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Arthur Mongan
Universitas Sam Ratulangi
Medicine & Pharmacology

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HUBUNGAN ANTARA DERAJAT PENYAKIT GINJAL KRONIK DENGAN NILAI AGREGASI TROMBOSIT DI RSUP PROF. DR. R. D. KANDOU MANADO Tandi, Melti; Mongan, Arthur; Manoppo, Firginia
e-Biomedik Vol 2, No 2 (2014): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v2i2.5076

Abstract

Abstract: Chronic kidney disease has got a lot of attention and more widely studied despite reached end stage renal failure, patients still live a long life witha fairly good quality of life although the prevalence is increases throughout the year. one of the circumstances in chronic kidney disease is uremia which is a clinical and laboratory syndrome that occurs inorgans. In uremia interference with platelet function, the production ofprostacyclinin blood vesselswould increase, and excessurea levels in blood would be a potential vasodilator and platelet aggregation antagonist. Methods: An analytic observational cross-sectional study. Samples were patients that diagnosed with chronic kidney disease at the Hospital Clinic of Nephrology-Hypertension Prof. Dr.R. D.Kandou Manado in December toFebruary 2014. Criteria included were patients  <80 years old and has been diagnosed with chronic kidney disease in this case had done a physical examination and investigations by doctors, using medical record of urea-creatinine and also a complete blood countand platelet aggregation in Prokita Laboratory Manado. Forstatistical analysisusedShapiro-Wilk testalsoPearsonCorrelationstest. Result: There were 20 patients with chronic kidney disease sampled in this study. It was found that there is a relationship between of urea-creatinine and aggregation results in trace ADP5(P=0.004) while the value ADP10 no significant correlation(P =0.399). Conclusion: In chronic kidney disease patients, urea-creatininewiththe value of platelet aggregation intrace ADP5had a relation ship while intrace ADP10 had not a relationship. Keywords: Chronic kidney disease, platelet aggregation.
PERBANDINGAN JUMLAH TROMBOSIT PADA DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI VASKULAR DAN TANPA KOMPLIKASI VASKULAR DI RSUP PROF. DR. R. D. KANDOU Widiarto, Nina S; Posangi, Jimmy; Mongan, Arthur; Memah, Maya
e-Biomedik Vol 1, No 1 (2013): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v1i1.4153

Abstract

Abstract: Diabetes mellitus (DM) is a degenerative disease which has increased from year to year. Type 2 diabetes has the highest number of cases. There is a change in platelet count in type 2 diabetes. The change in platelet count can lead to vascular complications in DM. This was a descriptive analytic study with a cross sectional design by using the medical record data of type 2 diabetic patients in the outpatient department of Prof. DR. R. D. Kandou Hospital, Manado. Subjects who met the inclusion criteria were 72 patients; 36 patients with vascular complications and 36 patients without vascular complications. Data were analyzed by using the Mann-Whitney test to determine the ratio of the platelet count in patient with type 2 diabetes patient with and without vascular complication, with α = 0.05. The Mann-Whitney test showed that there was no significant difference in platelet count among patients with type 2 diabetes, with and without vascular complication (P = 0.051). Conclusion: There was no significant difference in the platelet count of type 2 diabetes patients with and without vascular complication.Keywords: type 2 diabetes mellitus, vascular complication, platelet countAbstrak: Diabetes Melitus (DM) merupakan salah satu penyakit degeneratif yang semakin meningkat jumlahnya dari tahun ke tahun. Jenis DM yang paling banyak kasusnya ialah DM tipe 2. Pada DM tipe 2 terjadi perubahan jumlah trombosit, yang dapat menyebabkan terjadinya komplikasi vaskular pada DM. Penelitian ini bersifat deskriptif analitik dengan rancang penelitian cross sectional dengan menggunakan data rekam medik pasien DM tipe 2 yang rawat jalan di RSUP Prof. DR. R. D. Kandou Manado. Subjek penelitian yang memenuhi kriteria inklusi berjumlah 72 pasien; 36 pasien dengan komplikasi vaskular dan 36 pasien tanpa komplikasi vaskular. Hasil penelitian diuji menggunakan uji Mann-Whitney untuk mengetahui perbandingan jumlah trombosit pada pasien DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vascular, α = 0,05. Uji Mann-Whitney menunjukkan bahwa perbedaan jumlah trombosit tidak bermakna antara pasien DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular (p=0,051). Simpulan: Tidak terdapat perbedaan bermakna antara jumlah trombosit pada pada DM tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular.Kata kunci: DM tipe 2, komplikasi vaskular, jumlah trombosit
Co-Authors Firginia Manoppo Jimmy Posangi Maya Memah Melti Tandi Nina S Widiarto