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All Journal The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Majalah Kedokteran Nusantara The Journal Of Medical School Jurnal Review Pendidikan dan Pengajaran (JRPP) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia El-Mujtama: Jurnal Pengabdian Masyarakat Gudang Jurnal Multidisiplin Ilmu Jurnal Pengabdian Bidang Kesehatan El-Mujtama: Jurnal Pengabdian Masyarakat

Syahril Pasaribu

Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Sumatera Utara / RSUP H. Adam Malik Medan

Author-ID : 3453510

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FAKTOR RISIKO KEJADIAN KECACINGAN PADA ANAK USIA PRA SEKOLAH Novianty, Sri; Pasaribu, H. Syahril; Pasaribu, Ayodhia Pitaloka
Majalah Kedokteran Indonesia Vol 68 No 2 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pendahuluan: Infeksi parasit usus merupakan masalah kesehatan utama di negara berkembang, terutama pada anak sering menyebabkan mortalitas dan morbiditas. Penyebab utama infeksi parasit usus adalah cacing yang ditularkan melalui tanah disebut soil-transmitted helminths (STH) yaitu cacing gelang (Ascaris lumbricoides), cacing cambuk (Trichuris trichiura) dan hookworm (Ancylostomaduodenale dan Necatoramericanus).Strategi yang direkomendasikan oleh World Health Organization (WHO)untuk mengontrol penyakit tersebut pertama kali difokuskan pada anak usia sekolah, saat ini anak usia pra sekolah juga menjadi salah satu populasi berisiko tinggi penyakit ini. Oleh karena itu penting diketahui faktor risiko kejadian kecacingan pada anak usia sekolah.

Two or Three Consecutive Days Albendazole Treatment Has Better Efficacy than Single-Dose Albendazole Treatment for Trichuriasis Dina Evalina Gultom; Muhammad Ali; Ayodhia Pitaloka Pasaribu; Syahril Pasaribu
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.920

BACKGROUND: Soil-transmitted helminth (STH) infection is endemic in Indonesia. Singledose albendazole is routinely used to control STH infections. Some studies found that repeated-dose of albendazole showed better efficacy. There is no study in Indonesia to compare single-dose and repeated-dose albendazole for against STH infections.METHODS: A randomized, open clinical trial was conducted in July-September 2018 among primary school children. Stool samples were collected before treatment and on day 7, 14, 21, and 28 after treatment then stained using the Kato-Katz method. Group I received three consecutive days, group II received two consecutive days, and Group III received single-dose of albendazole. Cure rate (CR) and egg reduction rate (ERR) were compared using Chi-square tests, and eggs per gram (EPG) was compared using the Kruskal Wallis test (p<0.05).RESULTS: One hundred ninety-five subjects enrolled and divided into 65 subjects in each group. The CR and ERR of trichuriasis after three consecutive days (79.5% and 97.4%) and two consecutive days regimen (70.3% and 91.9%) were higher than single-dose regimen (32.2% and 74.6%) with p<0.001, but not for ascariasis or hookworm infection. The highest efficacy was found in three consecutive days regimen group. Trichuris trichiura EPG was significantly different among the three groups on day 7, 14, 21, and 28 after treatment (p<0.001).CONCLUSION: Three and two consecutive days albendazole have better efficacy than single-dose of albendazole for trichuriasis, but not for ascariasis or hookworm infection. Two consecutive days albendazole is better choice for treating trichuriasis with more adherence and less side effect than three consecutive days regimen.KEYWORDS: soil-transmitted helminth infection, albendazole, single-dose, repeated-dose

Enterobiasis pada Anak Siska Mayasari Lubis; Syahril Pasaribu; Chairuddin P Lubis
Sari Pediatri Vol 9, No 5 (2008)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Enterobiasis merupakan infeksi yang sering terjadi dalam satu keluarga atau pada orang yang tinggaldalam satu rumah. Infeksi cacing sering diduga pada anak yang menunjukkan rasa gatal di sekitar anuspada waktu malam hari. Anal swab merupakan metode terbaik dalam mendiagnosis enterobiasis.Pemeriksaan periodik disertai dengan pengobatan yang adekuat akan dapat membantu mengurangi kejadianenterobiasis pada anak. Meskipun demikian, masih terdapat kesulitan dalam mengontrol enterobiasis olehkarena mudahnya penularan dan reinfeksi

Efektivitas Kombinasi Artesunat-Klindamisin dengan Kinin-Klindamisin pada Pengobatan Malaria FalciparumTanpa Komplikasi pada Anak Erika S. Panjaitan; Syahril Pasaribu; Muhammad Ali; Munar Lubis; Chairuddin P. Lubis; Ayodhia P. Pasaribu
Sari Pediatri Vol 13, No 6 (2012)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp13.6.2012.420-5

Latar belakang. Kombinasi antimalaria termasuk artemisinin sering tidak sesuai secara farmakokinetika sehingga berpotensi untuk resistensi. Untuk itu penilaian terhadap kombinasi artemisinin dengan obat yang mempunyai waktu paruh yang pendek diperlukan dalam pengobatan malaria falciparumtanpa komplikasi pada anak. Tujuan. Untuk membandingkan efektifitas kombinasi artesunat-klindamisin dengan kinin-klindamisin pada pengobatan malaria falciparumtanpa komplikasi pada anak.Metode. Penelitian dilakukan dengan metode uji klinis acak terbuka yang dilaksanakan pada bulan Oktober sampai November 2010 di Mandailing Natal, Propinsi Sumatera Utara. Subjek berusia 7 sampai 12 tahun dan dijumpai Plasmodium falciparumpada pemeriksaan darah tepi. Kelompok I menerima kombinasi artesunat-klindamisin (artesunat 4mg/kg, dan klindamisin 7mg/kg, per dosis). Kelompok II menerima kombinasi kinin-klindamisin (kinin 4 mg/kg dan klindamisin 7mg/kg, per dosis). Kedua kelompok beri obat dua kali sehari selama tiga hari berturut-turut. Parasitemia dihitung pada hari 1, 2, 3, 7, 14, dan 28. Analisis didasarkan intention to treat analysis.Hasil. Penelitian diikuti dua ratus anak. Adequate clinical parasitological respons dari artesunat-klindamisin dijumpai berbeda secara bermakna dibandingkan kinin-klindamisin 94% dan 62% (p=0,0001). Kesembuhan artesunat-klindamisin dicapai hari ke-3 dan ke-4 belas 97% (p=0,001). Kesembuhan kinin-klindamisin dicapai pada hari ke-14 dan ke-28 92% (p=0.236). Pada pengamatan tidak dijumpai efek samping yang serius.Kesimpulan.Kombinasi artesunat-klindamisin lebih efektif dari pada kinin-klindamisin pada pengobatan malaria falciparumtanpa komplikasi pada anak

Efikasi Kinin-Doksisiklin pada Pengobatan Malaria Falsiparum Tanpa Komplikasi Fitri Arianty Lubis; Syahril Pasaribu; Chairuddin P. Lubis
Sari Pediatri Vol 10, No 4 (2008)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp10.4.2008.246-9

Pengobatan malaria masih merupakan masalah yang sering dihadapi karena terjadinya resistensi terhadap beberapa obat anti malaria. Kombinasi dua macam obat saat ini yang sering dipergunakan, terutama pada daerah hiperendemis, untuk meningkatkan efikasi dari obat tersebut. Kombinasi kinin-doksisiklin adalah salah satu kombinasi obat anti malaria yang dapat diberikan sebagai terapi alternatif untuk pengobatan malaria falsiparum tanpa komplikasi. Pada beberapa penelitian ditunjukkan bahwa kombinasi kedua obat ini mempunyai efikasi yang baik.

Perubahan Kadar Natrium dan Kalium Serum Akibat Pemberian Glukosa 40% pada Latihan Fisik Akut Wahyudi Wahyudi; Suryani Ginting; Charles Siregar; Chairul Yoel; Syahril Pasaribu; Munar Lubis
Sari Pediatri Vol 10, No 2 (2008)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp10.2.2008.77-82

Latar belakang. Glukosa sumber energi untuk latihan fisik dan berpengaruh pada keseimbangan metabolisme tubuh. Glukosa menyebabkan masuknya ion natrium ke dalam sel. Sewaktu ATP terhidrolisis menjadi ADP, protein pembawa mengalami fosforilasi dan perubahan konformasi yang menyebabkan ion natrium dilepaskan ke cairan ekstrasel. Kemudian dua ion kalium berikatan di sisi ekstrasel masuk ke sel.Tujuan. Untuk mengetahui dan membandingkan perubahan kadar natrium dan kalium serum sebelum dan setelah latihan fisik akut pada kelompok yang diberikan air putih dan air berglukosa 40%.Metode. Empat puluh anak SLTP sehat yang dipilih secara acak sederhana mendapat minuman glukosa 40% (dosis 1 g/kgBB yang dilarutkan dalam 300cc air) (n=20) dan air putih sebanyak 300 cc (n=20). Semua anak diberi minum 10 menit sebelum latihan fisik, kemudian dilakukan latihan fisik selama 10 menit. Sampel darah vena diambil sebelum anak minum dan setelah melakukan latihan fisik.Hasil. Terjadi perubahan penurunan natrium serum berbeda bermakna setelah latihan fisik akut (p<0,05) pada kelompok air putih, sedangkan pada kelompok air berglukosa 40% terjadi peningkatan natrium serum. Perbandingan kadar natrium serum kedua kelompok berbeda bermakna (p<0,05). Kadar kalium serum tidak mengalami perubahan (p>0,05) pada kedua kelompok.Kesimpulan. ï¿½ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ï¿½ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ ï¿½ -Pemberian minuman berglukosa 40% sebelum latihan fisik akut dapat menyebabkan peningkatan kadar natrium serum.

Efficacy of mebendazole and levamisole, alone or in combination, for soil-transmitted helminthiasis Ifo Faujiah Sihite; Muhammad Ali; Ayodhia P. Pasaribu; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 54 No 1 (2014): January 2014
Publisher : Indonesian Pediatric Society

BackgroundThe World Health Organization (WHO) recommends four, single-dose drugs (albendazole, levamisole, mebendazole, and pyrantel pamoate) for management of soilÂtransmitted helminthiasis (STH). Previous studies have shown varied and inconsistent outcomes of these STH treatments.ObjectiveTo compare the efficacy of mebendazole and levamiÂsole, alone or in combination, for the treatment of STH.MethodsAn open randomized controlled trial was conducted in Secanggang, North Sumatera from August to October 2009. School-aged children with STH infection were randomized into three groups. Group I received a single dose of mebendazole (500 mg); group II received a single dose of levamisole (2.5 mg/kg); and group III received a single dose of mebendazole-levamisole combined. Stool samples were collected at baseline, and the 1st, 2nd, 3rd, and 4th weeks after treatment and examined by the Kato-Katz technique. Statistical analyses were Kruskal-Wallis test for cure rate and Analysis of Variance (ANOVA) test for egg reduction rate. ResultsSTH was diagnosed in 197 children with the following parasite species: Ascariasis (96 children, 48.7%), Trichuriasis (58 children, 29.4%), and mixed infection (43 children, 21.8%). We found no hookworm infection in any of our subjects. Groups I and III had significantly higher efficacy (P=0.0001) against STH (egg reduction rate 99.3% and 99.9%; cure rate 92.2% and 98.4%, respectively) at 4th week of treatment.ConclusionA single dose of mebendazole alone and combined with levamisole have better efficacy compared to a single dose of levamisole for the treatment of STH. The highest efficacy of these treatments is noted at the 4th week after drug administration

Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis Windya Sari Nasution; Muhammad Ali; Ayodhia Pitaloka Pasaribu; Syahril Pasaribu; Chairuddin P. Lubis
Paediatrica Indonesiana Vol 54 No 2 (2014): March 2014
Publisher : Indonesian Pediatric Society

Background Trichuris trichiura is one of the most commonsoil-transmitted helminths, estimated to infect l billion peopleworldwide. Several studies have compared the efficacies ofalbendazole and diethylcarbamazine, but the efficacy of acombination of these two drugs has been inconclusive.Objective To assess the effectiveness of a single dose ofalbendazole compared to a combination of albendazole anddiethylcarbamazine for trichuriasis treatment.Methods A randomized, clinical open trial was conducted fromJune to September 2009 on elementary school children withtrichuriasis from two villages in the North Sumatera Province.Stool specimens were collected at baseline and at days 7, 14,21, and 28 after treatment, and examined by the Kato Katzmethod. Subjects were randomized into two groups. Group Ireceived a single dose of albendazole (400 mg) and group IIreceived albendazole (400 mg) plus diethylcarbamazine (6 mg!kg). Statistical analyses used were Chi square test for cure ratesand Wilcoxon rank test for egg reduction rates.Results One hundred eight children were enrolled andrandomized into group l (53 children) and group II (55children). The prevalence of T. trichiura infection was 54.7%.There were no significant differences (P=0.52) in the curerate between groups I and II (66% and 60%, respectively) or inegg reduction rates at day 28 (54.5% and 60.07%, respectively,P= 0.10).Conclusion Albendazole alone and abendazole combinedwith diethylcarbamazine have similar efficacies for trichuriasistreatment, in terms of cure rates and egg reduction rates.

Mebendazole vs. mebendazole-pyrantel pamoate for soil-transmitted helminthiasis infection in children Fereza Amelia; Muhammad Ali; Syahril Pasaribu
Paediatrica Indonesiana Vol 53 No 4 (2013): July 2013
Publisher : Indonesian Pediatric Society

AbstractBackground Soil-transmitted helminthiasis (STH) is the mostcommon infection in developing countries. Although it causeshigh morbidity, it is still difficult to find the efficacy dose ofantihelmintics for its treatment.Objective To determine the efficacy ofmebendazole and mebendazole-pyrantel pamoate in treating STH infection in children.Methods We conducted a randomized open-label controlled trialfrom July to September 2009 in Secanggang, Langkat District,North Sumatera Province, Indonesia, on primary school-agedchildren. Before the intervention, data on age, sex, nutritionalstatus, and STH infection status were collected. The childrenwere randomized into two groups. Children in group I received asingle dose of 500 mgmebendazole while they in group II receiveda single dose of 500 mg of mebendazole combined with 10 mg/kgBW of pyrantel pamoate. We examined subjects' stool specimenson days 7, 14, 21, and 28 after treatment to determine cure ratesand egg reductions. Statistical analyses were performed by Chisquare and student's Ttest with 95% confidence intervals and Pvalues of< 0.05 considered to be significant.Results We found that the cure rates were 95.4%, 78.5%, and893%for Ascaris lumbricoides, Trichuris trichiura, and mixed (A lumbricoidesand T trichiura) infections, respectively, in the mebendazole group.The cure rates were 98.5%, 89.2%, and 90.2% for A lumbricoides,T trichiura, and mixed infections, respectively, in the mebendazolepyrantelpamoate group. Although the cure rate results were notsignificantly different between the 2 treatment groups, the total eggsper gram (EPG) was significantly lower for both A lumbricoides andT trichiura infections (P=0.001 and P=0.002, respectively) in thecombination therapy group than in the mebendazole alone group.Conclusion Mebendazole in combination with pyrantel pamoatehas higher efficacy than mebendazole alone in terms of faster eggreduction rates. However, the cure rates of these two antihelminticsregimens are similar.

Effect of length of albendazole treatment against Trichuris trichiura infection Aridamuriany D Lubis; Syahril Pasaribu; Muhammad Ali; Munar Lubis
Paediatrica Indonesiana Vol 53 No 5 (2013): September 2013
Publisher : Indonesian Pediatric Society

Background Trichuris trichiura is one of the most common soil-transmitted helminth that infects school-aged children. A single dose of albendazole has been shown to have wide variations in cure and egg reduction rates. Some studies have suggested that repeated doses of albendazole might increase its effectiveness.Objective To compare the anti-trichuriasis effect of 400 mg albendazole taken daily for five consecutive days vs. seven consecutive days.Methods A randomized open clinical trial was conducted from August to September 2009 on elementary school children at Jaring Halus in the North Sumatera Province. Stool specimens were collected before treatment and on days 7, 14, 21, and 28 after initiation of treatment, and examined by the Kato Katz method. Subjects were randomized into two groups. Group I received 400 mg albendazole daily for five consecutive days and Group II received 400 mg albendazole daily for seven consecutive days. Cure rates and egg reduction rates were compared using Chi-square and T-tests, respectively.Results One hundred twenty-one children were enrolled, consisted of 61 children in Group I and 60 in Group II. For the first week after treatment ended, the cure rates in Group II was higher (86.7%) than in the Group I (39.3%) (P=0.001), as well as in the second week after treatment ended (88.3% vs 68.9%, P=0.017). However, after 3rd and 4th weeks, the cure rates were no longer significantly different. Egg reduction rate was also statistically higher in the Group II [20.3 (SD 23.77) %] compared to Group I [6.6 (SD 11.30) %].Conclusions Albendazole for seven consecutive days is more effective in curing Trichuris trichiura infection in the 1st and 2nd weeks after treatment compared to that of five consecutive days, as well as in egg reduction rate, but the length of treatment does not influence the cure rate after the 3rd and 4th weeks.

Co-Authors Abdurrozaq Hasibuan Adillida Adillida Amelia, Fereza Andaresta, Novi Araafi, Alif Ardila, Maisyah Aridamuriany D Lubis Ariyansyah, Fauzy Armila Armila Ayodhia P. Pasaribu Ayodhia P. Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayodhia Pitaloka Pasaribu Ayu, Delfriana Aznan Lelo Azwan H. Lubis Berlian Hasibuan Bidasari Lubis Bidasari Lubis Bugis Mardina Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairuddin P. Lubis Chairul Yoel Chairul Yoel Charles Siregar Charles Siregar Dachrul Aldy Danny Dasraf Dedi Satria Putra Dewi Sari Dina Evalina Gultom Dini Lailani Ditho Athos P. Daulay Dwika Ardelya Pratiwi Emil Azlin Erika S. Panjaitan Erniwaty P Panggabean Evi Kamelia Fauzi Rizal Fitri Arianty Lubis Fitri Asymida Hasibuan, Arini Salsabila HENDRI WIJAYA Ichwan HH Batubara Ifo Faujiah Sihite Inke Nadia Diniyanti Lubis Iskandar Z Lubis Iskandar Z. Lubis Isra Firmansyah Jenny Ginting Latifah Mutiah Nurhidayah Lily Irsa Lubis, Ade Irma Seftyani Mahadi Mahadi Mahruzzaman Naim Maisyah Ardila Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muhammad Ali Muharani, Anisa Munar Lubis Nasution, Ummi Kalsum Nelly Rosdiana Nisrina Nisrina Novianty, Sri Novianty, Sri Nurhandayani dr Oktapiani, Friska Dela Pasaribu, Ayodhia Pitaloka Pasaribu, Ayodhia Pitaloka Pratiwi, Dwika Ardelya Purnama Fitri Raspiyahni, Raspiyahni Regita Cahyani Rita Angraini RIZKA AULIA Rizka Tiara ROSIHAN ANWAR Rusdidjas Rusdidjas Salianto Salianto, Salianto Seftyani, Ade Irma Siska Mayasari Siska Mayasari Lubis Sri Alemina Ginting Sri Rezky Gantina Sri Sofyani Suryani Ginting Susilawati Syafruddin Haris Syamsidah Lubis T. Ernalisna T. Murad El-Fuad T. Razif Tiangsa Sembiring Tiangsa Sembiring Tjut Dharmawati Tri Faranita Wahyudi Wahyudi Windya Sari Nasution Wisman Dalimunte Wisman Dalimunthe Wulan Andika Y Dimyati Yahya G. Lubis Yazid Dimyati Yoyoh Yusroh Yunnie Trisnawati

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