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All Journal Jurnal Tumbuhan Obat Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Pengembangan Pendidikan Jurnal Riset Kimia UNEJ e-Proceeding JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Jurnal Ilmu Kefarmasian Indonesia Journal of Pharmaceutical Care Anwar Medika Berkala Penelitian Hayati Journal of Tropical Pharmacy and Chemistry
Mochammad Amrun Hidayat
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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OBAT HERBAL (HERBAL MEDICINE) : APA YANGPERLU DISAMPAIKAN PADA MAHASISWA FARMASI DAN MAHASISWA KEDOKTERAN? Hidayat, Moch Amrun
Jurnal Pengembangan Pendidikan Vol 3, No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

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Abstract

Abstrak. Negaratropis seperti Indonesia memiliki berbagai tanaman yang dapat dijadikan sebagaiobat herbal. Permasalahan yang masih dirasakan adalah bagaimana membelajarkanobat tersebut kepada mahasiswa kedokteran dan farmasi. Untuk proses tersebutpaling tidak mahasiswa perlu diberi bekal tentang aspek regulasi monografi,bentuk sediaan & interaksi obat herbal dengan penekanan yang berbeda. Kata kunci :Obat herbal, mahasiswa
POTENSI EKSTRAK DAN FRAKSI DAUN Gardenisa augusta SEBAGAI AGEN ANTIBAKTERI TERHADAP Staphylococcus aureus Sari, Dewi Diana; Seniarta, I Wayan; Hidayat, Mochamad Amrun
Journal of Pharmaceutical Care Anwar Medika (J-PhAM) Vol 2 No 2 (2020): Volume 2, Nomor 2, Juni 2020
Publisher : STIKES Rumah Sakit Anwar Medika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (733.957 KB) | DOI: 10.36932/jpcam.v2i2.32

Abstract

Pneumonia merupakan suatu infeksi yang terjadi pada parenkim paru. Pneumonia dapat disebabkan oleh berbagai macam mikroorganisme, salah satunya adalah bakteri Staphylococcus aureus. Kaca piring (Gardenia augusta) merupakan tumbuhan yang berpotensi dimanfaatkan sebagai agen antibakteri baru. Secara tradisional dapat dimanfaatkan untuk mengobati penyakit infeksi, seperti diare, disentri, dan infeksi vagina. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol dan fraksi daun kaca piring pada S. aureus. Pengujian dilakukan dengan metode difusi cakram terhadap kelompok uji dan kelompok kontrol. Kelompok uji terdiri dari ekstrak etanol dan fraksi daun kaca piring konsentrasi 10, 20, 30, 40, dan 50% b/v. Kelompok kontrol terdiri dari gentamisin cakram 10 μg ( kontrol positif) dan DMSO 10% (kontrol negatif). Hasil pengujian menunjukkan ekstrak etanol, fraksi heksana, dan fraksi etil asetat memiliki aktivitas antibakteri terhadap S. aureus, tetapi fraksi etanol air tidak menunjukkan adanya aktivitas antibakteri pada konsentrasi yang sama. Aktivitas antibakteri yang paling tinggi terlihat pada fraksi etil asetat. Golongan senyawa yang terkandung pada fraksi etil asetat, antara lain alkaloid, terpenoid, dan flavonoid
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Waru Gunung (Hibiscus macrophyllus) dan Fraksinya terhadap Staphylococcus aureus Afif Rifqie Maulana; Bawon Triatmoko; Mochammad Amrun Hidayat
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.16432

Abstract

Infection is one of the main causes of world health problems, especially in developing countries like Indonesia, one of which is an acute respiratory infection caused by bacteria such as Staphylococcus aureus. Therapeutics are used for the treatment of infections today with antibiotics. However, there are many cases of bacterial resistance to antibiotics that need to develop alternatives derived from plants. One of the plants that have antibacterial activity is the leaves of Waru Gunung (Hibiscus macrophyllus). The purpose of this study was to determine whether the ethanolic extract of H. macrophyllus leaves and their fractions have antibacterial activity against S. aureus. The method used in this antibacterial activity test is the disk diffusion method with a test concentration of 5%, 10%, 15%, 20%, and 25%. The results of this study indicate that all test samples have antibacterial activity except in the water fraction. The highest antibacterial activity was obtained in the ethyl acetate fraction which attracted semipolar compounds in the ethanolic extract of H. macrophyllus leaves. The antibacterial activity of the test samples in sequence from high to low includes ethyl acetate fraction, ethanolic extract, n-hexane fraction, and water fraction.
Formulasi dan Penentuan Stress Testing Sediaan Krim M/A dan A/M Ekstrak Etanol Edamame (Glycine max) (Formulation and Stress Testing of Ethanol Extract Edamame (Glycine max) O/W and W/O Cream) Oktavia Catur Xenograf; Budipratiwi Wisudyaningsih; Siti Muslichah; Moch. Amrun Hidayat
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Edamame is a species of soybean (Glycine max) that contains isoflavone which has tyrosinase inhibitory activity. The aims of this study were to determine the effect of formulation on genistein content and the effect of storage temperature (25 °C and 50 °C) on oil in water (o/w) and water in oil (w/o) cream physicochemical characteristics (viscosity, spreadability, and pH). Genistein level was determined using thin layer chromatography (TLC) densitometry method and stability test was determined using stress testing method. The result showed that formulation gave no effect on genistein content in o/w and w/o cream with recovery values of 95.4178 ± 2.2815 % and 101.8276 ± 5.0063 %, respectively. The storage at 25 °C gave no effect on physicochemical characteristic, while the storage at 50 °C decreased viscosity value and increased spreadability value of cream.   Keywords: edamame, isoflavone, cream, stress testing
Uji Aktivitas Protein Larut Air Umbi Porang (Amorphophallus muelleri Blume) terhadap Escherichia coli dan Staphylococcus aureus Putu Gita Maya Widyaswari Mahayasih; Tri Handoyo; Mochammad Amrun Hidayat
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The objective of this study was to determine antibacterial activity of water soluble protein of Porang (Amorphalus muelleri Blume) tuber. The water soluble protein extract was tested against both Eschericia coli and Staphylococcus aureus using filter paper disk method. The inhibition zone of bacterial growth was calculated for both of bacterial cultures. It was found that water soluble protein exhibited antibacterial activity at linear range 0.3-1.9 μg and 0.1-1.9 μg for E. coli and S. aureus respectively, sugesting that S. aureuswas more susceptible than E. coli to this protein. From the electrophoretic profile using 12.5% sodium dodecyl sulfate (SDS) and comassie blue staining (CBS), two protein bands were observed with molecular weight 17 and 19 kDa respectively. The water soluble protein were further evaluated using periodic acid staining (PAS). Pink band with molecular weight 250 kDa and > 250 kDa was found in PAS profile, sugesting the availability of carbohydrate molecule in water soluble protein extract of porang tubers.
Aktivitas Inhibitor α-Glukosidase Ekstrak Etanol Daun Kenitu (Chrysophyllum cainito L.) (α-Glucosidase Inhibitor Activity of Ethanol Extract Kenitu Leaves (Chrysophyllum cainito L.)) Fatimatuz Zuhro; Endah Puspitasari; Siti Muslichah; Moch. Amrun Hidayat
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Kenitu (Chrysophyllum cainito L.) grows in Jember region, East Java, with several variants which can be distinguished from the color and shape of the fruit. They are small round (BK), large round (BB), green oval (HL), and red round (MB). Kenitu leaves have been shown to provide antidiabetic activity in vivo, but the molecular mechanism still unknown yet. One of the oral antidiabetic is a class of α-glucosidase inhibitor. This research aimed to test the activity of Saccharomyces cerevisiae α-glucosidase inhibitor of several variants of kenitu leaves in Jember, as well as phytochemical screening. Simplicia powder was extracted using 70% ethanol with ultrasonication method to obtain a thick extract. α-glucosidase inhibitor activity test was carried out on the negative control solution (without extract) and the sample solution (extract) using chromogenic method. Phytochemical screening was done by TLC and tube test. IC50 value of ethanol extract kenitu leaves variant BK, BB, HL, and MB were 5.476 ± 0.039, 4.869 ± 0.018, 9.465 ± 0.012, and 11.836 ± 0.048 µg/ml, respectively. Based on the LSD test, IC50 values between variants of kenitu leaves were significantly different (p < 0,05). Phytochemical screening result showed that ethanol extract kenitu leaves contain saponin, triterpenoids, flavonoids, and phenolic compounds. Those compounds were suspected to contribute on α-glucosidase inhibitor activity, but more study still needed to isolate the active compounds and evaluate each isolate for its α-glucosidase inhibitor activity. Keywords: α-glucosidase inhibitor, kenitu leaves, ethanol extract
Pengaruh Ekstrak Metanol, Fraksi N-Heksana dan Fraksi Metanol Biji Pepaya (Carica papaya L.) terhadap Motilitas Spermatozoa Tikus (Effect of the Methanol Extract, Hexane Fraction and Methanol Fraction of Papaya Seeds (Carica papaya L.) on Rat Spermato Novi Prasetyaningrum; Siti Muslichah; Moch Amrun Hidayat
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Lack of contraceptive choices which meet the requirements is one of the contributing factors to less participation of man in contraceptive use. This research aimed to study the effectiveness of papaya seeds on rat spermatozoa motility. The rats were separated into 4 groups: negative control group (CMC-Na 1%), methanol extract of papaya seeds (100 mg/kg BW) treatment group, n-hexane fraction of papaya seeds (100 mg/kg BW) treatment group, and methanol fraction of papaya seeds (100 mg/kg BW) treatment group. Each treatment group consisted of 5 rats. Each group was administrated orally for 20 days. On 21st day, the rats were sacrified, the spermaatozoa were and were observed on their motility. The data then was anallyzed using Anova followed with LSD. The sperms which moved progressively in negative control, methanol extract, n-hexane fraction and methanol fraction were 67.6%, 29.8%, 38% and 10.6% respectively the methanol fraction of papaya seeds is more potent in reducing sperm motility. Keywords: antifertility, papaya seeds, spermatozoa motility
PENDEKATAN ETNOBOTANI TUMBUHAN OBAT UNTUK PERMASALAHAN SEKSUAL SUKU TENGGER DI DESA ARGOSARI, LUMAJANG, INDONESIA Weka Sidha Bhagawan; Ubaidillah Abdel Barsyaif; Mochammad Amrun Hidayat
Jurnal Tumbuhan Obat Indonesia Vol 14 No 2 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i2.4169

Abstract

ABSTRACT The people of Tengger in Argosari village receive their knowledge of traditional medicine from their ancestors. This traditional knowledge is inherited and subsequently preserved across generations. This ethnobotanical medicinal plant study began with the participation observatory method and interviewed 28 local Tenggerese people who were selected by purposive and snowball sampling. Ethnobotanical data were analyzed to understand the proportion of cited plants. The analysis was calculated to obtain species use-value (SUV), family use-value (FUV), and fidelity level (FL). We have inventoried 16 species of plants belonging to 9 families to treat five types of sexual problems. The result showed that Piper betle L. had the highest SUV (1.21). Zingiberaceae was recorded as the largest family (6 plant species) with high FUV (0.69). Rhizome (47,06%) and leaves (41.18%) are the most dominant parts used as ingredients in traditional medicine. The majority of Argosari villagers prepare medicinal plants by decoction techniques (94.12%), then use them orally (94.12%). Pimpinella pruatjan Molkenb. (purwoceng) that is used for aphrodisiac has the highest FL value (78.57%). So it has the potential to be developed related to its pharmacological effects and the content of its active secondary metabolites. Since P. pruatjan is categorized as rare and protected species, so it requires a policy on its use as raw material for traditional medicines. Keywords: Ethnobotany, Medicinal plants, Sexual problems, Tengger tribe, Argosari Village. ABSTRAK Masyarakat suku Tengger di desa Argosari mendapatkan ilmu pengobatan tradisional dari nenek moyang mereka. Pengetahuan tumbuhan obat ini diwariskan dan selanjutnya dilestarikan dari generasi ke generasi. Pendekatan etnobotani tumbuhan obat ini dimulai dengan metode participation observatory dan mewawancarai 28 masyarakat lokal suku Tengger yang diseleksi secara purposive dan snowball sampling. Analisis data etnobotani digunakan untuk memahami proposi tumbuhan yang tersitasi, yaitu: species use-value (SUV), family use-value (FUV), dan fidelity level (FL). Studi ini telah berhasil menginventarisasi 16 spesies tumbuhan yang termasuk dalam 9 famili untuk pengobatan 5 jenis penyakit permasalahan seksual. Sirih (Piper betle L.) memiliki SUV tertinggi yaitu 1,21, sedangkan Zingiberaceae terdata sebagai famili terbanyak (6 spesies tumbuhan) dengan FUV tertinggi (0,69). Rimpang (47,06%) dan daun (41,18%) merupakan bagian yang dominan digunakan sebagai bahan obat tradisional. Mayoritas masyarakat desa Argosari mempreparasi tumbuhan obat tersebut dengan tehnik dekokta (94,12%), selanjutnya menggunakannya secara oral (94,12%). Pimpinella pruatjan Molkenb. (purwoceng) yang berfungsi sebagai tumbuhan afrodisiak memiliki nilai FL tertinggi (78,57%), sehingga sangat berpotensi dikembangkan terkait efek farmakologis dan kandungan metabolit sekunder aktifnya. P. pruatjan termasuk dalam spesies langka dan dilindungi sehingga memerlukan kebijakan dalam pemanfaatannya sebagai bahan baku ramuan obat tradisional. Kata kunci: Etnobotani, Tumbuhan obat, Permasalahan seksual, Suku Tengger, Desa Argosari.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK AIR DAN EKSTRAK METANOL BEBERAPA VARIAN BUAH KENITU (Chrysophyllum cainito L.) DARI DAERAH JEMBER Moch. Amrun H.; Umiyah Umiyah; Evi Umayah U
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 13 No 1 (2007): December 2007
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/322

Abstract

Star apple or Chrysophyllum cainito L., family Sapotaceae; which is indigenous in Central America has been grown locally arround Jember, East Java. Ethnobotanical data exhibits its medicinal properties such as: soothing inflammation in laringitis and pneumonia, treatment for diabetes mellitus and cancer remedy which are related to free radical mechanism. Therefore, it is necessary to determine its free radical scavenger activity.There are three types of Jember’s star apple fruit (local name: kenitu): big size, green color with round shape (kenitu hijau bulat); medium size, green color with oval shape (kenitu hijau lonjong); and small size, red purplish color with round shape (kenitu merah bulat). Previous research shown that both water and methanol extracts of kenitu hijau lonjong has DPPH free radical scavenger activity as its antioxidant capacity. In recent research the DPPH free radical scavenger activity was performed on both water and methanol extract of these three types of kenitu. The results showed that kenitu merah bulat exhibits the highest antioxidant activity of these three types with IC50 = 426.118 and 169.094 ppm for methanol and water extracts sequentially in 60th minutes.
Penentuan Kadar Genistein dan Aktivitas Hambatan Tirosinase Kedelai (Glycine max) Terfermentasi Aspergillus oryzae ESTIKA YUNINDARWATI; EVI UMAYAH ULFA; ENDAH PUSPITASARI; MOCHAMMAD AMRUN HIDAYAT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Tujuan dari penelitian ini adalah menentukan kadar genistein dan aktivitas hambatan dari ekstrak kedelai terfermentasi dan non-fermentasi. Kedelai difermentasi oleh Aspergillus oryzae selama 4 hari dan dimonitor kadar genistein serta aktivitas hambatan tirosinase setiap hari. Kadar genistein ditentukan menggunakan densitometer-KLT sedangkan aktivitas hambatan tirosinase dievaluasi menggunakan metode spektrofotometri. Hasil penelitian menunjukkan bahwa kadar genistein meningkat pada saat fermentasi hari ke-1 sampai ke-3 (45,645-1256,042 μg/g ekstrak) tetapi pada hari ke-4 kadarnya menurun (54,373 μg/g ekstrak). Aktivitas hambatan tirosinase juga mengalami peningkatan pada saat fermentasi hari ke-1 sampai ke-3 (dilihat pada nilai IC50) dan menurun saat fermentasi hari ke-4. Disimpulkan bahwa kadar genistein berkaitan dengan aktivitas hambatan tirosinase (R2 = 0,949).
Co-Authors Afif Rifqie Maulana Annisa Ragdha Eka Nuryuanda Antonius Nugraha Widhi Pratama, Antonius Nugraha Widhi Bambang Kuswandi Bambang Kuswandi Bambang Kuswandi Bawon Triatmoko Dewi Dianasari Diana Holidah Dianasari, Dewi Endah Puspitasari Endah Puspitasari ESTIKA YUNINDARWATI Evi Umayah U Evi Umayah Ulfa Fatimatuz Zuhro Fatimatuzzahra Fatimatuzzahra Ika Barokah Suryaningsih Ika Puspita Dewi Indah Yulia Ningsih Indah Yulia Ningsih Lisa Kusuma Wardhani Maidy Frista Rosanti Mandasari, Virda Fitra Muhammad Fahmi Naufal Muhammad Fantoni Novi Prasetyaningrum Noviani Tri Wahyuning Nuri Nuri Nuri Nuri Oktavia Catur Xenograf Panida, Rahma Riska Putu Gita Maya Widyaswari Mahayasih Sari, Dewi Diana Seniarta, I Wayan TRI HANDOYO Ubaidillah Abdel Barsyaif Ulfa Elfiah Umiyah Umiyah Weka Sidha Bhagawan YUNITA