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All Journal Journal Pharmaceutical Science and Application (JPSA) Jurnal Ilmiah Medicamento
Ni Putu Sinta Mahasuari
Universitas Udayana
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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EFFECT OF METHANOL CONCENTRATION AS A SOLVENT ON TOTAL PHENOLIC AND FLAVONOID CONTENT OF BELUNTAS LEAF EXTRACT (Pulchea indica L.) Ni Putu Sinta Mahasuari; N. L. P. Vidya Paramita; A.A Gede Rai Yadnya Putra
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p05

Abstract

Background: Beluntas (Pluchea indica L.) is an Indonesian plant that grows wild and is used as traditional medicine. Beluntas leaves are reported to contain phenolic, and flavonoid is a part of phenolic compounds. Phenolic compounds other than flavonoids include 1,3,4,5-tetra-O-caffeoylquinic acid, 3,4,5-tri-O-caffeoylquinic acid, chlorogenic acid, and ferulic acid. Flavonoid compounds in beluntas leaves are quercetin, apigenin, luteolin and chrysoeriol. Methanol solvents are reported to be able to extract higher polyphenol and flavonoid contents than other solvents. Objective: The purpose of this study is to determine the effect of 20%, 50% and 75% solvent concentration of methanol on total phenol and total flavonoid levels of beluntas leaf extract. Methods: In this study, the extraction process was carried out by maceration, the determination of total phenol content was carried out by the Follin-Ciocalteu method. Determination of total flavonoid levels was carried out by the Colorimetric method. Data on phenol and flavonoid levels were analyzed statistically. Results: The yield of beluntas leaf extract in this study was respectively from the lowest methanol concentration of 24.094% w/w, 31.126% w/w, 24.838% w/w. The value of total phenol levels increased with increasing methanol concentration, namely 124.84 mg GAE/g, 138.3 mg GAE/g, and 147.91 mg GAE/g. The highest total flavonoid value in 75% methanol extract is 69.72 mg QE/g, followed by 20% methanol extract at 46.29 mg QE/g and the lowest is found in 50% methanol extract at 32.80 mg QE/g. The results of statistical analysis using the Kruskal-Wallis test showed that there were significant differences (p<0.05) in the value of total phenol levels and total flavonoids of the three extracts. Conclusion: The difference in the concentration of methanol solvents affects the value of total phenol levels and total flavonoids with the highest value produced by a 75% methanol solvent. Keywords: Beluntas Leaves (Pluchea indica L.), Total Phenol Content, Total Flavonoid Content, Gallic Acid, Quercetin.
UJI HEDONIK PRODUK BOREH PENURUN DEMAM DARI BAWANG MERAH (Allium cepa L.) dan KULIT BATANG PULE (Alstonia scholaris L.) Ni Putu Sinta Mahasuari; Ni Kadek Cornelia Ayu Trisna; Ni Kadek Karyawati; Andrew Borneo Salian Pawarrangan
Jurnal Ilmiah Medicamento Vol 6 No 2 (2020): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v6i2.845

Abstract

Bawang merah merupakan salah satu bumbu masakan yang memiliki khasiat dibidang kesehatan yakni sebagai penurun demam. Bawang merah mengandung florogusin, sikloalanin, metialin, dan kaemferol yang berperan untuk menurunkan demam. Selain bawang merah kulit batang pule juga memiliki khasiat sebagai penurun demam dan obat tekanan darah tinggi. Demam merupakan suatu keadaan suhu tubuh diatas normal sebagai akibat peningkatan pusat pengatur suhu dihipotalamus. Pemberian terapi obat tradisional pada pengobatan demam di Indonesia beragam, salah satunya pemberian jamu. Campuran dari tanaman bawang merah, kulit batang pule, air jeruk nipis, minyak kelapa, serbuk cendana, garam yang dibuat dalam bentuk sediaan boreh dapat mengobati demam.
Co-Authors Anak Agung Gede Rai Yadnya Putra Andrew Borneo Salian Pawarrangan N. L. P. V. Paramita Ni Kadek Cornelia Ayu Trisna Ni Kadek Karyawati