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All Journal Sari Pediatri Paediatrica Indonesiana Jurnal RSMH Palembang
Raden Muhammad Indra
Department Of Child Health, Universitas Sriwijaya Medical School/Dr. Moh. Hoesin General Hospital, Palembang, South Sumatra, Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Faktor yang Memengaruhi Luaran Kualitas Hidup Anak dengan Hidrosefalus Setelah Pemasangan Shunt Ventrikulo-Peritoneal di Rumah Sakit Umum dr. Mohammad Hoesin Palembang Erni Desmita; Masayu Rita Dewi; Syarif Darwin; Trijoso Permono; Irfannuddin Irfannuddin; Raden Muhammad Indra
Sari Pediatri Vol 23, No 5 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.5.2022.299-305

Abstract

Latar belakang. Anak hidrosefalus dengan VP shunt dapat mengalami penurunan kualitas hidup (QoL) akibat berbagai faktor yang hingga kini belum banyak diteliti.Tujuan. Menilai luaran QoL anak hidrosefalus dengan VP shunt dan faktor yang memengaruhinya.Metode. Anak berusia 5-18 tahun dengan hidrosefalus yang dipasang VP shunt tahun 2010-2015 diidentifikasi melalui rekam medis. Orangtua kemudian diwawancarai dengan panduan kuesioner HOQ (hydrocephalus outcome questionnaire). Hasil meliputi skor QoL pada aspek fisik, kognitif, dan keseluruhan. Skor 0 menunjukkan luaran terburuk dan skor 1 terbaik.  Dilakukan analisis perbedaan skor berdasarkan faktor risiko (usia saat pemasangan, etiologi, adanya kejang dan komplikasi shunt) dan analisis kategorik berdasarkan pencapaian skor standar penelitian terdahulu (0,69).Hasil. Terdapat 95 anak yang diidentifikasi, 18 meninggal dan 46 dengan data tidak lengkap sehingga terdapat 31 anak yang dianalisis.  Skor HOQ yang didapatkan, yaitu fisik 0,75±0,27, sosial-emosional 0,78±0,22, kognitif 0,66±0,31, dan keseluruhan 0,73±0,25. Skor HOQ keseluruhan lebih rendah pada anak dengan komplikasi. Kejang (RR 2,52) dan komplikasi shunt (RR 4,85) berhubungan dengan luaran buruk. Analisis multivariat menunjukkan hanya komplikasi yang berhubungan dengan QoL buruk (adjusted OR 15,11).Kesimpulan. Luaran QoL ditemukan lebih baik dibandingkan penelitian sebelumnya. Kejang dan komplikasi shunt dapat berpengaruh negatif terhadap luaran QoL anak hidrosefalus dengan VP shunt.
Laporan kasus berbasis bukti: Efektivitas Kortikosteroid dalam Pengobatan Spasme Infantil Teti Hendrayani; Masayu Rita; Syarif Darwin; Raden Muhammad Indra
Sari Pediatri Vol 23, No 6 (2022)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.6.2022.409-16

Abstract

Latar belakang. Spasme infantil (SI) adalah suatu sindrom epilepsi berat dengan awitan masa bayi. Hormon adrenokortikotropik(ACTH) merupakan obat utama pada SI. Karena ACTH tidak tersedia di Indonesia, kortikosteroid dipertimbangkan sebagai obat pengganti. Tujuan. Telaah bukti membandingkan efektivitas kortikosteroid (prednison atau prednisolon) dan ACTH dalam mengobati SI.Metode. Penelusuran literatur secara terstruktur pada pangkalan data Pubmed, Cohcrane dan Google Scholar.Hasil. Didapatkan 19 artikel, dua artikel yang terpilih kemudian menjalani telaah kritis, terdiri dari satu meta-analisis dan satu meta-analisis network terhadap uji klinis acak terkontrol. Bukti yang tersedia menunjukkan bahwa kortikosteroid terutama prednisolon oral dosis tinggi (4 mg/kg/hari atau 40-60 mg/kg/hari) memiliki efektivitas setara dengan ACTH dalam menghentikan spasme atau menyebabkan perbaikan elektroensefalografi pada anak-anak dengan SI, meski tingkat kepastian bukti tergolong rendah.Kesimpulan. Prednisolon oral dosis tinggi dapat digunakan untuk pengobatan SI apabila ACTH tidak tersedia.
Depression in children with thalassemia major: prevalence and contributing factors Venty Venty; Rismarini Rismarini; Dian Puspitasari; Yudianita Kesuma; Raden Muhammad Indra
Paediatrica Indonesiana Vol 58 No 6 (2018): November 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.161 KB) | DOI: 10.14238/pi58.6.2018.263-8

Abstract

Background Thalassemia major is a chronic disease requiring lifetime treatment. A recent study showed that 11-62% of thalassemia patients developed depression, which is associated with high morbidity and mortality. Understanding the extent of the problem related to depression and its contributing factors is important for early management. Objective To determine the prevalence and contributing factors for depression in children with thalassemia major. Methods This cross-sectional observational analytic study included thalassemia major patients aged 7 to <18 years in the Department of Child Health, Dr. Moh. Hoesin General Hospital (RSMH) in Palembang from June to July 2018 and had received blood transfusions at least 3 times. Subjects completed the Children's Depression Inventory (CDI) questionnaire. Depression was defined as a total score > 13. Data were analyzed using SPSS for Windows ver. 22.0. Results There were 64 patients included in this study, with mean age 12 (SD 3) years and 82.8% female. Most subjects came from families with low socio-economic status and low parental education. Deferiprone was the most commonly used type of iron-chelating agent. Depression was detected in 34.4% of respondents. Multivariate analysis revealed that factors affecting depression in children with thalassemia major were low maternal education (OR 4.014; 95%CI 1.066 to 15.112) and use of deferasirox (OR 4.129; 95%CI 1.168 to 14.601). Conclusion Prevalence of depression in children with thalassemia major is 34.4%. Low maternal education and deferasirox use as an iron-chelating agent are associated with depression in children with thalassemia major.
Achievement of full enteral feeding using volume advancement in infants with birth weight 1,000 to Teti Hendrayanti; Afifa Ramadanti; Indrayady Indrayady; Raden Muhammad Indra
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.173-7

Abstract

Background Early enteral feeding is one of the efforts to improve gastrointestinal adaptability in preterm infants. Volume advancement (VA) enteral feeding has been associated with less time to reach full feeding, which can improve outcomes. Objective To evaluate the duration of VA needed to achieve full enteral feeding (FEF) in low birth weight (LBW) and very low birth weight (VLBW) infants and related factors. Methods This prospective study was done in infants with birth weight 1,000 to <2,000 grams in the Neonatal Ward and NICU of Dr. Moh. Hoesin General Hospital, Palembang, South Sumatera. All infants underwent VA feeding. The time needed to achieve FEF (150 ml/kg/day) was recorded. Several clinical factors were analyzed for possible associations with the success rate of achieving FEF within 10 days of feeding. Results Thirty-five infants were included in this study with a mean gestational age of 31.83 (SD 2.67) weeks. Their median body weight at the start of protocol was 1,400 (range 1,000 – 1,950) grams and 80% had hyaline membrane disease. Median time to achieve FEF was 11 (range 8–21) days, with 48.6% subjects achieving FEF in <=10 days. Gestational age <32 weeks (OR 5.404, 95%CI 0.963 to 30.341), birth weight <1,500 grams (OR 5.248, 95%CI 0.983 to 28.003), and male (OR 4.751, 95%CI 0.854 to 26.437) gender were associated with the failure of achieving FEF within 10 days of feeding, however, no factors remained statistically significant after multivariate analysis. Conclusion Full enteral feedings in infants with birth weight 1,000 to <2,000 grams with VA feeding are achieved within a median of 11 days. Gestational age, birth weight, and gender are not associated with time needed to achieve FEF.
Effectiveness Of Ranitidine Providing Compared With Omeprazol In Children With Gastroesofageal Reflux Disease Hasri Salwan; Rizki Nandasari Sulbahri; Raden Muhammad Indra; Sri Kesuma Astuti
Jurnal RSMH Palembang Vol. 1 No. 1 (2020): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.133 KB) | DOI: 10.37275/jrp.v1i1.1

Abstract

Background. The drugs that are often given to children with GERD are stomach acidsuppressants, namely the H2 receptor antagonist and proton pump inhibitor (PPI) classof drugs, but the effectiveness of the two drugs is still controversial. Objective. Toevaluate the use of PPIs and H2 RA in children with GERD through evidence-basedcase studies. Methods. Systematic search for literature using the search instrumentPUBMED, Cochrane, Google Scholar, Pediatrica Indonesiana, and Sari Pediatri.Searches included systematic review articles, randomized controlled clinical trials andcohort studies. Abstract only studies, non-clinical evaluation results, and case reportswere excluded. Results. The study was obtained from three RCT studies comparingthe effectiveness of omeprazole and ranitidine in the treatment of GERD, all of whichhave differences. Azizollahi et al demonstrated that after 2 weeks of standard doses ofomeprazole or ranitidine there was a comparable significant improvement. Ummarinoet al demonstrated that omeprazole was significantly better than high-dose ranitidine.Cucchiara et al (1993) showed that high doses of ranitidine were as good as omeprazole.Another study by Pfefferkorn et al showed no significant effect on the addition ofomeprazole therapy combined with ranitidine in preventing the incidence of NAB. Astudy by Boccia et al comparing omeprazole, ranitidine, and non-therapy, found verylow relapse rates. Conclusion. Evidence regarding the use of ranitidine versusomeprazole in infants and children is lacking. Based on one study specifically in theinfant age group, omeprazole and ranitidine were of comparable effectiveness. A higherdose of ranitidine may have a better effect. In terms of complete symptom relief,omeprazole is likely to be superior to ranitidine.
Evidence-based case report: Coinfection of COVID-19 in children and administration of antibiotics Fifi Sofiah; Marselya Ulfa; Azwar Aruf; Raden Muhammad Indra
Jurnal RSMH Palembang Vol. 1 No. 2 (2020): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.872 KB) | DOI: 10.37275/jrp.v1i2.8

Abstract

A B S T R A C TBackground. COVID-19 in childrenalthoughmostly mild,but can also cause seriousillness and even death. Coinfection, especially bacterialcan increase the severity of thedisease. There is yet sufficient evidence about the role of antibiotics in childhoodCOVID-19 with coinfection.Objective. To review the available evidence on thecoinfection in childhood COVID-19 and the role of antibiotic administration.Method.Online literature search using Pubmed database, google scholar dan Cohcranelibrary Results.No study was found that directly evaluate the efficacy of antibiotic inchildhood COVID-19 with coinfection. Three meta-analyses found rates of coinfectionof 5.6%-14% and one case series identified a very high rate (94.2%). Most frequentpathogens included Mycoplasma pneumonia, Streptococcus pneumonia,andinfluenza/parainfluenza viruses. Two RCTsandone case series on antibioticadministration, but all three studies did not address coinfection status.All threestudies evaluated the combination of azithromycin and hydroxychloroquine. Nochanges in illness severity or mortality attributed to the medications, one studyindicated more rapid viral load clearance associated with azithromycin. ConclusionThere is a lack of evidence on the role of antibiotics in the management of childhoodCOVID-19with coinfection. Azithromycin can be considered in some cases.
Co-Authors Afifa Ramadanti Azwar Aruf Dian Puspita Sari Erni Desmita Fifi Sofiah Hasri Salwan Indrayady Indrayady Irfannuddin Irfannuddin Marselya Ulfa Masayu Rita Masayu Rita Dewi Rismarini Rismarini Rizki Nandasari Sulbahri Sri Kesuma Astuti Syarif Darwin Syarif Darwin Teti Hendrayani Teti Hendrayanti Trijoso Permono Venty Venty Yudianita Kesuma, Yudianita