Henny A. Puspitasari
Department Of Child Health, Dr. Cipto Mangunkusumo Hospital/Faculty Of Medicine Universitas Indonesia, Jakarta

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Studi Urodinamik pada Anak Henny A. Puspitasari; Rinda M. Riswandi
Majalah Kedokteran UKI Vol. 32 No. 3 (2016): JULI-SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Studi urodinamik digunakan dalam evaluasi anak dengan inkontinensia urin atau gejala lower urinary tracts symptoms (LUTS) selama proses berkemih. Studi urodinamik dapat memberikan data objektif mengenai tekanan pada buli dan tingkat aliran urin selama proses pengisian buli dan proses berkemih. Data objektif tersebut digunakan untuk menilai fungsi neuromuskular dan disfungsi saluran kemih, mengidentifikasi penyebab disfungsi buli dan gangguan berkemih, serta menentukan tata laksana yang tepat. Kata kunci: urodinamik, inkontinensia urin, lower urinary tracts symptoms. Abstract Urodynamic test is used to investigate children who have urinary incontinence or other lower urinary tract symptoms (LUTS). It provides objective data of bladder storage and urinary flow rate during filling and voiding process. Datas are used to assess neuromuscular function and urinary tract dysfunction, to identify the cause of bladder and voiding dysfunction, also to determine the appropriate disease management. Keywords: urodynamic, urinary incontinence, lower urinary tracts symptoms
Pengalaman Transplantasi Ginjal pada Anak di Jakarta Sudung O. Pardede; Eka Laksmi Hidayati; Cahyani Gita Ambarsari; Henny Adriani Puspitasari; Partini P. Trihono; Taralan Tambunan
Sari Pediatri Vol 21, No 1 (2019)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.256 KB) | DOI: 10.14238/sp21.1.2019.44-9

Abstract

Latar belakang.Transplantasi ginjal merupakan terapi yang efektif untuk penyakit ginjal kronik (PGK) stadium 5 atau gagal ginjal terminal. Transplantasi ginjal di dunia pertama kali dilakukan pada tahun 1950an. Di Indonesia, transplantasi ginjal pada orang dewasa telah dilakukan pada tahun 1977 dan semakin berkembang dan telah dilakukan di beberapa kota di Indonesia. Transplantasi ginjal pada anak pertama kali dilakukan di Rumah Sakit Dr. Cipto Mangunkusomo pada bulan Maret 2013, terhadap seorang anak lelaki berusia 13 tahun dengan gagal ginjal terminal yang disebabkan sindrom nefrotik, dengan ginjal yang diperoleh dari non-related living donor. Ini merupakan transplantasi ginjal yang pertama kali dilakukan pada anak di Indonesia.Tujuan. Melaporkan data tentang kegiatan transplantasi ginjal yang dilakukan di Jakarta.Metode. Penelitian ini merupakan penelitian retrospektif yang mengambil data dari catatan medis. Hingga tahun 2018 telah dilakukan 11 kali transplantasi ginjal pada 10 orang anak terdiri atas 9 laki-laki dan 1 perempuan, dengan 1 kasus re-transplan. Rentang usia adalah 8-18 tahun, dengan penyakit dasar terdiri atas sindrom nefrotik (3 anak), dan ginjal hipoplasia (7 anak). Donor untuk kesebelas transplan anak tersebut terdiri atas 4 non-related living donor dan 7 orang related living donor, yaitu 5 orang donor ayah dan 2 orang donor ibu. Hasil. Di antara 10 pasien transplan, 3 orang menggunakan biaya pribadi atau asuransi swasta dan 8 orang dengan biaya dari Badan Penyelenggara Jaminan Sosial (BPJS). Hingga bulan Agustus 2018, di antara kesepuluh anak tersebut, 7 orang hidup dan di antaranya 2 orang mengalami rejeksi pada tahun ke-3 (1 orang konversi kembali ke hemodialisis dan 1 orang telah menjalani re-transplan). Tiga pasien meninggal akibat infeksi berat.Kesimpulan. Transplantasi ginjal di Rumah Sakit Dr. Cipto Mangunkusomo dimulai pada tahun 2013, dengan donor hidup yang sebagian besar berasal dari orangtua, dengan pembiayaan sebagian besar menggunakan BPJS.
Iron profiles of preterm infants at two months of chronological age Henny Adriani Puspitasari; Endang Windiastuti; Aryono Hendarto
Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.931 KB) | DOI: 10.14238/pi56.5.2016.277-84

Abstract

Background Preterm infants are vulnerable to iron deficiency (ID) due to lack of maternal iron stores, repeated phlebotomy, and the body’s increased demand for iron during growth. The risk of ID increases at 2 months of age, when hemoglobin (Hb) levels start to decrease. Adequacy of body iron level is assessed by ferritin, serum iron (SI), transferrin saturation (Tfsat), total iron-binding capacity (TIBC), and Hb measurements. Objective To describe iron profiles in preterm infants at 2 months of chronological age (CA). Methods This cross-sectional study was conducted in 2-month-old infants, born at 32-36 weeks of gestational age, and who visited the Growth and Development Clinics at Cipto Mangunkusumo, Fatmawati, or Budi Kemuliaan Hospitals. Parental interviews and medical record reviews were done during the clinic visits. Complete blood count, blood smear, SI, TIBC, Tfsat, and ferritin level tests were performed. Results Eighty-three subjects were enrolled in this study. Most subjects were male (51%) and born to mothers >20 years of age (93%). Subjects’ birth weights ranged from 1,180 g to 2,550 g. The prevalence of iron deficiency anemia (IDA) was 6% and that of ID was 10%. The lowest Hb level found in IDA infants was 6.8 g/dL, while the lowest ferritin level was 8.6 ng/mL. Median values for the other tests were as follows: SI 48 µg/dL, TIBC 329µg/dL, and Tfsat 17%. Subjects with IDA were all male (5/5), mostly achieved more than twice their birth weight (4/5), were non-iron supplemented (3/5), born to mothers with low educational background (3/5), and of low socioeconomic status (3/5). Conclusion The prevalence of IDA is 6% and that of ID is 10%. Most subjects with ID and IDA have low SI, high TIBC, low Tfsat, and low ferritin level. Most of the all-male IDA subjects weigh more than twice their birth weight, are non-iron supplemented, and born to mothers with low educational background and low socioeconomic status.
Does protein intake correlate with tubular function in very preterm neonates? Henny Adriani Puspitasari; Partini Pudjiastuti Trihono; Pustika Amalia Wahidiyat
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.245-55

Abstract

Background High protein intake in very preterm neonates (VPN) is important for growth. However, preterm kidneys have fewer functional nephrons and many of the ones present may be immature. Studies have shown that high protein intake induces nephron hypertrophy, proteinuria, and glomerular sclerosis, which lead to tubular injury. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a biomarker that is released during proximal tubular cell injury. The uNGAL to creatinine (uNGAL/Cr) ratio is commonly performed for normalization. Objective To assess for a possible association between protein intake and uNGAL/Cr ratio in VPN. Methods A prospective cohort study was conducted in two NICUs in Jakarta. Subjects’ urine specimens were collected at 0-48 hours, 72 hours, and 21 days after birth to determine uNGAL/Cr ratio as a biomarker of tubular injury. Protein was administered according to study sites NICU guidelines. Protein intake was recorded daily from 14-21 days of age for formula and measured twice with a human milk analyzer for breast milk. ELISA was used to measure uNGAL concentration. Low protein intake was defined as <3g/kg/day and high protein intake was defined as ?3g/kg/day. Maternal and perinatal variables were recorded from medical records. Results Fifty-nine VPN were recruited, of whom 39 completed the study. Median uNGAL/Cr ratio ranged from 0.32-104.11 ng/mg. The uNGAL/Cr ratio was not correlated with protein intake but was inversely correlated with gestational age and birth weight [r = -0.320, P=0.019 for the 72-hr (T2) urinary collection]. Higher uNGAL/Cr levels were associated with maternal infection [14.4 (range 4.4-104.1) vs 7.2 (range 0.5–32.4) ng/mg, P=0.004 at the 0-48-hr (T1)], maternal anemia [6.9 (range 1.2–66.6) vs 1.7 (range 0.3–89.2) ng/mg, P=0.001 at the 21-day (T3)] and nephrotoxic medication [15.9 (range 1.3–63.8) vs 1.0 (range 0.4–8.6) ng/mg, P=0.026 at the 72-hr]. Conclusion Protein intake according to current nutritional guidelines does not correlate with tubular injury in VPN, as measured by uNGAL/Cr ratio. Maternal infection, maternal anemia, lower birth weight, and nephrotoxic medication, were associated with higher uNGAL/Cr levels in VPN.
Telaah Perbandingan Panduan Klinis Sindrom Nefrotik Idiopatik Resisten Steroid pada Anak Sudung Oloan Pardede; Reza Fahlevi; Edwin Kinesya; Eka Laksmi Hidayati; Henny Adriani Puspitasari; Partini Pudjiastuti Trihono
Sari Pediatri Vol 25, No 3 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.3.2023.137-46

Abstract

Latar belakang. Sebagai salah satu penyakit ginjal anak tersering di dunia, sindrom nefrotik dapat dibedakan menjadi sensitif dan resisten steroid. Penelitian dan tata laksana sindrom nefrotik resisten steroid pada anak terus berkembang. Panduan klinis yang digunakan seringkali berbeda dan bervariasi antar fasilitas kesehatan ataupun negara di dunia.Tujuan. Membandingkan panduan klinis sindrom nefrotik idiopatik resisten steroid pada anak. Metode. Kami menentukan topik dan lingkup bahasan yang akan dibahas. Sesudah itu, dilakukan telaah dan perbandingan terhadap empat panduan klinis dari Ikatan Dokter Anak Indonesia tahun 2012, Kidney Disease: Improving Global Outcomes tahun 2021, Indian Society of Pediatric Nephrology tahun 2021, dan International Pediatric Nephrology Association tahun 2020. Empat lingkup bahasan kajian antara lain diagnosis, pemeriksaan penunjang, batasan kriteria, dan terapi.Hasil. Didapatkan beberapa perbedaan mendasar yang ditemukan, antara lain, adanya periode konfirmasi, beberapa istilah baru, anjuran pemeriksaan genetik, serta pilihan utama terapi imunosupresan. Kesimpulan. Sesudah menelaah panduan klinis sindrom nefrotik idiopatik resisten steroid dari Ikatan Dokter Anak Indonesia tahun 2012 dan panduan klinis baru lainnya, ditemukan beberapa pebedaan dasar. Oleh karena itu, diperlukan pembaharuan konsensus sindrom nefrotik resisten steroid yang disesuaikan dengan bukti ilmiah terbaru serta ketersediaan fasilitas kesehatan dan obat-obatan di Indonesia.
Analysis of the Impact of Continuous Ambulatory Peritoneal Dialysis on Nutritional Status in Pediatric Chronic Kidney Disease Putri Amirah; Henny Adriani Puspitasari; Cut Nurul Hafifah
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 2 No. 4 (2023): APGHN Vol. 2 No. 4 November 2023
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.2.4.2023.1-10

Abstract

Background: Chronic kidney disease (CKD) is a serious problem for all age groups, particularly in children. Several studies have shown that patients with CKD who underwent dialysis, including Continuous Ambulatory Peritoneal Dialysis (CAPD), experienced malnutrition, short stature and growth retardation. This study aimed to evaluate the correlation between the indicators of CAPD regiments with the nutritional status of pediatric patients with CKD and factors that influence it. Method: We conducted a cross-sectional study by collecting secondary data from medical records such as disease stage and duration, the most recent CAPD regimen, etiology, and comorbidities. Data on nutritional status was then obtained by measuring body weight, height, and upper arm circumference. The measurement was then plotted using the WHO anthropometry application or the CDC growth chart. Demographic data such as the education level of father and mother, family economic status, age, and gender were obtained by filling out the Case Report Form (CRF). Result: A total of fifteen respondents were included in this study. Children with CKD who underwent CAPD primarily had normal nutritional status with very short stature. Furthermore, no significant association was found between the CAPD regiments with the nutritional status of children with chronic kidney disease who are undergoing CAPD (p>0.05). Conclusion: Children with CKD who underwent CAPD primarily had normal nutritional status with very short stature. There was no correlation between the parameters of CAPD regiments with the nutritional status of CKD patients who underwent CAPD. This indicates that the regiment used in this study is already quite satisfactory as it does not impact the nutritional status of those patients.
Urinary screening for early detection of kidney disorders in asymptomatic Indonesian adolescents Ferry Liwang; Reza Fahlevi; Henny Puspitasari; Eka Hidayati; Sudung Pardede; Pringgodigdo Nugroho
Paediatrica Indonesiana Vol. 66 No. 3 (2026): May 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Chronic kidney disease (CKD) in children, with global incidence ranging from 15–74.7 cases per million, can lead to lifelong sequelae and impose a significant healthcare burden. In Indonesia, Survei Kesehatan Indonesia 2023 showed that among individuals aged 15–24 years, 0.02% had CKD, and 16.2% of those with CKD underwent hemodialysis. Given that the early stages are frequently asymptomatic, urinary screening provides a simple, non-invasive method for early detection and prevention of future deterioration in kidney function. Objective To measure the prevalence of abnormal urinary findings in healthy, asymptomatic Indonesian adolescents aged 12–18 years using dipstick testing and microscopic urinalysis. Methods Over a 2-year period (2023–2024), we screened healthy, asymptomatic adolescents aged 12–18 years using spot (non–first-morning) urine specimens. Urine dipstick and microscopic tests were performed. Data collected included clinical characteristics and urine findings. Abnormalities such as isolated proteinuria, hematuria, leukocyte esterase, nitrite, and crystals were analyzed. Results Among 406 subjects (55.9% male; median age 15.67 years), 17% had isolated proteinuria, 14.3% had isolated hematuria, and 5.9% had both. Microscopic analysis revealed erythrocytes ≥3/hpf in 3.4% of subjects, and proteinuria +3 in 0.5% of subjects. Leukocyte esterase and nitrite were positive in 10.6% and 1.2% of subjects, respectively, though only 18.6% of leukocyte esterase–positive cases had leukocyte sediment >5/hpf. Abnormal crystals were found in 29.6% of cases, mainly associated with high urine specific gravity or urate crystals. Conclusion Proteinuria and hematuria, markers of early kidney damage, are detectable in asymptomatic adolescents. Routine urinary screening should be considered for Indonesian adolescents to facilitate early diagnosis and intervention.