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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Journal of Innovation and Applied Technology Universa Medicina Majalah Kesehatan FKUB Berkala Ilmiah Kedokteran Duta Wacana JIMR - Journal of Islamic Medicine Research Journal of General Procedural Dermatology and Venereology Indonesia
Herwinda Brahmanti
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Association between environmental allergen sensitization with severity of atopic dermatitis in children and young adult at Dr. Sardjito General Hospital, Yogyakarta Brahmanti, Herwinda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.988 KB)

Abstract

The important role of aeroallergens and food allergens as the most common environmental allergens in exacerbationof atopic dermatitis (AD) iswell known. Sensitization is an essential processwhich correlateswith clinicalmanifestationof AD. The study of AD in Indonesia, especially in Yogyakarta, has not been reported, yet. The aim of study is toevaluate the association between sensitization of environmental allergens with clinical severity of AD in children andyoung adult at Dr. Sardjito General Hospital, Yogyakarta. An analytic observational cross sectional study wasperformed on 33 children and young adult with AD. The severity of disease was determined by SCORing AtopicDermatitis (SCORAD). Assessment of sensitization was performed using specific IgE serum, atopy patch test, andprick test. Data were analyzed using chi-square or Fisher exact test and prevalence ratio (PR) with significancevalue of p<0.05 and 95%confidence interval (CI). The results showed that specific IgE positivity was associatedwith severity of AD. Percentage of specific IgE positivity to house dust mite was significantly higher in subject withmoderate/severe AD compared to those of mild AD (p=0.049; PR 1.13; 95% CI 1.01-1.59). The result was alsosimilar for cat dander (p=0.041; PR 1.1; 95%CI 1.09-4.98), cow’s milk (p=0.038; PR 1.21; 95% CI 1.02-2.2),and egg white (p=0.027; PR 1.23; 95% CI 1.15-2.97). Whereas specific IgE positivity to fish allergen was notstatistically different in subject with moderate/severe AD compared to those with mild AD (p=0.061; PR 0.8; 95%CI 0.76-2.8). According to atopy patch test and prick test result, no association was found between allergensensitization and severity of AD. If allmethodswere combined to increase the sensitivity of sensitizationmeasurement,then the association was found for all allergens. It could be concluded that environmental allergens sensitization isassociated with severity of AD in children and young adult at Dr. Sardjito General Hospital, Yogyakarta.Key words: atopic dermatitis-disease severity-sensitization-aeroallergen-food allergen
HUBUNGAN ANTARA KADAR HORMON DEHYDROEPIANDROSTERONE SULFATE (DHEAS) SERUM DENGAN AKTIVITAS PENYAKIT URTIKARIA KRONIS PADA PEREMPUAN Brahmanti, Herwinda; Rofiq, Aunur; Cholis, Mochammad
Majalah Kesehatan FKUB Vol 4, No 4 (2017): MAJALAH KESEHATAN FAKULTAS KEDOKTERAN
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.752 KB) | DOI: 10.21776/ub.majalahkesehatan.2017.004.04.1

Abstract

Abstrak Urtikaria merupakan lesi kulit yang terdiri dari reaksi wheal dan flare. Sebanyak 15-20% penduduk pernah mengalami urtikaria dalam kehidupannya, dan 25% diantaranya mengalami urtikaria kronik. Kejadian urtikaria lebih banyak dijumpai pada perempuan. Adanya hubungan antara proses imunologis  dan aktivitas neuroendokrin menjadi salah satu hipotesis yang mendasari patogenesis urtikaria. Ditemukannya peran DHEAS dalam fungsi imunomodulator dan antiinflamasi dapat menjadi dasar adanya peran dari terganggunya fungsi DHEAS akibat defisiensi dengan proses inflamasi pada urtikaria. Rancangan penelitian observasional potong lintang dilakukan untuk mengetahui adanya hubungan antara kadar hormon dehidroepiandrosteron sulfat (DHEAS) serum dengan aktivitas penyakit urtikaria kronis pada perempuan. Hasil uji Kruskall Wallis dengan post hoc Man Whittney menunjukkan adanya perbedaan yang bermakna antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (p = 0,000). Analisis uji Spearman menunjukkan adanya korelasi negatif yang kuat antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (r = -0,933; p = 0,000). Hal ini menunjukkan bahwa pada kadar yang lebih tinggi maka  hormon DHEAS dapat bersifat protektif terhadap perburukan klinis urtikaria, dan sebaliknya pada kondisi urtikaria yang kronis terjadi penurunan kadar hormon DHEAS serum. Dapat disimpulkan bahwa pada wanita, ada hubungan antara kadar DHEAS serum dengan aktivitas penyakit urtikaria kronis. Hasil ini memperkuat kemungkinan terjadinya penurunan kadar DHEAS serum yang berperan dalam patogenesis urtikaria kronis. Kata kunci: aktivitas penyakit, dehidroepiandrosteron sulfat serum, urtikaria kronis
TERAPI METHOTREXATE PADA PASIEN DENGAN VASKULOPATI LIVEDOID Lilasari, Sekar Puspita; Brahmanti, Herwinda; Retnani, Diah Prabawati
Majalah Kesehatan FKUB Vol 5, No 1 (2018): Majalah Kesehatan Fakultas Kedokteran
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1641.398 KB) | DOI: 10.21776/ub.majalahkesehatan.005.01.8

Abstract

Penyakit Vaskulopati livedoid (VL) adalah penyakit hialinisasi vascular yang jarang dan ditandai dengan ulkus rekuren, kronik, pada ekstremitas bawah serta livedoid reticularis dan atrophie blanche. Akibat patogenesis yang belum jelas, belum ada konsensus terapi untuk VL. Methotrexate merupakan salah satu modalitas terapi berupa imunosupresan untuk vaskulitis. Dilaporkan satu kasus laki-laki usia 21 tahun dengan adanya luka yang nyeri dan berulang sejak 15 tahun. Luka dapat sembuh sendiri dan meninggalkan bercak kecoklatan disertai bercak putih yang mengkilat. Tidak ada penyakit penyerta sistemik lain. Pemeriksaan dermatologik pada kedua cruris dan kedua dorsum pedis didapatkan ulkus multipel, bentuk bulat dan ireguler, batas tegas, disertai dengan livedo reticularis dan atrophie blanche. Terapi awal yang diberikan adalah metilprednisolon 1x16 mg per oral namun dalam 2 minggu terjadi rekurensi. Kemudian diberikan methotrexate 15mg/minggu per oral, setelah 2 minggu didapatkan perbaikan yang dinilai dari jumlah ulkus baru yang muncul. Namun perlu follow-up lebih lanjut untuk mengetahui rekurensi.  
Commersial Drug Patch Test for Identifying Etiologic Drug of Adverse Cutaneous Drug Reaction Vidya Hana Dwi Ayuningtyas; Herwinda Brahmanti
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.11266

Abstract

Adverse cutaneous drug reaction (ACDR) is a challenging condition for clinician, especially in determining the etiologic drug. Identification of etiologic drug become more difficult when the patient consume multiple drugs at once. As cellular immunity response is the main mechanism underlying exanthematous eruption, the most common type of ACDR, patch test rise as the reliable diagnostic modality to find the etiologic drug as this test represent the same mechanism as ACDR. In this paper, we reported commercial drug patch test application testing Griseofulvin, Amoxicillin, Ibuprofen, Aspirin and Clindamycin in 37 years old woman with history of drug induced-exfoliative dermatitis six months ago. Patch test technique involves patient preparations, test drug formulation, test drug patching and evaluation on day 2, 4 and 7. Before doing patch test, patient must not take any corticosteroid or immunosuppressant drug within one month ahead. The suspected drug consist of Griseofulvin, Ibuprofen and Clindamycin. Amoxicillin was chosen as the cross reacted drug for Griseofulvin while Aspirin was chosen as the cross reacted drug of Ibuprofen. All tested drugs were formulated as homogenous powder with 10% concentration and mixed with white paraffin. The formulated drug was patched to patient’s back using 7 mm diameter finn chamber. The evaluation result showed positive reaction towards Griseofulvin and weak positive reaction towards Amoxicillin
Formulasi Krim Anti-Aging Pada Kulit Daerah Tropis Berbasis Ekstrak Daun Kelor, Minyak Kenanga Dan Minyak Lemon Sebagai Bioaktif Vivi Nurhadianty; Herwinda Brahmanti; Sinta Murlistyarini; Safira Khanza; Citra Wahyu Rizkita; Chandrawati Cahyani
Journal of Innovation and Applied Technology Vol 7, No 1 (2021)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiat.2021.007.01.7

Abstract

Loss of moisture in the skin and exposure to high UV rays can cause dry, thin, inelastic skin and wrinkles. Proper anti-aging cream can reduce and prevent skin damage. Moringa leaf extract and cananga oil have specific bioactive properties such as antioxidants and antibacterials. Meanwhile, lemon oil is high in vitamin C and can improve the collagen structure in the skin. To produce anti-aging cream, essential oils as active ingredients are added with various compositions and then formulated and on the skin of the dorsal hand. The results showed that the cream produced was homogeneous but still required the addition of an emulsifier. The cream also meets SNI in terms of pH. The creams in formulas 7 and 9 provide significant results in reducing the level of aging. In this study, it needs to take a longer time to determine the stability of the cream.
The Formulation of Hypoallergenic Massage oil using Local Essential Oil of Indonesia Chandrawati Cahyani; Herwinda Brahmanti; Luthfi Kurnia Dewi; Vivi Nurhadianty
Journal of Innovation and Applied Technology Vol 7, No 1 (2021)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiat.2021.007.01.11

Abstract

A laboratory study was conducted to investigate the possibility of producing a hypoallergenic massage oil using local essential oil. The main concept behind the study was the application of massage oil formula which is in contact with skin need to be allergen free. This study used four types of local essential oil, i.e. cananga, clove, citronella and a fraction of citronella oil.  Two types of carrier oils were used, i.e. extra virgin olive oil and grape seed oil. The study searches the concentration of essential oil which is safe to be used in the formula, not giving an allergy reaction. The concentration of essential oil studied were one and two percent respectively, and an allergy test will also be conducted to the carrier oil themselves. The allergy test was conducted toward 30 respondents. 
Association between environmental allergen sensitization with severity of atopic dermatitis in children and young adult at Dr. Sardjito General Hospital, Yogyakarta Herwinda Brahmanti; Niken Trisnowati; Retno Danarti; Hardyanto Soebono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.988 KB)

Abstract

The important role of aeroallergens and food allergens as the most common environmental allergens in exacerbationof atopic dermatitis (AD) iswell known. Sensitization is an essential processwhich correlateswith clinicalmanifestationof AD. The study of AD in Indonesia, especially in Yogyakarta, has not been reported, yet. The aim of study is toevaluate the association between sensitization of environmental allergens with clinical severity of AD in children andyoung adult at Dr. Sardjito General Hospital, Yogyakarta. An analytic observational cross sectional study wasperformed on 33 children and young adult with AD. The severity of disease was determined by SCORing AtopicDermatitis (SCORAD). Assessment of sensitization was performed using specific IgE serum, atopy patch test, andprick test. Data were analyzed using chi-square or Fisher exact test and prevalence ratio (PR) with significancevalue of p<0.05 and 95%confidence interval (CI). The results showed that specific IgE positivity was associatedwith severity of AD. Percentage of specific IgE positivity to house dust mite was significantly higher in subject withmoderate/severe AD compared to those of mild AD (p=0.049; PR 1.13; 95% CI 1.01-1.59). The result was alsosimilar for cat dander (p=0.041; PR 1.1; 95%CI 1.09-4.98), cow’s milk (p=0.038; PR 1.21; 95% CI 1.02-2.2),and egg white (p=0.027; PR 1.23; 95% CI 1.15-2.97). Whereas specific IgE positivity to fish allergen was notstatistically different in subject with moderate/severe AD compared to those with mild AD (p=0.061; PR 0.8; 95%CI 0.76-2.8). According to atopy patch test and prick test result, no association was found between allergensensitization and severity of AD. If allmethodswere combined to increase the sensitivity of sensitizationmeasurement,then the association was found for all allergens. It could be concluded that environmental allergens sensitization isassociated with severity of AD in children and young adult at Dr. Sardjito General Hospital, Yogyakarta.Key words: atopic dermatitis-disease severity-sensitization-aeroallergen-food allergen
Correlation between LL-37 Levels and Scoring of Atopic Dermatitis (SCORAD) in Atopic Dermatitis in dr. Saiful Anwar General Hospital Malang Sasi Purwanti; Santosa Basuki; Herwinda Brahmanti
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.385 KB)

Abstract

ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic, recidive inflammatory skin disease that is associated with hyper-reactivity of the immune response to environmental allergens. LL-37 is an antimicrobial peptide which plays an important role in the pathogenesis of AD. Several studies conducted to find out LL-37 expression on the skin of patients showed varying and contradictory results. Studies aimed to find out the association of LL-37 levels in circulation with AD degree of severity are still very limited. The aim of this study are to determine the relationship between serum LL-37 levels and Scoring Atopic Dermatitis (SCORAD) score and to determine the relationship between serum LL-37 levels and the severity of atopic dermatitis.Method: This study is analytic observational cross sectional study. The subjects are 30 patients with AD who came to Outpatient Care for Dermatovenereology and Outpatient Care for Pediatric Allergy in dr.Saiful Anwar General Hospital (RSSA) Malang and fulfilled the inclusion and exclusion criteria. The subjects are grouped into 2 groups based on AD severity, i.e. mild and moderate-severe based on SCORAD index. The measured variable is serum LL-37 levels with enzyme-linked immunosorbent assay (ELISA) method.Results: The mean serum LL-37 levels are 12.46.7 ng/ml for mild degree AD and 9.46.06 ng/ml for moderate/severe degree AD. Statistical analysis using Pearson parametric statistic test shows no significant correlation (p> 0.05) between serum LL-37 levels and SCORAD score in patients with AD. Serum levels of LL-37 in this study are lower than the normal score in circulation.Conclusions: LL-37 serum levels in AD do not experience an increase and is not related to SCORAD score.Keywords: Atopic Dermatitis, LL-37, SCORAD
INFEKSI MENULAR SEKSUAL MULTIPEL PADA PEREMPUAN HAMIL TRIMESTER KEDUA (LAPORAN KASUS) Arum Krismi; Herwinda Brahmanti; Satiti Retno Pudjiati
Berkala Ilmiah Kedokteran Duta Wacana Vol 1, No 1 (2015): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v1i1.5

Abstract

Infeksi Menular Seksual (IMS) dapat menimbulkan dampak yang serius pada kehamilan berupa kehamilan ektopik, aborsi spontan, kematian janin dalam rahim, prematuritas, infeksi kongenital dan perinatal serta infeksi puerperal pada ibu. Seorang perempuan hamil berusia 21 tahun mengeluhkan adanya kutil di sekitar kelamin dan dekat anus, serta keputihan berwarna putih keruh dari kemaluan sejak ± 2 bulan yang lalu. Pada perut bagian bawah dan kedua pangkal paha terdapat makula dan papul hiperpigmentasi, teraba keras, multipel, tersebar; pada vulva, perineum dan perianal terdapat papul verukosa multipel dengan luas area (perianal) ± 6 x 5 cm2. Pemeriksaan inspekulo pada cervix didapatkan bintik-bintik kemerahan (strawberry cervix), cervix dan fornix tertutup discharge putih keabuan berbuih dan vagina tertutup discharge putih homogen menggumpal. Diagnosis kerja adalah siflis sekunder, trichomoniasis, dan kandidiasis vulvovaginalis (KVV) pada kehamilan. Penegakan diagnosis dilakukan berdasarkan anamnesis, status dermato-venereologis, pemeriksaan fsik (inspekulo), laboratorium, histopatologis, dan serologis. Infeksi Menular Seksual dapat diderita oleh seorang pasien jika terdapat sumber penularan. Perubahan-perubahan yang terjadi selama kehamilan, baik perubahan dalam respon imun, hormonal maupun anatomis, menyebabkan perempuan hamil lebih rentan untuk menderita IMS multipel. Kata kunci: infeksi menular seksual, perempuan hamil, siflis sekunder, tricho¬moniasis, kandidiasis vulvovaginalis
The management of seborrheic dermatitis 2020 Widaty, Sandra; Bramono, Kusmarinah; Listiawan, Muhammad Yulianto; Yosi, Ariyati; Miranda, Eliza; Rahmayunita, Githa; Brahmanti, Herwinda; Lim, Henry W
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Seborrheic dermatitis (SD) is a chronic relapsing dermatitis manifesting in the seborrheic area, affecting infants or adults. In Indonesia, the prevalence of SD is 0.99–5.8% of all dermatology cases from 2013 to 2015. SD has been known to be a prominent manifestation among HIV patients, but there is an increasing trend in the general population. Therefore, in 2017, the Indonesian Society for Dermatology and Venereology proposed a consensus for the management of SD in Indonesia based on the discussion from 12 dermatological centers. Concurrent with the development of new drugs, this study aims to evaluate and develop a guideline for the treatment of seborrheic dermatitis in Indonesia to update the previous guidelines in 2017. Methods: Systematic review was based on evidence-based methods, and scientific evidences were acquired through systematic search. Evidence analysis was in accordance with the level of evidence. The available evidences were evaluated, and conclusion was based on the grade of recommendation. Critical appraisal was conducted by experts in dermatology and venereology. Results: Severity of SD can be determined by using the Seborrheic Dermatitis Area Severity Index. The principle of scalp SD management is controlling the scalp condition in a cost-effective manner to make patients comfortable. The recommendations for treatment of adult SD are topical agents, such as antifungals, nonsteroidal anti-inflammatory agents with antifungal properties, corticosteroids, and calcineurin inhibitors. Conclusion: We have updated and added newer agents for the treatment of SD. The approach is divided into scalp or nonscalp and also adult or infantile SD.
Co-Authors Abdul Gofur Ariyati Yosi Arum Krismi AUNUR ROFIQ Aunur Rofiq Chandrawati Cahyani Chandrawati Cahyani Cholis, Mochammad Citra Wahyu Rizkita Dhelya Widasmara Ekasari, Dhany Prafita Eliza Miranda Githa Rahmayunita Hardyanto Soebono Henry Wan-Peng Lim Kusmarinah Bramono Lilasari, Sekar Puspita Lim, Henry W Luthfi Kurnia Dewi M. Yulianto Listiawan Miranda, Eliza Niken Trisnowati Pratita, Raras Retnani, Diah Prabawati Ristiawan Muji Laksono Safira Kanza Sandra Widaty Sandra Widaty Santosa Basuki Santosa Basuki Sari, Diane Tantia Sasi Purwanti Satiti Retno Pudjiati Satiti Retno Pudjiati Shahdevi Nandar Kurniawan, Shahdevi Nandar Sinta Murlistyarini Tazakka, Achmad Aidil Vidya Hana Dwi Ayuningtyas Vivi Nurhadianty, Vivi Widiatmoko, Arif Widodo Mardi Santoso, Widodo Mardi Wuriandaru Kurniasih Yosi, Ariyati