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All Journal Majalah Obat Tradisional
Rismawati Laila Qodariah
Aretha Medika Utama, Biomolecular Research Center, Jalan Babakan Jeruk II No. 9, Bandung 40163, West Java, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Ethanol Extract of Detam 1 Soybean Seed (Glycine Max L. Merr) for Chronic Kidney Disease Therapy by In Vitro Study Sijani Prahastuti; Meilinah Hidayat; Stella Tinia Hasiana; Wahyu Widowati; Annisa Amalia; Rismawati Laila Qodariah; Rizal Rizal; Satrio Haryo Benowo Wibowo; Hanna Sari Widya Kusuma
Majalah Obat Tradisional Vol 24, No 3 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.45053

Abstract

Chronic Kidney Disease (CKD) has increased incidence and prevalence in developing nations. In this in vitro study, we evaluated the cells proliferative effects, fibronectin (FN), transforming growth factor β (TGF-β1), and Reactive oxygen species (ROS) - level inhibition potential of ethanol extract of detam 1 soybean seed (EEDS) on glucose-induced kidney mesangial cells (SV40 MES 13). The cells proliferation assay used 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)2H-tetrazolium (MTS) assay. FN and TGF-β1 level were measured using ELISA assay kit and ROS level using flow cytometry. Level of   FN, TGF-β1 and ROS, on CKD cells model (5 mM, 10 mM glucose-induced mesangial cell) treated with EEDS 6.25 µg/mL were lower significantly compared to positive control,  EEDS improve cells viability and decrease FN, TGF-β1 and ROS level in glucose-induced kidney mesangial cells as CKD cells model.
Co-Authors Annisa Amalia Hanna Sari Widya Kusuma Meilinah Hidayat Rizal Rizal Satrio Haryo Benowo Wibowo Sijani Prahastuti Stella Tinia Hasiana Wahyu Widowati