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All Journal The Indonesian Biomedical Journal Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS)
Ayodhia Pitaloka Pasaribu
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran, Universitas Sumatera Utara/ Rumah Sakit Umum Pusat H. Adam Malik, Medan
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Two or Three Consecutive Days Albendazole Treatment Has Better Efficacy than Single-Dose Albendazole Treatment for Trichuriasis Dina Evalina Gultom; Muhammad Ali; Ayodhia Pitaloka Pasaribu; Syahril Pasaribu
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.920

Abstract

BACKGROUND: Soil-transmitted helminth (STH) infection is endemic in Indonesia. Singledose albendazole is routinely used to control STH infections. Some studies found that repeated-dose of albendazole showed better efficacy. There is no study in Indonesia to compare single-dose and repeated-dose albendazole for against STH infections.METHODS: A randomized, open clinical trial was conducted in July-September 2018 among primary school children. Stool samples were collected before treatment and on day 7, 14, 21, and 28 after treatment then stained using the Kato-Katz method. Group I received three consecutive days, group II received two consecutive days, and Group III received single-dose of albendazole. Cure rate (CR) and egg reduction rate (ERR) were compared using Chi-square tests, and eggs per gram (EPG) was compared using the Kruskal Wallis test (p<0.05).RESULTS: One hundred ninety-five subjects enrolled and divided into 65 subjects in each group. The CR and ERR of trichuriasis after three consecutive days (79.5% and 97.4%) and two consecutive days regimen (70.3% and 91.9%) were higher than single-dose regimen (32.2% and 74.6%) with p<0.001, but not for ascariasis or hookworm infection. The highest efficacy was found in three consecutive days regimen group. Trichuris trichiura EPG was significantly different among the three groups on day 7, 14, 21, and 28 after treatment (p<0.001).CONCLUSION: Three and two consecutive days albendazole have better efficacy than single-dose of albendazole for trichuriasis, but not for ascariasis or hookworm infection. Two consecutive days albendazole is better choice for treating trichuriasis with more adherence and less side effect than three consecutive days regimen.KEYWORDS: soil-transmitted helminth infection, albendazole, single-dose, repeated-dose
Intravenous and Oral Paracetamol Have the Same Effect in Reducing Fever in Pediatric Patients Fitri Asymida; Yazid Dimyati; Bidasari Lubis; Aznan Lelo; Muhammad Ali; Ayodhia Pitaloka Pasaribu; Syahril Pasaribu
Molecular and Cellular Biomedical Sciences Vol 4, No 3 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v4i3.147

Abstract

Background: The antipyretic effect of intravenous versus oral paracetamol is not well known. This study was aimed to compare the antipyretic effect of intravenous and oral paracetamol therapy to reduce fever.Materials and Methods: This was an open-label randomized clinical trial study. The subjects were children who presented to Pediatric Ward and Emergency of Haji Adam Malik Hospital, aged from 2 months to 18 years old, with axillary temperature ≥38.0ºC. Subjects were divided into two groups, group 1 received 15 mg/kg paracetamol intravenous and group 2 received the same dose of paracetamol but given through intravenous. The temperature reduction was analyzed by ANOVA, and the change in temperature was recorded at 0, 15, 30, 60, 120, and 180 minutes after drug administration.Results: In the first group, the mean temperature was decreased (p<0.001) from 15 to 180 minutes after the administration of paracetamol. Nausea was documented as the adverse effect for both oral and intravenous administration groups.Conclusion: The administration of 15 mg/kg paracetamol, either though intravenous or oral, have similar effect in reducing fever in children. Paracetamol therapy though intravenous route can be given if it cannot be given orally.Keywords: antipyretic, pediatrics, fever, intravenous, oral, paracetamol
Accuracy of NADAS criteria to establish diagnosis in children with suspected congenital heart disease Rahmawati Rahmawati; Rizky Adriansyah; Yunnie Trisnawati; Juliandi Harahap; Pertin Sianturi; Ayodhia Pitaloka Pasaribu
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.267-73

Abstract

Background The majority of congenital heart disease is diagnosed during evaluation of a murmur detected either during a routine follow-up or while assessing an intercurrent illness. NADAS criteria might be useful as a screening test to differentiate pathologic from innocent murmurs. Objective To assess the accuracy of NADAS criteria in diagnosing pathology in children with suspected congenital heart disease. Methods This diagnostic study included children aged 1 month - 12 years who visited the Outpatient Pediatric Cardiology Clinic at Haji Adam Malik General Hospital, Medan, North Sumatera. Inclusion criteria from history and physical examination were recurrent acute respiratory illness (ARI), poor nutritional status, failure to thrive, cardiac murmurs, and/or a history of cyanosis. Results Seventy children underwent NADAS screening, of whom 60 had CHD. In the <5-year age group, 63.3% had heart disease. All patients had poor nutritional status, both CHD and non-CHD patients. All CHD patients had an abnormal electrocardiogram (ECG), while 88.33% had a history of recurrent ARI, 80% had abnormal chest x-ray, and 55% had abnormal S2 heart sound on auscultation. A grade 3 or higher systolic murmur was found in 78.33% of patients who had CHD. There were 55 children who had a NADAS score of 3 or higher, of which 53 children with CHD and 2 children non CHD (1 of the 2 children non CHD showed only 3 minor criteria of the NADAS score and had infantile fibrosarcoma). The other 15 children had a NADAS score of less than 3 with 7 children with CHD and 8 children without CHD. Conclusion The NADAS criteria can be used as a screening test to diagnose disease in children suspected of having CHD for cut-off score at 3 (1 major + 2 minor), with 87.14% accuracy, 88.33% sensitivity, 80% specificity, and 0.883 AUC value.
Co-Authors Aznan Lelo Bidasari Lubis Dina Evalina Gultom Fitri Asymida Juliandi Harahap Muhammad Ali Muhammad Ali Pertin Sianturi Rahmawati Rahmawati Rizky Adriansyah Syahril Pasaribu Yazid Dimyati Yunnie Trisnawati