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All Journal PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman JURNAL ATOMIK
Winni Astuti
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science

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PENENTUAN KADAR ASAM AMINO ESENSIAL (FENILALANIN, TREONIN, TIROSIN DAN VALIN) PADA TELUR PENYU DAN TELUR AYAM RAS Agnes Lebang; Saibun Sitorus; winni astuti
JURNAL KIMIA MULAWARMAN Vol 15 No 2 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v15i2.410

Abstract

Determination of amino acid essential’s content (phenylalanin, threonin, tyrosin and valine) on turtle eggs and chicken eggs. Turtle eggs and chicken eggs are a high animal protein source and easy to obtain. This research has been carried out by categorizing of turtle eggs and chicken eggs by size and continued analysis of water content by Methods of Gravimetry, analyzes protein content total by the Method of Kjeldahl and analysis of the levels of essential amino acids with Method of HPLC (High Performance Liquid Chromatography). In this study, the researcher found the water content in the mix (large, medium and small) is 73,1891% and mixture of chicken eggs of different size is 73,1820%. Results of total protein content with used Kjeldahl method mixture based on the size of turtle eggs is 9,3114% and mixture chicken eggs is 10,2691%. Results of the amino acid content with used HPLC (High Performance Liquid Chromatography) method on a mixture of turtle eggs is Phenylalanin 1,69%, Threonin 1,16%, Tyrosin 2,46% and Valine 1,46%. Mixture of chicken eggs is Phenylalanin 0,30%, Threonin 0,61%, Tyrosin 1,03% and Valine 0,55%
STUDI DOCKING MOLEKULAR SENYAWA KUERSETIN, KALKON DAN TURUNANNYA SEBAGAI INHIBITOR SEL KANKER PAYUDARA MC-7 (MICHIGAN CANCER FOUNDATION-7) Resy Lelita; Rahmat Gunawan; Winni Astuti
JURNAL ATOMIK Vol 2 No 2 (2017)
Publisher : Jurusan Kimia FMIPA UNMUL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.717 KB)

Abstract

Studi Docking Molekular senyawa Kuersetin, Kalkon dan turunannya sebagai inhibitor sel kanker payudara MCF-7 (Michigan Cancer Foundation-7) telah dilakukan . Hasil yang didapatkan bahwa energi docking setelah proses penambatan pada mode 1 dari ke empat senyawa uji yaitu Kuersetin -7.4 Kkal/mol, 2-(3,4- dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on -6.8 Kkal/mol, Kalkon -6.9 Kkal/mol dan 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on -6.6 Kkal/mol. Kuersetin membentuk ikatan hidrogen dengan asam amino Asam Aspartat 61, Arginin 65, Arginin 68, Fenilalanin 71 dan Serin 75. 2-(3,4- dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on membentuk ikatan hidrogen dengan asam amino Alanin 59, Aparagin 102 dan Arginin 105. Kalkon membentuk ikatan hidrogen dengan asam amino Asam Glutamat 94. Dan 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on membentuk ikatan hidrogen dengan asam amino Tirosin 67. Kuersetin dinilai lebih berpotensi sebagai kandidat obat antikanker dibandingkan 2-(3,4- dihidroksifenil)-5,7-dihidroksi-3-metoksi-3,4-dihidro-2H-1-benzopyran-4-on, chalcone and 3-(2,4-dihidroksifenil)-1-fenilpropan-1-on. Kata Kunci : Kanker Payudara, Docking Molekular, Kuersetin, Kalkon, Protein sel kanker payudara Michigan Cancer Foundation -7 (MCF-7).
Co-Authors Agnes Lebang Delina Khairunnisa Diasttri Wahyu Rahmah Day Dzulkarnain Dzulkarnain Eno Julia Shafarini Erwin Erwin Fajarwati Siska Hendric Surya Putra Lila Karina Nuryanti Muhammad Taufik A. A. R Rahmat Gunawan Resy Lelita Rezky Estrada Rudi Kartika, Rudi Saibun Sitorus Wulan Verani