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All Journal Majalah Obstetri dan Ginekologi Strada Jurnal Ilmiah Kesehatan (SJIK)
Widjiati Widjiati
Universitas Airlangga
Dentistry Health Professions Medicine & Pharmacology Public Health

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Penurunan progesterone-induced blocking factor (PIBF) sebagai penanda preeklampsia Achmad Salman; Budi Wicaksono; Erry Gumilar Dachlan; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.819 KB) | DOI: 10.20473/mog.V24I12016.13-18

Abstract

Background: Pathogenesis of preeclampsia still a controversial research objects. Progesterone induced blocking factor has protective effects in pregnancy.Objectives: To compare PIBF serum level and placental weight and investigate correlation between both in preeclampsia.Methods: This experimental study used 16 Mus musculus with normal pregnancy and 16 Mus musculus that were injected with anti Qa-2 to create a preeclampsia model. Terminations of were performed in day 16th, followed by ELISA examination for PIBF serum level and placental weight measurement.Result: PIBF serum level significantly reduced on preeclampsia model  compared with control (33,21±29,36 ng/ml vs 105,76±59,69 ng/ml; p<0,05). There was no different of placental weight in preeclampsia model compared with control (97,75±50,74 mg vs 116,09±44,45 mg; p>0,05). There was no significant correlation between PIBF serum level and placental weight.Conclusion: Decreased of PIBF serum level could be used as a marker of preeclampsia. Decreased of PIBF serum level may be correlate with placental pathology in preeclampsia.
An IGF-1 Levels Decrease in SOPK-RI Model Mice After A Low-Carb Diet Ermawati Ermawati; Budi Santoso; Widjiati Widjiati; Hany Puspita Aryani
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.298

Abstract

The aim of this study is to analyze the IGF-1 levels decrease in mice modeled by Polycystic Ovary Syndrome Insulin Resistance post carbohydrate high in protein. True Experimental Design with a Posttest Control Group Design research using 36 tails, female Wistar Rattus Norvegicus Strains, 3 months, 100-200 grams and randomly divided into 3 groups, namely K-(n =12, negative control group), K+(n=12, positive control group) and KP(n=12, treatment group). SOPK-IR modeling is done by mice in the injection of the hormone testosterone provionate at a dose of 100 mg/kg BW for 28 days, on the last day after injection a vaginal swab is performed to identify the condition of diestrus. The measurement of IGF-1 levels used the Enzyme-Linked Immunosorbent Assay method. Data analysis techniques used ANOVA test and LSD post hoc test. The results obtained mean levels of IGF-1 at K- (234.126±32.568) ng/mL, K+ (169.662±30.150) ng/mL, KP (146.528±29.562) ng/mL (p=0.000)
The Effect of Mackerel Oil During Pregnancy on Apoptotic Index in the Cerebrum of Newborn Rattus Norvegicus Ali Madinah; Widjiati Widjiati; Hermanto Tri Joewono; Siti Nur Kholifah; Mikra Latisfian
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.540

Abstract

This study is a true experiment with a posttest-only control group design. 30 pregnant Rattus norvegicus aged 2-3 months were randomly divided into 3 groups, namely the control group (K), the mackerel oil treatment group (P1), and the omega-3 supplements group (P2). The experimental animals were acclimatized and superovulated. The treatment was given at day 1-17 of pregnancy. 3 newborn Rattus norvegicus with the criteria of the largest, medium, and lightest body weight were taken from each parent to be made preparations on the 18th day. Examination of preparations carried out by immunohistochemistry. The mean ± SD of the apoptosis index in the cerebrum were 4.93 ± 0.87 (K), 2.53 ± 0.45 (P1), and 3.72 ± 0.54 (P2). The results of statistical tests showed that there was a significant effect on the apoptotic index in the cerebrum of newborn Rattus norvegicus between groups with p-value <0.05.
Co-Authors Achmad Salman Ali Madinah Budi Santoso Budi Wicaksono Ermawati Ermawati Erry Gumilar Dachlan, Hany Aryani Puspita Hermanto Tri Joewono Mikra Latisfian Siti Nur Kholifah