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HUBUNGAN ANTARA DERAJAT PENYAKIT GINJAL KRONIK DENGAN NILAI AGREGASI TROMBOSIT DI RSUP PROF. DR. R. D. KANDOU MANADO Tandi, Melti; Mongan, Arthur; Manoppo, Firginia
e-Biomedik Vol 2, No 2 (2014): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v2i2.5076

Abstract: Chronic kidney disease has got a lot of attention and more widely studied despite reached end stage renal failure, patients still live a long life witha fairly good quality of life although the prevalence is increases throughout the year. one of the circumstances in chronic kidney disease is uremia which is a clinical and laboratory syndrome that occurs inorgans. In uremia interference with platelet function, the production ofprostacyclinin blood vesselswould increase, and excessurea levels in blood would be a potential vasodilator and platelet aggregation antagonist. Methods: An analytic observational cross-sectional study. Samples were patients that diagnosed with chronic kidney disease at the Hospital Clinic of Nephrology-Hypertension Prof. Dr.R. D.Kandou Manado in December toFebruary 2014. Criteria included were patientsÂ <80 years old and has been diagnosed with chronic kidney disease in this case had done a physical examination and investigations by doctors, using medical record of urea-creatinine and also a complete blood countand platelet aggregation in Prokita Laboratory Manado. Forstatistical analysisusedShapiro-Wilk testalsoPearsonCorrelationstest. Result: There were 20 patients with chronic kidney disease sampled in this study. It was found that there is a relationship between of urea-creatinine and aggregation results in trace ADP5(P=0.004) while the value ADP10 no significant correlation(P =0.399). Conclusion: In chronic kidney disease patients, urea-creatininewiththe value of platelet aggregation intrace ADP5had a relation ship while intrace ADP10 had not a relationship. Keywords: Chronic kidney disease, platelet aggregation.

LIMFOSIT PLASMA BIRU DAN JUMLAH LEUKOSIT PADA PASIEN ANAK INFEKSI VIRUS DENGUE DI MANADO Arruan, Rosnatalia D.; Rambert, Glady; Manoppo, Firginia
eBiomedik Vol 3, No 1 (2015): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.3.1.2015.7412

Abstract: Dengue is an arboviral disease that is widely spread across the world by Aedes mosquitoes. The early onset of dengue virus infection is difficult to identify due to indistinctive clinical symptoms. Therefore, simple laboratory test is required in the early diagnosis of dengue virus infection. Laboratory test that include routine blood test and blue plasma lymphocyte are important as rapid and relatively cheap diagnostic tool. Blue plasma lymphocytes derived from lymphoid which acts as an immune response that can be found in 4% of peripheral blood on 98% dengue hemorrhagic fever cases. Besides the increases in blue plasma lymphocytes, dengue virus infection can also causes leucopenia. Leucopenia in Dengue Hemorrhagic Fever (DHF) is characterized by the decrease of neutrophile count that happened during the early critical phase (third day of fever). This is a cross-sectional study using samples of 37 children who are infected with dengue virus in RS Advent Manado, RS TNI AD Wolter Monginsidi, RS Pancaran Kasih Manado during December 2014 to January 2015. Inclusion criteria are children below age 15, who have NS1 or IgG/IgM positive, who are on the third until seventh day of fever, whose parents or guardian have signed the informed consent. Conclusion: Leucopenia (leukocyte count below 4000/mm3) was found in children with dengue virus infection who had their routine blood test. Blue plasma lymphocytes are not always found in patients with NS1-AG, IgG/IgM positive.Keywords: dengue virus infection, leucocyte, blue plasma lymphocyteAbstrak: Dengue adalah penyakit arboviral yang paling banyak tersebar di dunia yang ditularkan nyamuk Aedes. Awal infeksi virus dengue sulit untuk dikenali sebab tidak menunjukkan gejala klinis khas. Karena itu, pemeriksaan laboratorium sederhana dapat berperan dalam pengenalan infeksi virus, adalah pemeriksaan darah rutin dan limfosit plasma biru yang cepat dan murah. Limfosit plasma biru sebagai respon imun dengan persentase 4% di darah tepi pada 98% kasus demam beradarah dengue. Selain peningkatan limfosit plasma biru, infeksi virus dengue juga dapat menyebabkan leukopenia. Leukopenia pada demam berdarah dengue didominasi penurunan jumlah neutrofil yang terjadi pada awal fase kritis (hari ketiga demam). Penelitian ini menggunakan desain cross sectional dengan sampel penelitian 37 pasien anak yang terinfeksi virus dengue di RS Advent Manado, RS TNI AD Wolter Mongisidi, RS Pancaran Kasih Manado pada bulan Desember 2014 sampai Januari 2015. Kriteria masukan adalah Anak usia kurang dari 15 tahun, hari ketiga sampai ketujuh demam, NS1 atau IgG/IgM positif, Orangtua atau wali bersedia menandatangani informed consent. Simpulan: Pada pasien anak dengan infeksi virus dengue yang dilakukan pemeriksaan darah rutin ditemukan adanya leukopenia dengan jumlah leukosit dibawah 4000/mm3.Kata kunci: infeksi virus dengue, leukosit, limfosit plasma biru

KADAR HEMOGLOBIN DAN UJI TOURNIQUET PADA PASIEN ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO Hardi, Joseph; Rambert, Glady; Manoppo, Firginia
e-Biomedik Vol 3, No 1 (2015): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v3i1.7418

Abstract: Dengue infection is a systemic and dynamic disease that has a broad spectrum. The key for good management and results is to know and understand arising signs. Various examination is necessary for diagnosis, one of them are the examination of hemoglobin levels and tourniquet test. This research was a cross sectional study. Samples were obtained from 37 pediatric patients with dengue virus infection of the total population sample of 72 patients in RS Advent Manado, RSU GMIM Pancaran Kasih Manado, and RSAD Robert Wolter Mongisidi Teling. The results of this study show the hemoglobin levels on pediatric patients with dengue virus infection mostly in normal levels and not all patients show positive tourniquet test results.Keywords: dengue, hemoglobin levels, tourniquet testAbstrak: Infeksi dengue adalah suatu penyakit sistemik dan dinamik yang memiliki spektrum yang luas. Kunci keberhasilan dalam pengelolaan dan hasil yang baik adalah mengenal dan memahami tanda-tanda yang timbul. Diperlukan berbagai pemeriksaan penunjang salah satu diantaranya adalah pemeriksaan kadar hemoglobin dan uji tourniquet. Penelitian ini merupakan penelitian cross sectional. Sampel penelitian diperoleh 37 pasien anak dengan infeksi virus dengue dari total populasi sampel 72 pasien di RS Advent Manado, RSU GMIM Pancaran Kasih Manado, dan RSAD Robert Wolter Mongisidi Teling. Hasil penelitian menunjukkan gambaran hemoglobin pada pasien anak dengan infeksi virus dengue sebagian besar dalam kadar normal dan tidak semua menunjukkan uji tourniquet positif.Kata kunci: dengue, kadar hemoglobin, uji tourniquet

PERBANDINGAN JUMLAH TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 YANG MENGGUNAKAN ASPIRIN DAN TIDAK MENGGUNAKAN ASPIRIN Palimbunga, Dwi P.; Pandelaki, Karel; Mongan, Arthur E.; Manoppo, Firginia
eBiomedik Vol 1, No 1 (2013): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.1.1.2013.1618

Abstract: Patients with type-2 diabetes mellitus are characterized by an acceleration thrombopoiesis, an increased platelet turnover and a decreased platelet survival time which affect platelet count, that cause the increasing of proportion of large and reactive platelets, and hence more thrombogenic. People with diabetes have a two- to fourfold increase in the risk of dying from the complications of cardiovascular disease. Aspirin therapy is recommended for the primary and secondary prevention of cardiovascular events in most people with diabetes. This study was an descriptive analytic method with cross sectional study design. The subjects in this study involve 112 people, 56 people treated with aspirin, and the 56 others were not who signed in endocrine metabolic department of RSUP Prof. Dr. R. D Kandou Manado. Data were taken from medical record. The Mann-Whitney test showed that there was no significant difference between the platelet count in patients with type-2 diabetes mellitus treated with aspirin and patients who were not. Conclusion: There was no significant difference between the platelet count in patients with type-2 diabetes mellitustreated with aspirin and patients who were not. Key word:Aspirin, Type-2 Diabetes Mellitus, Platelet Count Abstrak: Pada pasien diabetes melitus tipe-2 terjadi percepatan trombopoiesis, peningkatan pergantian trombosit dan penurunan waktu hidup trombosit yang mempengaruhi jumlah trombosit, yang menyebabkan terjadinya peningkatan ukuran trombosit yang lebih besar dan reaktif, sehingga bersifat trombogenik. Risiko kematian karena komplikasi penyakit jantung meningkat dua sampai empat kali lipat. Aspirin digunakan sebagai pencegahan primer dan sekunder terhadap kejadian kardiovaskular pada pasien diabetes. Tujuan penelitian ini untuk melihat perbedaan jumlah trombosit pada pasien diabetes melitus tipe-2 yang menggunakan aspirin dan tidak menggunakan aspirin. Penelitian ini bersifat deskriptif analitik dengan rancang penelitian cross sectional. Subjek dalam penelitian ini berjumlah 112 orang, 56 orang yang menggunakan aspirin dan 56 orang lainnya tidak menggunakan aspirin yang terdaftar di Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Data diambil dari catatan rekam medik. Hasil penelitian menggunakan uji Mann-Whitney,menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara jumlah trombosit pada pasien diabetes melitus tipe-2 yang menggunakan aspirin dan tidak menggunakan aspirin (p=0,059). Simpulan: Tidak terdapat perbedaan signifikan antara jumlah trombosit pada pasien diabetes melitus tipe 2 yang menggunakan aspirin dan tidak menggunakan aspirin. Kata Kunci: Aspirin, Diabetes Melitus Tipe-2, Jumlah Trombosit

KARAKTERISTIK ERITROSIT PADA PASIEN ANAK DENGAN INFEKSI VIRUS DENGUE DI MANADO Kewo, Indah R. A.; Rambert, Glady; Manoppo, Firginia
eBiomedik Vol 3, No 2 (2015): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.3.2.2015.8438

Abstract: Dengue infection is a kind of viral infectious disease that can cause death. There are several hematological abnormalities frequently found in dengue infection, as follows: leukopenia, thrombocytopenia, coagulation disorders, bone marrow suppression, as well as increases in hemoglobin level and hematocrit value due to leakage of plasma. This study aimed to obtain the characteristic features of erythrocytes in children infected with dengue virus in Manado. This study used a cross sectional design and was conducted from December 2014 until January 2015 at Pancaran Kasih GMIM Hospital, Wolter Monginsidi Hospital, and Advent Hospital in Manado. Examination of the characteristics of erythrocytes was conducted at Prokita Malalayang Laboratory. Samples were 37 patients. The results showed that low erythrocyte count was found in 2 patients (5.41%); normal erythrocyte count in 34 patients (91.9%); and increased erythrocyte count in 1 patient (2.7%). Low mean copuscular volume (MCV) (MCHC) was found in 35 patients (94.6%), and increased MCHC in 2 patients (5.4%). Conclusion: Most children with dengue viral infection in Manado had normal erythrocyte count, along with MCV and MCHC in the range of the reference values (normocytic and normochromic).Keywords: Dengue virus infection, the number of erythrocytes, MCV, MCHC.Abstrak: Infeksi virus dengue merupakan penyakit infeksi yang dapat menyebabkan kematian. Kelainan hematologi sering muncul pada demam berdarah dengue diantaranya leukopenia, trombositopenia, gangguan koagulasi, penekanan sumsum tulang, juga terjadi peningkatan kadar hemoglobin dan nilai hematokrit karena kebocoran plasma yang dapat menyebabkan kematian. Penelitian ini bertujuan untuk mengetahui karakteristik eritrosit pada anak yang terinfeksi virus dengue di Manado. Desain penelitian potong lintang dengan jumlah sampel 37 pasien. Penelitian ini dilaksanakan di RSU Pancaran Kasih GMIM Manado, RS Wolter Mongisidi Manado, dan RS Advent Manado pada bulan Desember 2014 sampai Januari 2015. Pemeriksaan karakteristik eritrosit dilakukan di Laboratorium Prokita Malalayang. Hasil penelitian memperlihatkan jumlah eritrosit rendah ditemukan pada 2 orang (5,41%); normal 34 orang (91,9%); dan meningkat 1 orang (2,7%). Nilai mean copuscular volume (MCV) rendah pada 8 orang (21,6%); normal 28 orang (75,7%); dan meningkat 1 orang (2,7%). Nilai mean copuscular hemoglobin consentration (MCHC) normal pada 35 orang (94,6%), dan meningkat 2 orang (5,4%). Simpulan: Pada sebagian besar pasien anak dengan infeksi virus dengue di Manado didapatkan jumlah eritrosit dalam batas nilai normal, serta nilai MCV dan MCHC berada diantara rentang nilai rujukan (normositik dan normokromik).Kata kunci: infeksi virus dengue, eritrosit, MCV, MCHC

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