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All Journal Journal of Tropical Biodiversity and Biotechnology Indonesian Food and Nutrition Progress
Mulyati Mulyati
Faculty of Biology, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

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Kidney Function Test of Female Wistar Rat (Rattus norvegicus Berkenhout, 1769) of Subchronic Toxicity Test of Arthrospira maxima and Chlorella vulgaris Mulyati Mulyati; Anita Yuliana; Slamet Widiyanto
Journal of Tropical Biodiversity and Biotechnology Vol 4, No 3 (2019): Desember
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.42306

Abstract

Arthrospira maxima and Chlorella vulgaris are contained a high protein and antioxidant levels that can be used as functional foods or supplements to improve health. Furthermore, this material needs to be monitored for safety. The aims of this research were determined the subchronic toxicity test of microalgae A. maxima and C. vulgaris on kidney function. Parameters of this research were creatinine levels, urea levels, kidney index, and histological structure of the kidney glomerular. Besides that, the progression of body weight was observed. Five teen female Wistar rats (Rattus norvegicus Berkenhout,1769) divided into three groups randomly were one control group and two treatment groups using A. maxima and C. vulgaris in the same dose were 2500 mg/kg of body weight. Subchronic toxicity test was conducted by oral gavage every day during 90 days — the measurement of creatinine levels and urea levels on the 30th, 60th, and 90th day. Kidney index and glomerular histology of rat’s kidney was prepared after necropsy at the end of this research. Base on the results, it can be concluded that consume of Arthrospira maxima, and Chlorella vulgaris at 2500 mg/kg of body weight increased creatinine and urea levels. Bodyweight, kidney index, and pathological glomerular cells of histological kidney were still in normal value.
Ulva lactuca Linnaeus Potentially Promotes Reproductive Indices and Depressive-like Behavior of Hypertriglyceridemia Male Wistar Rats (Rattus norvegicus Berkenhout, 1769) Anggoro Chandra Yulistiyanto; Mayumi Hersasanti; Rahadian Yudo Hartantyo; Laksmindra Fitria; Abdul Razaq Chasani; Mulyati Mulyati
Journal of Tropical Biodiversity and Biotechnology Vol 5, No 3 (2020): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.57924

Abstract

Excessive consumption of fatty foods can lead to hyperlipidemia, which is often coupled with hypertriglyceridemia (HTG), a condition where blood plasma triglyceride (TG) levels elevated beyond normal levels. This condition may disturb physiological functions of the body, such as reproductive functions, and other physiological imbalances leading to chronic stress and depression. Ulva lactuca is a potential natural treatment for HTG, as it contains various nutrients to aid physiological functions. This seaweed also has high levels of Cd, which can increase depression. Therefore, research on the potential benefits of U. lactuca should be followed by an investigation of its health risks. This research aimed to examine the effects of HTG and treatment with U. lactuca on reproduction and depressive-like behavior of male Wistar rats (Rattus norvegicus Berkenhout, 1769). The data collected in this research include body weight, serum TG concentration, gonadosomatic index (GSI), serum testosterone concentration using competitive ELISA, and depressive-like behaviors assessed using the Forced Swim Test (FST) and Open Field Test (OFT). Data were analyzed using One-Way ANOVA followed by DMRT, independent- and paired-samples t-test, and Kruskal-Wallis H test with a significance value of α=0.05. Body weight, serum TG and testosterone concentration, GSI, and depressive-like behaviors were increased by the HTG condition. Ulva lactuca at the1500 mg/kg BW/day did not significantly affect body weight, testosterone concentration, and depressive-like behaviors of HTG rats. Meanwhile, this treatment significantly increased the GSI and depressive-like behaviors of healthy rats. These results suggest that Ulva lactuca treatment not only enhances gonad growth and development but also increases depressive-like behaviors.
In Vivo Evaluation of Heavy Metal Decontaminated Marine Macroalgae (Ulva lactuca L.) Using Bilimbi (Averrhoa bilimbi) Juice and Its Potency As Nephroprotector Ashfiya Hanif Hasnadewi; Mulyati Mulyati; Ardaning Nuriliani; Fajar Sofyantoro
Indonesian Food and Nutrition Progress Vol 20, No 1 (2023)
Publisher : Indonesian Association of Food Technologists

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ifnp.85312

Abstract

Ulva lactuca is a functional food ingredient with high antioxidant content. The presence of heavy metal contaminants in natural Ulva lactuca needs to be eliminated. Ulva lactuca was investigated for its potential as a nephroprotector in female Wistar rats. The study assessed Blood Urea Nitrogen (BUN) levels, creatinine levels, and kidney histopathology. The experiment included a Group I (control), Group II (administered 1000 mg/Kg BW/day of natural Ulva lactuca), and Group III (administered 1000 mg/Kg BW/day of heavy metal decontaminated Ulva lactuca using bilimbi juice). After 30 days of oral treatment, no significant differences were observed in BUN levels before and after treatment. However, significant variations were found in Group III compared to the Group I creatinine levels after treatment. Both natural and heavy metal decontaminated Ulva lactuca showed no adverse effects on kidney function. Notably, heavy metal decontaminated Ulva lactuca exhibited improved kidney histopathology, suggesting its potential as a nephroprotector. Further research is needed to explore its broader applications in promoting kidney health.
Co-Authors Abdul Razaq Chasani Anggoro Chandra Yulistiyanto Anita Yuliana Ardaning Nuriliani Ashfiya Hanif Hasnadewi Fajar Sofyantoro Laksmindra Fitria Mayumi Hersasanti Rahadian Yudo Hartantyo Slamet Widiyanto