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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN The Journal of Pure and Applied Chemistry Research Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Martanto Martosupono
Fakultas Biologi, Universitas Kristen Satya Wacana Salatiga
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology

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Effect of Vitamin E Tocotrienol and Its Combination with Ascorbic Acid to Types of Leukocytes White Rat (Rattus norvegicus L.) Lestariningrum, Nur Auliani; Karwur, Ferry Fredy; Martosupono, Martanto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.87 KB) | DOI: 10.30659/sainsmed.v4i1.384

Abstract

Background: Immunity is not separated from the role of leukocytes with various types and functions. Tocotrienol is one of the vitamin E group of compounds with antioxidant properties which to play an important role in cell repair. The aims to determine how much of the effect of vitamin E tocotrienols and its combination with ascorbic acid on the types of leukocytes.Design and Method: Preparation of blood lear dosage edge is a technique used to determine the effect of treatment between types of leukocytes. The design of experiment was conducted with three treatment that feed intake vitamin E tocotrienols and ascorbic acid and their combination with the control and 3 repetitions. Quantitative data leukocyte counts obtained by calculating the percentage of each type of leukocytes in each treatment group and the mean of the data obtained compared with normal leukocyte counts. In addition, the data is processed by the leukocyte counts of variance test using a completely randomized design (CRD) and BNT level of 5% to determine the differences between treatments.Result: The administration of vitamin E tocotrienols and its combination with ascorbic acid influenced significantly (P> 0.05) to increase the neutrophil are 31.66% and 33.66%, 24.33% and 22.33% respectively, when compared with controls. On the other hand, there is a decrease in the percentage of lymphocytes are 26.66% and 29.16%, 19.50% and 17.00% respectively, when compared with controls. Vitamin E tocotrienols and combined with ascorbic acid did not give significant effect (P <0.05) the percentage of eosinophils, basophils and monocytes.Conclusion: The administration of vitamin E tocotrienols and its combination with ascorbic acid to give effect to the increase in neutrophils (Sains Medika, 4(1):46-56).
The Polyphenolics and Health Effects of Pomegranate Nge, Sonya Titin; Martosupono, Martanto; Karwur, Ferry Fredy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1505.69 KB) | DOI: 10.30659/sainsmed.v6i1.342

Abstract

Pomegranate (Punica granatum L.) is a useful fruit which mostly consumed as fresh fruit and can also be used as a various of processed products. Reports proved pomegranate were beneficial to health. Polyphenolic compounds in pomegranate especially ellagitannin (hydrolyzed), anthocyanins, gallotannin,and ellagic acid can maintain oral hygiene, healthy skin from the effects of free radicals caused by UV radiation, has the ability to synthesize cholesterol, destroying free radicals in the human vascular system and can prevent prostate cancer. In vitro and in vivo test has shown the fruit is acting as anti diabetic drug, and hypolipidemic, anticarcinogenic, antibacterial, anti inflamation, and antiviral. This review presenting an overview about the bioactive compound contents, physiological and health function of the fruit.
Effect of beta-Carotene from Yellow Ambon Banana Peel on Rat Serum Retinol Level Suparmi, Suparmi; Prasetya, Harka; Martosupono, Martanto; Sunaryanto, Lasmono Tri
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 2 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.377 KB) | DOI: 10.21776/ub.jpacr.%y.03.02.174

Abstract

Vitamin A Deficiency (VAD) is associated with significant morbidity and mortality from common childhood infections and is the world’s leading preventable cause of childhood blindness. Studies showed that carotenoid is one of the promissed vitamin A source. However the studies  on  carotenoid from yellow  banana peel and its potential as a natural source of vitamin A has not been widely reported. This study was conducted to measure the blood serum retinol levels of rats after administration of β-carotene from yellow ambon banana peel. This was an experimental study with post test only control group design, with sample size of 18 rats with age 1 month, devided into 3 groups. β-carotene dose administered based on the dose of red capsules vitamin A are (200,000 doses SI) for toddlers aged 12-59 months. Serum retinol levels were measured using a spectrophotometer according metide. This present study showed that the blood serum  level in group treated with  of β - carotene from yellow ambon banana peel (28.35 ± 1.61 mg/ dL ), was significantly different (p < 0.05) from that of   control group ( 22.08 ± 1.35 mg /dL ). β-carotene from yellow ambon banana peel are potential as provitamin A.
Review: Bioaktifitas Senyawa 1,8-Sineol pada Minyak Atsiri Efruan, Gian Kirana; Martosupono, Martanto; Rondonuwu, Ferdy Samuel
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.84 KB)

Abstract

Banyak persenyawaan yang terkandung dalam minyak atsiri, senyawa 1,8-sineol merupakan salah satu senyawa yang biasanya terkandung dalam minyak atsiri, bahkan ada beberapa tumbuhan yang memiliki kandungan utamanya adalah senyawa 1,8-sineol. 1,8-sineol merupakan eter siklik dengan rumus empiris C10H18O dan nama sistematik 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane yang termasuk ke dalam kelompok komponen hidrokarbon teroksigenasi monoterpen. Kandungan senyawa 1,8-sineol dalam minyak atsiridihasilkan dari berbagai familia tumbuhan. Familia Lamiaceae merupakan familia dengan genus terbanyak yang menghasilkan 1,8-sineol, yang kandungan senyawanya di atas 50% adalah Rosmarinus officinalis dan Thymus capitellatus, Familia Myrtaceae: Eucalyptus globulus, Myrcianthes cisplatensis, dan Melaleuca leucadendra. Familia Asteraceae: Artemisia kermanensis, Familia Burseraceae: Protium heptaphyllum, dan kandungan persentase senyawa 1,8-sineol tertinggi dimiliki oleh spesies Eucalyptus globulus. Senyawa 1,8-sineol memiliki karakteristik segar dan aroma camphor dan rasa pedas yang memiliki bioaktifitas yang banyak manfaatnya, yaitupenurunan aktivitas lokomotor (antikejang), anti-kanker dan anti-tumor, antibakteri baik untuk beberapa bakteri gram-positif dan beberapa bakteri gram-negatif, antifungi, antiinflamasi, antioksidan, sebagai insektisida atau repelan, dan dapat mengurangi resiko penyakit kardiovaskular.
Co-Authors Budhi Prasetyo Ferdy Samuel Rondonuwu, Ferdy Samuel Ferry Fredy Karwur Gian Kirana Efruan, Gian Kirana Harka Prasetya Lasmono Tri Sunaryanto Nur Auliani Lestariningrum, Nur Auliani Nurhadi Rinto Herry Mambrasar Soenarto Notosoedarmo Sonya Titin Nge Suparmi Suparmi