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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Universa Medicina Amerta Nutrition
Lusiantari, Rokhima
Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats Lusiantari, Rokhima; Pramaningtyas, Miranti Dewi; Nurmasitoh, Titis; Pattimura, Rachmi Hidayati; Dewanti, Anggita
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.13-18

Abstract

BackgroundShortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.MethodsThis study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data. ResultsThere was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).Conclusion Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.
DERAJAT FIBROSIS DAN NAS PADA HEPAR TIKUS DIABETES MELLITUS TIPE 2 REMAJA Mohamad Alif Ramadan; Miranti Dewi Pramaningtyas; Rokhima Lusiantari
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.151315

Abstract

 Diabetes melitus merupakan penyakit kronis ditandai dengan peningkatan glukosa darah. Prevalensi diabetes mellitus tipe 2 pada pada anak-anak dan remaja 6,5%.  Kondisi Diabetes Mellitus tipe 2 dapat menyebabkan gangguan NAFLD hingga NASH. Tujuan Penelitian ini untuk mengetahui efek diabetes melitus tipe 2 terhadap gambaran fibrosis dan skor NAFLD pada histologi hepar tikus remaja. Penelitian ini menggunakan desain post-test only control group. Kelompok perlakuan diinduksi diet tinggi lemak 2 minggu dan streptozotosin. Kelompok kontrol positif diberi streptozotosin dan kelompok kontrol negatif diberi pakan standar. Organ hepar dibuat preparat histopatologi dengan pewarnaan Hematoksilin Eosin (HE). Pembacaan preparat berdasarkan kriteria NAFLD activity score (NAS) dan derajat fibrosis. Analisis data menggunakan Kruskal-Wallis Test dengan post-hoc Mann-Whitney U. Hasil pengamatan histopatologi hepar dengan kriteria NAS 1.80 ± 0.447 (K-), 2.20 ± 0.447 (K+), dan 1.60 ± 0.548 (P). Rata-rata hasil terkait derajat fibrosis 1.00 ± 0.000 (K-), 1.60 ± 0.894 (K+), dan 1.00 ± 1.000 (P). Hasil analisis perbandingan kriteria NAS antar kelompok tidak signifikan (p>0,05) dan begitu juga dengan fibrosis tidak signifikan (p>0,05). Kesimpulan penelitian ini tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe 2 dengan gambaran histopatologi hepar pada tikus remaja.
Penurunan Kadar Malondialdehid Aorta Abdominal Tikus Hiperkolesterolemia yang Diinduksi Mentega Putih setelah Pemberian Probiotik: Penurunan Kadar Malondialdehid Aorta Abdominal Tikus Hiperkolesterolemia setelah Pemberian Probiotik Dewanti, Alfi Brillianti Chrisna; Lusiantari, Rokhima; Pramaningtyas, Miranti Dewi
Amerta Nutrition Vol. 8 No. 2 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i2.2024.290-294

Abstract

Background: One of the risk factors for hypercholesterolemia is a high-fat diet. Hypercholesterolemia can cause an increase in free radicals in the body, one of which is malondialdehyde (MDA). Probiotics are food additives that have a positive effect on digestive health. The potential of probiotics as antihypercholesterolemia still requires further study. Objectives: To determine the effect of adding probiotics on MDA levels of the abdominal aorta in a hypercholesterolemic rat model. Methods: Nineteen male Wistar rats were divided into 5 groups: negative control (C-), positive control (C+), and three probiotic groups (T1, T2, and T3). The negative control group received standard food while the positive group received standard food and shortening. The probiotic group received standard feed and white butter, with probiotics at three different doses as treatment for 10 weeks. After termination, the abdominal aortic MDA levels were checked. Analysis of the data obtained used the Kruskal-Wallis test. Results: The mean levels of abdominal aortic MDA were 1.78 ± 0.11 nmol/g, 5.23 ± 0.51 nmol/g, 4.02 ± 0.02 nmol/g, 3.46 ± 0.16 nmol/g, and 2.20 ± 0.06 nmol/g for groups C-, C+, T1, T2, and T3, respectively. The statistical analysis showed that there was a significant difference in the abdominal aortic MDA levels (p<0.05). The T3 group showed the lowest abdominal aortic MDA levels of all. Conclusions: The administration of probiotics to male Wistar rats induced by shortening had a significant effect on the abdominal aortic MDA levels.
Co-Authors Dewanti, Alfi Brillianti Chrisna Dewanti, Anggita Miranti Dewi Pramaningtyas Mohamad Alif Ramadan Nurmasitoh, Titis Pattimura, Rachmi Hidayati