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All Journal Pharmaciana: Jurnal Kefarmasian
Haafizah Dania
Faculty of Pharmacy, Universitas Ahmad Dahlan
Medicine & Pharmacology

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Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic Lalu Muhammad Irham; Dyah Aryani Perwitasari; Yudha Rizky Nuari; Wirawan Adikusuma; Haafizah Dania; Rita Maliza; Made Ary Sarasmita; Rocky Cheung; Adi Wira Septama
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.474 KB) | DOI: 10.12928/pharmaciana.v13i1.24052

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023. Since the pandemic emerged, the growing number of publications related to TMPRSS2 as a SARS-CoV-2 receptor worldwide has increased rapidly with various findings and qualities. It is important to determine the trend of TMPRSS2 publication as no such studies currently exist that represent the publication trend related to this critical field of study. Here, we employed a bibliometric-based approach to evaluate the research trends of TMPRSS2 mechanistically as the SARS-CoV-2 receptor. We identified 1012 research documents published between 2020 and 2022 for this study. The most common document category was "Research Article" (646 articles, 63.84%) followed by "Review Article" (261 articles, 25.79%), and letters to editors (57 articles, 5.63%). Germany was the most cited country with a total of citations (9400 citations), followed by the USA (6409 citations) and China (1788 citations), respectively. In conclusion, given the impact of COVID-19, this study indicated TMPRSS2 as a SARS-CoV-2 receptor as a timely and highly relevant research topic.
Medication adherence and glycemic control outcomes among type 2 diabetes mellitus patients Mita Ardila; Haafizah Dania; Siswandi; Woro Harjaningsih; Dyah Aryani Perwitasari; Imaniar Noor Faridah; Adnan; Chatarina Danik Wijayanti; Lidwina Tika Trisnawati; Andri Christianalusi; Ikhwan Dwi Wahyu Nugroho; Dwi Tiva Widyanti
Pharmaciana Vol. 16 No. 2 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i2.30954

Abstract

Type 2 Diabetes Mellitus (T2DM) remains a major public health concern in Indonesia due to its high prevalence and potential to cause various long-term complications when glycemic control is not adequately maintained. Medication adherence and barriers to treatment are important factors that may influence therapeutic outcomes. This study investigated medication adherence, insulin-related treatment barriers, and their association with glycemic outcomes among patients with T2DM at RSPAU dr. Suhardi Hardjolukito Hospital, Yogyakarta. Employing a cross-sectional approach, this research gathered data between September and October 2024. Criteria for eligibility included adult individuals with T2DM who were treated with oral antidiabetic agents, insulin, or both and provided informed consent. Medication-taking behavior was evaluated by utilizing the Medication Adherence Report Scale (MARS-5) framework, while barriers to insulin therapy were evaluated using a specific questionnaire. Associations between adherence status and glycemic parameters were examined through Fisher's Exact Test. A total of 73 patients participated, most of whom were receiving oral therapy (65.8%), a combination of metformin and glimepiride (19.2%), or metformin and acarbose (11.0%). Among insulin users, the majority had low barriers to insulin use (92.0%). Statistical analysis yielded p-values of 0.038 and 0.000 for the associations between medication adherence and fasting blood glucose as well as HbA1c levels, and for the relationship between adherence status and random blood glucose measurements, a p-values = 0.542 was obtained. The findings demonstrated that therapeutic compliance is significantly correlated with both HbA1c and fasting blood sugar levels among individuals suffering from type 2 diabetes mellitus at RSPAU dr. Suhardi Hardjolukito Hospital, Yogyakarta. These results highlight the contribution of adherence behavior to successful glycemic management. Therefore, healthcare professionals are advised to implement strategies that encourage medication adherence to optimize glycemic control.
Co-Authors Adi Wira Septama Adnan Andri Christianalusi Chatarina Danik Wijayanti Dwi Tiva Widyanti Dyah Aryani Perwitasari Ikhwan Dwi Wahyu Nugroho Imaniar Noor Faridah Lalu Muhammad Irham Lidwina Tika Trisnawati Made Ary Sarasmita Maliza, Rita Mita Ardila Rocky Cheung Siswandi Wirawan Adikusuma Woro Harjaningsih Yudha Rizky Nuari