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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Agromedicine and Medical Sciences Pharmacon JSFK (Jurnal Sains Farmasi & Klinis) Abdimasku : Jurnal Pengabdian Masyarakat Journal of Pharmaceutical Care Anwar Medika Journal of Pharmaceutical and Sciences. Journal of Agropharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Dianasari, Dewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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POTENSI EKSTRAK ETANOL HERBA APU-APU (PISTIA STRATIOTES) DAN FRAKSI-FRAKSINYA SEBAGAI ANTIOKSIDAN DENGAN METODE DPPH Dianasari, Dewi; Firdiyansari, Irawati
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9148

Abstract

Free radicals play an important role in cell damage and degenerative diseases such as coronary heart disease, stroke, premature aging and others. Compounds that can inhibit free radicals are antioxidants. One of the plants that has a high phenolic compound and can be a source of natural antioxidants, apu-apu or Pistia stratiotes. This research was conducted to scientifically prove the antioxidant activity of the apu-apu herbal extract (Pistia stratiotes) and its fractions by the DPPH method. The sample used in the form of all parts apu-apu (apu-apu herb) obtained from the Sumbersari District, Jember Regency. In this study the DPPH method was used with a DPPH concentration of 0.1 mM, incubation time of ethanol extract 40 minutes, fraction of n-hexane 50 minutes, ethyl acetate fraction 45 minutes, ethanol-water fraction 40 minutes,vitamin C 35 minutes and measured at wavelength 517 nm . The results of the average antioxidant activity (IC50) were apu-apu herbal extract 16.675 µg / mL ± 0.239, n-hexane fraction 29.915 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038, ethanol-water fraction 9.090 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038, ethanol-water fraction 9.090 µg / mL ± 0.156, ethyl acetate fraction 11.875 µg / mL ± 0.038 / mL ± 0.122, and vitamin C 3.263 µg / mL ± 0.032. Vitamin C as a positive control had the highest activity, whereas the apu-apu sample which had the highest antioxidant activity was the ethanol-water fraction, and the lowest was the n-hexane fraction. The conclusion of this study is apu-apu herbal ethanol extract and its fractions have antioxidant activity, from high to low sequentially: ethanol-water fraction, ethyl acetate fraction, apu-apu herbaceous fraction, n- fraction hexane.
POTENSI EKSTRAK ETANOL DAN FRAKSI-FRAKSINYA DARI TIGA VARIETAS JAHE SEBAGAI AGEN ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Dianasari, Dewi; Puspitasari, Endah; Ningsih, Indah Yulia; Triatmoko, Bawon; Nasititi, Fauzia Ken
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ?emprit ginger (Zingiber officinale var. Amarum), ? gajah? ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 ?g (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Aktivitas Antibakteri Ekstrak Etanol Herba Apu-Apu (Pistia Stratiotes) Terhadap Staphylococcus Aureus Dianasari, Dewi; Iftitah, Maulidya Barikatul
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 1 (2019): Volume 2, Nomor 1, Desember 2019
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.197 KB) | DOI: 10.36932/jpcam.v2i1.13

Abstract

S. aureus merupakan salah satu bakteri gram positif yang dapat menyebabkan infeksi bernanah, infeksi kulit ataupun infeksi serius seperti mastitis, pneumonia dan infeksi saluran kencing. Penemuan senyawa aktif baru berasal dari tumbuhan merupakan potensi alternatif sebagai agen antibakteri. Salah satunya ialah tanaman dengan famili Araceae dari genus Pistia yaitu Pistia stratiotes atau yang biasa dikenal dengan sebutan apu-apu. Penelitian ini dilakukan untuk membuktikan secara ilmiah adanya aktivitas antibakteri dari ekstrak etanol herba apu-apu (Pistia stratiotes) terhadap Staphylococcus aureus. Uji antibakteri dengan metode difusi cakram dilakukan pada 6 kelompok, yaitu 4 kelompok perlakuan ekstrak etanol herba apu-apu dengan berbagai konsentrasi (10%; 20%; 30%; dan 40%), satu kelompok uji berisi kontrol negatif yaitu DMSO 10%, dan satu kelompok uji lainnya berisi kontrol positif yaitu gentamisin cakram 10µg. Aktivitas antibakteri ekstrak etanol herba apu-apu (Pistia stratiotes) terhadap S. aureus dari yang tinggi ke rendah secara berurutan adalah konsentrasi 40%, konsentrasi 30%, konsentrasi 20%, konsentrasi 10% dengan nilai diameter zona hambat berturut-turut sebesar 9,0 mm ± 0,30; 8,1 mm ±0,20; 7,4 mm ± 0,33; dan 6,5 mm ±0,17. Berdasarakan hasil penelitian, maka dapat disimpulkan bahwa ekstrak etanol herba apu-apu pada konsentrasi 10%; 20%; 30%; dan 40% memiliki aktivitas antibakteri terhadap S. aureus.
Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia) Nuri, Nuri; Puspitasari, Endah; Hidayat, Mochammad Amrun; Ningsih, Indah Yulia; Triatmoko, Bawon; Dianasari, Dewi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.143-150.2020

Abstract

The leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G. ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL).
The Phytochemical Identification And Antibacterial Activity Test Of Leucas Lavandulifolia Against Escherichia Coli Nidya Meilani; Dianasari, Dewi; Indah Yulia Ningsih
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53717

Abstract

Diarrhea is defined as a condition where the stool changes or becomes softer or more liquid with a frequency of 3 or 4 times a day. Based on its etiology, diarrhea is caused by several microorganisms, one of which is bacteria. The bacteria that causes diarrhea most often found in Indonesia is Escherichia coli. One type of plant that has the potential as an antibacterial is the Leucas lavandulifolia or Lenglengan plant. Based on ethnopharmaceutical studies, lenglengan leaves are commonly used to treat insomnia, pinworms, coughs with phlegm, epilepsy and digestive disorders. This research was carried out using lenglengan leaf ethanol extract with concentrations of 2.5%, 5%, 10%, 20% and 40%. In this study, phytochemical screening was also carried out using the TLC method. Antibacterial testing was carried out using the well diffusion method. The results obtained were the formation of a clear zone around the well, which indicated activity inhibiting bacterial growth. The results of testing antibacterial activity against E.coli showed that the ethanol extract of langlengan leaves at concentrations of 2.5%, 5%, 10%, 20% and 40% had antibacterial activity with clear zone results of 1.04 ± 0.33 , 12.71 ± 0.34, 13.90 ± 0.60, 15.23 ± 0.36, and 19.32 ± 0.79 mm.  The results of the phytochemical screening showed that ethanol extract of lenglengan leaves contained alkaloids, saponins, flavonoids, terpenoids/steroids and polyphenols. It can be concluded, the ethanol extract of lenglengan leaves has antibacterial activity against E.coli where the greater  sample concentration, the greater  activity.
Penetapan Kadar Asam Klorogenat dan Aktivitas Antioksidan Ekstrak NADES dari Biji Kopi Hijau Robusta (Coffea canephora) Menggunakan Metode MAE dan UAE sebagai Bahan Baku Kosmetik Alishlah, Tanfidz; Nuri, Nuri; Dianasari, Dewi; Rahman Hakim, Arif
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.937

Abstract

Antioxidants are essential for protecting skin cells from free radicals, causing oxidative damage, and supporting human skin’s health. Natural antioxidants are abundant in plants, particularly in Robusta green coffee beans (Coffea canephora), which are rich in chlorogenic acid (CA), a key contributor to antioxidant properties. Efficient extraction methods are necessary to obtain these bioactives effectively. Advanced extraction technology, such as Ultrasound-Assisted Extraction (UAE) and Microwave-Assisted Extraction (MAE), enhances mass transfer and reduces processing time compared to conventional methods. This study quantified chlorogenic acid using Thin Layer Chromatography-Densitometry (TLC-densitometry) and evaluated the antioxidant activity using the DPPH method of NADES (betaine–triethylene glycol) liquid extracts from Robusta coffee green beans extracted via UAE and MAE. Chlorogenic acid concentration of MAE (3.64 mg CA/g extract ± 0.06) was higher than that of UAE (2.69 mg CA/g extract ± 0.04). The antioxidant activity (IC₅₀) values were 3266.66 μg/mL ± 67.97 (UAE) and 2598.05 μg/mL ± 29.42 (MAE), indicating higher efficiency for MAE. When expressed as chlorogenic acid equivalents in NADES extracts, IC₅₀ values were 9.04 μg/mL ± 0.13 (UAE) and 9.44 μg/mL ± 0.07 (MAE). NADES-MAE could be a promising method to acquire raw materials with high antioxidant activity, especially for cosmetic formulation.
Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan Dianasari, Dewi; Fajrin, Fifteen Aprila
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.812

Abstract

Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).
Skrining Fitokimia dan Evaluasi Antibakteri Ekstrak NADES (Natural Deep Eutectic Solvents) Daun Iler (Coleus atropurpureus L. Benth) terhadap Bakteri Penyebab Folikulitis Ulfa, Evi Umayah; Pratama P., M. Reynaldi Archan; Dianasari, Dewi
Journal of Agropharmacy Vol. 1 No. 1 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The iler plant (Coleus atropurpureus) can be used as an efficacious medicinal plant. The chemical contents of the iler plant include essential oils, alkaloid, polyphenols, tannins and flavonoids. This content can be used as an antibacterial. This study aims to determine the antibacterial activity of iler leaves (Coleus atropurpureus) against bacterial folliculitis (Staphylococcusaureus). The NADES combination used is choline chloride:sorbitol with a ratio of 1:1, 2:1, and 3:1. The extraction method uses the UAE method and the antibacterial activity test uses the well diffusion method. The positive control used was Ciprofloxacin. The diameter of the inhibition zone for S. aureus bacteria is in a ratio of 1:1 (4,53 mm), 2:1 (6,29 mm), and 3:1 (8,12). The results of the phytochemical screening test obtained showed that the NADES extract of Iler leaves was positive for containing alkaloids, flavonoids, polyphenols and tannins.
Pelatihan Pembuatan Jamu Tradisional di Kelurahan Karangrejo, Sumbersari, Jember Dianasari, Dewi; Puspitasari, Endah; Triatmoko, Bawon
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 6, No 2 (2023): Mei 2023
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33633/ja.v6i2.1058

Abstract

Beberapa sentra usaha terdapat di Kabupaten Jember, salah satunya berada di Kelurahan Karangrejo, Kecamatan Sumbersari, Kabupaten Jember. Salah satunya adalah usaha produksi jamu tradisional yang dijalankan oleh kelompok mitra, yakni ibu-ibu warga RT 02/ RW07 Lingkungan Kalikotok, Kelurahan Karangrejo, Kecamatan Sumbersari, Kabupaten Jember. Permasalahan yang dihadapi adalah kurangnya pengetahuan mitra terkait proses produksi dan pengemasan produk   yang higienis agar menghasilkan jamu yang aman, bermutu, dan berkhasiat, serta teknik pemasaran produk yang efektif dan efisien. Untuk mengatasi permasalahan tersebut, maka dilakukan kegiatan program pengabdian kepada masyarakat. Kegiatan pengabdian yang telah dilaksanakan antara lain penyuluhan tentang tanaman obat dan obat tradisional, pelatihan dan praktik CPOTB, pelatihan dan praktik produksi jamu dan pengemasannya, serta pemasaran produk jamu. Kegiatan ini dapat mengatasi permasalahan mitra , menghasilkan produk jamu yang aman,bermutu dan berkualitas,  sekaligus dapat meningkatkan perekonomian mitra.
Pelatihan Pembuatan Serbuk Jamu Instan di Kelurahan Karangrejo, Kecamatan Sumbersari, Kabupaten Jember Dianasari, Dewi; Puspitasari, Endah; Nuri, Nuri; Triatmoko, Bawon; Muslichah, Siti
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 7, No 1 (2024): JANUARI 2024
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62411/ja.v7i1.1835

Abstract

Salah satu jenis olahan tanaman obat adalah dalam bentuk jamu. Salah satu sentra usaha produksi jamu tradisional dijalankan oleh ibu-ibu warga RT 02/ RW07 Lingkungan Kalikotok, Kelurahan Karangrejo, Kecamatan Sumbersari,Kabupaten Jember. Permasalahan yang dihadapi mitra yaitu produk jamu yang akan dibuang jika tidak laku pada hari tersebut, karena masa simpan jamu yang sangat singkat dan akan berubah rasa. Untuk mengatasi tersebut, maka perlu dilaksanakan kegiatan pengabdian berupa pelatihan diversifikasi produk olahan jamu berupa pembuatan serbuk jamu instan, cara pengemasan dan pemasarannya. Pelatihan dilaksanakan dengan metode demonstrasi langsung pembuatan dan pengemasan serbuk jamu jahe wangi instan, serta pemaparan materi tentang cara pemasarana yang efektif dan efisien.Kegiatan pelatihan dapat meningkatkan pengetahuan, mengatasi permasalahan mitra, dan juga dapat meningkatkan omset penjualan mitra, sekaligus meningkatkan kesejahteraan mitra.Kata kunci: serbuk jamu instan, jamu
Co-Authors Arif Rahman Hakim Bawon Triatmoko Endah Puspitasari Evi Umayah Ulfa Fifteen Aprila Fajrin Firdiyansari, Irawati Iftitah, Maulidya Barikatul Indah Yulia Ningsih Indah Yulia Ningsih Mochammad Amrun Hidayat Nasititi, Fauzia Ken Nidya Meilani Nuri Nuri Pratama P., M. Reynaldi Archan Tanfidz Alishlah, Tanfidz