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All Journal Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas
Phebe Hendra
Faculty of Pharmacy, Universitas Sanata Dharma
Health Professions Medicine & Pharmacology Public Health

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EFEK HEPATOPROTEKTIF DAN NEFROPROTEKTIF BIJI ALPUKAT PADA TIKUS TERINDUKSI KARBON TETRAKLORIDA Phebe Hendra; Gidion Krisnadi; Ni Luh Putu Dian Perwita; Ike Kumalasari; Yuditha Anggarhani Quraisyin
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.145 KB) | DOI: 10.22146/tradmedj.8230

Abstract

The aim of this research to investigate the hepatoprotective and nephroprotecitve effects of Avocado seeds against carbon tetrachloride in rats. The rats was treated with the infusion and decoction of avocado seeds at doses 360.7, 642.1, 1142,9 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2mL/kg) was given on the 7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours application for the serum transaminase and creatinine. The increasing of serum transaminase and creatinine in carbon tetrachloride-treated rats, were significantly decreased (p<0.05) with both pretreatment of infusion and decoction of avocado seeds. Based on the research, it can be concluded that infusion and decoction of avocado seeds have a potent protective action upon carbon tetrachloride-induced hepatic and renal damage in rats.
High Frequency of CYP2A6*4, CYP2A6*7, and CYP2A6*9 Alleles Detected Among Patients with Type 2 Diabetic: Genetic Study in The Private Hospital in Yogyakarta Christine Patramurti; Dita Maria Virginia; Fenty Fenty; Christianus Heru Setiawan; Jeffry Julianus; Phebe Hendra; Nicholas Adi Perdana Susanto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 2 (2022)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.863 KB) | DOI: 10.24071/jpsc.003902

Abstract

Smoking is a risk factor for type 2 diabetic (T2DM), since the nicotine in cigarettes can cause insulin resistance and increase lipolysis. Both of these can worsen the condition of patients with T2DM and increase treatment failure. Nicotine is metabolized to cotinine by the CYP2A6 enzyme encoded by the CYP2A6 gene. This gene is highly polymorphic, with several inactive alleles, which are CYP2A6 *4, CYP2A6 *7, and CYP2A6 *9. Someone who has an inactive gene will experience being a slow or poor metabolizer. Therefore, the nicotine metabolism will decrease, nicotine blood levels will increase, causing therapy failure among patients with T2DM. This study aims to determine the distribution of CYP2A6*4, CYP2A6*7, and CYP2A6*9 among patients with T2DM who have been routinely treated using oral antidiabetics. We also investigated whether HbA1c levels is a predictor for the success of the treatment. This observational study was conducted with a cross-sectional design. Polymerase chain reaction was used to analyze the three inactive alleles with specific primers. Based on our study, there is a high frequency of the inactive alleles, i.e., CYP2A6*4, CYP2A6*7, and CYP2A6*9, among the patients with T2DM. The presence of these inactive alleles will worsen and reduce the effectiveness of the therapy. Smoking cessation programs are needed to increase the effectiveness of the anti-diabetic therapy.
Co-Authors Christianus Heru Setiawan Christine Patramurti Dita Maria Virginia Fenty Fenty Gidion Krisnadi Ike Kumalasari Jeffry Julianus Ni Luh Putu Dian Perwita Nicholas Adi Perdana Susanto Yuditha Anggarhani Quraisyin