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All Journal Transformasi: Jurnal Pengabdian Masyarakat WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) The Indonesian Biomedical Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Patologi Indonesia Jurnal Sewaka Bhakti Aesculapius Medical Journal Indonesian Journal of Cancer INCOME: Indonesian Journal of Community Service and Engagement Jurnal Pandu Husada
Desak Putu Oki Lestari
Universitas Warmadewa
Religion Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Hubungan antara Ukuran Tumor, Grade, Invasi Uretra, Intravasa, Perineural dan Overekspresi COX-2 pada Metastasis Karsinoma Sel Skuamosa Penis ke Kelenjar Getah Bening Inguinal Desak Putu Oki Lestari; Ketut Mulyadi Mulyadi
Majalah Patologi Indonesia Vol 24 No 3 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.428 KB)

Abstract

Background Penile cancer was a health problem in Bali. Clinicopathology and biological marker COX-2 were important predictive factor used for inguinal lymph node metastasis. The aim of this study was to find out relationship between clinicopathological prognostic factors (tumor size, grade, urethral invasion, intra vasa invasion, perineural invasion) and COX-2 exprerssion in metastases of SCC penile to the inguinal lymph nodes. Methods This observational crossectional study included 47 samples of SCC penis preparation from penectomy with inguinal lymphadenectomy since January 1st 2008-Desember 31st 2013 at Department of Anatomical Pathology Faculty of Medicine University of Udayana/Sanglah Hospital Denpasar. Sample of this study was divided into 2 groups: 16 cases SCC positive metastasis and 31 cases negative metastasis. Rediagnosis clinico-pathological prognostic factor was done, immunohistochemistry COX-2 staining was performed. The data were analized using chi-square (α=0.05). Results This study show significant positive correlation between tumor size ≥5 cm (p=0.002), grade (p=0.002), urethra invasion (p=0.014), intra vasa invasion (p=0.00), perineural invasion (p=0.00) with metastasis. COX-2 expression (+2) and (+3) have higher risk on occurrence of metastasis than (0) and (+1) (p=0.00). Conclusion Clinico-pathologic factors and COX-2 expression could be used to predict metastases of SCC penile to the inguinal lymph nodes. Key words: clinicopathologic prognosis factor, COX-2, inguinal lymph nodes metastasis, squamous cells carcinoma penis.
Risiko Kandidiasis Serviks pada Wanita Usia Subur Akseptor Kontrasepsi Hormonal Ni Wayan Armerinayanti; Desak Putu Oki Lestari
WMJ (Warmadewa Medical Journal) Vol 3 No 1 (2018): May 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.1.640.21-26

Abstract

Abstrak Kontrasepsi Hormonal merupakan salah satu metode kontrasepsi yang paling diminati oleh Wanita Usia Subur (WUS) di Indonesia termasuk di Bali. Dewasa ini mulai timbul pro dan kontra mengenai penggunaan kontrasepsi hormonal terkait berbagai efek samping yang ditimbulkan, salah satunya dikatakan berkaitan dengan kandidiasis serviks. Tujuan penelitian ini adalah untuk mengetahui risiko kandidiasis serviks pada WUS akseptor kontrasepsi hormonal. Penelitian ini menggunakan rancangan case control yang disarangkan pada penelitian pap smear (nested case control). Kemudian akan dibandingkan seberapa besar efek paparan kontrasepsi hormonal antara kelompok kasus (kandidiasis serviks) dengan kelompok kontrol (non kandidiasis serviks) secara deskriptif analitik melalui uji statistik chi-square dengan p
Strengthening the Role of Cadres and Village Midwives to Support the Cervical Cancer Awareness Movement in Puhu Payangan Village, Gianyar, Bali, Indonesia Desak Putu Oki Lestari; Sri Ratna Dewi; Ni Wayan Armerinayanti
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.879 KB) | DOI: 10.22146/jpkm.43355

Abstract

Cervical cancer is the most common type of cancer in Balinese women, and most of the cervical cancer patients came in advanced condition. The health survey conducted in the village of Puhu, Payangan, Gianyar, found that the coverage of cervical cancer screening is 12%, which is considered as low. Payangan’s sub-district health centers (Puskesmas) have made an effort to give free PAP smear screenings to the local community, but it still has not received a good response. This is related to the community’s lack of knowledge on cervical cancer, low awareness of cancer screening, and false stigma about PAP smear examination. To overcome this problem, an effort is needed to increase awareness about the need for PAP smear screening by shaping it into a cervix cancer awareness movement "Gardavi", involving village midwives and housewife members of Empowerment and Family Welfare Group (PKK) in Puhu Village as cadres. Methods that are used in this community service include training for midwives, activation of tiered information system involving midwives-cadres and the community, knowledge provision as well as motivating cadres. This event is done to increase the role of village midwives and cadres to actively participate in PAP smear screenings in their region, therefore, it may increase screening outcomes and lower mother morbidity and mortality numbers due to cervical cancer. This event results in increased midwives’ knowledge and skill on the technique of sampling PAP smear independently, increased visits to the Community Health Sub-Center (Pustu) for PAP smear examination, creation of a midwives-cadres-community coordination system, cadres independently playing an active role in motivating the village community to do screening, as well as increased cadres’ optimism.
Simvastatin Improves Renal Function and Glomerulosclerosis in Ischemic-reperfusion Injury Putu Nita Cahyawati; Desak Putu Oki Lestari; Ayu Savitri Siskayani; I Made Toya Ariawan
The Indonesian Biomedical Journal Vol 12, No 2 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i2.1082

Abstract

BACKGROUND: Statin is an anti-cholesterol drug that is widely prescribed throughout the world. Statins are mainly used to treat and prevent cardiovascular disease. Several studies have found the pleiotropic effect of statin. However, related effect of statin in kidney failure is still unclear. Ischemic-reperfusion (I/R) injury is a major cause of acute kidney failure. This study aims to determine the effect of simvastatin on kidney function and glomerular conditions by periodic acid-schiff staining in I/R injury.METHODS: Eighteen male Swiss mice were grouped into sham operation group (GSO), I/R injury group (GIRI), and simvastatin group (GSIM). The GSO group was performed by sham operation and pretreatment of 1% carboxymethylcellulose (CMC) for 3 days. The GIRI group was performed by I/R procedure and pretreatment of 1% CMC for 3 days and the GSIM group was performed by I/R procedure and pretreatment of 10 mg/kg BW simvastatin for 3 days. Blood urea nitrogen (BUN) and creatinine serum were assessed to determine kidney function. Histopathological analysis of glomerulosclerosis was assessed by the extent of glomerular damage (sclerosis), capillary loops, and synechia. The data were analyzed by one-way ANOVA followed by post hoc Tukey’s test (p<0.05).RESULTS: The creatinine and BUN levels in the GIRI group were the highest (0.97±0.48) compared with the other groups. The glomerulosclerosis index in the GSO group was 0.75±0.56, the GIRI group was 3.55±0.61, and the GSIM group was 2.08±1.37. There was a significant difference in the glomerulosclerosis index between the GSO and GIRI groups, but there was no significant difference between the GIRI and GSIM groups. These differences include the formation of sclerosis in the glomerulus, capillary loop, and synechiae.CONCLUSION: Simvastatin improves kidney function and glomerulosclerosis in I/R injury.KEYWORDS: ischemic-reperfusion injury, simvastatin, glomerulosclerosis
PEMBERDAYAAN KELOMPOK SEBAYA DAN KONSELING DI SMP WIDYA SAKTI UNTUK MENINGKATKAN GERAKAN SEHAT REPRODUKSI REMAJA Sri Ratna Dewi; Desak Putu Oki Lestari; , Ni Wayan Armerinayanti; I Wayan Suwarna
JURNAL SEWAKA BHAKTI Vol 3 No 2 (2019): Sewaka Bhakti
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.473 KB) | DOI: 10.32795/jsb.v3i1.514

Abstract

Adolescent are a transition period and highly sensitive to the influence of new values. The problems they face are also quite complex, one of which concerns reproductive health. Some studies suggest that peers are the most dominant factor in influencing the adolescent reproductive health behaviors. This dedication activity aims to increase adolescent knowledge and activate the role of peers and counseling teachers in disseminating correct information about reproductive health. The method of implementing activities in the form of providing material on adolescent reproductive health by a talk from the expert, training and mentoring to peer groups in carrying out mini counseling, as well as training and counseling for counseling teachers. After the implementation of this program obtained increased peer group knowledge and counseling teachers on adolescent reproductive health respectively as much as 50% and 30.8%. In addition, all peer groups are able to conduct mini-counseling as well as to do better counseling. Through this activity it is hoped that peer group partners and counseling is able to play an active role in continuously spreading information about adolescent reproductive health so that it can produce other peers who help keep the healthy atmosphere of the adolescents.
Prevalensi Ekspresi Epidermal Growth Factor Receptor (EGFR) pada Karsinoma Penis Gede Khrisnanda Arya Dharma; Desak Putu Oki Lestari; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
AMJ (Aesculapius Medical Journal) Vol. 1 No. 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.338 KB)

Abstract

Abstrak Kanker penis merupakan penyakit keganasan pada laki laki yang ditemukan paling tinggi di Bali dibandingkan dengan daerah lain di Indonesia. Sekitar 95% keganasan pada penis adalah jenis karsinoma sel skuamosa (KSS). Perkembangan terapi kanker saat ini telah mencapai targeted terapi, sedangkan belum banyak penelitian pada kanker penis. Perkembangan targeted terapi berdasarkan overekspresi EGFR telah banyak berkembang dan telah dipakai sebagai individual terapi terutama pada kanker paru. Penelitian ini bertujuan untuk mengetahui ekspresi EGFR pada KSS penis. Penelitian ini merupakan penelitian deskriptif observasional untuk mengetahui prevalensi ekspresi EGFR dari pemeriksaan imuno histokimia, sel tumor terpulas positif berwarna coklat kuat mengelilingi seluruh membran sel tumor. Hasil penelitian dari 141 sampel karsinoma sel skuamosa penis yang diambil dari biopsi, operasi penektomi parsial, dan operasi penektomi total didapat prevalensi ekspresi EGFR yang terpulas positif pada sel tumor kanker penis sebanyak 8 kasus (5,7%) dengan distribusi umur tertinggi pada kelompok umur 41-60 tahun sebanyak 66 kasus (46,8%). Pengetahuan tentang overekspresi EGFR pada kanker penis dapat dijadikan dasar rujukan pemberian anti EGFR terutama pada kanker penis dengan stadium lanjut.
Specific Histologic Type of Leiomyoma Related to Estrogen Receptor Expression Ni Wayan Armerinayanti; Desak Putu Oki Lestari; I Gde Sastra Winata
WMJ (Warmadewa Medical Journal) Vol 7 No 2 (2022): November 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.2.4601.55-59

Abstract

Uterine Leiomyoma or fibroid is the most common gynecologic benign neoplasm which arising from monoclonal proliferation of smooth muscle cells in uterine wall. Some specific types of uterine leiomyoma, such ascellular leiomyoma, symplastic leiomyoma, mitotically active leiomyoma andmyxoid leiomyomahave different histomorphology from usual type leiomyoma. It also have wide variety of tumors size, but this study found that no correlation between type of leiomyoma and its size. Additional non-invasive therapy that predominantly developed in leiomyoma include many antagonist agents of estrogenic receptor. So, important to determine of estrogen receptor activity before that hormonal therapy prescription.Histopathology parameter that predict estrogen receptor activity in leiomyoma was not well understood. This study also try to correlate between specific histologic type of leiomyoma and estrogen receptor activity. This study was a retrospective crossectional study which analized by pearson chi-square test with p value < 0.05 and CI 95%. Result: There was significant correlation between specific histologic type of leiomyoma and estrogen receptor expression (p=0.007; p<0.05). Key Words: Leiomyoma, Estrogen Receptor
The Relationship Between Cervical Cancer Severity and miRNA-205 Expression in Bali Kartika Sari; Desak Putu Oki Lestari; Novitasari Novitasari; Yudhi Nugraha; Vivitri Dewi Prasasty; Septi Panca Sakti
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16 No 2 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i2.4106

Abstract

Cervical cancer is the one of leading cause of death for women worldwide. It occurs due to infection with the human papilloma virus (HPV) which attacks the cervix in the female reproductive organs. The detecting cervical cancer method is by using pap smears and liquid based cytology (LBC) and vaccinations. However, both methods are limited in detecting cervical cancer quickly and accurately. This study aims to find potential biomarkers that will be used to quickly detect the development of cervical cancer. Large-scale studies have shown that microRNA-205 (miRNA) regulation has a very important role in various types of cancer including cervical cancer. The extraction and synthesis of cDNA from 26 preparations of cervical cancer paraffin blocks were measured by quantitative real time PCR to evaluate the expression of miRNA-205 as a biomarker of cervical cancer in cervical cancer samples. Statistical results showed that there was a significant difference in the expression of miRNA-205 which was relatively higher in cervical cancer patients (p<0.05) miRNA-205. In addition, the increased expression of miRNA-205 is associated with an increase in the severity of cervical cancer. We conclude that miRNA-205 is a potential candidate for cervical cancer molecular biomarker.
Penggunaan Flap Transposisi Untuk Rekonstruksi Pipi Setelah Eksisi Nevus Kongenital Multipel I Nyoman Putu Riasa; Desak Putu Oki Lestari; Alexandria Stephanie Suparman
JURNAL PANDU HUSADA Vol 2, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v2i2.7002

Abstract

Nevus kongenital multipel pada wajah memberikan dampak kosmetik yang buruk dan merupakan tantangan bagi ahli bedah plastik untuk mencapai hasil kosmetik terbaik. Hal ini memberikan dampak yang signifikan terhadap efek psikososial negatif pada pasien anak bahkan setelah pengobatan. Sebuah kasus anak laki-laki berusia 5 tahun datang dengan nevus kongenital multipel di pipi kanannya dalam dimensi yang bervariasi. Eksisi dilakukan untuk menghilangkan banyak nevus, kemudian menggunakan flap transposisi pedikel distal untuk menutup defek. Kemudian nevus dikirim ke laboratorium untuk pemeriksaan histopatologi menggunakan pewarnaan heamtoxylin dan eosin. Hasil patologi menunjukkan spilus nevus. Eksisi nevus kongenital multipel wajah, diikuti oleh flap transposisi, adalah metode rekonstruksi yang sangat baik dan cepat dengan hasil estetika yang menjanjikan. Flap lokal memberikan hasil terbaik untuk rekonstruksi wajah karena kesesuaian yang baik dengan kulit dalam hal warna, tekstur, dan ketebalan serta mematuhi salah satu prinsip dasar dalam operasi plastik "ganti seperti dengan" untuk menyamarkan bekas luka operasi, margin garis flap didesain agar berada di sepanjang batas anatomis. Selain itu, kesimetrian wajah perlu diperhatikan dalam rekonstruksi ini. Flap transposisi untuk rekonstruksi pipi merupakan pilihan terbaik untuk menutup defek tentunya dengan mempertimbangkan unit fungsional dan aspek estetika pasien.
PKM PEMBERDAYAAN KADER DAN BIDAN DESA PEREAN KANGIN UNTUK MENINGKATKAN GERAKAN SADARI KANKER PAYUDARA Analysa Analysa; Desak Putu Oki Lestari; I Gusti Alit Artha
JURNAL SEWAKA BHAKTI Vol 9 No 2 (2023): Sewaka Bhakti
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/jsb.v9i2.3691

Abstract

In 2021 there were 10 breast cases from the Baturiti sub-district which carried out examinations in the PA laboratory at Tabanan Hospital. 6 of them (60%) turned out to be cases of malignancy, and 4 of them (66.66%) stage III and IV which are the final stages of breast cancer. Perean Kangin Village which is one of the villages in the Baturiti sub-district with the most cases of breast tumors. The long-lasting pandemic has contributed to the decreased activity of cadres and increased delays in breast cancer screening. If the patient can be detected early and get treatment as soon as possible, it will give hope for recovery and a better life expectancy. One of the early detection of breast cancer is breast self-examination (BSE). It is hoped that re-activating midwives and village cadres will motivate the community to do BSE. The result of this PKM was an increase in the knowledge and attitude of cadres towards BSE. We also provide investment goods in the form of digital baby and adult weight measuring devices, stunting mats and height measuring devices for early detection of health problems.
Co-Authors Alexandria Stephanie Suparman Analysa Analysa Analysa Analysa, Analysa Artha, I Gusti Alit Astuti, Ni Luh Putu Vina Juni Ayu Savitri Siskayani Cahyawati, Putu Nita Gede Khrisnanda Arya Dharma I Gde Sastra Winata I Gusti Alit Artha I Ketut Suwiyoga I Made Toya Ariawan I Nyoman Putu Riasa I Wayan Sudiarta I Wayan Suwarna Kartika Sari Kerans, Fransiscus Anthony Ketut Mulyadi Mulyadi Luh Gde Evayanti M. Yusuf Ni Luh Putu Eka Kartika Sari Ni Wayan Armerinayanti Ni Wayan Armerinayanti Ni Wayan Armerinayanti Ni Wayan Armerinayanti, Ni Wayan Novitasari Novitasari Perdana, I Gede Sukma Okta Primadi, Putu Riasa, I Nym Putu Riasa, I Nyoman Putu Sari, Ini Luh Putu Eka Kartika Sari, Ni Luh Putu Eka Kartika Septi Panca Sakti Sri Ratna Dewi Sukmadewi, Desak Ketut Tristiana Vivitri Dewi Prasasty Yudhi Nugraha