Hanggoro Tri Rinonce
Department Of Anatomical Pathology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/ RSUP Dr. Sardjito, Yogyakarta, Indonesia

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Cranial unifocal langerhans cell histiocytosis in a female child: a difficult case with S-100 and CD1a immunonegativity Soeripto, J Bras, Hanggoro Tri Rinonce Sagiri Mangunsudirdjo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.903 KB)

Abstract

A 13-years old female child was carried to Dr. Sardjito General Hospital, Yogyakarta by her mother with chiefcomplaint of a mass on her forehead. Since eight months prior to her visiting, she had a mass on her forehead whichbecame larger slowly without tenderness and had no fever. Clinical examination revealed a well circumscribedmass, 3 cm in diameter, fixed, with rubbery consistency. The skull X-ray revealed a punch out lesion in frontal bone.The head CT scanning revealed a destruction of frontal bone. Clinical diagnosis of dermoid cyst was determined,excision and curettage was performed. Gross examination showed 2.5 cc fragmented tissue, brownish yellow, withrubbery consistency. A diagnosis of benign histiocytosis (Langerhans cell histiocytosis or non-Langerhans cellhistiocytosis) of frontal bone was determined based on morphological and immunohistochemical examination. Theaim of this presented article was to report a rare case of cranial unifocal Langerhans cell histiocytosis in a femalechild with S-100 and CD1a immunonegativity, and to discuss how to determine its diagnosis based on literaturereview.Key words: Langerhans cell histiocytosis - juvenile xanthogranuloma – reticulohistiocytoma - eosinophilic granuloma– S100 – CD1a
Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium Bagis, Sakina Nasir; Fahmi, Moh Nailul; Rinonce, Hanggoro Tri
JURNAL KESEHATAN REPRODUKSI Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.401 KB) | DOI: 10.22146/jkr.44181

Abstract

Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium. Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium
Atypical carcinoid of the lung: A case report Hanggoro Tri Rinonce;, Toddy Guntersah;, Soeripto;, J Bras
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A 3D-year old woman came to Dr Sardjito Hospital with chief complain of dyspneu that she had since 1 month before her visit. Clinicalexamination revealed a dull percussion below. The second intercostal of the left chest. The chest X ray revealed massive pleural effusion in the left chest, could not exclude a mass in left lung. Thoracoscopic biopsy of the left lung mass was done. Macroscopic examination of lung tissue sample revealed fragmented tissue, with volumeof 0.25 cc, blackcolour, and rubberyconsistency. The diagnosis of atypicalcarcinoid with small cell carcinoma as a differential diagnosis was determined based on morphological pattern. Immunohistochemical staining examination showed expression of cytokeratin, CAM5.2, and synaptophysin, but showed negative expression of chromogranin, CD56, and TTF-1 .A diagnosis of an atypical carcinoid was confirmed based on the immunohistochemicalexamination. A very rare case of atypical carcinoid of the lung in a non-smoker 3D-yearoldwoman with morphologicaldiagnostic problem solved by immunohistochemical staining was reported.
Cranial unifocal langerhans cell histiocytosis in a female child: a difficult case with S-100 and CD1a immunonegativity Hanggoro Tri Rinonce Sagiri Mangunsudirdjo Soeripto, J Bras
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.903 KB)

Abstract

A 13-years old female child was carried to Dr. Sardjito General Hospital, Yogyakarta by her mother with chiefcomplaint of a mass on her forehead. Since eight months prior to her visiting, she had a mass on her forehead whichbecame larger slowly without tenderness and had no fever. Clinical examination revealed a well circumscribedmass, 3 cm in diameter, fixed, with rubbery consistency. The skull X-ray revealed a punch out lesion in frontal bone.The head CT scanning revealed a destruction of frontal bone. Clinical diagnosis of dermoid cyst was determined,excision and curettage was performed. Gross examination showed 2.5 cc fragmented tissue, brownish yellow, withrubbery consistency. A diagnosis of benign histiocytosis (Langerhans cell histiocytosis or non-Langerhans cellhistiocytosis) of frontal bone was determined based on morphological and immunohistochemical examination. Theaim of this presented article was to report a rare case of cranial unifocal Langerhans cell histiocytosis in a femalechild with S-100 and CD1a immunonegativity, and to discuss how to determine its diagnosis based on literaturereview.Key words: Langerhans cell histiocytosis - juvenile xanthogranuloma – reticulohistiocytoma - eosinophilic granuloma– S100 – CD1a
The accuracy of fine needle aspiration biopsy to diagnose breast neoplasm Hifdza Faza Felisha; Hanggoro Tri Rinonce; Sumadi Lukman Anwar; Ery Kus Dwianingsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.264 KB) | DOI: 10.19106/JMedSci005103201907

Abstract

Breast lump is a very common complaint among women, especially during the reproductive year. Fine needle aspiration biopsy (FNAB) is a less invasive procedure. It is usually performed as an initial diagnosis prior to the operative procedure. The accuracy of the FNAB in Indonesia needs to be elaborated. The study aimed to evaluate the sensitivity and specificity of FNAB in diagnosing breast neoplasm. This is a retrospective study with cross sectional design, involving 145 patients with breast lump who underwent FNAB and histopathology examination in Dr. Sardjito General Hospital, Yogyakarta, from 2012 to 2014. Data analysis showed that female to male ratio was 23. 2:1 commonly occurred at 41-50 years old. Forty-one cases (28.28%) diagnosed as a benign lesion with fibrocystic changes as the most frequentcase (11.19%). The malignant case was 104 cases (71.72%) with ductal carcinoma as the highest case (51.49%). FNAB achieved a sensitivity of 85.58%, a specificity of 100% and a total accuracy of 89.66% in determining the benign or malignant breast lump. The accuracy, sensitivity and specificity of FNAB in diagnosing ductal carcinoma were 83.58%, 85.51% and 81.54%, respectively. The accuracy, sensitivity and specificity of FNAB to diagnose fibrocystic changes lesion were 85.82%, 26.67% and 93.28%, respectively. FNAB can be used as an alternative diagnostic tool to diagnose breast neoplasm. It provides rapid, cheaper, effective, valuable, and less invasive procedure in diagnosis of breast lump. 
WIF1 Qualitative-Methylation from Peripheral Blood Could Not Be Used as Biomarker for The Risk of Nasopharyngeal Carcinoma or Smoking Behavior in Yogyakarta Panel Aditya Kurniawan; Erika Diana Risanti; Saihas Suhda; Hanggoro Tri Rinonce; Ery Kus Dwianingsih; Jajah Fachiroh
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.810

Abstract

BACKGROUND: Tobacco smoking plays an important role in nasopharyngeal carcinoma (NPC) risk. The Wingless-related integration site (WNT) Inhibitory Factor 1 (WIF1) as one of the tumor suppressor gene (TSG), functions to control cell proliferation through suppression of WNT signaling pathway. WIF1 methylation is one of epigenetic mechanisms which causes overactivated of WNT pathway in NPC development. WIF1 methylation from buffy coat related to smoking status and NPC risk is not known yet.METHODS: This was a nested case-control study involving 39 newly diagnosed NPC patients and 40 healthy controls. All subjects were enrolled at Dr. Sardjito Hospital, Yogyakarta. Subjects were male, with known smoking status, duration, and quantity of cigarette consumed. Parallel DNA isolated from buffy coat was used for WIF1 DNA methylation analysis, by using methylation-specific PCR (MSP) method. Chi-square analysis was used to determine distribution of differences among groups. Two tailed p-value≤0.05 was considered as statistically significant.RESULTS: No significant difference between WIF1 methylation of cases and controls (p=0.30), nor smoking habit among smokers (p=0.51) and non-smokers (p=0.43).CONCLUSION: WIF1 methylation from buffy coat could not be used as an NPC marker nor as a smoking behavior marker.KEYWORDS: buffy coat, cigarette smoking, methylation, nasopharyngeal carcinoma, WIF1
Association of Peripheral Blood RASSF1A and CDKN2A Methylation Status with Smoking Behaviour in Nasopharyngeal Carcinoma Erika Diana Risanti; Aditya Kurniawan; Laila Wahyuningsih; Ery Kus Dwianingsih; Hanggoro Tri Rinonce; Jajah Fachiroh
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.381

Abstract

BACKGROUND: Hypermethylation of RASSF1A and CDKN2A is one of epigenetic factor underlies nasopharyngeal carcinoma (NPC) development. Smoking behavior as an NPC’s risk factor causes aberrant DNA methylation. RASSF1A and CDKN2A promoter hypermethylation from peripheral blood cells correlates with smoking behavior. The use of body fluids including peripheral blood as a specimen for DNA methylation analyzes are widely developed, as less invasive method compared to the use of tissue biopsy. This study aims to observe the association between RASSF1A and CDKN2A methylation in peripheral blood and smoking behavioramong NPC patients.METHODS: Newly diagnosed NPC subjects were recruited from ear-nose-throat (ENT) outpatient clinic of Dr. Sardjito Hospital, Yogyakarta. DNA from buffycoat of 19 smokers and 20 non-smokers NPC’s patients were isolated. Bisulphite modification was applied to 500 ng of the isolated DNA. The methylation status was detected by MSP (methylation-specific polymerase chain reaction (PCR)). The association between smoking status and promoter hypermethylation was analysis using Chi-Square test.RESULTS: MSP analysis of RASSF1A showed that 68.42% smoker and 75% non-smoker NPC’s patients were methylated. MSP analysis of CDKN2A showed that 21.05% smoker and 25% non-smoker NPC’s patients were methylated. There was no association between smoking behavior with RASSF1A and CDKN2A methylation (p>0.05).CONCLUSION: Statistical analysis showed that smoking behavior is not associated with methylation of RASSF1A and CDKN2A among NPC’s patients.KEYWORDS: DNA methylation, CDKN2A, RASSF1A, Nasopharyngeal carcinoma, Smoking
Hubungan Kadar Interferon Gamma (IFN-γ) Pada Cairan Asites Dan Darah Dengan Grade Karsinoma Ovarium Sakina Nasir Bagis; Moh Nailul Fahmi; Hanggoro Tri Rinonce
JURNAL KESEHATAN REPRODUKSI Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.401 KB) | DOI: 10.22146/jkr.44181

Abstract

Latar Belakang: Kanker ovarium dapat digolongkan berdasarkan grade, yang dibagi menjadi low grade dan high grade. IFN-γ memiliki efek anti-tumor dan juga pro-tumor. Penelitian tentang kadar IFN-γ pada asites dan darah serta hubungannya dengan grade belum banyak dilakukan.Tujuan: Mengetahui hubungan kadar interferon gamma (IFN-γ) dengan grade karsinoma ovarium pada cairan asites dan darah.Metode: Penelitian cross sectional dengan sampel asites dan darah dari pasien karsinoma ovarium yang dilakukan operasi di RSUP Dr. Sardjito.Hasil dan Pembahasan: Pada sampel asites rata-rata pada low grade sebesar 0,57 pg/ml, pada high grade sebesar 0,68 pg/ml, pada sampel darah rata-rata pada low grade sebesar 0,74 pg/ml, pada high grade sebesar 0,84 pg/ml. Namun perbedaan rata-rata tersebut tidak signifikan (asites, p=0,780; darah, p=0,861). Pada cairan asites dan darah, rata-rata pada asites sebesar 0,66 pg/ml, pada darah 0,81 pg/ml, namun perbedaan rata-rata tersebut tidak signifikan (p=0,568).Kesimpulan: Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) cairan asites dan darah pada karsinoma ovarium low grade dan high grade. Tidak terdapat perbedaan rata-rata yang signifikan antara kadar interferon-gamma (IFN- γ) pada cairan asites dan darah karsinoma ovarium. Kata Kunci: asites, darah, grade, interferon gamma (IFN-γ), karsinoma ovarium
Prevalensi malaria di Asmat, Papua: Gambaran situasi terkini di daerah endemik tinggi Josephine Debora; Hanggoro Tri Rinonce; Maria Fransiska Pudjohartono; Pritania Astari; Monica Gisela Winata; Fadli Kasim
Journal of Community Empowerment for Health Vol 1, No 1 (2018)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1411.845 KB) | DOI: 10.22146/jcoemph.38309

Abstract

ABSTRAK Malaria merupakan salah satu penyakit yang terus endemik di beberapa daerah di Indonesia walaupun pemerintah telah melakukan berbagai usaha untuk mengobati dan mencegah malaria. World Health Organization (WHO) menargetkan insidensi kasus malaria pada tahun 2030 dapat turun hingga 90% dibandingkan tahun 2015.Asmat merupakan salah satu daerah endemik tinggi dan menjadi salah satu daerah target program eliminasi malaria, namun belum ada publikasi data rinci terkait malaria di Asmat, Papua. Penelitian ini bertujuan untuk mengetahui prevalensi malaria di Asmat pada tahun 2017 dan melihat tren kejadian malaria yang merupakan salah satu indikator evaluasi program eliminasi malaria di Indonesia. Penelitian ini merupakan penelitian deskriptif observasional yang dilakukan selama pelaksanaan kegiatan Kuliah Kerja Nyata - Peduli Bencana (KKN-PB) Universitas Gadjah Mada (UGM), pada tanggal 17 Maret hingga 30 April 2018 di Asmat, Papua. Penelitian dilakukan dengan analisis data sekunder dan observasi. Data sekunder diambil dari Dinas Kesehatasn Kabupaten Asmat, kemudian dianalisis dan dipaparkan secara deskriptif. Dilakukan pula observasi lingkungan di Distrik Agats, Atsj, dan Sawaerma untuk mengetahui kemungkinan faktor-faktor risiko malaria. Pada tahun 2017, prevalensi malaria di kabupaten Asmat yaitu 12,37% dengan 7,90 % kasus malaria klinis dan 4,46% kasus malaria yang telah tegak diagnosisnya berdasarkan hasil pemeriksaan laboratorium. Prevalensi tersebut meningkat dibandingkan tahun 2016. Pusat Kesehatan Masyarakat (Puskesmas) Atsj merupakan puskesmas dengan prevalensi malaria tertinggi, yaitu sebesar 27,70%. Kejadian malaria ini kemungkinan dipengaruhi oleh lingkungan fisik (suhu, kelembaban, kerapatan dinding rumah, pengunaan kawat kassa, curah hujan), lingkungan biologi (adanya semak dan rawa), lingkungan kimia (salinitas dan pH), serta kebiasaan masyarakat. Hasil penelitian ini menunjukkan bahwa penanganan malaria di Asmat masih menjadi tantangan besar bagi petugas kesehatan dan pemerintah. Diperlukan penelitian lebih lanjut untuk mengetahui faktor penyebab masih tingginya kejadian malaria agar kebijakan yang diambil lebih tepat.  KATA KUNCI prevalensi; malaria; endemik; Asmat; Papua ABSTRACT Malaria is still an endemic disease in Indonesia, despite years of government efforts to cure and prevent malaria. World Health Organization (WHO) has a goal to reduce malaria case incidence globally at least 90% in 2030 compared with 2015.Asmat is one of the high endemic areas in Indonesia, making Asmat one of the target areas for malaria elimination programs. However, the published data regarding malaria in Asmat is limited. This study aimed to investigate the prevalence of malaria in Asmat in 2017 and assess the trend of malaria prevalence, as an indicator in evaluating malaria elimination programs. This study was descriptive observational research which was performed from March 17th until April 30th 2018, as part of Kuliah Kerja Nyata - Peduli Bencana (KKN-PB) Universitas Gadjah Mada (UGM), in Asmat Regency. This study was using secondary data analysis and environmental observation. Secondary data was obtained from Department of Health in Asmat Regency and presented descriptively. Environmental observation in Agats, Atsj, and Sawaerma District was also conducted to find out the possible risk factors of malaria. In 2017, malaria prevalence in Asmat was 12.37% with 7.9% cases being clinically diagnosed malaria, and the other 4.46% laboratory diagnosed malaria. The prevalence in 2017 was higher than in 2016. Among all the districts in Asmat, Atsj had the highest prevalence (27.70%). Malaria prevalence was possibly affected by multiple factors, such as physical environment (temperature, humidity, houses’ wall density, and the use of wire net), biological environment (house surrounded by bush or swamp), chemical environment (pH and salinity), and habits in community. These findings suggest that malaria control is still a big challenge for health-care workers and government. Further research is needed to study the exact causes of high malaria prevalence in Asmat, so that more appropriate policies can be done to overcome the problem.KEYWORDS prevalence; malaria; endemic; Asmat; Papua
Survei status gizi balita di Agats, Asmat, Papua: Analisis situasi pascakejadian luar biasa gizi buruk Maria Fransiska Pudjohartono; Hanggoro Tri Rinonce; Josephine Debora; Pritania Astari; Monica Gisela Winata; Fadli Kasim
Journal of Community Empowerment for Health Vol 2, No 1 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.377 KB) | DOI: 10.22146/jcoemph.39235

Abstract

A recent extraordinary event of malnutrition in children in Asmat, Papua, Indonesia has drawn enormous attention. To help in post-emergency rehabilitation, Gadjah Mada University sent a Kuliah Kerja Nyata – Peduli Bencana (KKN-PB) team to Agats, Asmat in March 17 – April 20, 2018. As part of situation analysis, the team surveyed the nutritional status of under five-years-old children in Agats, Asmat. The subjects were under five-year-old children coming to posyandus in five areas in Agats in March-April 2018. The data of sex, age, weight, and height were obtained, then the nutritional status in the form of Z-scores for weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) was calculated using WHO Anthro version 3.2.2 software. Nutritional status was determined based on criteria from World Health Organization (WHO). Among the 372 children, 35 (9.4%) children were underweight and 7 (1.9%) were severely underweight. Twenty one (5.7%) children were stunted and 12 (3.2%) were severely stunted. As many as 23 (6.2%) children were found to be wasted and 6 (1.6%) were severely wasted. The percentages of children with malnutrition found in this survey were lower than the percentages for Indonesia and Papua overall, but percentages in two posyandus were higher than the national and Papua percentages. The relatively low total percentages may be accounted for by concentration of malnutrition cases in districts other than Agats and lack of coverage of children absent from posyandu. Prevalence of malnutrition varied in different age groups possibly due to inadequacy of complementary foods, changes in incidence of infections, and addition of siblings. Further surveys are needed using home visits that will also enable to analyze of socio-economic factors at the same time as nutritional status determinants in Agats and other districts in Asmat.