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HUBUNGAN ANTARA LAMA HEMODIALISIS DENGAN KUALITAS HIDUP PASIEN PENYAKIT GINJAL KRONIK (STUDI DI RSUP DR.KARIADI SEMARANG) Aidillah Mayuda; Shofa Chasani; Fanti Saktini
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.27 KB) | DOI: 10.14710/dmj.v6i2.18531

Abstract

Latar belakang: Penyakit ginjal kronik (PGK) sebagai akibat kerusakan struktural dan fungsional ginjal memiliki progresifitas tinggi berlanjut sebagai end stage renal disease (ESRD) dan memerlukan suatu terapi pengganti ginjal seperti hemodialisis. Terapi hemodialisis jangka  panjang akan mempengaruhi berbagai aspek kehidupan dan berdampak pada penurunan kualitas hidup pasien.Tujuan: Menganalisis hubungan antara lama menjalani hemodialisis dengan kualitas hidup penderita penyakit ginjal kronik di RSUP dr Kariadi Semarang.Metode: Penelitian ini menggunakan desain cross sectional. Subjek penelitian ini merupakan pasien penyakit ginjal kronik di RSUP Dr.Kariadi Semarang periode Maret-Juni 2016. Diperoleh 44 subjek dengan metode consecutive sampling. Data yang digunakan adalah data primer, yaitu hasil pengisian kuesioner KDQOL SF™1.3 dan data sekunder berupa rekam medis.Hasil: Kualitas hidup pasien dengan kategori baik, cukup dan kurang berturut-turut sebagai berikut: 7 (11,4%), 16(36,4%), 5(15,9%) pada hemodialisis < 5 tahun dan 5(11,4%), 6(13,6%), 5(11,4%) pada hemodialisis ≥5 tahun. Dengan analisis fisher’s diperoleh nilai p=0,732. Pada uji somers’d diperoleh nilai p=0,781 antara lama hemodialisis dengan kualitas hidup.Variabel perancu seperti usia, pendidikan, pekerjaan, pendapatan, status pernikahan, penyakit mendasari, menunjukkan hubungan tidak bermakna dengan kualitas hidup. Sedangkan jenis kelamin dan IMT berpengaruh terhadap kualitas hidup.Simpulan: Tidak terdapat perbedaan maupun hubungan yang signifikan secara statistik antara lama hemodialisis dengan kualitas hidup pasien penyakit ginjal kronik di RSUP Dr.Kariadi Semarang.
Procalcitonin Outperforms NLR as a Sepsis Predictor in Pneumonia Patients: A Cross-Sectional Study from a Tertiary Hospital in Padang, Indonesia Dina Fitri Fauziah; Aidillah Mayuda; Wici Septiyeni; Siska Armeinesya; Firmaweni; Atikah Dafri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1251

Abstract

Background: Pneumonia remains a significant cause of morbidity and mortality worldwide, with sepsis being a severe complication. Early identification of sepsis is crucial for prompt treatment and improved outcomes. This study aimed to evaluate the performance of procalcitonin (PCT) and neutrophil-lymphocyte ratio (NLR) as predictors of sepsis in pneumonia patients at a tertiary hospital in Padang, Indonesia. Methods: A cross-sectional study was conducted on 110 adult pneumonia patients admitted to Dr. M. Djamil General Hospital Padang between 2022 and 2023. Data on demographics, clinical characteristics, NLR, and PCT levels were collected from electronic medical records. Sepsis was defined according to established clinical criteria. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic accuracy of NLR and PCT in predicting sepsis. Results: The study population had a mean age of 57.72 ± 14.41 years, with 56.4% being male. Of the 110 patients, 73.6% had community-acquired pneumonia (CAP) and 26.4% had hospital-acquired pneumonia (HAP). Sepsis was present in 55.5% of the patients. The median NLR and PCT levels were significantly higher in the sepsis group compared to the non-sepsis group (NLR: 14 vs. 6.6, p=0.002; PCT: 2.17 vs. 0.24, p=0.000). ROC analysis showed that PCT had a higher area under the curve (AUC) compared to NLR (0.724 vs. 0.676), indicating better diagnostic accuracy. The optimal cut-off point for PCT was 0.455, with a sensitivity of 65.6% and specificity of 65.3%. For NLR, the cut-off point was 10.375, with a sensitivity of 63.9% and specificity of 63.3%. Conclusion: PCT demonstrated superior diagnostic accuracy compared to NLR in predicting sepsis among pneumonia patients in this study. However, NLR remains a valuable tool, especially in resource-limited settings where PCT testing may not be readily available.
Procalcitonin Outperforms NLR as a Sepsis Predictor in Pneumonia Patients: A Cross-Sectional Study from a Tertiary Hospital in Padang, Indonesia Dina Fitri Fauziah; Aidillah Mayuda; Wici Septiyeni; Siska Armeinesya; Firmaweni; Atikah Dafri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1251

Abstract

Background: Pneumonia remains a significant cause of morbidity and mortality worldwide, with sepsis being a severe complication. Early identification of sepsis is crucial for prompt treatment and improved outcomes. This study aimed to evaluate the performance of procalcitonin (PCT) and neutrophil-lymphocyte ratio (NLR) as predictors of sepsis in pneumonia patients at a tertiary hospital in Padang, Indonesia. Methods: A cross-sectional study was conducted on 110 adult pneumonia patients admitted to Dr. M. Djamil General Hospital Padang between 2022 and 2023. Data on demographics, clinical characteristics, NLR, and PCT levels were collected from electronic medical records. Sepsis was defined according to established clinical criteria. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic accuracy of NLR and PCT in predicting sepsis. Results: The study population had a mean age of 57.72 ± 14.41 years, with 56.4% being male. Of the 110 patients, 73.6% had community-acquired pneumonia (CAP) and 26.4% had hospital-acquired pneumonia (HAP). Sepsis was present in 55.5% of the patients. The median NLR and PCT levels were significantly higher in the sepsis group compared to the non-sepsis group (NLR: 14 vs. 6.6, p=0.002; PCT: 2.17 vs. 0.24, p=0.000). ROC analysis showed that PCT had a higher area under the curve (AUC) compared to NLR (0.724 vs. 0.676), indicating better diagnostic accuracy. The optimal cut-off point for PCT was 0.455, with a sensitivity of 65.6% and specificity of 65.3%. For NLR, the cut-off point was 10.375, with a sensitivity of 63.9% and specificity of 63.3%. Conclusion: PCT demonstrated superior diagnostic accuracy compared to NLR in predicting sepsis among pneumonia patients in this study. However, NLR remains a valuable tool, especially in resource-limited settings where PCT testing may not be readily available.