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Pembuatan Tablet Hisap Campuran Jambu Biji Merah (Psidium guajava L.) dan Angkak (Monascus purpureus) Menggunakan Metode Kempa Langsung dan Granulasi Kering Adityo Fajar Nugroho; Ning Ima Arie Wardayanie; Hendra Wijaya
Warta Industri Hasil Pertanian Vol 37, No 2 (2020)
Publisher : Balai Besar Industri Agro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32765/wartaihp.v37i2.6403

ABSTRAK: Jambu biji merah mempunyai kadar vitamin C yang cukup tinggi dan angkak mengandung lovastatin yang berfungsi sebagai anti-kolesterol. Interaksi antara vitamin C dan lovastatin bersifat sinergis sehingga vitamin C dapat meningkatkan penyerapan lovastatin. Penelitian ini bertujuan membuat tablet hisap dari campuran jambu biji merah dan angkak menggunakan metode kempa langsung dan granulasi kering. Variabel penelitian adalah jenis formula yang digunakan dan metode pada proses pembuatan tablet. Evaluasi karakteristik fisik dilakukan baik terhadap granul maupun produk tablet hisap. Hasil menunjukkan bahwa formulasi campuran 10% serbuk jambu biji merah dan 20% angkak yang dibuat dengan cara granulasi kering memberikan kualitas tablet hisap terbaik dalam penelitian ini. Granul formulasi memiliki tingkat kekeringan 3,7%, laju alir 13 detik, dan sudut diam 31°. Tablet hisap yang terbentuk memiliki ukuran dan bobot yang seragam, nilai kekerasan 0,5 kp, kerapuhan 0%, waktu 4 menit dan kadar vitamin C sebesar 89,60 mg/100g.Kata kunci: angkak, granulasi kering, jambu biji, kempa langsung, tablet hisapABSTRACT: Red guava have high vitamin C content and angkak (red yeast rice) contains lovastatin as an anti-cholesterol. There was a synergistic interaction between Vitamin C and lovastatin so that vitamin C could increase lovastatin absorption. The research aims was formulating lozenges from a mixture of red guava and angkak using direct compression and dry granulation methods. The research variables were types of formulation and production methods of lozenges. The granules and lozenges were evaluated for their physical characteristics. The results showed that the mixture formulation of 10% red guava powder and 20% angkak using the dry granulation method gave the best results in this research. The granules have a 3,7% dryness level, a flow rate of 13 seconds, and a standpoint of 31°. While the lozenges have uniformly tablet size and weight, hardness value of 0,5 kp, 0% friability, disintegration time at 4 minutes, and vitamin C content of 89,60 mg / 100g.Keywords: angkak, dry granulation, guava, direct compression, lozenges

Isolasi Senyawa β-Karoten dari Minyak Kelapa Sawit Mentah (Elaeis Guineensis Jacq.) dengan Metode Kromatografi Kolom Terbuka Hendra Wijaya; Ning Ima Arie Wardayanie; Rizki Maryam Astuti; Rahmad Arif
Warta Industri Hasil Pertanian Vol 35, No 2 (2018)
Publisher : Balai Besar Industri Agro

Minyak kelapa sawit mentah dapat dijadikan sebagai sumber β-karoten karena jumlahnya yang melimpah dan tingginya kadar β-karoten. Penelitian ini bertujuan mengisolasi β-karoten minyak sawit mentah (Elaeis guineensis Jacq.) dengan metode kromatografi kolom terbuka. Ekstraksi total karotenoid dilakukan dengan metode transesterifikasi-adsorpsi-desorpsi dan metode saponifikasi. Variabel yang diteliti pada metode transesterifikasi-adsorpsi-desorpsi adalah perbandingan kaolin terhadap metal ester-nya yaitu rasio 1:2, 1:3, 1:4 sedangkan variabel pada metode saponifikasi adalah waktu saponifikasi 0, 30 menit dan 60 menit. Hasil ekstrak total karotenoid dari metode yang terbaik dilanjutkan isolasi dengan kromatografi kolom terbuka. Hasil ekstrak dan isolat dikarakterisasi dengan kromatografi lapis tipis, spektrofotometer UV-VIS dan HPLC. Hasil penelitian menunjukkan bahwa metode ekstraksi saponifikasi pada suhu 56 °C selama 60 menit menghasilkan recovery β-karoten paling tinggi yaitu sebesar 80.90% dan berbeda secara statistik dengan perlakuan lainnya. Isolasi β-karoten dengan kromatografi kolom terbuka dilakukan dengan eluen heksana, aseton, etil asetat dan metanol (27:4:2:2), isolat yang dihasilkan memiliki Rf yang sama dengan standar dan absorbansi maksimum pada panjang gelombang yang berdekatan dengan standar. Konsentrasi β-karoten yang diperoleh adalah 178.43 ± 20.37 ppm dengan % recovery 78.09%.

Pengembangan Teknologi Pengolahan Serbuk Minyak Buah Merah (Pandanus conoideus Lamk) untuk Sediaan Bahan Tambahan Pangan Nami Lestari; Lukman Junaidi; Hendra Wijaya; Ning Ima Arie Wardayanie; Santi Ariningsih, M.Si
Warta Industri Hasil Pertanian Vol 38, No 2 (2021)
Publisher : Balai Besar Industri Agro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32765/wartaihp.v38i2.7371

Pemanfaatan minyak buah merah sebagai bahan tambahan pangan masih terbatas. Penelitian sebelumnya menghasilkan serbuk minyak buah merah yang menggumpal dan mempunyai kelarutan yang rendah dalam fase cair. Penelitian ini bertujuan mengembangkan teknologi dan formulasi pembuatan serbuk minyak buah merah yang tidak menggumpal serta mempunyai kelarutan dalam air dan kandungan beta karoten yang cukup tinggi. Metode penelitian dilakukan dengan penambahan proses homogenisasi sebelum proses pengeringan semprot dan variasi bahan pengisi (maltodekstrin dan siklodekstrin). Hasil penelitian menunjukkan mutu serbuk minyak buah merah dipengaruhi oleh proses homogenisasi menggunakan emulsifier (lesitin) sebelum dilakukan pengeringan dengan alat pengering semprot. Serbuk minyak yang dihasilkan berbentuk kristal, berwarna merah oranye dan teksturnya tidak menggumpal. Kadar β-karoten tertinggi didapat pada serbuk minyak buah merah dengan penambahan siklodekstrin (1:2), yaitu 5,97 mg/kg. Rendemen berkisar antara 16,5 – 29,8 % dan kelarutan berkisar antara 49,13 sampai 89,32%. Sedangkan Analisis morfologi menggunakan SEM memperlihatkan bahwa serbuk minyak buah merah berbentuk bulat tidak beraturan, tersebar secara merata dan tidak membentuk flokulasi dengan ukuran 20-70 µm.

(Studi Toksisitas Akut dan Subakut dari Ekstrak Minyak Buah Merah pada Tikus Sprague Dawley) Toshiaki Nishigaki; Fitriya N.A. Dewi; Hendra Wijaya; Hidekazu Shigematsu
Warta Industri Hasil Pertanian Vol 28, No 01 (2011)
Publisher : Balai Besar Industri Agro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32765/warta ihp.v28i01.2620

Pandanus conoideus is exclusively grown in papua island and its neighbor areas and its fruit (buah merah) has been utilized as food supplement by the native papua people for a long period. recently it was found that its extract oil (SMB) contains contents of carotenoids ,especially a novel micronutrient beta-cryptoxanthin .we consider that SBM is a potent chemopreventive supplement against some types of cancer and provide health benefits for chronic diseases .in the present studies, we evaluated acute ad subacute toxicities of SBM using Sprague Dawley rats.Oral acute toxicity of SBM using female rats was not observed and LD 50 was more than 2 ml/kg in subacute toxicity study ,SMB was orally administered at 0.1,0.3 and 1.0 ml/kg to male and female rats for consecutive 4 weeks .no findings associated with SBM observed we consecutive 4 weeks .no findings associated with were observed we conclude that SBM is a safe food supplement.

(Method for HPLC Analysis of Active Compounds in Ginger (Zingiber officinale) Yus Maria Novelina.S; M Maman Rohaman; Hendra Wijaya
Warta Industri Hasil Pertanian Vol 28, No 02 (2011)
Publisher : Balai Besar Industri Agro

The studies Ginger (zingiber officinale) is one of herb plant which contains various of active compounds,which is proved has function has to human health .in indonesia , there are 3 main ginger variaties,those are :giant gingger (zingiber officinale var .officinale),emprit ginger (Zingiber officinale var. amarum ), and red ginger (Zingiber officinale var.rubrum) .Each ofthem has different characteristic and function .the problems which often occurs are ginger counterfeting,often mixed with other gingers.this counterfeiting difficult to be detected with conventional test method. therefore needed study about characteristic of each ginger with HPLC so counterfeiting able to be traced .Asensitive and accurate high-performance liquid chromatography (HPLC) method has been developed to determine the quantity of active componen in the methanolic extract of Zingiber officinale Bioactive component was separated on persuit C18 Column (250 mm x4.6 mm,particle size:5 um)with gradient system of water and acetonitrile as mobile phase. the calibration plot was linear in the range of 0.10-150 mg/L .of 6-,8-,10-gingerol and the correlation coefficient of o.9998 was indicative of good linear dependence of peak area on concentration .the limit of detection (LOD) OF 6-gingerol ,8-ginggerol ,6-shogaol and 6-shogaol and the correlation coefficient were 2,34 1,06; 1,25, and 0,67 mg/l and limit of detection (LOD)were 7,81 :3,53 :3,53; 4,18 and 2,29 mg/lrespectively.the developed HPLC method was found selective,precise and accurate,and can be used for routine analysis of gingers in the quality control laboratories .

Identifikasi dan Fraksinasi Karotenoid pada Minyak Buah Merah (Pandanus conoideus) Erka Fitria; Nur Wulandari; Purwiyatno Hariyadi; Hendra Wijaya
Warta Industri Hasil Pertanian Vol 37, No 1 (2020)
Publisher : Balai Besar Industri Agro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32765/wartaihp.v37i1.5686

Karotenoid adalah golongan pigmen dengan struktur isoprenoid yang memiliki berbagai manfaat bagi kesehatan. Buah merah (Pandanus conoideus) merupakan sumber karotenoid yang potensial karena memiliki kadar karotenoid yang tinggi. Buah merah menyebar luas di daerah Papua dan Papua Nugini dan banyak digunakan sebagai makanan dan bahan masakan. Beberapa jenis karotenoid telah berhasil diidentifikasi namun dalam jumlah yang relatif sedikit, antara lain α-karoten, β-karoten, α-kriptoxanthin, dan β-kriptoxanthin. Oleh karena itu, penelitian ini dilakukan dengan tujuan mengidentifikasi karotenoid yang ada pada minyak buah merah selain α-karoten, β-karoten, α-kriptoxanthin, dan β-kriptoxantin. Dari penelitian ini, enam jenis karotenoid berhasil teridentifikasi dari ekstrak total karotenoid seperti (3S, 5R, 6R)-3,5-dihidroksi-6,7-didehidro-5,6-dihidro-12'-apo-β-karoten-12'-al, 10'-apo-beta-karotenal, (3S, 3'S, 5R, 5'R, 8'R, 9'cis)-3'-metil-6,7-didehidro-5,5',6,8'–tetrahidro–5',8'-epoksi-β,β-karotene-3,5-diol, phytoene, 3-hidroksi–3'-okso-β,ε-karoten, dan violaxanthin. Selain itu, terdapat dua fraksi terpilih dari hasil fraksinasi dengan Flash Column Chromatography untuk diidentifikasi lebih lanjut. Dari fraksi tersebut teridentifikasi lima jenis karotenoid pada fraksi kedua, termasuk dua di antaranya yaitu capsantin dan kriptoxantin yang belum teridentifikasi sebelumnya pada ekstrak total karotenoid. Diprediksi terdapat α-karoten dan β-karoten pada fraksi pertama apabila dilihat dari persamaan waktu retensinya dengan standar.

(Manihot utilissima Pohl.)(The Effects of Sucrose and Citric Acid Concentration on the Co-crystallization of Fermented Cassava (Manihot utilissina Pohl) Extract) Indra Neffi Ridwan; Titin Sriyogasari; Hendra Wijaya; Ela Turmala Sutrisno
Warta Industri Hasil Pertanian Vol 21, No 02 (2004)
Publisher : Balai Besar Industri Agro

The purpose of this research is to study the effect of interaction between sucrose and citric acid concentration on the quality of co-crystallization of fermented cassava (manihot utillisima pohl). Extract. The benefit of this research is to diversify cassava fermented product in order to type of food product that is more pratical in its consumption. s a result this product will create an increasing economic value of cassava. The experiment was carried out using the randomized block desing withpattern factorial and 3 times replicating. The frist factor is sucrose concentration (40%; 50%; and 60%) and the second factor is citric acid concentration (1% ; 1.5%; and 2%). Parameter analyzed during the experiment were moinsture content, total sugar, solubility, and organoleptic test using prefence test type with 15 panelist which cover color, taste, flavor, and apperance. Basedc on the result of organoleptic test of microcrystal fermented cassava extract that perferred by panelist were it was produced with 40% of surcose and 1.5% of citric acid concentraction. This fermented cassava extract produced by this methods contain moinsture content 2.14% and total sugar 56.05%, and has solubility 26.84%.

(Antioxidants : Mechanism of Action and Its Function in Human Body) Hendra Wijaya; Lukman Junaidi
Warta Industri Hasil Pertanian Vol 28, No 02 (2011)
Publisher : Balai Besar Industri Agro

Antioxidant could be defined by several means. Antioxidant is a substance that could postpone and delay oxidation of molecule substrate in human body ,i.e ; protein ,carboydtrate,lipid and DNA, by oxidant. antioxidant that works in the human body's biological system is called a biological antioxidant Biological antioxidants can be grouped into :1) enzymatic antioxidants (endogenous) ,2) non-enzymatic antioxidants (endogenaous) and, 3) antioxidants from food (exogenous0.Enzymatic antioxidants (endogenous) include superoxide dismutase ,catalase ,glutathione peroxidase, glutaredoksin, tioredoksin, peroksiredoksin ,and coenzyme q10.non-enzymatic antioxidants (ENDOGENOUS) are carotenoids,vitamin E and vitamin C those antioxidants are able to work in hydrophobic and hydrophilic cellular environment so as to from a strong network of cooperation in preventing the occurrence of oxidative damage .some of the functions of antioxidants in the human body that can be expressed are ; preventive defense the human body against oxidants ,strong defense system against free redicals ,prevent the occurrence atherosclerosis in blood vessels,regulation of metabolism such as disabling lipoksigenase.

Mutagenicity Study of Pandanus Conoideus Oil Takanori Maeda; Haruka Miyakita; Manami Goto; Akemi Ito; Hendra Wijaya; Inggrid S. Surono; Toshiaki Nishigaki
Warta Industri Hasil Pertanian Vol 30, No 02 (2013)
Publisher : Balai Besar Industri Agro

Pandanus conoideus (buah merah or tawi) is exclusively grown in Papua island and its neighbor areas, and indigenous people have been consuming it as functional food for thousand years. We have reported safety and anti-tumor effects of Buah Merah extract oil (S.B.M) in experimental animals. However, mutagenicity or genotoxicity of S.B.M has not been evaluated. We carried out mutagenetic evaluation of S.B.M by in vitro Ames test using salmonella typhimurium TA98, TA100, TA1535 and TA1537 and escherichia coli WR2uvrA with or withou the activation of S9 mixture. Concentrations used for this test were 313-500ug/plate. The results show that there is no increase in revertant colonies, suggesting that S.B.M has no mutagenic activities under the conditions of this study.

(The Effectiveness of Bamboo Charcoal as a Cigarette Smoke Filter) Lukman Junaidi; Hendra Wijaya
Warta Industri Hasil Pertanian Vol 28, No 01 (2011)
Publisher : Balai Besar Industri Agro

Research on effectiveness effectiveness of using bamboo charcoal for cigarette smoke filter has been conducted .the aim of research was to investigate the characteristics of bamboo charcoal as a cigarette smoke filter .the results show the type of bambo charcoal andong and betung as well as particle size give no significance influence on benzene and chloroform adsorption ,while in contrarily give significance influence on significance influence on benzene and chloroform adsorption,while in contrarily give significance influence on 0idium adsorption .usingthe cigarette filter added with bamboo charcoal andong and betung could increase 90% tar adsorption in cigarette smoke compare to tar adsorption by cigarette filter without bamboo charcoal added .while bamboo charoal filter andong and betung could increase nicotine adsorption in cigarette smoke only 45% and 19% respectively compare to tar adsorption by cigarette filter without bamboo charcoal added. The size of mesh of bamboo charcoal filter andong and betung give same level of influence on tar and nicotine adsorption.the lower the size of mesh the higher the effectiveness on tar and nicotine adsorption.

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