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All Journal Sari Pediatri Biomedical Journal of Indonesia Paediatrica Indonesiana Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal 'Aisyiyah Medika Journal of Industrial Engineering
Afifa Ramadanti
Department Of Child Health, Universitas Sriwijaya Medical School/Dr. Moh. Hoesin General Hospital, Palembang, South Sumatra, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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Comparison between Leukocyte Esterase Activity (LEA) and Histopathology Examination in Identifying Chorioamnionitis Cases Novianesari, Putri H; Bernolian, Nuswil; Maulani, Henni; Ramadanti, Afifa; Theodorus, Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.754 KB) | DOI: 10.32771/inajog.v7i1.823

Abstract

Objective: To compare sensitivity and specificity of LEA to histopathology examination in diagnosing chorioamnionitis. Methods: We compared diagnostic tests in dr. Mohammad Hoesin hospital, Palembang, from September 2015 to April 2016. Ninety-one pregnant women were included. LEA and histopathology examination were carried out with neonatal sepsis as main outcome. Data were analysed by SPSS version 21.0 and Med-calc statistic. Results: Chorioamnionitis was detected in 54 (77.1%) patients with gestational period ≥37 weeks and in 16 (22.9%) patients with gestational period <37 weeks. Duration of membrane rupture was significantly associated with chorioamnionitis (p = 0.001 and p = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (p = 0.014 and p = 0.036). LEA value with cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in preterm pregnancy group. Conclusion: LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy. Keywords: Chorioamnionitis, Histopathology, Leukocyte esterase activity, Neonatal sepsis, Salafia criteria       Tujuan: Membandingkan sensitifitas dan spesifisitas diagnosis korioamnionitis antara pemeriksaan Leukocyte esterase activity (LEA) terhadap histopatologi. Metode: Penelitian uji diagnostik dilakukan di RSUP dr. Mohammad Hoesin Palembang selama periode September 2015 – April 2016,  91 wanita hamil yang memenuhi kriteria inklusi selanjutnya dilakukan pemeriksaan LEA, Histopatologi dan luaran sepsis neonatorum. Data kemudian dianalisis dengan menggunakan software SPSS versi 21.0 dan Med-calc statistic. Hasil: Korioamnionitis terdeteksi pada 54 (77,1%) pasien dengan usia gestasi ≥37 minggu dan 16 (22,9%) pada usia gestasi <37 minggu. Durasi lamanya pecah ketuban akan berpengaruh secara signifikan terhadap kejadian korioamnionitis (p = 0,001 dan p = 0,011), Sepsis neonatorum juga secara signifikan berhubungan dengan kejadian korioamnionitis pada kedua kelompok (p = 0,014 dan p = 0,036). Kadar LEA dengan cut off point >0,5 secara signifikan mampu memprediksi kejadian korioamnionitis dengan sensitivitas 98,6%, spesifisitas 95,2% dan nilai akurasi yang lebih baik ditemukan dalam penegakan diagnosis korioamnionitis pada kelompok kehamilan preterm. Kesimpulan: Pemeriksaan LEA memiliki kekuatan prediksi yang sangat baik terhadap kejadian korioamnionitis dengan akurasi yang lebih baik dalam mendiagnosis korioamnionitis pada kehamilan preterm. Kata kunci: Korioamnionitis, Histopatologi, Leukocyte Esterase Activity,Sepsis Neonatorum, Kriteria Salafia
Hubungan Derajat Asfiksia dengan Kejadian Hipoglikemia pada Neonatus di RSUP Dr. Mohammad Hoesin Palembang Lumbantoruan, Regina Paranggian; Ramadanti, Afifa; Lestari, Hertanti Indah
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Pengkajian pertama yang dilakukan pada bayi saat lahir yaitu dengan menggunakan nilai Apgar melalui pemeriksaan fisik singkat. Nilai Apgar yang menurun dapat menyebabkan asfiksia pada neonatus. Keadaan asfiksia dapat menyebabkan ketidakseimbangan suhu tubuh dan terjadi hipotermia yang mengakibatkan berkurangnya aliran oksigen ke jaringan dan neonatus akan mengalami hipoglikemia. RSUP Dr. Mohammad Hoesin Palembang sebagai rumah sakit pendidikan dan rujukan nasional belum memiliki data mengenai hubungan asfiksia dan hipoglikemia ini. Penelitian ini dilakukan untuk mengetahui lebih jauh mengenai hubungan derajat asfiksia dan kejadian hipoglikemia pada neonatus di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini adalah penelitian observasional analitik dengan menggunakan rancangan potong lintang (cross-sectional study). Sampel penelitian adalah seluruh rekam medik pasien neonatus di RSUP Dr. Mohammad Hoesin Palembang dari Januari 2015 sampai Desember 2015. Analisis pada penelitian ini menggunakan uji Chi-square, bermakna apabila nilai p<? (?=0,05). Dari 106 neonatus, 84,9% adalah asfiksia ringan, diikuti berturut-turut oleh asfiksia sedang (13,2%), dan asfiksia berat (1,9%). Dari 90 neonatus tidak asfiksia dan derajat asfiksia ringan didapatkan 35,6% neonatus hipoglikemia dan 64,4% neonatus tidak hipoglikemia. Derajat asfiksia sedang dan berat didapatkan 37,5% neonatus hipoglikemia dan 62,5% neonatus tidak hipoglikemia. Dari hasil penelitian, tidak terdapat hubungan bermakna antara derajat asfiksia dan kejadian hipoglikemia pada neonatus dengan p=1,000.  Tidak terdapat hubungan bermakna antara derajat asfiksia dan  kejadian hipoglikemia pada neonatus di RSUP Dr. Mohammad Hoesin Palembang. 
Hubungan Derajat Asfiksia dengan Kejadian Hipoglikemia pada Neonatus di RSUP Dr. Mohammad Hoesin Palembang Regina Paranggian Lumbantoruan; Afifa Ramadanti; Hertanti Indah Lestari
Biomedical Journal of Indonesia Vol. 3 No. 1 (2017): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Pengkajian pertama yang dilakukan pada bayi saat lahir yaitu dengan menggunakan nilai Apgar melalui pemeriksaanfisik singkat. Nilai Apgar yang menurun dapat menyebabkan asfiksia pada neonatus. Keadaan asfiksia dapatmenyebabkan ketidakseimbangan suhu tubuh dan terjadi hipotermia yang mengakibatkan berkurangnya aliranoksigen ke jaringan dan neonatus akan mengalami hipoglikemia. RSUP Dr. Mohammad Hoesin Palembang sebagairumah sakit pendidikan dan rujukan nasional belum memiliki data mengenai hubungan asfiksia dan hipoglikemia ini.Penelitian ini dilakukan untuk mengetahui lebih jauh mengenai hubungan derajat asfiksia dan kejadian hipoglikemiapada neonatus di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini adalah penelitian observasional analitikdengan menggunakan rancangan potong lintang (cross-sectional study). Sampel penelitian adalah seluruh rekammedik pasien neonatus di RSUP Dr. Mohammad Hoesin Palembang dari Januari 2015 sampai Desember 2015. Analisispada penelitian ini menggunakan uji Chi-square, bermakna apabila nilai p<α (α=0,05). Dari 106 neonatus, 84,9%adalah asfiksia ringan, diikuti berturut-turut oleh asfiksia sedang (13,2%), dan asfiksia berat (1,9%). Dari 90 neonatustidak asfiksia dan derajat asfiksia ringan didapatkan 35,6% neonatus hipoglikemia dan 64,4% neonatus tidakhipoglikemia. Derajat asfiksia sedang dan berat didapatkan 37,5% neonatus hipoglikemia dan 62,5% neonatus tidakhipoglikemia. Dari hasil penelitian, tidak terdapat hubungan bermakna antara derajat asfiksia dan kejadianhipoglikemia pada neonatus dengan p=1,000. Tidak terdapat hubungan bermakna antara derajat asfiksia dankejadian hipoglikemia pada neonatus di RSUP Dr. Mohammad Hoesin Palembang.
HUBUNGAN PENGETAHUAN, SIKAP DAN DUKUNGAN KELUARGA DENGAN IMUNISASI DASAR PADA BAYI Widia Wati; Erma Puspita Sari; Afifa Ramadanti; Diah Sukarni
Jurnal 'Aisyiyah Medika Vol 7, No 1: Februari 2022 Jurnal 'Aisyiyah Medika
Publisher : stikes 'aisyiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/jam.v7i1.786

Abstract

Latar Belakang: Imunisasi merupakan salah satu cara upaya preventif pencegahan penyakit melalui pemberian kekebalan tubuh. Hasil studi pendahuluan di Poskesdes Panang Jaya setelah dilakukan wawancara pada 10 ibu yang memiliki bayi, mayoritas ibu memiliki pengetahuan yang kurang tentang imunisasi, sikap yang kurang baik tentang imunisasi serta kurangnya dukungan keluarga terhadap imunisasi. Tujuan: Untuk mengetahui hubungan pengetahuan, sikap dan dukungan keluarga terhadap kelengkapan imunisasi dasar di Wilayah Kerja Poskesdes Panang Jaya. Metode: Penelitian menggunakan jenis survey analitik dengan pendekatan cross sectional yang dilakukan di Wilayah Kerja Poskesdes Panang Jaya Kecamatan Gunung Megang Kabupaten Muara Enim, pada bulan Agustus 2021. Populasi penelitian adalah ibu yang memiliki bayi usia > 9 bulan–12 bulan yang ada di Desa Panang Jaya berjumlah 39 orang, sampel penelitian menggunakan total populasi. Data dalam penelitian ini diperoleh dari wawancara menggunakan kuesioner dengan diuji statistik Chi-square. Hasil: Hasil penelitian dari uji statistik chi-square menunjukkan ada hubungan pengetahuan (p value 0,016), dan sikap (p value 0,047) dan tidak ada hubungan dukungan keluarga (p value 0,608) dengan imunisasi dasar. Saran: Diharapkan pada petugas kesehatan untuk dapat meningkatkan penyuluhan tentang imunisasi dan pendekatan persuasif pada ibu yang memiliki bayi agar dapat merubah persepsi ibu yang kurang baik terhadap imunisasi sehingga imunisasi dasar pada bayi didapat secara lengkap. Kata Kunci: Imunisasi Dasar, Pengetahuan, Sikap, Dukungan Keluarga
Faktor Risiko Kebocoran Udara Pulmonal pada Neonatus yang Dirawat di Ruang Perawatan Neonatus Intensif Rumah Sakit Mohammad Hoesin Palembang Afifa Ramadanti; Iman Hendarman
Sari Pediatri Vol 15, No 6 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp15.6.2014.403-7

Abstract

Latar belakang. Kebocoran udara pulmonal (KUP) merupakan akumulasi udara di luar paru yang dapat terjadi secara spontan/idiopatik atau sekunder. Faktor risiko terjadinya KUP pada neonatus adalah penyakit membran hialin, ventilasi mekanik, aspirasi mekonium, sepsis, pneumonia, dan malformasi kongenital.Tujuan. Menentukan faktor risiko KUP pada neonatus yang dirawat di ruang perawatan neonatal intensif Rumah Sakit Umum Mohammad Hoesin Palembang (RPNI-RSMH).Metode. Studi kasus-kontrol dengan data rekam medis dari bulan Januari 2007 sampai Desember 2010. Kelompok kasus adalah neonatus dengan KUP dan kelompok kontrol adalah neonatus sehat yang disesuaikan terhadap jenis kelamin, usia gestasi, dan berat badan. Analisis dilakukan secara bivariat dan multivariat.Hasil. Didapatkan 37 kasus dan 111 kontrol. Terdapat hubungan bermakna antara KUP dengan ventilasi tekanan positif (OR 5,625, CI 3,914-8,085), bronkopneumonia (OR 5,625, CI 3,914-8,085), sepsis neonatorum (OR 5,269, CI 3,728-7,447) dan hernia diafragmatika (OR 4,265, CI 3,178-5,723).Kesimpulan. Ventilasi tekanan positif (VTP), bronkopneumonia, sepsis neonatorum dan hernia diafragmatika merupakan faktor risiko KUP pada neonatus
Procalcitonin vs. the combination of micro-erythrocyte sedimentation rate and C-reactive protein for diagnosing neonatal bacterial sepsis Afifa Ramadanti; Renya Hiasinta; Herman Bermawi; Erial Bahar
Paediatrica Indonesiana Vol 57 No 4 (2017): July 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.643 KB) | DOI: 10.14238/pi57.4.2017.205-10

Abstract

Background Given the high rates of mortality and morbidity in neonatal sepsis, rapid, easy-to-use, and inexpensive biomarkers with high sensitivity and specificity are needed to diagnose neonatal sepsis. Procalcitonin is often used as a predictor in identifying neonatal sepsis, but C-reactive protein (CRP) and micro-erythrocte sedimentation rate (m-ESR) may also be valid biomarkers of neonatal sepsis.Objective To compare the accuracy of procalcitonin to the combination of CRP and m-ESR, as well as to find cut-off points for the three tests, in diagnosing bacterial neonatal sepsis.Methods Subjects were neonates hospitalized from July to October 2016 in Mohammad Hoesin Hospital, Palembang with sepsis at clinical presentation and healthy neonates with sepsis risk factors. All subjects underwent complete blood counts, CRP, m-ESR, blood cultures, and  procalcitonin examinations.Results Ninety-four infants were included, of whom 26 had proven sepsis. The combined values of m-ESR and CRP had 85% sensitivity, 59% specificity, and 66% accuracy. A procalcitonin (PCT) cut-off point of 9.7ng/mL showed 100% sensitivity, 96% specificity, and 97% accuracy level, which were significantly higher than the combined values of m-ESR and CRP.Conclusion The combined values of m-ESR (13 mm/hour) - CRP (17 mg/dL) and procalcitonin alone (2ng/mL) are both valid for the diagnosis of bacterial neonatal sepsis, but the accuracy of procalcitonin at 9.7ng/mL is significantly greater. 
Achievement of full enteral feeding using volume advancement in infants with birth weight 1,000 to Teti Hendrayanti; Afifa Ramadanti; Indrayady Indrayady; Raden Muhammad Indra
Paediatrica Indonesiana Vol 60 No 4 (2020): July 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.4.2020.173-7

Abstract

Background Early enteral feeding is one of the efforts to improve gastrointestinal adaptability in preterm infants. Volume advancement (VA) enteral feeding has been associated with less time to reach full feeding, which can improve outcomes. Objective To evaluate the duration of VA needed to achieve full enteral feeding (FEF) in low birth weight (LBW) and very low birth weight (VLBW) infants and related factors. Methods This prospective study was done in infants with birth weight 1,000 to <2,000 grams in the Neonatal Ward and NICU of Dr. Moh. Hoesin General Hospital, Palembang, South Sumatera. All infants underwent VA feeding. The time needed to achieve FEF (150 ml/kg/day) was recorded. Several clinical factors were analyzed for possible associations with the success rate of achieving FEF within 10 days of feeding. Results Thirty-five infants were included in this study with a mean gestational age of 31.83 (SD 2.67) weeks. Their median body weight at the start of protocol was 1,400 (range 1,000 – 1,950) grams and 80% had hyaline membrane disease. Median time to achieve FEF was 11 (range 8–21) days, with 48.6% subjects achieving FEF in <=10 days. Gestational age <32 weeks (OR 5.404, 95%CI 0.963 to 30.341), birth weight <1,500 grams (OR 5.248, 95%CI 0.983 to 28.003), and male (OR 4.751, 95%CI 0.854 to 26.437) gender were associated with the failure of achieving FEF within 10 days of feeding, however, no factors remained statistically significant after multivariate analysis. Conclusion Full enteral feedings in infants with birth weight 1,000 to <2,000 grams with VA feeding are achieved within a median of 11 days. Gestational age, birth weight, and gender are not associated with time needed to achieve FEF.
Diagnostic value of platelet indices for neonatal bacterial sepsis Ading Rohadi; Afifa Ramadanti; Indrayady Indrayady; Achirul Bakri
Paediatrica Indonesiana Vol 60 No 5 (2020): September 2020
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi60.5.2020.253-8

Abstract

Background Neonatal bacterial sepsis is a major cause of neonatal morbidity and mortality worldwide. Blood culture as a gold standard, as well as C reactive protein (CRP), micro erythrocyte sedimentation rate (micro ESR), white blood count (WBC), and immature-to-total (I/T) ratio as a sepsis screens are currently used methods, but their utility may be limited due to delayed reporting. Platelet indices are one of the parameters which can be helpful in the diagnosis of neonatal bacterial sepsis. Objective To evaluate the use of platelet indices, either alone or in combination, with other laboratory screening parameters to diagnose neonatal bacterial sepsis. Methods Neonates admitted to the Neonatal Unit of RSUP Dr. Muhammad Hoesin Hospital, Palembang, South Sumatera, and showing symptoms of sepsis were included in this study. Subjects underwent testing for blood culture, sepsis screen (CRP, micro ESR, WBC, I/T ratio), and platelet indices [platelet count, mean platelet volume (MPV), and platelet distribution width (PDW)]. Results The 107 neonates who fulfilled the inclusion criteria consisted of 42 neonates with proven bacterial sepsis (positive blood culture), 10 neonates with probable bacterial sepsis (positive sepsis screen and negative blood culture), and 55 with clinical bacterial sepsis (negative in both blood culture and sepsis screen). There were no significant differences in platelet count among the proven bacterial sepsis, probable bacterial sepsis, and clinical bacterial sepsis groups. Platelet count < 150,000/ml, PDW ³ 16.8 fL, MPV ³ 10.8 fL and combinations of the three, were highly specific markers for proven sepsis, with specificities of 92.3%, 97%, 75.4%, and 80%, respectively. However, all of these parameters were poor predictive markers for positive cultures in neonatal clinical bacterial sepsis, with sensitivities of 19%, 7.1%, 35.7%, and 23.8%, respectively. Conclusion Platelet indices have high specificity but low sensitivity for the prediction of proven neonatal bacterial sepsis.
Music for pain in healthy neonates Nessie Amelia Ramli; Afifa Ramadanti; Indrayady Indrayady; Yuli Doris Memy
Paediatrica Indonesiana Vol 61 No 2 (2021): March 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.2.2021.69-73

Abstract

Background The neonatal pain threshold is 30-50% lower than in adults and older children because of immature pain inhibition function in nervous centers. Acute pain in neonates results in behavioral, physiological, and cerebral blood flow changes that may lead to intraventricular bleeding and periventricular leukomalacia. Music is believed to reduce pain perception as it distracts, influencing the parasympathetic and sympathetic nervous system by decreasing pulse rate, blood pressure, and breathing, hence, promoting a relaxed state. Objective To evaluate effects of music intervention on physiological parameters and pain perception in healthy newborns undergoing a painful medical procedure (immunization injection). Methods This was a double-blind, randomized control trial study. A recorded instrumental lullaby “Nina Bobo” was given for 5 minutes to the music group and no music for control, prior injection of Hepatitis B 0. The evaluation of heart rate and SpO2 were performed at baseline, 30 seconds, and 5 minutes after injection. Pain perception were measured by Neonatal Infant Pain Scale (NIPS) at 30 seconds and 5 minutes after injection. Results Total of 51 subjects were enrolled. There were no difference of SpO2 and NIPS between both music and control groups. Music improved heart rate after 30 seconds and 5 minutes after injection, median 126 (range 55-149) bpm from median 136 (range 78-154) bpm, and even lower than baseline [mean 128.9 (SD 12.5) bpm; P=0.019]. The control showed no improvement of heart rate mean 124,34 (SD 18,45) from 124,73 (SD 18,39); P=0.875There were no significant differences between the 2 groups. Conclusion Music is not effective in improving oxygen saturation, heart rate, and is not effective in reducing the degree of pain.
Ceftazidime as an empiric therapy for neonatal sepsis Indrayady Indrayady; Afifa Ramadanti; Yulia Iriani; Herka Pratama Putra
Paediatrica Indonesiana Vol 61 No 4 (2021): July 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.4.2021.198-204

Abstract

Background Sepsis is still the leading cause of death in neonates in developing countries. Proper administration of antibiotics is important for managing neonatal sepsis. The microorganisms that cause neonatal sepsis, as well as their sensitivity patterns, change over time and differ from one place to another. Since 2001, ceftazidime has been used as an empirical antibiotic for managing neonatal sepsis at Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera, but its effectiveness is questionable. Objective To evaluate the effectiveness of ceftazidime as an empiric therapy for neonatal sepsis. Methods This study was pre-experimental, for one group, pre- and post-test, was conducted in 49 neonates with neonatal sepsis in the Neonatal Ward at Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera, from April to September 2019. The effectiveness of ceftazidime was determined based on clinical and laboratory improvements 72 hours after ceftazidime administration. Results Of 49 neonates, 28 experienced clinical and laboratory improvement, while 21 experienced improvement in only one parameter, either clinical or laboratory. Gram positive bacteria were found in 22/49 subjects. Conclusion There is a significant difference on white blood cell count and CRP level between before and after ceftazidime administration but overall ceftazidime is no longer effective as empiric antibiotic therapy in neonatal sepsis.
Co-Authors Achirul Bakri Ading Rohadi Akbari, Atika AMALIAH, LISSABERTI Andrina, Hana Deny Salverra Yosy, Deny Salverra Diah Sukarni Elsi, Yuanita Rimadini Erial Bahar ERMA PUSPITA SARI Fauzi, Moretta Damayanti Henni Maulani Herka Pratama Putra Herman Bermawi Hertanti Indah Lestari Hertanti Indah Lestari, Hertanti Indah Iman Hendarman Indra Saputra Indra, Raden Muhammad Indrayady Indrayady Indrayady, Indrayady Julius Anzar, Julius Latifah, Murwani Emasrissa Lumbantoruan, Regina Paranggian Mariana Audini Maulani, Henni Nessie Amelia Ramli Novianesari, Putri H Nuswil Bernolian Peby Maulina Lestari, Peby Maulina Putri H Novianesari Raden Muhammad Indra Regina Paranggian Lumbantoruan Renya Hiasinta Ria Nova, Ria Santika Sari Stevanny, Bella Sutrisno, Muhammad Al Farisi Teti Hendrayanti Theodorus Theodorus Theodorus Theodorus Widia Wati Yuli Doris Memy Yulia Iriani, Yulia