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All Journal Journal of Agromedicine and Medical Sciences PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Tropical Pharmacy and Chemistry
Indah Yulia Ningsih
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Genistein Content and Tyrosinase Inhibitory Activity of Edamame (Glycine max) Extracts Indah Yulia Ningsih; Lisa Kusuma Wardhani; Annisa Ragdha Eka Nuryuanda; Endah Puspitasari; Mochammad Amrun Hidayat
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.461

Abstract

The study aimed to determine genistein content and tyrosinase inhibition activity of 70% ethanolic and ethyl acetate extracts of edamame (Glycine max) with an extraction time of 15, 30, and 60 minutes. Extraction was performed using the ultrasonication method. Determination of genistein content was carried out using TLC-densitometry. Furthermore, all samples were tested for their tyrosinase inhibition activity using the spectrophotometric assay. Ethyl acetate extract with 60 min of extraction time exhibited the highest extraction yield (6.414% w/w), the highest genistein content (0.169 ± 0.007% w/w), and the highest tyrosinase inhibition activity (IC50 = 72.420 ± 0.550 µg/mL). It was known that the genistein content of 70% ethanolic and ethyl acetate extracts affected tyrosinase inhibition activity with correlation coefficient (r) values of 0.9973 and 0.9826, respectively. G. max was suggested as a tyrosinase inhibitor agent from natural sources for skin whitening product development due to its isoflavones content, mainly genistein.
The Phytochemical Identification And Antibacterial Activity Test Of Leucas Lavandulifolia Against Escherichia Coli Nidya Meilani; Dianasari, Dewi; Indah Yulia Ningsih
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53717

Abstract

Diarrhea is defined as a condition where the stool changes or becomes softer or more liquid with a frequency of 3 or 4 times a day. Based on its etiology, diarrhea is caused by several microorganisms, one of which is bacteria. The bacteria that causes diarrhea most often found in Indonesia is Escherichia coli. One type of plant that has the potential as an antibacterial is the Leucas lavandulifolia or Lenglengan plant. Based on ethnopharmaceutical studies, lenglengan leaves are commonly used to treat insomnia, pinworms, coughs with phlegm, epilepsy and digestive disorders. This research was carried out using lenglengan leaf ethanol extract with concentrations of 2.5%, 5%, 10%, 20% and 40%. In this study, phytochemical screening was also carried out using the TLC method. Antibacterial testing was carried out using the well diffusion method. The results obtained were the formation of a clear zone around the well, which indicated activity inhibiting bacterial growth. The results of testing antibacterial activity against E.coli showed that the ethanol extract of langlengan leaves at concentrations of 2.5%, 5%, 10%, 20% and 40% had antibacterial activity with clear zone results of 1.04 ± 0.33 , 12.71 ± 0.34, 13.90 ± 0.60, 15.23 ± 0.36, and 19.32 ± 0.79 mm.  The results of the phytochemical screening showed that ethanol extract of lenglengan leaves contained alkaloids, saponins, flavonoids, terpenoids/steroids and polyphenols. It can be concluded, the ethanol extract of lenglengan leaves has antibacterial activity against E.coli where the greater  sample concentration, the greater  activity.
Peran Studi Etnofarmasi Dalam Pencarian Tumbuhan Obat Yang Berpotensi Dikembangkan Sebagai Antidiabetes Indah Yulia Ningsih
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 12 No. 01 Juli 2015
Publisher : Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRAK Prevalensi penyakit diabetes mellitus mengalami peningkatan di seluruh dunia dan kini disebut sebagai salah satu penyakit utama yang berpengaruh pada kesehatan manusia. Banyak dokter meresepkan politerapi dengan dua atau lebih agen hipoglikemik untuk mengontrol kadar glukosa darah. Pasien juga harus meminum obat dalam jangka panjang, sehingga terjadi peningkatan efek samping, biaya, dan ketidakpatuhan. Hal ini mendorong pasien mencari alternatif pengobatan lain seperti obat herbal. Dalam rangka pencarian tumbuhan obat yang berpotensi dikembangkan sebagai antidiabetes, dapat dilakukan studi etnofarmasi. Pendekatan ini telah diterapkan dalam beberapa penelitian mengenai penggunaan tumbuhan obat untuk mengontrol diabetes mellitus pada sistem pengobatan tradisional di berbagai budaya. Kata kunci: etnofarmasi, diabetes mellitus, tumbuhan obat. ABSTRACT The prevalence of diabetes mellitus has been increasing worldwide and it becomes one of the main diseases which affect human health. Many clinicians prescribe polytheraphy with two or more hypoglycemic agents to achieve better glucose control as a common practice. Patients also have to take drugs for long-term therapy with their attendant side effects in addition to their high costs. It may increase non-adherence therapy of diabetic patients. As a result, patients choose alternative treatment by using herbal medicines. To search new antidiabetic medicinal plants, we can use ethnopharmacy study as an option. This approach has been used to search locally important plant species to control diabetes mellitus in traditional medicinal systems of different cultures. Key words: ethnopharmacy, diabetes mellitus, medicinal plants.
PENGARUH ELISITOR BIOTIK DAN ABIOTIK PADA PRODUKSI FLAVONOID MELALUI KULTUR JARINGAN TANAMAN Indah Yulia Ningsih
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 11 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v11i2.829

Abstract

ABSTRAK Kultur jaringan tanaman merupakan alternatif produksi metabolit sekunder bioaktif, seperti flavonoid, yang efisien dan sangat menguntungkan. Flavonoid termasuk golongan senyawa fenolik alami pada buah, sayur, biji, kulit batang, akar, batang, dan bunga yang memiliki berbagai aktivitas biologis. Dengan menerapkan kultur jaringan tanaman, maka dapat dilakukan peningkatan produktivitas metabolit sekunder melalui perubahan ekspresi jalur metabolisme. Salah satu caranya adalah dengan menggunakan elisitor, baik elisitor biotik maupun abiotik. Elisitor bekerja dengan cara memicu pembentukan metabolit sekunder melalui pengaktifan jalur sekunder dalam merespon stres biotik dan abiotik. Hingga saat ini masih terus dilakukan berbagai penelitian untuk mengetahui jenis dan mekanisme kerja elisitor yang efektif dalam peningkatan produksi flavonoid. Kata kunci: kultur jaringan tanaman, flavonoid, elisitor biotik, elisitor abiotik. ABSTRACT Plant tissue culture appears to be a good alternative for production of bioactive secondary metabolites, such as flavonoids. These metabolites are naturally phenolic compounds in fruits, vegetables, seeds, bark, roots, stems, and flowers with various biological activities. Application of this method can increase secondary metabolites productivity through changes in expression of metabolic pathways, mainly by biotic and abiotic elicitors utilization. Elicitors influence secondary metabolites production through secondary pathway activation as a major response to biotic and abiotic stresses. Many studies have been being performed to find elicitors with an outstanding influence on the accumulation of flavonoids and its mechanisms. Key words: plant tissue culture, flavonoids, biotic elicitors, abiotic elicitors.
Co-Authors Annisa Ragdha Eka Nuryuanda Dianasari, Dewi Endah Puspitasari Lisa Kusuma Wardhani Mochammad Amrun Hidayat Nidya Meilani