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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Farmasi Higea
Fatimah Fatimah
Program Studi Analis Kesehatan, STIKES Karya Putra Bangsa Tulungagung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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THE IDENTIFICATION OF ANTIBACTERIAL COMPOUNDS IN CLOVE STEM EXTRACT (Syzygium aromaticum) AND ITS EFFECTIVENESS IN INHIBITING THE GROWTH OF Escherichia coli Yunita Diyah Safitri; Ana Amalia; Fatimah Fatimah; Afidatul Muadifah
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 1 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i1.28089

Abstract

Clove plants usage in daily life is very diverse, such as kitchen spices, mixtures of various drinks, and medicines. Clove is a spice plant that contains clove oil which is known as an antibacterial agent. The clove stem has a fairly high clove oil content, but this is not widely known by the public. Clove oil is known to have the ability as a fungicide, bactericide, insecticide, and nematicide. The purpose of this study is to identify antibacterial compounds and the effectiveness of clove stem extract on the growth of Escherichia coli. We used GCMS (Gas Chromatography Mass Spectrometry) analysis to identification antibacterial compounds. Antibacterial activity test using paper disc method by measuring the diameter of the inhibition zone formed from clove stem extract at doses of 30%, 50%, and 70% against Escherichia coli. The results of the study were analyzed using ANOVA with significance (p<0.05). The identification of the active compound showed 13 kinds of compounds were found with the dominant compound was alpha-pinene. The results of the antibacterial test showed the antibacterial activity of clove stem extract at doses of 30%, 50% and 70% with inhibition zones formed 12 mm, 12.7 mm, and 14.1 mm respectively. 
Perbandingan Aktivitas Antibakteri Rebusan Batang, Bunga dan Daun Cengkeh (Syzygium aromaticum) Terhadap Pertumbuhan Bakteri Escherichia coli ATCC 25922 Ekke Dwinda Intaningtyas; Fatimah Fatimah; Yunita Diyah Safitri
Jurnal Farmasi Higea Vol 15, No 1 (2023)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v15i1.473

Abstract

Escherichia coli merupakan pathogen penyebab diare yang dapat menginfeksi manusia melalui air atau makanan yang terkontaminasi. Penggunaan antibiotik yang tidak bijak dalam mengatasi infeksi bakteri dapat menimbulkan resistensi terhadap antibiotik. Cengkeh merupakan salah satu bahan alam yang memiliki potensi sebagai antibakteri dikarenakan kandungan eugenol yang ada pada tanaman cengkeh baik pada batang, daun maupun bunga. Penelitian ini bertujuan untuk mengetahui perbandingan aktivitas rebusan batang, bunga dan daun cengkeh (Syzygium aromaticum) dalam menghambat pertumbuhan bakteri Escherichia coli. Metode yang digunakan dalam penelitian ini adalah cakram kertas (Kirby-Bauer) dengan mengukur zona hambat yang terbentuk dari hasil aktivitas antibakteri ekstrak. Hasil penelitian ini menunjukkan baik batang, daun dan bunga memiliki aktivitas antibakteri yang kuat dengan rata – rata zona hambat yang terbentuk adalah 17 mm, 13 mm, dan 19 mm secara berurutan. Hambatan pertumbuhan bakteri yang tertinggi yaitu terdapat pada bunga cengkeh. Kesimpulan penelitian ini adalah ekstrak yang paling optimal dalam menghambat pertumbuhan Escherichia coli diantara rebusan batang, bunga dan daun cengkeh (Syzygium aromaticum) adalah bunga cengkeh. 
Co-Authors Afidatul Muadifah Ana Amalia Ekke Dwinda Intaningtyas Safitri, Yunita Diyah