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Gastroprotective effect of Canna edulis Ker. ethanolic extract in piroxicam-induced rats Dara Pranidya Tilarso; Moch. Saiful Bachri; Wahyu Widyaningsih
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Medications derived from plants and pure natural ingredients have far lower side effects and risks than synthetic drugs. One side effect of piroxicam is irritation of the digestive tract. One of the therapeutic preventions to minimize peptic ulcers was utilizing Canna edulis Ker. This study aims to prove that ethanolic extract of Canna edulis Ker. can be used as an alternative to prevent piroxicam-induced peptic ulcers based on ulcer index parameters and the protection ratio. The rats were divided randomly into 6 groups consisting of 5 rats. The normal group was given food and water. The negative control group was given 0.5% CMC-Na. The extract groups were given various doses of ethanolic extract ofÂ Canna edulisÂ Ker. (50, 100, and 200 mg/kg BW). The positive control was given sucralfate at 360 mg/kg BW dose. Rats were treated orally for 14 days. One hour after the treatment on the 14th day, all groups except group I were orally administered with piroxicam dissolved in 0.5% CMC-Na at 1.8 mg/kg BW dose. Twenty-four hours later, animals were sacrificed, dissected, and their stomach organs were removed to analyze its number of ulcers. Ulcer observation was formed by giving a score and protection ratio. The mean ulcer index value was 0.33Â±0.58 for 50 mg/kg BW and 100 mg/kg BW ethanol extract treatment groups, while the 200 mg/kg BW group showed 0.67Â±0.58. The protection ratio was 83.33Â±28.87 in 50 mg/kg BW and 100 mg/kg BW treatment groups, while Â 66.67Â±28.87 was shown in the 200mg/kg BW group. Canna edulisÂ Ker. ethanolic extract has the gastroprotective ability by decreasing the index of gastric ulcers and increasing the protection ratio to the stomach of piroxicam-induced rats.

UJI AKTIVITAS ANTIBAKTERI FRAKSI DAUN BIDURI (Calotropis gigantea) TERHADAP Staphylococcus aureus Nurul Hidayah; Choirul Huda; Dara Pranidya Tilarso
JURNAL FARMASI DAN MAKANAN Vol 4 No 1 (2020): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i1.1456

Staphylococcus aureus adalah bakteri Gram positif yang berbentuk menggerombol. Bakteri Staphylococcus aureus merupakan penyebab utama infeksi nosokomial, keracunan makanan, dan sindrom syok toksik. Infeksi Staphylococcus aureus dapat terjadi ketika sistem imun melemah. Salah satu penanganan infeksi adalah menggunakan antibiotik, namun penggunaan antibiotik yang tidak tepat akan menimbulkan resistensi, sehingga terapi menggunakan obat tradisional menjadi pilihan alternatif. Obat tradisional yang berasal dari tanaman memiliki efek samping yang jauh lebih rendah tingkat bahayanya dibandingkan obat-obatan kimia. Salah satu tumbuhan yang dapat dimanfaatkan sebagai bahan obat adalah tanaman biduri (Calotropis gigantea L.). Tujuan penelitian ini adalah mengetahui aktivitas fraksi Aquadestilata, etil asetat dan n-heksan dari ekstrak daun biduri sebagai antibakteri terhadap bakteri Staphylococcus aureus. Daun biduri diekstraksi menggunakan metode maserasi dengan menggunakan pelarut 70% dan difraksinasi menggunakan pelarut Aquadestilata, etil asetat dan n-heksan. Uji aktivitas antibakteri fraksi daun biduri menggunakan metode difusi cakram dengan seri konsentrasi 10%, 20% dan 30%. Analisis statistik yang digunakan yaitu one way ANOVA yang bertujuan untuk mengetahui berpengaruh atau tidaknya variasi konsentrasi fraksi daun biduri terhadap pertumbuhan bakteri Staphylococcus aureus. Hasil penelitian yang telah dilakukan menunjukkan bahwa fraksi Aquadestilata dan etil asetat mempunyai aktivitas antibakteri. Fraksi Aquadestilata merupakan fraksi teraktif dalam menghambat aktivitas bakteri Staphylococcus aureus karena mengandung senyawa flavonoid, tanin dan saponin. Konsentrasi optimum fraksi daun biduri dalam menghambat pertumbuhan bakteri Staphylococcus aureus adalah 10% dengan rata-rata zona hambat sebesar 6,33 mm.

Program Pemberdayaan untuk Masyarakat Melalui Pelatihan Sediaan Hand Sanitizer Kombinasi Daun Sirih dan Buah Belimbing Wuluh di Desa Bendiljati Wetan Dara Pranidya Tilarso; Siti Anisa Ningrum; Ulfi Helmiana Dewi; Muhammad Ary F; Febry Irvanda
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 7 (2022): Volume 5 No 7 Juli 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i7.5932

ABSTRAK Upaya membersihkan tangan dapat dilakukan dengan menggunakan cairan pembersih tangan. Salah satunya dalam bentuk gel hand sanitizer. Hand sanitizer lebih efektif jika dibandingkan dengan mencuci tangan dengan air mengalir dan mudah didapatkan atau tersedia di pasaran. Pemanfaatan bahan alam dalam daun sirih dan buah belimbing wuluh dapat digunakan sebegai alternatif dalam pembuatan hand sanitizer. Kegiatan ini bertujuan untuk meningkatnya pengetahuan masyarakat mengenai pembuatan hand sanitizer dari bahan alami serta pelatihan singkat pembuatan sediaan hand sanitizer dengan bahan alam berkhasiat antibakteri dari daun sirih dan belimbing wuluh. Pelatihan dilakukan dengan metode praktik langsung pembuatan hand sanitizer yang diikuti oleh mitra sasaran “Tahu Vasco”. Kegiatan pelatihan pembuatan hand sanitizer memberikan pengetahuan mitra sasaran tentang pemanfaatan bahan alam dan bahan yang aman digunakan untuk hand sanitizer, serta informasi dalam pencegahan penularan Covid-19. Pelatihan pembuatan dan informasi terkait sediaan hand sanitizer telah meningkatkan pengetahuan dalam pencegahan penularan Covid-19. Mitra sasaran pengabdi juga sudah mengetahui cara pembuatan sediaan hand sanitizer setelah dilaksanakan kegiatan pelatihan pembuatan produk. Kegiatan ini telah meningkatkan ketertarikan mitra sasaran untuk membudidayakan tanaman daun sirih dan buah belimbing wuluh, serta memanfaatkan tanaman sebagai bahan alternatif untuk keberdayaan mitra sasaran dalam mengembangkan produk yang berasal dari bahan alam. Kata Kunci : Pelatihan, Hand sanitizer, Daun Sirih Hijau, Buah Belimbing Wuluh ABSTRACT Efforts to clean hands can be done by using hand sanitizer. One of them is in the form of a hand sanitizer gel. Hand sanitizer is more effective than washing hands with running water and is easily available or available in the market. Utilization of natural ingredients in betel leaves and wuluh starfruit can be used as an alternative in making hand sanitizers. This activity aims to increase public knowledge about the manufacture of hand sanitizers from natural ingredients as well as a brief training on making hand sanitizer preparations with natural ingredients with antibacterial properties from betel leaf and starfruit. The training was carried out using the direct practice method of making hand sanitizers, followed by the target partners of "Tahu Vasco". Training activities for making hand sanitizers provide target partners with knowledge about the use of natural materials and materials that are safe to use for hand sanitizers, as well as information on preventing the transmission of Covid-19. Training on the manufacture and information related to hand sanitizer preparations has increased knowledge in preventing the transmission of Covid-19. Partners targeted for service also already know how to make hand sanitizer preparations after product-making training activities are carried out. Conclusion: This activity has increased target partners' interest in cultivating betel leaf and wuluh starfruit plants, as well as utilizing plants as alternative materials for the empowerment of target partners in developing products derived from natural ingredients. Keywords: Training, Hand sanitizer, Green Betel Leaf, Wuluh Starfruit

Pelatihan Masyakarat Desa Gebang Tulungagung dalam Pembuatan Sediaan Serum Jerawat Daun Sirih Hijau dan Buah Belimbing Wuluh Dara Pranidya Tilarso
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 4 (2022): Volume 5 No 4 April 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i4.4847

ABSTRAK Berdasarkan potensi kandungan flavonoid dalam daun sirih dan buah belimbing wuluh, kemudahan untuk dibudidayakan pada lahan perkebunan dan pertanian oleh masyarakat, tanaman daun sirih dan buah belimbing wuluh ini dapat dimanfaatkan ke dalam bahan yang berkhasiat dalam suatu sediaan kosmetika. Kegiatan ini bertujuan untuk meningkatnya pengetahuan masyarakat mengenai keamanan kosmetik dan pelatihan singkat pembuatan sediaan kosmetika serum dengan bahan alam berkhasiat daun sirih dan belimbing wuluh. Pelatihan dilakukan dengan metode praktik pembuatan serum yang diikuti oleh warga. Kegiatan pelatihan pembuatan kosmetika memberikan pengaruh positif dalam bentuk wawasan dan kreatifitas masyarakat dalam pemanfataan bahan alam sebagai bahan berkhasiat kosmetika. Masyarakat tertarik untuk membudidayakan tanaman daun sirih dan buah belimbing wuluh yang dapat dimanfaatkan dalam penggunaan sehari-hari dalam pengatasan kulit yang berjerawat di lingkungan Desa Gebang, Kecamatan Tulungagung. Kata Kunci: Pelatihan, Serum, Daun Sirih Hijau, Buah Belimbing Wuluh ABSTRACT Based on the potential flavonoid content in betel leaf and wuluh starfruit, the ease with which it can be cultivated on plantation and agricultural land by the community, this betel leaf, and wuluh starfruit plant can be utilized as a nutritious ingredient in a cosmetic preparation. This activity aims to increase public knowledge about cosmetic safety and brief training in the manufacture of serum cosmetic preparations with natural ingredients efficacious betel leaf and wuluh starfruit. The training was carried out using the practical method of making serum which was followed by the residents. Cosmetics-making training activities have a positive influence in the form of insight and creativity of the community in the use of natural ingredients as cosmetic ingredients. The community is interested in cultivating betel leaf plants and wuluh starfruit which can be used in daily use in treating acne-prone skin in Gebang Village, Tulungagung District. Keywords: Training, Serum, Green Betel Leaf, Wuluh Starfruit

In Vitro Quality Test Of The Combination Of Kefir Milk Compound, Sweet Star Fruit Extract (Averrhoa Carambola L.) And Red Ginger Kartika Arum Wardani; Dara Pranidya Tilarso; Afidatul Muadifah; Choirul Huda
Jurnal EduHealth Vol. 14 No. 01 (2023): Jurnal eduHealth, Periode Januari-Maret, 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.654 KB)

Milk kefir is fermented milk produced by the activity of Lactic Acid Bacteria (LAB), yeast and acetic acid bacteria. Kefir milk contains many nutrients and properties, including immunomodulators, antibiotics, antioxidants and is rich in probiotics when compared to yogurt. Kefir milk from goats has more benefits than those from cow's milk, but it is still rarely in demand by the public because of its pungent aroma and taste. Star fruit is also known to have properties as an antibacterial, natural antioxidant and natural sucrose. Red ginger has also been widely recognized as a spice that has many properties as antibacterial, antioxidant, anti-inflammatory, and antiviral. In this study, researchers wanted to know the quality of the combination of Kefir milk with sweet star fruit juice and red ginger extract. The research will be carried out from February to May 2021. The kefir milk test includes bacteriological and physicochemical tests. The research design used a completely randomized design centered on one factor, namely the concentration of red ginger extract (0% control concentration, 4.5%, 6%, 7.5%). With Replica 3 times. Physicochemical tests are total acidity test, Vitamine c test and viscosity test. The results of the study showed that kefir fermented goat milk with the addition of star fruit juice and ginger juice was good for consumption, namely in treatment group 1 (containing 20% star fruit juice and 4.5% red ginger juice).

Formulasi dan aktivitas gel handsanitizer ekstrak daun sirih terhadap bakteri Staphylococcus aureus dan Escherichia coli Siti Anisaningrum; Dara Pranidya Tilarso; Amalia Eka Putri
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 7, No 1 (2023): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v7i1.8945

Gel hand sanitizer biasanya menyebabkan iritasi pada tangan, sehingga diperlukan inovasi hand sanitizer dari bahan alami yang lebih aman. Tujuan penelitian ini adalah mengembangkan formulasi ekstrak daun sirih hijau (Piper beetle L) dalam sediaan hand sanitizer terhadap berbagai gelling agent untuk menentukan basis gel hand sanitizer yang memiliki kualitas fisik sediaan yang baik dan untuk mengetahui aktivitas antibakterinya terhadap Staphylococcus aureus dan Escherichia coli secara in vitro. Basis dan formulasi hand sanitizer ekstrak daun sirih hijau dibuat dengan konsentrasi yang bervariasi. Kemudian dilakukan uji mutu fisik sediaan meliputi organoleptik, homogenitas, pH, daya sebar, viskositas, dan daya lekat yang diperoleh. F1 (Karbopol 940 0,5%), F4 (Na-CMC 3%), F5 (HPMC 4%). Kemudian dilakukan uji aktivitas antibakteri Staphylococcus aureus dan Escherichia coli secara in vitro dengan kontrol positif (Hand sanitizer Merk "D''). Hasil penelitian menunjukkan kriteria hand sanitizer dengan kualitas fisik yang baik. Sediaan diperoleh hand sanitizer gel berwarna hijau ekstrak daun sirih dengan formulasi gelling agent F1 (Karbopol 940 0,5%), F4 (Na-CMC 3%), F5 (HPMC 4 %) Pada uji aktivitas antibakteri gel hand sanitizer menunjukkan aktivitas antibakteri terhadap E.coli dan S. aureus.

Uji Aktivitas Antibakteri Fraksi Batang Pepaya (Carica papaya Linn.) terhadap Bakteri Escherichia coli ATCC 25922 Secara In Vitro Mia Audina Curnia Safitri; Amalia Eka Putri; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.247

Bakteri Escherichia coli ATCC 25922 merupakan mikroorganisme patogen yang menjadi penyebab terjadinya penyakit diare, meningitis, dan infeksi lainnya. Pengobatan yang umum untuk penyakit infeksi adalah antibiotik, akan tetapi terjadi banyak resistensi terhadap antibiotik yang disebabkan oleh penggunaan yang tidak tepat. Kasus resitensi tersebut mengakibatkan diperlukannya terapi alternatif untuk agen antibakteri yang berasal dari tumbuhan-tumbuhan yang memiliki potensi tinggi sebagai agen antibakteri. Batang pepaya mempunyai potensi sebagai agen antibakteri terhadap bakteri Escherichia coli ATCC 25922 yang merupakan bakteri patogen penyebab infeksi pada manusia. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri pada fraksi batang pepaya terhadap bakteri Escherichia coli ATCC 25922 dengan menggunakan metode difusi cakram serta untuk mengetahui fraksi batang pepaya yang memiliki zona hambat paling tinggi. Metode penelitian yang digunakan yaitu metode eksperimental. Sampel penelitian adalah batang pepaya yang di ekstraksi dengan menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak kemudian difraksinasi dengan menggunakan metode partisi cair – cair menggunakan pelarut n-heksana, diklorometana, dan aquadestilata. Fraksi batang pepaya dilakukan skrining fitokimia untuk mengetahui senyawa yang terkandung didalamnya. Kontrol positif yang digunakan yaitu tablet eritromisin 500 mg dan kontrol negatif yang digunakan yaitu masing-masing pelarut fraksi. Fraksi batang pepaya masing-masing dibuat dengan konsentrasi 1%. Analisa statistik dilakukan dengan menggunakan metode uji Shapiro-Wilk, Kruskal-Wallis, serta Mann-Whitney. Hasil uji aktivitas antibakteri fraksi batang pepaya menunjukkan hasil bahwa fraksi batang pepaya mempunyai aktivitas sebagai antibakteri terhadap bakteri Escherichia coli ATCC 25922. Fraksi n-heksana, diklorometana, dan aquadestilata batang pepaya masing-masing dengan konsentrasi 1% secara berurutan mempunyai rata-rata diameter zona hambat sebesar 12,57 ± 0,23 mm, 15,33 ± 0,35 mm, dan 18,97±0,58 mm. Aktivitas antibakteri diperkirakan berasal dari aktivitas senyawa flavonoid, tanin, dan saponin yang terkandung di dalam fraksi batang pepaya.

Pengaruh Konsentrasi PVA terhadap Stabilitas dan Aktivitas Antioksidan Masker Peel Off Ekstrak Kulit Jengkol (Archidendron pauciflorum (Benth.) Nielsen) Zahrina Hanny Nabila; Ary Kristijono; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.256

Abstract Jengkol skin (Archidendron pauciflorum (Benth.) Nielsen) has antioxidant activity because it contains flavonoid compounds, saponins, and alkaloids, so jengkol skin can be used as a facial treatment. The peel off mask preparation was chosen because is one type of cosmetic that is easy to use because it utilizes the ability to release the film layer when applied to the skin so that it can increase comfort in use and is expected to increase the antioxidant activity of jengkol skin extract. Components of masks such as PVA (Polyvinyl Alcohol) which act as filming agents, affect the physical properties of the mask, because it is the material underlying the peel off mask. A stability test needs to be carried out to ensure the durability of the mask during storage. This study aims to determine the stability and antioxidant activity of peel off masks of jengkol skin from various concentrations of PVA. The method used is maceration with 70% ethanol solvent. PVA was used with concentrations of 6%, 8% and 10%. The physical properties test includes organoleptic test, pH test, homogenity test, adhesion test, dispersion test, dry time test, and viscosity test. The antioxidant test of peel off mask preparations was carried out by DPPH method (1,1 Difenyl-2-picrylhydrazil). Based on the results of the study, it was obtained that the peel off mask preparation was stable for a maximum of 21 days of storage. Formula with a PVA concentration of 10% is the formula that has the best physical properties during storage but is the most unstable formula because there are more white lumps than other formulas on the 28th day. The IC50 values ??were 420.9 ?g/mL, 397.4 ?g/mL and 434.1 ?g/mL

Aktivitas Anti Candida albicans ATCC 14053 Sediaan Pasta Gigi Gel Ekstrak Daun Jengkol (Archidendron pauciflorum) dengan Kombinasi Na-CMC dan Karbomer: Activity of Anti-Candida albicans ATCC 14053 Toothpaste Gel Leaf Extract Jengkol (Archidendron pauciflorum) with Combination of Na-CMC and Carbomer Aria Agustina Achsia; Ary Kristijono; Dara Pranidya Tilarso
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.267

Jengkol leaf extract can inhibit the growth of the fungus Candida albicans because it contains flavonoids, saponins, and tannins. Candida albicans species are most commonly found in the oral cavity that can cause various diseases in humans as canker sores and skin lesions. The purpose of this study was to formulate jengkol leaf extract into gel toothpaste preparations by distinguishing variations in the concentration of carbomer as a gelling agent. The research method used is experimental. Jengkol leaf samples extracted using the maceration method with 70% ethanol. The concentration of active substance used in each formula was 7.5% based on the preliminary test results and the carbomer concentration used was 0.5% in formula I, 1% in formula II, 1.5% in formula III, and 2% in formula IV. The physical stability test consists of organoleptic, homogeneity, spreadability, viscosity, pH, and high foam for 28 days of storage. Antifungal activity test using the disc diffusion method. Statistic analysis performed using the Shapiro-Wilk, Levene Statistics, and One Way Anova methods. During 28 days of keeping all formula homogeneous stable. The viscosity increased in each formulation due to differences in the concentration of carbomer used, the higher of carbomer the more viscous of the preparation, the pH, foam height of the formulation was stable and met the standard. The particles are evenly distributed so that the formulation colors and odors have stable. The result of the antifungal activity test of toothpaste gel extract of 7,5% jengkol leaf has inhibition of 11 mm. The increase in carbomer concentration showed a significant difference in each formula based on the One Way Anova statistical analysis (p <0.05) and the addition of carbomers to the formula showed stable viscosity and high foam. The most stable formula is the formula I with a carbomer concentration of 0.5%.

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