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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung The Journal of Pure and Applied Chemistry Research JMM (Jurnal Masyarakat Mandiri)
Harka Prasetya
Bagian Ilmu Penyakit Mata Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Eye Center Rumah Sakit Islam Sultan Agung Semarang
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Other

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Perbandingan Aktivitas Antioksidan dan Toksisitas Antara Drop Vitamin A dari Karotenoid Kulit Pisang Ambon dan ß-Karoten Prasetya, Harka; Isradji, Israhnanto; Suparmi, Suparmi; Hardec, Adrian; Fahryzal, Muhammad; Azizah, Laili Durotul; Ashar, Dita Ferwina Utari
Majalah Kedokteran Bandung Vol 49, No 1 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (27.842 KB) | DOI: 10.15395/mkb.v49n1.981

Abstract

Pemanfaatan kulit pisang akibat peningkatan konsumsi pisang ambon perlu dilakukan, salah satunya sebagai alternatif sumber vitamin A alami (SUVITAL) untuk mengatasi kasus kekurangan vitamin A (KVA). Potensi karotenoid kulit pisang ambon sebagai SUVITAL belum banyak diteliti. Penelitian ini bertujuan menguji aktivitas antioksidan dan toksisitas terhadap hati dan ginjal dari drop vitamin A karotenoid kulit pisang ambon (DKKP) dibanding dengan β karoten (DBKM) pada kelinci (Oryctolagus cuniculus) galur New Zealand White. DKKP dan DBKM dibuat sesuai formula vitamin A per 50.000 IU/mL. Penelitian ini dilakukan di Laboratorium Biologi Fakultas Kedokteran Universitas Islam Sultan Agung selama September–Oktober 2015. Sebanyak 12 ekor kelinci jantan dibagi menjadi 3 kelompok: kontrol, DKKP, dan DBKM. Drop diberikan per oral sebanyak 5 mL/ekor/hari selama 7 hari. Efek antioksidan diuji berdasar atas kadar malondialdehyde (MDA) dan retinol serum darah, sedangkan toksisitas terhadap hati dan ginjal ditentukan berdasar derajat kerusakan hepatosit dan sel epitel tubulus proksimal ginjal. Hasil uji LSD menunjukkan bahwa kadar MDA dan retinol serum darah kelinci yang diberi DKKP tidak berbeda signifikan (p>0,05) dibanding dengan DBKM, demikian juga dengan skor kerusakan hepatosit dan sel epitel tubulus proksimal ginjal. Aktivitas antioksidan drop vitamin A dari karotenoid kulit pisang ambon sama dengan drop β-karoten murni. Drop vitamin A dari karotenoid kulit pisang tidak toksik terhadap histopatologi hati dan tubulus proksimal ginjal. [MKB. 2016;49(1):1–7]   Kata kunci: Antioksidan, drop vitamin A, karotenoid, kulit pisang ambon, toksisitasAntioxidant Activity and Toxicity of Vitamin A Drop from Ambon Peel Carotenoid and Pure ß-carotene   The increased consumption of ambon banana has resulted in increased amount of banana peel; which opens an opportunity to use them as a natural vitamin A alternative source to prevent vitamin A deficiency (VAD). The potential use of banana peel as a vitamin A supplement has not been much investigated. This study was conducted to measure the antioxidant activities and toxicity of vitamin A drop from carotenoids of Ambon banana peel (DKKP) in comparison with the vitamin A drop containing pure β-carotene (DBKM) on New Zealand White rabbits’ liver and kidney (Oryctolagus cuniculus) . The DKKP and DBKM were formulated according to the formula of vitamin A per 50,000 IU/ml. Twelve male rabbits were divided into 3 groups, i.e., control, DKKP, and DBKM. DKKP and DKKP groups received 5 ml/day oral dose for 7 days. Malondialdehyde (MDA) and retinol from blood serum were measured as the parameters of antioxidant activities while the hepatocyte and proximal tubule epithelium damage score were used to detect toxicity in liver and kidney. LSD test results showed that the levels of MDA and retinol in the blood serum of the DKKP group were not significantly different (p> 0.05) from those of the DBKM group. A similar situation was also seen for the hepatocyte damage score of the liver and proximal tubular epithelial cells of kidney. The antioxidant activities of vitamin A drop from banana peel carotenoid was equal to that of the vitamin A drop from pure β-carotene. Vitamin A drop from carotenoid of banana peel is safe to be consumed and have no effect on hepatic histopathology and renal proximal tubules. [MKB. 2016;49(1):1–7]   Key words: Ambon banana peel, antioxidant, carotenoid, toxicity, vitamin A drop
Antioxidant Activity of The Crude Carotenoid Pigment Extract from Yellow Ambon Banana (M. parasidiaca sapientum) Peel: Its Potency as Vitamin A Supplement Suparmi, Suparmi; Prasetya, Harka
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (701.223 KB) | DOI: 10.30659/sainsmed.v4i1.389

Abstract

Background: Carotenoid pigment is one of the promising sources of provitamin A because it has been shown to have capacity to be converted into vitamin A by the body. This present study aimed at evaluating the antioxidant activity in vitro using the DPPH and assessing the encapsulation of the crude carotenoid pigment extracted from Musa parasidiaca sapientum peel.Method: The total vitamin A carotenoid in the banana peel was assessed using the double beam Varian Cary 50 spectrophotometer at 470 nm. Then it was converted to microgram per gram of the banana peel using the NAS-NRC equation. The extraction was conducted using acetone. The antioxidant activity was assessed using DPPH (1.1-difenil-2-dipikrilhidrazil). The antioxidant activity of carotenoid crude extract was compared to that of marker â-karoten antioxidant (E-Merck, No. 1.02236). IC50 values were calculated using the regression formula. The dried carotenoid crude extract was encapsulated with dextrin filler.Result: The water content level of ambon banana was 50.68 % ± 3.35 %. The peel of the yellow ambon banana has a total carotenoid of 6.203 ± 0.004 μg/g. The converted carotenoid vitamin A was 124.06 ± 0.08 IU. The IC50 value of the yellow ambon banana crude extract was 2350.3 ppm meaning higher than the marker â-caroten (565.76 ppm). The encapsulation technique increased the pigment stabilization of the yellow ambon banana which will be used for vitamin A supplement.Conclusion: The crude extract of carotenoid pigment of the yellow ambon banana peel has an antioxidant potential although it is less efficient compared to that of â-carotene. The IC50 value of the crude extract of carotenoid pigment of the yellow banana ambon is 2350.3 ppm, higher than marker â -caroten (Sains Medika, 4(1):78-88).
Effect of beta-Carotene from Yellow Ambon Banana Peel on Rat Serum Retinol Level Suparmi, Suparmi; Prasetya, Harka; Martosupono, Martanto; Sunaryanto, Lasmono Tri
The Journal of Pure and Applied Chemistry Research Vol. 3 No. 2 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.377 KB) | DOI: 10.21776/ub.jpacr.%y.03.02.174

Abstract

Vitamin A Deficiency (VAD) is associated with significant morbidity and mortality from common childhood infections and is the world’s leading preventable cause of childhood blindness. Studies showed that carotenoid is one of the promissed vitamin A source. However the studies  on  carotenoid from yellow  banana peel and its potential as a natural source of vitamin A has not been widely reported. This study was conducted to measure the blood serum retinol levels of rats after administration of β-carotene from yellow ambon banana peel. This was an experimental study with post test only control group design, with sample size of 18 rats with age 1 month, devided into 3 groups. β-carotene dose administered based on the dose of red capsules vitamin A are (200,000 doses SI) for toddlers aged 12-59 months. Serum retinol levels were measured using a spectrophotometer according metide. This present study showed that the blood serum  level in group treated with  of β - carotene from yellow ambon banana peel (28.35 ± 1.61 mg/ dL ), was significantly different (p < 0.05) from that of   control group ( 22.08 ± 1.35 mg /dL ). β-carotene from yellow ambon banana peel are potential as provitamin A.
Association Between Screen Time, Vitamin A Consumption Behavior, and Computer Vision Syndrome in Preclinical Medical Students Prasetya, Harka; Rahmawati, Atik; Andira, Aisyah Putri; Suparmi, Suparmi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3346

Abstract

Computer Visual Syndrome (CVS) refers to visual disturbances induced by electronic media such as computers, laptops, tablets, and smartphones. This research aimed to determine the association between screen time, vitamin A consumption behavior, and CVS symptoms among preclinical medical students. Ninety-five students from a single class at the Faculty of Medicine, Universitas Islam Sultan Agung, Indonesia, participated in this cross-sectional study. Data were collected using an online survey platform in February 2022. The screen time, vitamin A consumption behavior, and CVS were measured using a validated questionnaire. The average daily screen time of the respondents was more than 10 h, with the majority having a moderate vitamin A consumption patterns (66.3%) and experienced CVS (63.2%). The most prevalent CVS symptom identified among these respondents was eye fatigue (62.1%), while double vision and inflamed or watery eyes were the least reported CVS symptoms (9.5% and 8.4%, respectively). The Chi-Square test revealed that there was no correlation between screen time and CVS (p > 0.05), but there was a significant correlation between vitamin A consumption and CVS (p < 0.05). In conclusion, CVS is observed among preclinical medical students due to increased screen time and decreased vitamin A consumption. Therefore, there is a need to develop strategies to manage screen time and vitamin A consumption among students at risk for developing a CVS during their academic careers.
PEMERIKSAAN VISUS SERTA EDUKASI MENGENAI MATA MERAH DAN PENGGUNAAN OBAT TETES Prasetya, Harka; Pritasari, Alteriana Mydriati Sita; Rahmawati, Atik; Bellarinatasari, Nika; K, Hikban Fiqhi; K, Raditya Pradana Daryosta; Wibowo, Wakhid; Setiyono, Agus; Kurniawan, Ajik; Ariana, Tirtanti Siwi; Ningsih, Tri; Lestari, Puji; Ratnasari, Tyas Puji; A'yunina, Qurrotu; Suparmi, Suparmi
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 1 (2024): Februari
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i1.20395

Abstract

Abstrak: Tingkat pengetahuan dan kesadaran warga pesantren dalam menjaga kesehatan mata masih tergolong rendah, maka pengabdian kepada masyarakat (PkM) ini bertujuan memberikan pemeriksaan dan konsultasi mata, serta edukasi mengenai mata merah dan penggunaan tetes mata di Pondok Pesantresn (Ponpes) Islam Baitussalam, Mijen, Semarang. Kegiatan pemeriksaaan kesehatan mata dan edukasi diikuti oleh warga Ponpes Baitussalam, Mijen Semarang sebanyak 173 orang, yang berusia antara 7-76 tahun. Evaluasi keberhasilan edukasi dilaksanakan melalui pemberian pertanyaan sebelum dan sesudah penyuluhan. Hasil pemeriksaaan mata diperoleh bahwa 43,9% peserta memiliki penglihatan yang normal, 38,2% memerlukan kacamata, 16,2% mengalami myopia, dan 15% memerlukan rujukan. Edukasi mengenai mata merah dan penggunaan tetes mata bermanfaat untuk meningkatkan pengetahuan sebesar 10% bagi warga pesantren Baitussalam, Mijen Semarang. Warga mengharapkan bahwa PkM dapat dilaksanakan secara berkesinambungan dan ada kerjasama dengan optik maupun rumah sakit yang dapat memberikan kacamata gratis sesuai hasil pemeriksaaan maupun operasi katarak gratis.Abstract: The level of knowledge and awareness of residents in keeping eye health is still low, so devotion to the community (PkM) waas aimed at providing examination and eye consultation, as well as education about red eyes and the use of eye drops in Pondok Pesantresn (Ponpes) Islam Baitussalam, Mijen, Semarang. The eye health examination and education activities were followed by the citizens of Ponpes Baitussalam, Mijen Semarang of 173 people, who are between 7-76 years of age. Evaluation of educational success was carried out by asking questions before and after the examination. Eye examinations showed that 43.9% of participants had normal vision, 38.2% needed glasses, 16.2% had myopia, and 15% needed reference. Education about red eyes and the use of eye drops is beneficial to increasing knowledge by 10% for the residents of the Baitussalam, Mijen Semarang. Citizens expect that the PkM can be implemented continuously and there is cooperation with optics and hospitals that can provide free glasses according to the results of the examination as well as free cataract surgery.
Co-Authors A'yunina, Qurrotu Agus Setiyono Andira, Aisyah Putri Ariana, Tirtanti Siwi Ashar, Dita Ferwina Utari Atik Rahmawati Azizah, Laili Durotul Fahryzal, Muhammad Hardec, Adrian Israhnanto Isradji K, Hikban Fiqhi K, Raditya Pradana Daryosta Kurniawan, Ajik Lasmono Tri Sunaryanto Martanto Martosupono Nika Bellarinatasari Ningsih, Tri Pritasari, Alteriana Mydriati Sita PUJI LESTARI Ratnasari, Tyas Puji Suparmi Suparmi Suparmi Wibowo, Wakhid