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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Universa Medicina Jurnal Surya Medika Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JURNAL EDUCATION AND DEVELOPMENT Amerta Nutrition Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Biomedika dan Kesehatan Jurnal Kedokteran Universitas Palangka Raya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Inisiasi Jurnal Inovasi Pengabdian dan Pemberdayaan Masyarakat Jurnal Kedokteran Hewan Biomedika Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Miranti Dewi Pramaningtyas
Department Of Physiology, Faculty Of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Honey improves lipid profile of diet-induced hypercholesterolemic rats Nurmasitoh, Titis; Pramaningtyas, Miranti Dewi
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.177-186

Abstract

BackgroundCoronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia. One of the natural products that has been developed for the treatment of hypercholesterolemia is honey. Honey contains fructooligosaccharides, various vitamins, minerals, and enzymes which are supposedly able to lower blood cholesterol levels. This research aimed to study the influence of honey on the levels of blood total cholesterol, triglyceride, and low density lipoprotein (LDL) levels in Wistar rats. MethodsThis study was of experimental post test control group design. Twenty-four male Wistar rats (Rattus norvegicus) were randomly divided into 4 groups. K1 was the negative control group (with normal diet), K2 was the positive control group (with high-fat diet), P1 was fed a high-fat diet for 7 days, followed by high-fat diet plus honey for the next 7 days. P2 was fed a high-fat diet for 7 days, followed by regular diet plus honey for the next 7 days. After completion of this treatment, total cholesterol, triglycerides, and LDL levels were measured by the cholesterol oxidase phenol+aminophenazone (CHOD-PAP) method using enzymatic spectrophotometry principles. ResultsThere were significant differences in total cholesterol, triglyceride, and LDL levels between all groups after day 15 (p<0.05). ConclusionHoney supplementation was able to reduce the blood levels of total cholesterol, triglycerides, and LDL. Honey supplementation accompanied by non-cholesterol feeds could more effectively lower total cholesterol, triglycerides, and LDL serum levels in Wistar rats.
Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats Lusiantari, Rokhima; Pramaningtyas, Miranti Dewi; Nurmasitoh, Titis; Pattimura, Rachmi Hidayati; Dewanti, Anggita
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.13-18

Abstract

BackgroundShortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.MethodsThis study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data. ResultsThere was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).Conclusion Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEIKUTSERTAAN TES INSPEKSI VISUAL ASETAT DI KULON PROGO Putri, Merisa Dinda; Fitriati, Yasmini; Pramaningtyas, Miranti Dewi; Hasibuan, Diah Hydrawati Sari
Biomedika Online First
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v0i0.10031

Abstract

ABSTRAKInspeksi Visual Asetat (IVA) merupakan pemeriksaan ginekologi dengan mengamati serviks secara visual menggunakan asam cuka untuk melihat sel yang mengalami dysplasia. Ada beberapa faktor yang menyebabkan wanita enggan melakukan pemeriksaan ini, diantaranya: pengetahuan, sikap, keterjangkauan jarak, keterpaparan informasi, dukungan suami, dan dukungan petugas kesehatan. Penelitian ini bertujuan mengetahui faktor-faktor yang mempengaruhi keikutsertaan wanita usia subur dalam tes IVA di Kulon Progo. Metode penelitian ini menggunakan rancangan cross sectional. Populasi penelitian ini adalah wanita usia subur yang tinggal di Kulon Progo. Data penelitian yang diambil menggunakan kuesioner yang dilakukan dari bulan Agustus hingga September 2017. Sampel yang diambil sebanyak 100 sampel dengan teknik konsekutif sampling. Dalam penelitian ini, uji statistik yang digunakan adalah chi square atau Fisher dengan menggunakan software statistik. Hasil penelitian menunjukkan responden yang pernah mengikuti tes IVA sebanyak 94 responden (94%) dan yang belum pernah mengikuti tes IVA sebanyak 6 responden (6%). Variabel sikap dan dukungan petugas kesehatan memiliki hubungan statistik bermakna terhadap keikutsertaan tes IVA, sedangkan variabel pengetahuan, keterjangkauan jarak, keterpaparan informasi/media massa, dan dukungan suami/keluarga tidak memiliki hubungan statistik bermakna terhadap keikutsertaan tes IVA. Kata Kunci: Kanker Serviks, Tes IVA, Wanita Usia Subur, Dukungan Petugas Kesehatan ABSTRACTVisual Acetate Inspection (VAI) is a gynecological examination by observing the cervix visually using vinegar to see cells experiencing dysplasia. There are several factors that cause women do not want to carry out this examination, including: knowledge, attitude, distance affordability, information exposure, husband's support, and health workers support.This study aimed to determine the factors that influence the participation of women of childbearing age in the VAI test in Kulon Progo. This research method used cross sectional design. This research population were women of childbearing age who live in Kulon Progo. Research data were taken using a questionnaire conducted from August to September 2017. Samples were taken as many as 100 samples with consecutive sampling technique. In this study, the statistical test used was chi square or Fisher using statistical software. The results showed that respondents who had taken the VAI test were 94 respondents (94%) and those who had never taken the VAI test were 6 respondents (6%). The attitude and health workers support have a statistically significant relationship to the participation of VAI tests, while the knowledge, distance affordability, information exposure, and husband’s support have not statistically significant relationship to the participation of VAI tests Keywords: Cervical Cancer, IVA Test, Fertile Woman, Health Care Support
The Rate of Exclusive Breastfeeding Success on Working Mothers in Klaten Regency Kholifa Nur Ardhina; Miranti Dewi Pramaningtyas; Emi Azmi Choironi
Jurnal Surya Medika (JSM) Vol 6 No 1 (2020): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v6i1.1617

Abstract

Work is often the reason for mothers not to have the opportunity to give exclusively breastfeeding for 6 months to their babies. This reason is motivated by the lack of sufficient time to breastfeed or express milk. This is also experienced by breastfeeding mothers in the Klaten region who already have regulations on exclusive breastfeeding. This study aims to determine the large percentage of exclusive breastfeeding for working mothers in Klaten district. This study uses a categorical descriptive method involving 117 respondents. Primary data were collected from the midwife clinics of Ni'ma and Warsiti, the Belang Wetan posyandu, and several TKs in Klaten, which were included in the inclusion criteria. A total of 63 mothers (54%) who worked successfully gave exclusive breastfeeding to their children, while unsuccessful were 54 mothers (46%). The success rate of exclusive breastfeeding in the age group of 17-25 years was 14 subjects (11.97%), at the age of 26-35 years was 44 (37.61%) and at the age of 36-45 was 5 (4.27%). The educational background of successful working mothers is D4 / S1 of 21 subjects (17.95%). The occupational groups that succeeded in providing exclusive breastfeeding were Teachers (54.5%), Entrepreneurs (75%), Civil Servants (80%), BUMN Employees (66.7%), and Health Workers (90.9%). The percentage of success of exclusive breastfeeding for mothers who worked for ≤ 8 hours amounted to 57.1%, while mothers who worked> 8 hours amounted to 36.8%. The higher the level of mother's education, the higher the success rate of exclusive breastfeeding. The longer the mother works, the lower the success rate of exclusive breastfeeding.
DERAJAT FIBROSIS DAN NAS PADA HEPAR TIKUS DIABETES MELLITUS TIPE 2 REMAJA Mohamad Alif Ramadan; Miranti Dewi Pramaningtyas; Rokhima Lusiantari
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.151315

Abstract

 Diabetes melitus merupakan penyakit kronis ditandai dengan peningkatan glukosa darah. Prevalensi diabetes mellitus tipe 2 pada pada anak-anak dan remaja 6,5%.  Kondisi Diabetes Mellitus tipe 2 dapat menyebabkan gangguan NAFLD hingga NASH. Tujuan Penelitian ini untuk mengetahui efek diabetes melitus tipe 2 terhadap gambaran fibrosis dan skor NAFLD pada histologi hepar tikus remaja. Penelitian ini menggunakan desain post-test only control group. Kelompok perlakuan diinduksi diet tinggi lemak 2 minggu dan streptozotosin. Kelompok kontrol positif diberi streptozotosin dan kelompok kontrol negatif diberi pakan standar. Organ hepar dibuat preparat histopatologi dengan pewarnaan Hematoksilin Eosin (HE). Pembacaan preparat berdasarkan kriteria NAFLD activity score (NAS) dan derajat fibrosis. Analisis data menggunakan Kruskal-Wallis Test dengan post-hoc Mann-Whitney U. Hasil pengamatan histopatologi hepar dengan kriteria NAS 1.80 ± 0.447 (K-), 2.20 ± 0.447 (K+), dan 1.60 ± 0.548 (P). Rata-rata hasil terkait derajat fibrosis 1.00 ± 0.000 (K-), 1.60 ± 0.894 (K+), dan 1.00 ± 1.000 (P). Hasil analisis perbandingan kriteria NAS antar kelompok tidak signifikan (p>0,05) dan begitu juga dengan fibrosis tidak signifikan (p>0,05). Kesimpulan penelitian ini tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe 2 dengan gambaran histopatologi hepar pada tikus remaja.
Hyperlipidemia Diet Reduces Superoxide Dismutase Inhibition Rate in the Brain Organ of Rattus norvegicus Muhammad Luthfi Adnan; Miranti Dewi Pramaningtyas; Dini Islamiana; Hilmi Ardian Sudarto
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.8167

Abstract

Quail (Coturnix coturnix japonica L.) egg yolk is one of the high-fat foods which can trigger hyperlipidemia. The condition of hyperlipidemia can have an oxidative stress effect on the brain. Superoxide dismutase (SOD) is a natural antioxidant that acts as a defense mechanism against oxidative stress. The inhibition rate of SOD decreases when oxidative stress occurs. This study aims to determine the effect of quail egg yolk on the SOD inhibition rate of brain organs on a rat. This study used male Wistar rats aged 2-3 months with 200-300 grams of weight. The rats were divided into two groups. Each group was fed with ad libitum for two weeks. The A groups as control continued ad libitum consumption, and the B group was given additional quail egg yolk 5 ml / 200 g BW for 2 weeks. At the end of the study, the rats were terminated. The brain organs were examined for SOD inhibition rate with spectrophotometry. The mean SOD inhibition rate in the A and B groups was 74.14% ± 6.16 and 24.14% ± 5.65, respectively. The independent t-test showed significant differences in SOD inhibition rate between groups (p 0.001). Furthermore, quail egg yolk significantly reduced the SOD inhibition rate in the brain organ of the rat.
PEMBERIAN JAHE TERHADAP PERBAIKAN KADAR PROFIL LIPID DAN RISIKO ATEROSKLEROSIS PADA DISLIPIDEMIA Mohamad Alif Ramadan; Miranti Dewi Pramaningtyas
Jurnal Kedokteran Universitas Palangka Raya Vol 9 No 1 (2021): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.59 KB) | DOI: 10.37304/jkupr.v9i1.2861

Abstract

Dislipidemia merupakan salah satu faktor risiko terjadinya penyakit jantung coroner (PJK) yakni aterosklerosis. Menurut World Health Organization (WHO), angka kejadian dislipidemia tertinggi terjadi di Eropa dan dapat meningkatkan risiko terjadinya stroke iskemik. Jahe (Zingiber officinale) merupakan tanaman herbal yang memiliki beberapa kandungan untuk memperbaiki kadar profil lipid. Pemberian jahe dapat mempengaruhi kadar profil lipid dengan beberapa dosis dan jenis ekstrak jahe. Beberapa penelitian menyebutkan kadar flavonoid pada jahe dapat menurunkan kadar kolesterol dengan meningkatkan sintesis asam empedu. Kandungan 6-gingerol pada jahe dapat menurunkan kadar Low-density lipoprotein cholesterol (LDL-C) lewat penurunan kadar C-reactive protein (CRP) dan prostaglandin (PGE2). Peningkatan kadar High-density lipoprotein cholesterol (HDL-C) dipengaruhi oleh kandungan niacin pada jahe. Trigliserida dapat menagalami penurunan kadar didalam serum dengan meningkatkan aktivasi enzim lipoprotein lipase (LPL). Efek antioksidan pada jahe dapat menghambat mekanisme oksidasi LDL-C dengan inhibisi enzim reactive-oxygen-generating sehingga dapat menurunkan risiko aterosklerosis. Studi literatur ini menyimpulkan jahe berperan dalam perubahan profil lipid dan penurunan risiko dislipidemia akibat aterosklerosis. Hal ini dapat menjadi rekomendasi untuk penelitian eksperimental.
THE RELATIONSHIP BETWEEN WAIST CIRCUMFERENCE AND SYSTOLIC BLOOD PRESSURE Miranti Dewi Pramaningtyas; Kaka Citta Prasiddha; Reza Ishak Estiko
Jurnal Kedokteran Universitas Palangka Raya Vol 9 No 2 (2021): Jurnal Kedokteran
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v9i2.3437

Abstract

This cross-sectional study reported a link between waist circumference as an anthropometric index for central obesity and systolic blood pressure. The study used a cross-sectional method by linking systolic blood pressure data and waist circumference. A total of 45 male and female participants met the inclusion criteria in the study. The average waist circumference (cm) is 79.90 ± 10.41, and the average systolic blood pressure (mmHg) is 107.28 ± 11.01. Of all participants, 84.4% had normal systolic blood pressure, 13.3% prehypertension, 2.2% stage 1 hypertension. For waist circumference, 21 out of 27 men in the central obesity category (77.8%) had a normal waist circumference (22.2%). On the other hand, 6 out of 18 women are centrally obese (33.3%), and 12 women have a normal waist circumference (66.7%). Spearman's correlation results show p=0.344. Research shows that there is a relationship between waist circumference and systolic blood pressure with a weak correlation.
Delayed lactogenesis II and unsuccessful exclusive breastfeeding Miranti Dewi Pramaningtyas
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss2.art2

Abstract

No abstract
Correlation of Total Body Fat and Physical Fitness Index in Medical Students of Universitas Islam Indonesia Firdaus, Lidya Sabilla; Pramaningtyas, Miranti Dewi; Nugraha, Zainuri Sabta
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): December 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.119 KB) | DOI: 10.30659/sainsmed.v12i2.7733

Abstract

The World Health Organization suggests that total body fat is one of the main risk factors for metabolic syndrome which is the most significant cause of morbidity and mortality in the world. The excessive fat mass harms the function of the heart, lowers the oxygen uptake by working muscles. Excess of body fat may decrease physical fitness. This research aims to know the correlation of total body fat with physical fitness index in medical students of Universitas Islam Indonesia. This research used a cross-sectional study design. The research subjects consisted of 45 male medical students of Universitas Islam of Indonesia under 25 years old. Total body fat of its subject is measured by Bioelectrical impedance analysis method (Karada scan), while physical fitness index is measured by the Harvard Step Test. This study is tested by Spearman correlation. Mean of TBF (%) value was 23.68 ± 6.29. Mean of physical fitness index levels was 60.05 ± 31.27. Spearman correlation test has a result r = -0.314 with a significance of p = 0.038 (p<0.05), that means total body fat and physical fitness index has a significant negative correlation. There was a significant negative correlation between total body fat and physical fitness index
Co-Authors Adi Nugraha Adnan, Muhammad Luthfi Adyaksa, Dewa Nyoman Murti Al-Ghozi, Yasfi Suryalfihro Al-Ghozi Aprillia, Viola Budiastuti, Ernadita Dewanti, Alfi Brillianti Chrisna Dewanti, Anggita Dini Islamiana Dwi Nur Ahsani Dwi Nurwulan Pravitasari Emi Azmi Choironi Ety Sari Handayani Fadilatul Khusna Amalla Firdaus, Hana Afifah Firdaus, Lidya Sabilla Fitriati, Yasmini Hana Isnaini Al Husna Hasibuan, Diah Hydrawati Sari Hilmi Ardian Sudarto Kaka Citta Prasiddha Kholifa Nur Ardhina Kiasati, Aghnia Lusiantari, Rokhima Mohamad Alif Ramadan Mohamad Alif Ramadan Muhammad Luthfi Muhammad Luthfi Adnan Nurani, Mega Puspa Nurmasitoh, Titis Pamungkas, Katon Pattimura, Rachmi Hidayati Putri, Fara Amalia Putri, Merisa Dinda Rahmawati, Isna Arifah Ratna Wulandari Reza Ishak Estiko RIZKI FAJAR UTAMI Safira, Nazala Safitri, Amalia Adityas Dyah Sukarno, Rizky Triutami Wahdiyati, Siti Wahyana, Eka Budi Wantoputri, Noviani Ima Weningtyas, Vyanda Sri Widyaningsih, Niken Wijaya, Diani Puspa Yanasta Yudo Pratama Zainuri Sabta Nugraha, Zainuri Sabta