Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

0.23

P-Index

This Author published in this journals

All Journal Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Science and Technology Indonesia Majalah Ilmiah Pengkajian Industri Jurnal Ilmu Fisika CAHAYA tech Prosiding Seminar Nasional Unimus

Mardiyanto Mardiyanto

Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Universitas Sriwijaya, Indralaya (OI), Sumatera Selatan 30662, Indonesia

Author-ID : 315206

Aerospace Engineering Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Nursing Physics Public Health Transportation

Published : 10 Documents Claim Missing Document

Claim Missing Document

Articles

Title

Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design Najma Annuria Fithri; Mardiyanto Mardiyanto; Rennie Puspa Novita; Vicky Andrean
Science and Technology Indonesia Vol. 2 No. 4 (2017): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Preparation of SNEDDS aims to improve solubility and absorption of furosemide in the body to reduce the dosage and minimize the side effects of drugs. Ternary diagram constructed from composition mixture produced nanoemulsion in the range of 20-40% of capryol-90, 20-40% polysorbate-80 and 40-60% PEG-400. Formulations of SNEDDS using Design-Expert®10 with simplex-lattice-design method in the study was aimed to investigate the effect of SNEDDS each component's proportions towards test responses. Emulsification time, drug content and viscosity were best demonstrated by run-7 with consecutive values of 131.68±2.14 seconds, 99.89±2.68% and 0.87±0.0043 mm2/s. The optimum formula was obtained through entering test response parameter data of all thirteen formula. Drug content and emulsification time was 107.0 ± 1.44% and 155.59±1.56 seconds with viscosity value 0.91±0.00 mm2/s. From the physical stability studies, SNEDDS formulas were stable and did not show phase separation when exposed to temparature stress testing.

Characterization and Optimization of Capryol-90, Polysorbate-80, And Peg-400 Proportion in Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) With Simplex-Lattice-Design Mardiyanto Mardiyanto; Najma Annuria Fithri; Martina Tandry
Science and Technology Indonesia Vol. 3 No. 4 (2018): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Mefenamic acid as pain relief drug belongs to the biopharmaceutics classification system (BCS) class II which is practically insoluble in water causing extremely low dissolution in gastrointestinal tract. The self nanoemulsifying drug delivery system (SNEDDS) is a new innovation pharmaceutical dosage form that has effectively known to increase solubilization of hydrophobic drug in polar solvent. In this study the capryol-90 was selected as oil phase in SNEDDS as it showed maximal solubility of mefenamic acid (20 mg/mL). Combination of polysorbate-80 and PEG-400 as a generally regarded as safe (GRAS) excipient were used as surfactant and co-surfactant in SNEDDS due to its high HLB property that can increase mefenamic acid solubility in water. The ternary phase diagram of capryol-90, polysorbate-80, and PEG-400 was constructed in advance to obtain the component concentration of spontaneous nanoemulsion region. Model simplex-lattice-design cooperated in Design-Expert®10 was used to define SNEDDS mefenamic acid formula. Optimized mefenamic acid SNEDDS formula consisted of 20% capryol-90, 31.62% polysorbate-80, and 48.38% PEG-400. Characterization study of Optimized mefenamic acid SNEDDS formula showed improvement of drug content (102.820 ± 4.950)%, emulsification time (421.015 ± 1.290) second, and viscosity (0.927 ± 0.017) mm2/s 30oC. One way ANOVA statistical analysis result of optimal formula SNEDDS (105.210 ± 4.425)% of drug content, commercial generic caplet (0.917 ± 0.094)%, and mefenamic acid powder capsule (10.446 ± 0,333)% gave significant value (sig*) below than 0.05. Optimal formula proved that SNEDDS can significantly increase mefenamic acid dissolution of pH 7.4 (ileum fluid). The optimal formula of mefenamic acid SNEDDS successfully formed an uniformity droplet size (PDI 0.18) with mean size 241.9 nm and the surface charge has a value of -16.5 mV respectively.

The Chitosan-Sodium Alginate Submicro Particles Loading Herbal of Ethanolic Exract of Leaves Senna Alata. L for Curing of Bacterial Infection on Skin Mardiyanto Mardiyanto; Indah Sholihah; Thio Gunawan Jaya
Science and Technology Indonesia Vol. 5 No. 3 (2020): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Abstract Mardiyanto 1*, Indah Solihah 1, and Thio Gunawan Jaya 1 1Department of Pharmacy Faculty of Science Sriwijaya University *Corresponding Author : mardiyantoUNSRI@gmail.com This research was performed to detect the activity of the optimum formula of chitosan and sodium alginate submicro particles loading of the ethanol extract of leaves ketepeng cina (Senna alata L.) to P. acne growth. Submicro manufactured particles was used three variations of the formula from three of volume used of calcium chloride (CaCl2): 20, 40, and 100 mL based on ionic gelation method. The results obtained of %EE in formulas 1, 2 and 3 were 78.56%, 81.71%, and 77.48%. Formula 2 with a value of % EE of 81.71% was used as an optimum formula which indicates that the particles are well protected by chitosan and sodium alginate polymers so as to prevent particle damage during the homogenization process. The results of the diameter measurements showed that the optimal formula enters in the submicro particle range with the value obtained is 525,9455 nm. The submicro formula of chitosan alginate particles loading the ketepeng cina leaf ethanol extract was barely homogeneous which based on the results obtained by the PSA was 0.433 of PDI. The zeta potential value was +3.5 mV. The results of X-ray diffraction analysis or X ̶ Ray Diffraction produce a pattern shaped amorph with the resulting peak does not have a wide distance and pattern. In vivo testing using ketepeng cina leaf extract as submicro was decreased the P. acne lesion faster than using only ketepeng cina leaf extract because the submicro particle preparation has a small particle that is below to 600 nm making it easier to penetrate the skin pores to reach the target. The results of the analysis of the curing of many lesions on the skin of mice have a significance value of homogeneity. The one-way ANOVA test of < 0.05 was a significant effect of the test group on the decreasing in the number of lesions on the skin of the mouse.

Co-Authors Abu Khalid Rivai Ady Mara, Ady Agus Taufiq Amelia Wibowo Arif Djunaidy Budi Untari Catur Puput Wulandari Dian Fitriyani Elvaswer Elvaswer Enny Zarvianti Enny Zavianti Faris Alfarizi Indah Sholihah Ira Luvi Indah Astutik Linggar Septyoadhi Martina Tandry Marzuki Silalahi Najma Annuria Fithri Najma Annuria Fithri Rennie Puspa Novita Sulistioso G.S Sulistioso Giat Sukaryo Syahfandi Ahda Thio Gunawan Jaya Vicky Andrean Winda Surya Bery

Title Search

Found 3 Documents Search Journal : Science and Technology Indonesia

Abstract

Abstract

Abstract

Title

Found 3 Documents
Search
Journal : Science and Technology Indonesia