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Journal : Aesculapius Medical Journal

Prevalensi Ekspresi Epidermal Growth Factor Receptor (EGFR) pada Karsinoma Penis Gede Khrisnanda Arya Dharma; Desak Putu Oki Lestari; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
AMJ (Aesculapius Medical Journal) Vol. 1 No. 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Abstrak Kanker penis merupakan penyakit keganasan pada laki laki yang ditemukan paling tinggi di Bali dibandingkan dengan daerah lain di Indonesia. Sekitar 95% keganasan pada penis adalah jenis karsinoma sel skuamosa (KSS). Perkembangan terapi kanker saat ini telah mencapai targeted terapi, sedangkan belum banyak penelitian pada kanker penis. Perkembangan targeted terapi berdasarkan overekspresi EGFR telah banyak berkembang dan telah dipakai sebagai individual terapi terutama pada kanker paru. Penelitian ini bertujuan untuk mengetahui ekspresi EGFR pada KSS penis. Penelitian ini merupakan penelitian deskriptif observasional untuk mengetahui prevalensi ekspresi EGFR dari pemeriksaan imuno histokimia, sel tumor terpulas positif berwarna coklat kuat mengelilingi seluruh membran sel tumor. Hasil penelitian dari 141 sampel karsinoma sel skuamosa penis yang diambil dari biopsi, operasi penektomi parsial, dan operasi penektomi total didapat prevalensi ekspresi EGFR yang terpulas positif pada sel tumor kanker penis sebanyak 8 kasus (5,7%) dengan distribusi umur tertinggi pada kelompok umur 41-60 tahun sebanyak 66 kasus (46,8%). Pengetahuan tentang overekspresi EGFR pada kanker penis dapat dijadikan dasar rujukan pemberian anti EGFR terutama pada kanker penis dengan stadium lanjut.
Karakteristik Ibu Hamil Trimester III yang Mengalami Kecemasan dalam Menghadapi Persalinan pada Masa Pandemi Covid-19 di Klinik Kesehatan dan Rumah Bersalin Dewi Laksmi Nabire Papua Ni Ketut Santhiyogi Visnu Wardani; Putu Asih Primatanti; Ni Wayan Armerinayanti
AMJ (Aesculapius Medical Journal) Vol. 3 No. 2 (2023): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Covid-19 is an acute respiratory diseasse which was spread to all countries, one of which is Indonesia. One of the impact of this pandemic is causing many restrictions on almost all services, including health services. The maternal mortality rates (MMR) in Papua reached 200 per 100,000 live births. Anxiety is a problem that if not treated immediately can cause problems for the mother and baby, including the occurrence of resistance in the uterine arteries which causes stunted fetal growth. The purposes of this study is to determine characteristics of third trimester pregnant women who experience anxiety in dealing with childbirth during the COVID-19 pandemic at the Dewi Laksmi Nabire Maternity Health Clinic and Maternity Hospital, Papua. This research uses descriptive research method with cross sectional study design with non probability sampling technique purposive sampling method. The sample consisted of 195 third trimester pregnant women who had met the inclusion and exclusion criteria. The data collection instrument used a questionnaire in the form of a google form. Data analysis was performed univariately. The result showed majority of third trimester pregnant women experienced mild-severe anxiety in the age range of 20-35 years (29.3%), had sufficient knowledge (31.1%), received support from their husbands (11.9%), not working (54.3%), primigravida (43.2%), high education level (21.2%), and getting the COVID-19 issue (28.7%). For all pregnant women, it is hoped that this research can be used as informative material that can increase understanding regarding the description level of anxiety on pregnant women that will be giving birth during COVID-19.
Karakteristik Vaginal Birth After Caesarean (VBAC) pada Ibu dengan Locus Minoris Resistentiae (LMR) Periode Januari 2017 - Desember 2020 Putu Ayu Bunga Aurellia; Pande Made Ngurah Geriawan; Ni Wayan Armerinayanti
AMJ (Aesculapius Medical Journal) Vol. 3 No. 3 (2023): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

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Abstract

Vaginal Birth After Cesarean (VBAC) is a normal delivery process after having previously had a cesarean section. This process is carried out on mothers with former cesarean sections or Locus Minoris Resistant (LMR). The aim of this study was to find out the characteristics of Vaginal Birth After Caesarean (VBAC) in Mothers with Locus Minoris Resistance (LMR) for the period January 2017-December 2020. This study was a retrospective descriptive study with a sample of mothers with LMR who performed VBAC at the Sanjiwani Hospital. Gianyar, BRSUD Tabanan and RS Prima Medika Denpasar which were selected by purposive sampling method that met the inclusion criteria were then presented in tabular form. There were 37 patients out of 48 patients who underwent Trial of Labor After Caesarean (TOLAC) who successfully performed a VBAC with various characteristics, where as many as 32 people (86.5%) with age < 35 years, did not have a history of normal delivery as many as 24 people ( 64.9%), having a cesarean section frequency 1 time as many as 36 people (97.3%), patients with an indication of a previous cesarean section in a breech presentation as many as 14 people (37.9%), with a delivery distance of > 24 months as many as 37 people ( 100%) and gave birth to babies with a birth weight of 2500-4000 grams as many as 36 people (97.3%).