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All Journal Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) JIMR - Journal of Islamic Medicine Research
Sasi Purwanti
Faculty Of Medicine, Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Medicine & Pharmacology

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Pengaruh Perbedaan Konsentrasi Emulgator terhadap Karakterisasi Fisik Sediaan Krim Ekstrak Rosella (Hibiscus sabdariffa) Ike Widyaningrum; Sasi Purwanti
Jurnal Ilmiah Biosaintropis (Bioscience -Tropic) Vol 7 No 1 (2021): Agustus 2021
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

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The formulation and physical characterization test of rosella extract cream preparations have been carried out using various types of non-ionic emulsifier concentration ratios (combination of tween 80 and span 80). Comparison of the concentrations of tween 80 and span 80 used in this study were 2%, 3%, and 4%. The aim of this study included organoleptic test, homogeneity test, pH test, viscosity test, dispersion test, and emulsion type test. The result obtained from the physical characterization test were the organoleptic tests for the three formulas showed the same organoleptic results, namely red color, characteristic smell of rosella, and semisolid consistency. Homogeinity test shows that the formula is homogenous. The pH test showed that F1 4,29; F2 4,6; F3 5. Viscosity test showed that F1 432,4 mPas; F2 434,3 mPas; 435,3 mPas. The dispersion test was carried out without using a load of 50 g, 100 g, and 200 g. the results shown form the spreadability test of three formulas were were F1 5 cm; 5,5 cm; and 6 cm; F2 6 cm; 6,35 cm; 7,25; and 7,5 cm. F3 6,25 cm; 7,5 cm; 7,75 cm; 8 cm. The emulsion type indicated by the three formulas is oil in water. Based on these results, it can be seen that the emulsifier concentration has an effect on PH, viscosity, and spreadibility. The higher the concentration of emulsifier used, the higher pH value, viscosity, and spreadibility.
Pengaruh Pemberian secara Subkronik Minyak Atsiri Daun Sirsak (Annona muricata Linn.) terhadap Kadar Low Density Lipoprotein (LDL) dan High Density Lipoprotein (HDL) Serum Tikus Wistar Yunita Ika Pratiwi; Sasi Purwanti; Dini Sri Damayanti
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Introduction: The essential oil of soursop (Annona muricata Linn.) leaves contains terpenoid, alkaloid, and phenolic compounds. Terpenoid, alkaloid and phenolic function as antioxidants and antiinflammatory agents appropriately. When used in high concentrations and in long period, it may become toxic, which mayincreasein LDL and decrease in HDL. The study is to determine the safety of soursopleaf essential oil on LDL and HDL levels in wistar rats.Methods: This was an invivo experimental study with a control group post test only design using 20 male and 20 female wistar rats divided into 8 groups, consisting of KN (tween 80), P1 (1,25 mg/kgBW), P2 (2,5 mg/kgBW), and P3 (5mg/kgBW) both male and female rats. This study was conducted for 28 days then the LDL and HDL levels were checked after the treatment. Results were analized using One Way ANOVA test followed by Least Significant Difference (LSD). Results are assumed significant if p<0.05.Results and discussion: Administration of soursop leaf essential oil in P1 group showed the highest LDL levels and a higher dose of soursop leaf essential oil will cause a lower LDL levels in both male and female groups. The P2 group showed the highest HDL levels and P3 group had decreased HDL levels compared to P2 group in both male and female groups. The increasing of LDL levels and the decreasing of HDL levels in all treatment groups, is suspected to be caused by active compounds in soursop leaf essential oil, body weight differences and food consumption differences on rats.Conclusion: The doses between 1,25 to 5 mg/kgBW is considered to be safe, in which no increase in LDL and decrease in HDL in normal male and female rats was observed.Keywords: Essential oil of soursop leaves,Annona muricata Linn., Subchronic,LDL,and HDL.
Correlation between LL-37 Levels and Scoring of Atopic Dermatitis (SCORAD) in Atopic Dermatitis in dr. Saiful Anwar General Hospital Malang Sasi Purwanti; Santosa Basuki; Herwinda Brahmanti
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic, recidive inflammatory skin disease that is associated with hyper-reactivity of the immune response to environmental allergens. LL-37 is an antimicrobial peptide which plays an important role in the pathogenesis of AD. Several studies conducted to find out LL-37 expression on the skin of patients showed varying and contradictory results. Studies aimed to find out the association of LL-37 levels in circulation with AD degree of severity are still very limited. The aim of this study are to determine the relationship between serum LL-37 levels and Scoring Atopic Dermatitis (SCORAD) score and to determine the relationship between serum LL-37 levels and the severity of atopic dermatitis.Method: This study is analytic observational cross sectional study. The subjects are 30 patients with AD who came to Outpatient Care for Dermatovenereology and Outpatient Care for Pediatric Allergy in dr.Saiful Anwar General Hospital (RSSA) Malang and fulfilled the inclusion and exclusion criteria. The subjects are grouped into 2 groups based on AD severity, i.e. mild and moderate-severe based on SCORAD index. The measured variable is serum LL-37 levels with enzyme-linked immunosorbent assay (ELISA) method.Results: The mean serum LL-37 levels are 12.46.7 ng/ml for mild degree AD and 9.46.06 ng/ml for moderate/severe degree AD. Statistical analysis using Pearson parametric statistic test shows no significant correlation (p> 0.05) between serum LL-37 levels and SCORAD score in patients with AD. Serum levels of LL-37 in this study are lower than the normal score in circulation.Conclusions: LL-37 serum levels in AD do not experience an increase and is not related to SCORAD score.Keywords: Atopic Dermatitis, LL-37, SCORAD
Co-Authors Damayanti, Dini Sri Herwinda Brahmanti Ike Widyaningrum Santosa Basuki Yunita Ika Pratiwi