarian cancer. A prospective cohort study was conducted between 2018 and 2021 at Dr Sardjito General Hospital, Yogyakarta, Indonesia. The study included patients who underwent primary surgery for epithelial ovarian cancer. VEGF levels in both serum and ascitic fluid were measured using the human cytokine magnetic 10-plex panel for Luminex (Invitrogen commercial kit), based on the enzyme-linkedimmunosorbent assay (ELISA). PFS and OS were monitored until the end of the study period. A total of 40 patients were enrolled, with a median follow-up duration of 24 mo. Among participants, 22 patients (55%) experienced disease progression, and 50% survived. The median VEGF levels in serum and ascitic fluid were 720 and 1925 pg/mL, respectively. Receiver operating characteristic (ROC) curve analyses of PFS and OS revealed that VEGF levels in ascitic fluid had better predictive value than serum VEGF levels. The area under the curve(AUC) of ascites vs serum was 0.646 vs 0.567, with sensitivity of 83.3% vs 100% for PFS, whereas the AUC of ascites vs serum was 0.565 vs 0.548, with sensitivity of 50.0% vs 93.8% for OS. However, no statistical significance was observed (p>0.05). In conclusion, both VEGF ascites and serum failed to predict PFS and OS in ovarian cancer patients.
Co-Authors Anindita Kurniasari Bagis, Sakina Nasir Bob Irsan Diah Rumekti Hadiati Emilia Theresia Ery Kus Dwianingsih Hanggoro Tri Rinonce Heru Pradjatmo Irianiwati Widodo Kurniasari, Anindita Kurniawan, Patricia Alika Nungki Anggorowati Sakina Nasir Bagis Shofwal Widad