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All Journal Disease Prevention and Public Health Journal Universa Medicina Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Nurmasitoh, Titis
Departemen Fisiologi Fakultas Kedokteran Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Honey improves lipid profile of diet-induced hypercholesterolemic rats Nurmasitoh, Titis; Pramaningtyas, Miranti Dewi
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.177-186

Abstract

BackgroundCoronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia. One of the natural products that has been developed for the treatment of hypercholesterolemia is honey. Honey contains fructooligosaccharides, various vitamins, minerals, and enzymes which are supposedly able to lower blood cholesterol levels. This research aimed to study the influence of honey on the levels of blood total cholesterol, triglyceride, and low density lipoprotein (LDL) levels in Wistar rats. MethodsThis study was of experimental post test control group design. Twenty-four male Wistar rats (Rattus norvegicus) were randomly divided into 4 groups. K1 was the negative control group (with normal diet), K2 was the positive control group (with high-fat diet), P1 was fed a high-fat diet for 7 days, followed by high-fat diet plus honey for the next 7 days. P2 was fed a high-fat diet for 7 days, followed by regular diet plus honey for the next 7 days. After completion of this treatment, total cholesterol, triglycerides, and LDL levels were measured by the cholesterol oxidase phenol+aminophenazone (CHOD-PAP) method using enzymatic spectrophotometry principles. ResultsThere were significant differences in total cholesterol, triglyceride, and LDL levels between all groups after day 15 (p<0.05). ConclusionHoney supplementation was able to reduce the blood levels of total cholesterol, triglycerides, and LDL. Honey supplementation accompanied by non-cholesterol feeds could more effectively lower total cholesterol, triglycerides, and LDL serum levels in Wistar rats.
Black sugarcane decoction reduces rat brain ischemia Handayani, Ety Sari; Nugraha, Zainuri Sabta; Nurmasitoh, Titis; Kuswati, Kuswati; Ahsani, Dwi N.; Nanda, Ajeng G.
Universa Medicina Vol 35, No 1 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.40-45

Abstract

BackgroundThere are people in Yogyakarta, who use black sugarcane decoction (BSD) to prevent stroke. BSD contains policosanol and antioxidants. It has been proven that policosanol can reduce global ischemia in Mongolian gerbils. This study aims to evaluate the effect of BSD on brain ischemia in a rat stroke model. MethodsA laboratory experiment using eighteen 3-month old male Wistar rats without any defects, of 175-250 g body weight. Brain ischemia was produced by a 20-minute bilateral carotid communis artery oclusion (BCCAO).  Using a rat stroke model, brain ischemia was produced by a 20-minute BCCAO. The rats were randomized into three groups: BSD treated stroke model rats (group 1), non treated stroke model rats (group 2), and sham operated rats (group 3). BSD was administered by gavage for 1 week before BCCAO. Decapitation of rats was performed two hours post BCCAO. Brain tissues were stained with 2,3,5-triphenyltetrazolium chloride (TTC). Ischemic areas were analyzed using Image J softwere. Statistical analysis was conducted by one way ANOVA test.ResultsThe mean percentages of rat brain ischemic area differed between group 3 (0.0 ± 0.0%), group 2 (3.13 ± 0.59%) and group 1 (1.15 ± 0.47%) p =0.001). Post hoc test showed that there was no difference between group 3 with group 1. Instead, there was a significant difference between  group 2 and the other groups.ConclusionThe administration of BSD reduced rat brain ischemia after bilateral carotid artery ligation.
Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats Lusiantari, Rokhima; Pramaningtyas, Miranti Dewi; Nurmasitoh, Titis; Pattimura, Rachmi Hidayati; Dewanti, Anggita
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.13-18

Abstract

BackgroundShortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.MethodsThis study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data. ResultsThere was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).Conclusion Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.
Intermittent fasting decreases oxidative stress parameters in Wistar rats (Rattus norvegicus) Nurmasitoh, Titis; Utami, Shindy Yudha; Kusumawardani, Endah; Najmuddin, Abdulhalim Ahmad; Fidianingsih, Ika
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.31-38

Abstract

BackgroundChronic and degenerative diseases are closely related to modern lifestyles that tend to be deficient in physical activity but excessive in food intake. One method used to overcome this problem is dietary restriction through intermittent fasting. Intermittent fasting decreases the risk of chronic and degenerative diseases, e.g. by lowering oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and lipid profile in the blood. The present study aimed to determine the effect of intermittent fasting on plasma MDA levels and lipid profile of Wistar rats (Rattus norvegicus).MethodsThis research was a laboratory experimental research using a post test control group design. Twenty four male Wistar rats (Rattus norvegicus) were randomly assigned to 4 groups, ie control group (C), fasting group (F), non-fasting obese group (NFO), and fasting obese group (FO). Fasting treatment given in this research was intermittent fasting, comprising one day of fasting for 12 hours alternating with one day of normal feed ad libitum in the span of 8 weeks. After completion of treatment, blood was taken transcardially for examination of MDA levels and lipid profiles using spectrophotometry.ResultsThere were significant between-group differences in MDA levels and lipid profiles (p<0.05 for all parameters). Groups treated with intermittent fasting had lower levels of MDA, total cholesterol, triglycerides, and ow-density lipoprotein (LDL) than those without intermittent fasting. The high-density lipoprotein (HDL) levels were higher in the intermittent fasting group than the other groups.ConclusionIntermittent fasting has an effect on the oxidative stress parameters of Wistar rats (Rattus norvegicus).
Efek Konsumsi Daging Kambing terhadap Tekanan Darah Afid, Muhammad Dimas; Nurmasitoh, Titis
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 10, No 1 (2016): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.74 KB) | DOI: 10.12928/kesmas.v10i1.5209

Abstract

Background: The high prevalence of hypertension and its complications made the society more awareness. The people do some efforts to control blood pressure by limit the consumption of the food that could arise blood pressure such as mutton. The aim of this research was to determine the differences of average blood pressure before and after mutton consumption. Method: This research was a part of experimental method. The research was conduct at Belang Wetan, Klaten Utara. The sample of this research were 42 people with inclusion and exclusion criteria. The samples are chosen by consecutive sampling method. The blood pressure measured before mutton consumption and after 60 minutes after consuming with sphigmomanometer. Results: The average of systolic blood pressure before and after consumption was 105.48±10.41 113.76±7.6 mmHg into (p=0.00). While the average diastolikic blood pressure before and after mutton consumption was 67.62±7.9 to 75±5.52 mm Hg (p=0.00). Conclusion: There is a difference of average blood pressure before and after mutton consumption increasing blood pressure.
Mild anxiety and depression related to elevated dopamine level Fidianingsih, Ika; Nurmasitoh, Titis; Arjana, Adika Zhulhi; Devita, Ninda; Khoiriyah, Umatul
Universa Medicina Vol 38, No 1 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.451 KB) | DOI: 10.18051/UnivMed.2019.v38.48-55

Abstract

BackgroundDopamine is an important neurotransmitter that plays a role in the pathogenesis of anxiety and depression. Dopamine secretion occurs when there is a pleasurable stimulus. Blood dopamine levels have the potential to be developed as biomarkers of depression or anxiety, but previous studies related to the relationship between dopamine levels and levels of anxiety and depression are still controversial. The purpose of this study was to determine the correlation between anxiety and depression score with dopamine level in young adults. MethodsThis was an observational cross sectional study. A total of 43 subjects aged 18 to 40 years were recruited by consecutive non-random sampling according to inclusion and exclusion criteria. Anxiety and depression were assessed using the Beck anxiety inventory and Beck depression inventory-II questionnaire. Dopamine plasma level was measured using the enzyme-linked immunosorbent assay (ELISA). The Spearman rho correlation test was used to analyze the data and p<0.05 was considered significant.Results The median dopamine levels in respondents with mild, moderate and severe anxiety were respectively: 77.79; 63.43; 62.51 ng/mL (p=0.043). The median dopamine levels in respondents with reasonable depression, mood disorder, moderate and severe depression were respectively: 79.2; 61,32; 62,51; 60.24 (p=0.001). Correlation test results showed a weak correlation between dopamine and anxiety (r=- 0.310) and a moderate correlation for depression (r=-0.505).ConclusionMild anxiety and depression were associated with elevated dopamine level in young adults. Further studies are required to confirm the role of dopamine metabolism in anxiety and depression in young adults.
EFEK KONSUMSI DAGING KAMBING TERHADAP TEKANAN DARAH Afid, Muhammad Dimas; Nurmasitoh, Titis
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 10, No 1 (2016): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.74 KB) | DOI: 10.12928/kesmas.v10i1.5209

Abstract

Background: The high prevalence of hypertension and its complications made the society more awareness. The people do some efforts to control blood pressure by limit the consumption of the food that could arise blood pressure such as mutton. The aim of this research was to determine the differences of average blood pressure before and after mutton consumption. Method: This research was a part of experimental method. The research was conduct at Belang Wetan, Klaten Utara. The sample of this research were 42 people with inclusion and exclusion criteria. The samples are chosen by consecutive sampling method. The blood pressure measured before mutton consumption and after 60 minutes after consuming with sphigmomanometer. Results: The average of systolic blood pressure before and after consumption was 105.48±10.41 113.76±7.6 mmHg into (p=0.00). While the average diastolikic blood pressure before and after mutton consumption was 67.62±7.9 to 75±5.52 mm Hg (p=0.00). Conclusion: There is a difference of average blood pressure before and after mutton consumption increasing blood pressure.
PENGARUH PEMBERIAN PELEMBAP TERHADAP HASIL TES DISKRIMINASI DUA TITIK PADA PENGHUNI PANTI WREDHA ABIYOSO YOGYAKARTA Asyahidatul Muchlisah Fitriana; Titis Nurmasitoh; Rosmelia Malik
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 4, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss4.art6

Abstract

Latar Belakang Proses penuaan yang terjadi pada lansia  mengakibatkan perubahan pada sistem organ, terutama kulit yang dapat mengalami penurunan fungsi  sensoris. Fungsi  sensoris  dapat dideteksi secara sederhana menggunakan tes diskriminasi dua titik. Sementara itu, pemakaian pelembap dapat memperbaiki tampilan dan fungsi kulit pada lansia.  Tujuan Untuk mengetahui perbedaan hasil tes diskriminasi dua titik pada lansia di Panti Wredha Abiyoso Yogyakarta sebelum dan sesudah pemberian pelembap.  Metode Penelitian ini merupakan penelitian eksperimen yang menggunakan rancangan pre-test and post-test control group dan melibatkan 32 subjek penelitian yang terbagi pada kelompok kontrol dan kelompok eksperimen.  Hasil Analisis dengan uji T tidak berpasangan menunjukkan bahwa secara statistik terdapat perbedaan hasil tes diskriminasi dua titik yang signifikan antara  kelompok kontrol dan kelompok eksperimen  (p=0,001). Pada kelompok eksperimen, terdapat perbedaan nilai pre-test  dan  posttest  yang bermakna setelah pemberian pelembap  (p=0,007), sedangkan pada kelompok kontrol tidak terdapat perbedaan nilai yang signifikan antara hasil pre-test dan post-test (p=0,344).  Kesimpulan Terdapat perbedaan hasil tes diskriminasi dua titik yang bermakna pada lansia di Panti Wredha Abiyoso Yogyakarta antara kelompok kontrol dan kelompok eksperimen.  Kata Kunci: pelembap, tes diskriminasi dua titik, lansia
Effect of giving ethanol multistep doses to level of SGPT and SGOT in wistar rats (Rattus norvegicus) Istiqomah Kurniawati; Titis Nurmasitoh; Taufik Nur Yahya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art6

Abstract

Background: Ethanol is one types of alcohol used in beverages. Excessive use of ethanol causes damage to organs, especially in the liver. Liver, which is an organ in the body, serves as the metabolism of various substances including ethanol. Liver damage that occurs can be known with one of these liver function examination, which check the levels of SGPT and SGOT.Objective: This research aims to look for the difference of SGPT’s and SGOT’s levels between ethanol multistep doses group and control group in Wistar rats (Rattus norvegicus) SGPT and SGOT levels.Methods: This study used an experimental research design with post test only control group design. The sample consisted of 21 male Wistar rats, which were divided into 3 groups. Each group consisted of 7 rats. The first group (K1) was the control group, which was given aquades. The second group (K2) were given ethanol 20% as 2 g/kg pe roral. And the third group (K3) were given with 25% ethanol as 2.5g/kg peroral. The treatment was given for 4 weeks. At the 31st day blood was taken from orbitalis sinus as much as 1 ml for check the level of SGPT and SGOT.Results: The results are the average increase of SGPT and SGOT levels in K2 compared to the K1. While on K3 showed that the average levels of SGPT and SGOT were lower than K1. SGPT levels showed a significant difference (p0.05 ). Conclusion: There is significant differences in the levels of SGPT treatment group in comparison with the control group, but there is no significant differences in the level of SGOT.
Physical activities, exercises, and their effects to the immune system Titis Nurmasitoh
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 2, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss2.art4

Abstract

Every systems in human body correlate to maintain homeostasis. One of those systems which contribute to maintain homeostasis is the immune system. The immune system defends physiological functions against foreign substances and cancer cells through a complex and multilayered mechanism. The ability to defend against foreign substances and abnormal cells is done by two types of immune system, which are Innate immune system and adaptive/acquired immune system. There are also certain factors that affect the immune system, for instance physiological factor, nutrition, psychological factor, environental factor, and exercise or physical activities. Regular exercises and physical activities with moderate intensity will boost the immune system. Sedentary lifestyle and minimal physical activity will increase the risk of infectious diseases. While exercises and physical activity with high intensity will suppress the immune system hence increase the risk of infection.
Co-Authors Adika Zhulhi Arjana Afid, Muhammad Dimas Afid, Muhammad Dimas Ajeng G. Nanda, Ajeng G. Asyahidatul Muchlisah Fitriana Bowo, Endrawati Tri Bunga Nirwani Cahyaningrum, Yeny Dyah Dewa Ayu Citra Dewanti, Anggita Dwi N. Ahsani, Dwi N. Endrawati Tri Bowo Ety Sari Handayani Farida Juliantina Rachmawaty Ika Fidianingsih Istiqomah Kurniawati Khoiriyah, Umatul Kusumawardani, Endah Kuswati Kuswati Lusiantari, Rokhima Mahardina, Dewa Ayu Citra Miranti Dewi Pramaningtyas Najmuddin, Abdulhalim Ahmad Ninda Devita, Ninda Nirwani, Bunga Pattimura, Rachmi Hidayati Rosmelia Malik Taufik Nur Yahya Utami, Shindy Yudha Wijaya, Diani Puspa Yanasta Yudo Pratama Zainuri Sabta Nugraha, Zainuri Sabta