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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Sains dan Komunitas Pharmasipha
Irsan Fahmi Almuhtarihan
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Studi Penggunaan Flukonazol pada Pasien HIV/AIDS dengan Infeksi Oportunistik Jamur: Penelitian di RSUD Dr. Saiful Anwar Irsan Fahmi Almuhtarihan; Didik Hasmono; Hidajah Rachmawati; Agus Sunarko
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1882

Abstract

AIDS is characterized by a transition of opportunistic infections. The most common opportunistic infection is candidiasis with prevalence among HIV patients between 80% to 95%. Fluconazole is the main treatment for candidiasis, but combination with nystatin is often done. This study aims to determine the pattern of fluconazole dosages, dosage forms, and combinations given to HIV/AIDS patient with opportunistic fungal infection. This observational retrospective study was conducted on HIV/AIDS patients who were hospitalized with opportunistic fungal infections in the period of January 1st, 2015 to December 31st, 2015 who received fluconazole. Thirty-five patients were included in this study. Fluconazole monotherapy was used by 21 patients (43%), while combination therapy with nystatin was used by 28 patients (57%). Fluconazole monotherapy was generally preceded by the loading dose (1×400 mg) IV drip followed by maintenance doses (1x200 mg) IV drip in 6 patients (24%), whereas the combination of fluconazole and nystatin was generally used as fluconazole (1×200 mg) IV drip and nystatin (3×300,000 IU) PO in 7 patients (14%). Oral fluconazole was mostly (86%) given less than five days, whereas fluconazole IV drip was mostly (43%) given for 6-10 days. The patterns of fluconazole dosages, dosage forms, and combinations given to HIV/AIDS patient with opportunistic fungal infection was appropriate.
Studi pola administrasi penggunaan asetosal pada pasien stroke iskemik Almuhtarihan, Irsan Fahmi; Irianto, Jimmy Setiawan; Hasmono, Didik; Syifa, Nailis'
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 8 No. 1 (2024): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v8i1.11623

Abstract

Stroke iskemik disebabkan oleh peristiwa trombotik atau emboli yang menyempitkan arteri sehingga menyebabkan penurunan aliran darah ke otak. Oleh karena itu, terapi antiplatelet digunakan untuk menghambat pembentukan tromboksan. Asetosal dianggap sebagai antiplatet lini pertama dan efektivitasnya sudah diketahui dengan baik, namun masih terdapat kebingungan dalam praktik klinis mengenai dosis optimal untuk pencegahan dan pengobatan stroke. Penelitian ini bertujuan untuk mengetahui pola pemberian asetosal pada pasien stroke iskemik di RSUD dr. RSUD Moh Saleh Probolinggo. Penelitian ini bersifat observasional dengan metode retrospektif pada pasien stroke iskemik pada bulan Januari 2021 sampai dengan Desember 2021. Asetosal digunakan sendiri pada semua pasien (20 pasien). Semua pasien diberikan asetosal 1x80 mg p.o. Peralihan terapi dari clopidogrel (1x75 mg) p.o ke acetosal (1x80 mg) p.o. ditemukan pada satu sampel.
Validity And Reliability Of Mars-10 Questionnaire On Antipsychotic Adherence In Schizophrenia Patients Syifa, Nailis; Almuhtarihan, Irsan Fahmi; Habba, Erika Zahrotul Avia; Nazliza, Uhai’atun Nisa’; Nadifa, Jaza Faizun
Saintika Medika Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.33729

Abstract

Non-adherence in schizophrenia treatment is still a major problem in the successful treatment of schizophrenia. MARS-10 (Medication Adherence Report Scale-10) questionnaire is a self-reported questionnaire to measure patient’s adherence which has been implemented in some disease. However, there is still no study investigated the application of MARS-10 into schizophrenia patients in Indonesia. The purpose of this study was to determine the reliability and validity of the MARS-10 questionnaire in schizophrenia cases in Indonesia. This design of this study was a prospective, descriptive quantitative analysis approach with a cross-sectional design. Thirty schizophrenia patients from Saiful Anwar Hospital Malang, Lawang Mental Hospital, and UMM Hospital were used as research samples. Determining the validity of the questionnaire using the Pearson Product Moment correlation test, the correlation coefficient value r count is greater than the r table value, which is 0.361. In determining the reliability of the questionnaire, an analysis was carried out using the Cronbach's Alpha coefficient which showed the Cronbach's Alpha coefficient of 0.742. The results of the validity and reliability tests show that the MARS-10 questionnaire that has been translated into Indonesian is valid and reliable for measuring the level of compliance of schizophrenia patients with antipsychotic treatment in Indonesia.
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators Helmi, M.; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almuhtarihan, Irsan Fahmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
Co-Authors Agus Sunarko Ahmad Shobrun Jamil Didik Hasmono Habba, Erika Zahrotul Avia Hidajah Rachmawati Irianto, Jimmy Setiawan M. Helmi Muchlisin, M. Artabah Nadifa, Jaza Faizun Nailis Syifa Nazliza, Uhai’atun Nisa’ Syifa, Nailis'