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All Journal Medicina WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Meditory : The Journal of Medical Laboratory Majalah Patologi Indonesia Jurnal Sewaka Bhakti MAHESA : Malahayati Health Student Journal Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Indonesian Journal of Cancer Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan

Ni Wayan Armerinayanti, Ni Wayan

Universitas Warmadewa

Author-ID : 3094024

Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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KEMATIAN JANTUNG MENDADAK PADA WANITA UMUR 37 TAHUN DENGAN MIOKARDIOPATI HIPERTROFIK VAKUOLAR Armerinayanti, Ni Wayan; Sumadi, I Wayan Juli; Mulyadi, Ketut
Medicina Vol 46 No 2 (2015): Mei 2015
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.533 KB)

Kematian mendadak pada orang dewasa merupakan dasar masalah melakukan bedah mayat untukmencari penyebab kematian. Kasus seorang wanita umur 37 tahun ditemukan mati di dalamkamarnya, mayat dalam keadaan kaku, terdapat lebam mayat dan resapan darah subkutis kepala.Bedah mayat dilakukan di Rumah Sakit Kupang menemukan paru, otak, hati tidak menunjukkankelainan, sedangkan jantung dengan miokardium ventrikel kiri tebalnya 2 cm. Pada pemeriksaanhistopatologi jantung, sel-sel miokardium membengkak, mengandung vakuola jernih, inti sel terdesakke pinggir, tidak terdapat nekrosis, perdarahan, penebalan dari pembuluh darah, dan infiltrat neutrofil,pada pewarnaan periodic acid schiff menunjukkan hasil yang negatif. Pada pemeriksaan otak tidakdapat dibuktikan adanya penimbunan glikogen pada sel-sel glia. Berdasarkan temuan patologidisimpulkan kelainan tersebut adalah miokardiopati hipertrofik vakuolar tipe kardiak stadium IIIyang mengakibatkan kegagalan jantung atau aritmia sebagai penyebab kematian. [MEDICINA2015;46:135-8].Sudden death of adult people is a basic reason to do the autopsy to define exactly the causa of mortis.A case of a 37 year old woman found dead in her room and her deadly body has already in rigor and livormortis, also with blood spot on subcutaneous part of the head. The autopsy was held in general hospitalof Kupang, and there was no disorders found in the lung, brain, hepar, and the thickness of left myocardiacventrikel of heart is 2 cm. On histologic examination of heart specimen, myocardiac cells were swollen,with clear vacuolar, the nuclei displaced to periphery, there was no necrosis, haemorrhagic, thickeningof vascular, and neutrophil infiltrate. Periodic acid schiff staining has showed negative result. Therewas no evidence of glycogen storage on glial cells in brain examination. Based on pathologic finding weconcluded that the disorder was vacuolar hypertropic cardiomyopathy, cardiac type, stage III causingheart failure or arrhythmias as the causa of mortis. [MEDICINA 2015;46:135-8].

Ekspresi Matriks Metaloproteinase 9 pada Infiltrasi Karsinoma Tiroid Papiler Klasik dan Varian Folikuler Ni Wayan Armerinayanti; I Ketut Mulyadi; Luh Putu Iin Indrayani Maker
Majalah Patologi Indonesia Vol 26 No 2 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Latar belakangKarsinoma tiroid papiler (KTP) merupakan 80% dari seluruh karsinoma tiroid berdiferensiasi baik dengan 2 tipe paling sering yaitu KTP klasik dan KTP varian folikuler (KTPVF). Agresivitas antara kedua tipe KTP ini masih kontroversi dalam berbagai aspek klinikopatologik. Matriks metaloproteinase 9 (MMP-9) merupakan marka relevan dalam memprediksi agresivitas tumor karena mempengaruhi proses invasi dan metastasis. Tujuan penelitian ini adalah untuk mengetahui ekspresi MMP-9 dalam mempengaruhi luas infiltrasi KTP sehingga berkaitan dengan agresivitas KTP.MetodePenelitian ini menggunakan metode analitik potong lintang dengan jumlah sampel sebanyak 40 sediaan blok parafin pasien KTP Klasik dan KTPVF yang diperiksa secara histopatologi di Bagian Patologi Anatomi Fakultas Kedokteran Universitas Udayana/RSUP Sanglah Denpasar sejak tanggal 1 Januari 2011 sampai 30 Juni 2014. Sampel terdiri dari 10 KTP klasik intrakompartemen, 10 KTP klasik ekstrakompartemen, 10 KTPVF intra-kompartemen dan 10 KTPVF ekstrakompartemen. Selanjutnya dilakukan pulasan imunohistokimia MMP-9 pada seluruh sampel. Hasil penelitian dianalisis dengan uji one way anova dan regresi multipel ANCOVA dengan kemaknaan p<0,05.HasilTerdapat perbedaan rerata skor ekspresi MMP-9 antar keempat kelompok, di mana rerata skor ekspresi MMP-9 KTP klasik intrakompartemen 2,60±1,77; KTP klasik ekstrakompartemen 7,80 ±1,54; KTPVF intra-kompartemen 3,70±1,74 dan KTPVF ekstrakompartemen 7,00±1,80. Melalui uji one way anova terdapat perbedaan yang bermakna antara KTP intrakompartemen dengan KTP ekstrakompartemen (p<0,001). Uji regresi ANCOVA menunjukkan tidak terdapat pengaruh usia, jenis kelamin dan ukuran tumor terhadap skor ekspresi MMP-9 (p>0,05).KesimpulanPeningkatan maupun penurunan ekspresi MMP-9 mempengaruhi luas infiltrasi KTP sehingga ekspresi MMP-9 berkaitan dengan agresivitas KTP.

Strengthening the Role of Cadres and Village Midwives to Support the Cervical Cancer Awareness Movement in Puhu Payangan Village, Gianyar, Bali, Indonesia Desak Putu Oki Lestari; Sri Ratna Dewi; Ni Wayan Armerinayanti
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 1 (2021): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Cervical cancer is the most common type of cancer in Balinese women, and most of the cervical cancer patients came in advanced condition. The health survey conducted in the village of Puhu, Payangan, Gianyar, found that the coverage of cervical cancer screening is 12%, which is considered as low. Payangan’s sub-district health centers (Puskesmas) have made an effort to give free PAP smear screenings to the local community, but it still has not received a good response. This is related to the community’s lack of knowledge on cervical cancer, low awareness of cancer screening, and false stigma about PAP smear examination. To overcome this problem, an effort is needed to increase awareness about the need for PAP smear screening by shaping it into a cervix cancer awareness movement "Gardavi", involving village midwives and housewife members of Empowerment and Family Welfare Group (PKK) in Puhu Village as cadres. Methods that are used in this community service include training for midwives, activation of tiered information system involving midwives-cadres and the community, knowledge provision as well as motivating cadres. This event is done to increase the role of village midwives and cadres to actively participate in PAP smear screenings in their region, therefore, it may increase screening outcomes and lower mother morbidity and mortality numbers due to cervical cancer. This event results in increased midwives’ knowledge and skill on the technique of sampling PAP smear independently, increased visits to the Community Health Sub-Center (Pustu) for PAP smear examination, creation of a midwives-cadres-community coordination system, cadres independently playing an active role in motivating the village community to do screening, as well as increased cadres’ optimism.

PEMBERDAYAAN KELOMPOK SEBAYA DAN KONSELING DI SMP WIDYA SAKTI UNTUK MENINGKATKAN GERAKAN SEHAT REPRODUKSI REMAJA Sri Ratna Dewi; Desak Putu Oki Lestari; , Ni Wayan Armerinayanti; I Wayan Suwarna
JURNAL SEWAKA BHAKTI Vol 3 No 2 (2019): Sewaka Bhakti
Publisher : UNHI Press

Adolescent are a transition period and highly sensitive to the influence of new values. The problems they face are also quite complex, one of which concerns reproductive health. Some studies suggest that peers are the most dominant factor in influencing the adolescent reproductive health behaviors. This dedication activity aims to increase adolescent knowledge and activate the role of peers and counseling teachers in disseminating correct information about reproductive health. The method of implementing activities in the form of providing material on adolescent reproductive health by a talk from the expert, training and mentoring to peer groups in carrying out mini counseling, as well as training and counseling for counseling teachers. After the implementation of this program obtained increased peer group knowledge and counseling teachers on adolescent reproductive health respectively as much as 50% and 30.8%. In addition, all peer groups are able to conduct mini-counseling as well as to do better counseling. Through this activity it is hoped that peer group partners and counseling is able to play an active role in continuously spreading information about adolescent reproductive health so that it can produce other peers who help keep the healthy atmosphere of the adolescents.

The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma Lestari, Desak Putu Oki; Analysa, Analysa; Armerinayanti, Ni Wayan; Riasa, I Nyoman Putu; Artha, I Gusti Alit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1103

Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020 and 2023. From the statistical formula for the case-control study, a minimum sample of 15 is obtained for the case group with the criteria of high-grade TB, while 15 people were in the control group with low-grade TB. Immunohistochemistry (IHC) PD-L1 is positive if the membrane or cytoplasm is brown, and is negative if there is no brown color on the membrane or cytoplasm. Inferential statistics were used to evaluate the relationship between PD-L1 overexpression and low- and high-grade TB in cervical carcinoma using a chi-square test. Results: The results of this research revealed (p = 0.273) that there was no correlation between PD-L1 expression and high- and low-grade TB. Overexpression of PD-L1 was associated with a 2.250-fold increased risk of high-grade TB (OR = 2.250 with a 95% confidence interval of 0.103–1.915). Conclusions: The severity of TB does not correlate with PD-L1 expression. The functions of PD-L1 and other variables in the carcinogenesis of TB development are the cause of this weak association.

Correlation of Age, Tumor Size, and Histopathological Type with Indicator Tumor Progression of Penile Squamous Cell Carcinoma in Bali Astuti, Ni Luh Putu Vina Juni; Lestari, Desak Putu Oki; Sari, Ni Luh Putu Eka Kartika; Armerinayanti, Ni Wayan; Evayanti, Luh Gde; Perdana, I Gede Sukma Okta
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1340

Background: Penile cancer is a rare malignancy globally, but Bali accounts for approximately 40% of Indonesia’s cases. Age, tumor size, and histopathological type are recognized factors influencing penile cancer progression, with grade, depth of invasion, lymph node metastasis, and distant metastasis serving as key indicators. However, the prognostic value of these factors, particularly depth of invasion, remains debated. This study aimed to evaluate the correlation between age, tumor size, and histopathological type with indicators of tumor progression in penile squamous cell carcinoma (SCC) in Bali.Method: A cross-sectional analytical study was conducted on 160 cases of penile SCC. Dependent variables included tumor grade, depth of invasion, and lymph node metastasis, while independent variables were age, tumor size, and HPV status (inferred from histopathology). Age was categorized as 60 or ≥60 years, tumor size as 4 cm or ≥4 cm, and depth of invasion as T1–T4. Multivariate analysis using the chi-square test was performed to assess associations.Results: Most patients were aged ≥ 60 years, had HPV-independent SCC, tumor size ≥ 4 cm, grade 2 tumors, and T1 depth of invasion, with lymph node metastasis observed in a minority. Multivariate analysis revealed significant correlations between age, tumor size, and histopathological type with grade (p = 0.026, R² = 0.056), depth of invasion (p 0.001, R² = 0.445), and lymph node metastasis (p = 0.004, R² = 0.075). Tumor size demonstrated the strongest association with depth of invasion (OR = 9.618, p 0.001) and lymph node metastasis (OR = 6.846, p 0.001).Conclusion: Tumor size is a significant predictor of both depth of invasion and lymph node metastasis in penile SCC. Clinical assessment of tumor size should be emphasized as a key prognostic factor to guide early intervention strategies in patients with penile SCC in Bali.

Correlations of Protein 53 (p53) Expression with the Degree of Tumor Budding in Cervical Carcinoma Wardana, Ni Komang Sara Kusuma; Armerinayanti, Ni Wayan; Cahyawati, Putu Nita
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1270

Background: Cervical carcinoma is a malignant tumor that is most often found in the female reproductive system. Persistent Human Papillomavirus (HPV) infection is the most important factor in the development of cervical carcinoma. The E6 and E7 oncoproteins in HPV inhibit the action of p53. As a result, p53 transcription and the apoptosis process are inhibited. Tumor budding has been extensively studied and established as a significant prognostic factor. This study aims to determine the relationship between p53 expression and the degree of tumor budding of cervical carcinoma.Method: This cross-sectional study used 50 paraffin blocks and secondary data from patients diagnosed with cervical carcinoma stored at BaliMed Denpasar Hospital. Paraffin blocks were then subjected to immunohistochemical examination to evaluate p53 expression and HE examination to evaluate the degree of tumor budding. Data analysis was performed using the Spearman test and linear regression test with the SPSS 25 software program. Results: The results showed that thirty-two subjects had low expression of p53, and 62,5% of them had high-grade tumor budding. The p53 expression is lower in cervical cancer with highgrade tumor budding compared with low-grade tumor budding (rs = -0.33). There are significant correlations between p53 expression and the degree of tumor budding in patients with cervical carcinoma (p = 0.018). A total of 50 samples that met the inclusion and exclusion criteria were analyzed. The majority of patients were aged ≤ 50 years (58%) and had squamous cell carcinoma (90%) in the early stage (92%). Low p53 expression was found in 64% of samples. A significant negative correlation was found between p53 expression and tumor budding grade (p = 0.018; r = -0.333), which remained significant in multivariate analysis (p = 0.024; r² = -0.328), indicating that low p53 expression is associated with high-grade tumor budding. Conclusion: The p53 expression was significantly downregulated in cervical carcinoma with highgrade tumor budding. These findings indicate that tumor budding can be considered as a prognostic marker, but further research that sorts HPV dependent and HPV independent cervical carcinomas is needed.

Perbedaan Tingkat Pengetahuan Pencegahan Kanker Serviks SMA Negeri dan Swasta Kelas X Kabupaten Badung : knowledge level on cervical cancer prevention among class X high school female students in public versus the private schools within the Badung Regency. Made Intan Ryani Putri; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
Aesculapius Medical Journal Vol 2 No 1 (2022): Juni
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.2.1.2022.8-12

The average age for first having sexual intercourse outside of marriage, which is 14-19 years, is one of the causes of the risk of cervical cancer. This research compares the knowledge level on cervical cancer prevention among class X high school female students in public versus the private schools within the Badung Regency. A cross-sectional comparative study is used as the study designed, which includes a total sample of 336 female students (n=336) by utilizing questionnaires. Bivariate analysis with Interdependent T-test and Statistical Package for Social Sciences (SPPS) is appropriate for analyzing the gathered research data. The results of this study between public and private high schools in Badung Regency have different levels of knowledge about cervical cancer prevention. Data analysis shows that 99 (29.5%) female respondents in public high schools know about cervical cancer prevention, and only 80 (23.8%) female students from private schools. The findings of this study imply that school-based teaching is critical for increasing understanding and lowering cervical cancer rates, as well as collaborating with the health department to provide cervical cancer counseling and installing health-related information media in the school environment.

Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid Ni Wayan Armerinayanti
WMJ (Warmadewa Medical Journal) Vol 1 No 2 (2016): November 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.2.27.42-50

Goiter merupakan pembesaran kelenjar tiroid yang dapat berkaitan dengan gangguan primer pada organ tiroid ataupun akibat stimulasi hormonal atau faktor lain terhadap tiroid. Di Indonesia dan di Bali khususnya kasus karsinoma tiroid mengalami peningkatan sejalan dengan peningkatan kasus goiter endemik maupun non endemik. Goiter memiliki faktor risiko sebesar 2,5 kali lipat untuk menimbulkan karsinoma tiroid. Goiter dapat menimbulkan hiperplasia yang bersifat difusa maupun noduler (nodul tunggal dan multipel). Analisis klonal telah membuktikan bahwa hiperplasia merupakan proliferasi yang bersifat poliklonal. Pada tiroid, ditemukan perubahan pola monoklonal pada kelompok nodul yang sebelumnya merupakan nodul hiperplastik. Perubahan poliklonal menjadi monoklonal ini merupakan interaksi antara adanya lesi hiperplastik sebelumnya dengan predisposisi genetik yang selanjutnya menciptakan lingkungan mutagenik, ditandai oleh peningkatan proliferasi sel disertai pembentukan radikal bebas yang memicu adanya mutasi somatiktirosit. Pemberian suplementasi iodium pada kasus goiter endemik, dikatakan berkaitan dengan adanya kandungan iodine radioaktif nantinya justru menimbulkan kerusakan rantai DNA melalui tata ulang RET-TRK.Kata Kunci: goiter, predisposisi, karsinoma tiroid.Â [Goitre as Predisposing Factor of Thyroid Carcinomas].Goitre is an enlargement of thyroid gland which can be associated with primary thyroid disorders or stimulation of the gland by hormones and other factors. In Indonesia and especially in Bali, increase of Thyroid Carcinoma cases had been associated with either endemic or non endemic goiter. Goitre increases 2.5 fold risk of thyroid carcinoma. Goitre may cause diffuse and nodular hyperplasia (either single or multiple nodules). Clonal analysis has been discovered that hyperplasia is considered to be polyclonal proliferation. Monoclonal alterations had also been found in a subset of thyroid nodules that were previously considered hyperplastic. Alterations of polyclonal to monoclonal pattern was considered as interaction between past history of hyperplastic lesion and genetic predisposition which furthermore forming mutagenic environment such as increases of cell proliferation and also free radicals induce- somatic mutation. Iodine supplementation on endemic goiter related with radioactive iodine content which damaging DNA sequences in the form of RET-TRK rearrangement.Keywords: goitre, predispose, thyroid carcinoma.

Risiko Kandidiasis Serviks pada Wanita Usia Subur Akseptor Kontrasepsi Hormonal Ni Wayan Armerinayanti; Desak Putu Oki Lestari
WMJ (Warmadewa Medical Journal) Vol 3 No 1 (2018): May 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.1.640.21-26

Abstrak Kontrasepsi Hormonal merupakan salah satu metode kontrasepsi yang paling diminati oleh Wanita Usia Subur (WUS) di Indonesia termasuk di Bali. Dewasa ini mulai timbul pro dan kontra mengenai penggunaan kontrasepsi hormonal terkait berbagai efek samping yang ditimbulkan, salah satunya dikatakan berkaitan dengan kandidiasis serviks. Tujuan penelitian ini adalah untuk mengetahui risiko kandidiasis serviks pada WUS akseptor kontrasepsi hormonal. Penelitian ini menggunakan rancangan case control yang disarangkan pada penelitian pap smear (nested case control). Kemudian akan dibandingkan seberapa besar efek paparan kontrasepsi hormonal antara kelompok kasus (kandidiasis serviks) dengan kelompok kontrol (non kandidiasis serviks) secara deskriptif analitik melalui uji statistik chi-square dengan p

Co-Authors Ade Dwi Mahendra Agung Brahmanthya Nadine Kepakisan Agus Santosa Anak Agung Oka Lely Analysa - Artha, I Gusti Alit Asri Lestarini Astuti, Ni Luh Putu Vina Juni Cahyawati, Putu Nita Christo Timothy Mamangdean Desak Putu Oki Lestari Gde Candra Yogiswara Gede Bagus Gita Pranata Gede Khrisnanda Arya Dharma Gede Khrisnanda Arya Dharma I Gde Sastra Winata I Gede Krisna Arim Sadeva I Gede Wikania Wira Wiguna I Gusti Ngurah Fajar Viwakananda I Ketut Mulyadi I Komang Ardhika Gunawan I Komang Raditya Putra Pratama I Putu Agung Dhrestaketu Sumedang I Wayan Juli Sumadi I Wayan Suwarna Kadek Agus Kurniawan Kadek Berliantara Kadek Berliantara Kadek Meryndha Kumala Tungga Ketut Mulyadi Komang Indra Parama Arta Komang Yasmika Utami Komang Yasmika Utami Luh Gde Evayanti Luh Putri Wulandari dewi Luh Putu Iin Indrayani Maker Made Bramastya Nugraha Teja Kusuma Mulyawan Made Intan Ryani Putri Made Intan Ryani Putri Ni Ketut Santhiyogi Visnu Wardani Ni Ketut Santhiyogi Visnu Wardani Ni Luh Putu Eka Kartika Sari Ni Luh Putu Eka Kartika Sari Ni Putu Diah Witari, Ni Putu Ni Putu Eka Widiantari Pande Made Ngurah Geriawan Perdana, I Gede Sukma Okta Putu Ari Shanti Dewi Putu Asih Primatanti Putu Asih Primatanti Putu Ayu Bunga Aurellia Putu Ayu Bunga Aurellia Putu Indah Budi Apsari dewi Putu Mirah Wahyu Subagia Putri Putu Nita Cahyawati PUTU SARASWATI LAKSMI DEWI Riasa, I Nyoman Putu Romy Windiyanto Rusni, Ni Wayan Sari, Ni Luh Putu Eka Kartika Sri Ratna Dewi Suka Astini, Dewa Ayu Agung Alit Wardana, Ni Komang Sara Kusuma

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