Articles
<![CDATA[Trigger, Self Efficacy and Motivation in The Implementation of Cervical Cancer Screening ]]>
<![CDATA[Eko Winarti]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Suhatno Suhatno]]>;
<![CDATA[Rachmad Hargono]]>
<![CDATA[ Health Notions Vol 2, No 4 (2018): April ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (HNST) ]]>
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DOI: 10.33846/hn.v2i4.183
<![CDATA[Cervical cancer is currently ranked top among the various types of cancer that causes death in women in the world. The majority of women who diagnosed with cervical cancer did not do screening tests or did not follow up after abnormal results were found. The purpose of this research was to know how path analysis between motivation variable, self efficacy and trigger in the implementation of screening cervical cancer using Visual Inspection With Acetic Acid (VIA). This research used case control design. Sample size was based on the calculation of rule of the thumb. There were 410 respondents that were divided into 205 cases and 205 controls. The sample used multi stage random sampling method. The data were analyzed by using Partial Least Square - Structural Equation Modeling (PLS-SEM). There was a positive influence of trigger variable to self efficacy and motivation variable. There was positive influence of self efficacy variable toward motivation variable and the implementation of early detection of cervical cancer VIA. There was a positive influence of self efficacy variable and motivation to the execution of early detection of cervical cancer VIA. There was an indirect effect of trigger on the implementation of early detection of cervical cancer VIA.Keywords: Cervical cancer, Visual Inspection With Acetic Acid (VIA), Trigger, Self efficacy, Motivation]]>
<![CDATA[Characteristics of Polycystic Ovary Syndrome Polycystic (PCOS) at Soetomo General Hospital, Surabaya ]]>
<![CDATA[Dhifa Dwi Putra]]>;
<![CDATA[Dewi Ratna Sari]]>;
<![CDATA[Jimmy Yanuar Annas]]>;
<![CDATA[Budi Santoso]]>
<![CDATA[ Health Notions Vol 3, No 11 (2019): November ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (HNST) ]]>
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DOI: 10.33846/hn31105
<![CDATA[PCOS is an endocrine disease that occurs in women of reproductive age which is characterized by several clinical manifestations such as hyperandrogen, ovarian dysfunction, and polycystic ovarian features on ultrasound examination. PCOS is an endocrine disease that is closely related to metabolic diseases such as dyslipidemia, diabetes mellitus, and hypertension. Risk factors for this disease are age, environment, genetics, body mass index (BMI), and androgen exposure. The purpose of this study is to determine the profile of PCOS in Soetomo General Hospital, Surabaya. This study used a descriptive retrospective method, using medical record data at the obstetrical clinic at Soetomo General Hospital and fertility clinic at Graha Amerta. Most patients were found in the age range of 25-44 years. Based on the diagnosis of Rotterdam criteria, the phenotype D (Oligo / Amenorrhea and SOPK on USG) was the highest phenotype. People with PCOS who did not have metabolic diseases more than those who have. The highest number of sufferers was found in the category of overweight and obese BMI, which was 35.3% each. Most PCOS sufferers were reproductive age and most have phenotype D. Most sufferers have overweight and obese BMI and do not have metabolic diseases. Keywords: PCOS; infertile; retrospective]]>
<![CDATA[Oxygen Hyperbaric Exposure Induces GLUT4 Expression Reduction and No Folliculogenesis Alterations in Rat PCOS with Insulin Resistance Model ]]>
<![CDATA[Varianida Veterini]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Widjiati Widjiati]]>
<![CDATA[ Majalah Obstetri dan Ginekologi Vol. 23 No. 3 (2015): September - Desember 2015 ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/mog.V23I32015.112-117
<![CDATA[ Objectives: To know effect of hyperbaric oxygen therapy to GLUT4 expression and folliculogenesis in rat PCOS with insulin resistent model.Materials and Methods: this is an analytic experimental study used 30 rats induced by testosterone propionate injection 1 mg/100 g body weight daily for 28 consecutive days as a PCOS with insulin resistent model. Animal models divided into 3 groups. Negative control was not given treatment, positive control was given placebo. Treatment group was given hyperbaric oxygen 2.4 ATA 90 minutes 2x5 days. GLUT4 expression determined by immunohystochemistry to m. Gastrocnemius. Hematoxylin Eosin staining to rat ovaries were performed to know differentiation in folliculogenesis. The results were then compared.Results: There were significant decrease of GLUT4 expression in treatment group (mean0,84+0,47)compared to negative and positive control (mean3,96+3,16and3,36+2,17). There were no different folliculogenesis in these groups.Conclusion: Hyperbaric oxygen 2.4 ATA 90 minutes 2x5 days induce decrease of GLUT4 expression and no alterations in folliculogenesis in rat PCOS with insulin resistent model, therefore can not yet be used as alternative therapy in PCOS. ]]>
<![CDATA[Therapeutic effectiveness of rat bone marrow stem cells in Poly Cystic Ovary Syndrome Mice Model on folliculogenesis, TGF-β, GDF-9 expression, and estrogen, TNF- and androgen Levels ]]>
<![CDATA[Budi Santoso]]>;
<![CDATA[Agus Sulistyono]]>;
<![CDATA[Salmon Charles S]]>;
<![CDATA[Widjiati Widjiati]]>
<![CDATA[ Majalah Obstetri dan Ginekologi Vol. 24 No. 3 (2016): September - December ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/mog.V24I32016.90-93
<![CDATA[Objectives: to identify therapeutic effectiveness of Rat Bone Marrow stem cell in PCOS rats model on folliculogenesis, TGF-beta and GDF-9 expression and on estrogen, TNF-a and androgen levels.Material and Methods: this study is a laboratory experimental research with using animal testing. PCOS was induced by the administration of testosterone propionate hormone into 30 mice. The subjects of this study are divided into 2 groups: stem cell group and control group. The mice were injected with testosterone then vaginal swab was performed to determine the mice cycle. After determining mice in anestrous cycle, stem cell was injected. TNF-a was measured with immunohistochemistry and androgen was examined using ELISA. The data was measured by student t-test.Result: The average number of TNF-a expression in control group was lower than stem cell group (5.35 vs 2.34; p= 0.0026). The average androgen level for stem cell group was lower than mean for control group (2.31 vs 0.40; p= 0.0026).Conclusion: In this study of polycystic model mice, stem cell decreased the expression of TNF-a and androgen level]]>
<![CDATA[Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model ]]>
<![CDATA[Irma Maya Puspita]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Budi Utomo]]>
<![CDATA[ Majalah Obstetri dan Ginekologi Vol. 27 No. 3 (2019): December ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/mog.V27I32019.103-107
<![CDATA[Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculogenesis may recur in the case of PCOS.Materials and Methods: The subjects in this study were rats which were divided into 5 groups, consisting of 2 groups serving as a control group (negative and positive) and 3 groups as the treatment group. Each group consisted of 7 experimental animals. Negative control group was given with distilled water for 14 days. Positive control group was given with injections of testosterone propionate 1 mg/100 g BW intramuscularly in the thigh for 28 days to obtain a model of insulin-resistant PCOS and the distilled water was used as therapy. The treatment groups were given wth injections of testosterone propionate 1 mg/100gBW intra-muscularly for 28 days and then treated with green tea extract in doses of each 200 mg/kg, 400 mg/kg, and 800 mg/kg for 14 days. Rats were dissected on day 42 for harvesting the right and left ovary and heart blood sample was taken for examining insulin levels.Results: The results showed that administration of green tea extract on K5 can reduce insulin levels and increase folliculogenesis significantly (significance p <0.05).Conclusion: Green tea extract can reduce insulin levels and increase folliculogenesis in rats. PCOS - Insulin resistance at a dose of 800 mg/kg.]]>
<![CDATA[New vesicovaginal fistula formation in a rabbit model ]]>
<![CDATA[Eighty M Kurniawati]]>;
<![CDATA[Tri HS Hadi]]>;
<![CDATA[Nur AR Widiatmoko]]>;
<![CDATA[Widjiati Widjiati]]>;
<![CDATA[Fedik A Rantam]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Budi I Santoso]]>;
<![CDATA[Hari Paraton]]>;
<![CDATA[Gatut Hardianto]]>;
<![CDATA[Azami D Azinar]]>;
<![CDATA[Boedi Setiawan]]>
<![CDATA[ Majalah Obstetri dan Ginekologi Vol. 27 No. 3 (2019): December ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/mog.V27I32019.114-118
<![CDATA[Objective: To create an animal model of vesicovaginal fistula as a modality to develop therapy.Material and Methods: This study was an preliminary experimental study to create new fistula vesicovaginal formation in a rabbit model. Six female New Zealand white rabbits of Stem Cell Research and Development Center of Universitas Airlangga were used in this study and were divided into 3 groups in which there were 2 rabbits in each group. Vesicovaginal fistula formation was performed through laparotomy surgery. After the abdomen is opened, the Nasogastric tube is inserted vaginally into the anterior vaginal wall. The incision is made on the anterior vaginal wall and the posterior wall of the bladder. The Nasogastric tube that comes out of the vagina is inserted into the bladder incision to maintain the formation of vesicovaginal fistula. Both mucosal walls are sutured and tested to determine if there is any leak. Evaluation the model of vesicovaginal fistula was carried out 3 weeks postoperatively according the group.Result: Four out of six rabbits have formed vesicovaginal fistulas, which are from groups two and three. There are no complications during the treatment period until terminationConclusion: Rabbits have the potential to become experimental animals for the vesicovaginal fistula model. The best time to release a nasogastric tube to maintain a fistula is 2 weeks.]]>
<![CDATA[Ekstrak Daun Moringa oleifera terhadap Jumlah Folikel Tikus Model Sindroma Ovarium Polikistik ]]>
<![CDATA[Dessy Amelia]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Bambang Purwanto]]>
<![CDATA[ Jurnal Biosains Pascasarjana Vol. 19 No. 3 (2017): JURNAL BIOSAINS PASCASARJANA ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jbp.v19i3.2017.211-223
<![CDATA[AbstrakSindroma Ovarium Polikistik (SOPK) adalah gangguan endokrin-metabolik yang memberi konsekuensi berat untuk kesehatan wanita, termasuk paling banyak menyebabkan infertilitas. Resistensi insulin merupakan kelainan metabolik yang paling umum pada SOPK. Moringa oleifera terbukti dapat meningkatkan ekspresi insulin dan menurunkan derajat pada diabetes mellitus, sehingga hal ini memungkinkan dapat meningkatkan jumlah folikel pada tikus betina model SOP-resistensi insulin. Tujuan penelitan untuk mengetahui pengaruh ekstrak daun Moringa oleifera dalam berbagai dosis dapat meningkatkan jumlah folikel pada tikus betina model SOPK-resistensi insulin. Metode penelitian menggunakan tikus putih strain Wistar (Rattus norvegicus) 100-130 gram yang dibagi menjadi lima kelompok, yaitu kontrol normal, kontrol SOPK-resistensi insulin, SOPK-resistensi insulin diberi metformin, SOPK-resistensi insulin diberi ekstrak daun Moringa oleifera 250 mg/kgBB dan 500 mg/kgBB. Model SPOK-resistensi insulin dibuat dengan menginjeksi testoteron propionat selama 28 hari, setelah itu dilanjutkan pengobatan selama 14 hari. Penelitian ini menganalisis jumlah folikel pada ovarium tikus. Hasil penelitian menunjukkan kelompok kontrolSOPK-resistensi insulin menunjukkan penurunakan jumlah folikel secara signifikan dibandingkan dengan kelompok kontrol normal (p<0.05).Kelompok metfromin dan ekstrak daun Moringa oleifera menunjukkan peningkatan signifikan jumlah folikel dibandingkan dengan kelompok kontrol SOPK-resistensi insulin (p<0.05). Kesimpulan penelitian menunjukkan ekstrak daun Moringa oleifera meningkatkan jumlah folikel pada tikus betina model SOPK-resistensi insulin.Kata kunci—sindroma ovarium polikistik, Moringa oleifera, jumlah folikel]]>
<![CDATA[Kadar Malondialdehid tikus model Sindroma Ovarium Polikistik dengan daun kelor (Moringa oleifera) ]]>
<![CDATA[Lisa Purbawaning Wulandari]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Bambang Purwanto]]>
<![CDATA[ Jurnal Biosains Pascasarjana Vol. 19 No. 3 (2017): JURNAL BIOSAINS PASCASARJANA ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jbp.v19i3.2017.224-236
<![CDATA[AbstrakSindroma Ovarium Polikistik (SOPK) merupakan endokrinopati paling umum pada perempuan yang sering dikaitkan dengan resistensi insulin, hyperandrogenemia, peradangan kronis, dan oxydative stress. Tingkat oxydative stress pada SOPK diamati secara signifikan berkorelasi dengan obesitas, bahkan ditemukan memainkan peran penting dalam patogenesis kanker. Antioksidan adalah substansi yang diperlukan tubuh untuk menetralisir radikal bebas, penggunaan kelor (Moringa Oleifera) sebagai antioksidan perlu diteliti sebagai alternatif pengobatan terhadap oxydative stress pada SOPK dengan resistensi insulin. Penelitian eksperimen ini menggunakan tikus Rattus norvegicus strain wistar betina berusia 3 bulan dengan berat 100-130 gram dibagi menjadi 4 kelompok (n=8). Tikus model SOPK diberikan injeksi testosteron propionat sebesar 1 mg/100grBB secara intramuskular selama 28 hari, selanjutnya diberikan ekstrak daun kelor (Moringa Oleifera) dengan dosis 250 dan 500 mg/KgBB selama 14 hari. Kemudian dilakukan pengukuran berat badan dan pemeriksaan kadar Malondialdehid (MDA) dalam darah. Hasil penelitian menunjukan bahwa kadar MDA pada kelompok kontrol SOPK naik secara signifikan (p<0.05) dibandingkan dengan kontrol normal. Pemberian ekstrak daun kelor (Moringa Oleifera) 500 mg/KgBB menunjukan penurunan yang signifikan (p<0.05) terhadap kadar MDA dibanding kelompok kontrol SOPK. Pemberian ekstrak daun kelor (Moringa Oleifera) sebagai antioksidan terbukti dapat menurunkan kadar MDA tikus betina model SOPK dengan resistensi insulin. Kata kunci: Kadar Malondialdehid, ekstrak daun kelor (Moringa Oleifera), Sindroma Ovarium Polikistik]]>
<![CDATA[The Difference In Breastmilk Production Between Acupresure Point For Lactation And Oxytocin Massage ]]>
<![CDATA[Dwi Rahayu]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Esti Yunitasari]]>
<![CDATA[ Jurnal Ners Vol. 10 No. 1 (2015): April 2015 ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jn.v10i1.1852
<![CDATA[Introduction: Breastfeeding is the adaptation process experienced by postpartum mothers. If she has assisted carlier in breastfeeding, the mothers will succeed to continue breastfeeding. In reality milk ejection very little on the fi rst days after birth is a constraint in early breastfeeding. Acupressure points for lactation can increase milk production, help maximize prolactin and oxytocin receptors and minimize the side effects of delaying in the breastfeeding process. The objective of this study was to prove the difference effect of Acupressure Points for lactation and oxytocin massage to increase milk production and comfort on postpartum mothers. Methods: This study used a quasy-experiment design with pre-post test design with control group. The sample of this study was recruited using consecutive sampling, consist of 27 mother postpartum primiparous, divided into 3 groups. Comfort was measured with GCQ, and milk production measured with Weighing Test. Data measured before and after the intervention, and analyzed by ANOVA with α = 0.05.Results: The results showed there was a signifi cant difference in comfort between the Acupressure Points for Lactation, oxytocin massage and control group (p = 0.035). and there was a a signifi cant difference in milk production between the Acupressure Points for Lactation, oxytocin massage and Control group (p = 0013). Conclusion: Acupressure Points for Lactation effective to increase comfort and milk production in postpartum mothers in Kediri District Hospital. This technique should be used as an alternative intervention in treatment of postpartum mothers. Nurses need to teach these techniques to postpartum mothers to be more independent in reduxing the problem of lactation.]]>
<![CDATA[Peran Ayah dalam Keberhasilan Program Inisiasi Menyusui Dini (IMD) pada Bayi Yang Lahir secara Sectio Cesaria ]]>
<![CDATA[Sestu Retno D. A.]]>;
<![CDATA[Nursalam Nursalam]]>;
<![CDATA[Budi Santoso]]>;
<![CDATA[Rachmat H.]]>
<![CDATA[ Jurnal Ners Vol. 11 No. 2 (2016): Oktober 2016 ]]>
Publisher : <![CDATA[Universitas Airlangga ]]>
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DOI: 10.20473/jn.v11i2.2961
<![CDATA[Introduction: Delivery through Sectio Caesaria (SC) is one of the obstacles to doing Initiation of Breast Feeding. The readiness of new mothers to give her milk to the newborns in need of psychological preparation, because the mother has a role change. The achievement of the role of the mother can be successful if the mother close to the baby and get the support from the spouse (husband). Husband's role in the implementation of IMD is very important. Husband's involvement in the implementation of IMD include the provision of support and interaction. The husband is the closest person for breastfeeding mothers who are expected to always be on the maternal side, and are always ready to provide assistance. If mothers gain confidence and full support of her husband, the motivation for breastfeeding mothers will increase.The objective of this study was to know the role of husband in accompanied the mother with section caesarean in implementing of IMD.Methods: This study used observational eksplanatif, with cross-sectional design, the aims were collecting the respondent data to answer the strategic issues which were going on, which caused the post SC women do not implemented the IMD. Respondent: as many 282 post SC mothers who covered the inclusion and exclusion criteria. The study was conducted in the operating room (OK) Type B obstetrics hospitals, namely RSUD Jombang and RSUD Sogaten Madiun.Result: The test results Together showed there was an effect from Spouse support variable and spouse’s interaction to the implementation of IMD. Individual test result of spouse support to the effect of implementation of IMD, however variable of spouse’s interaction, there was no effect to the implementation of IMD. The implementation of IMD was effected by spouse support as many as 3,7%.Discussion:The mother that had the support from spouse had a higher motivation in implementation of IMD to the baby.]]>
