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All Journal Majalah Kedokteran Bandung Majalah Obstetri dan Ginekologi
R. Muharam
Medical Faculty of Indonesia University Jakarta
Health Professions Medicine & Pharmacology

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Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF Pratama, Gita; Agustina, Elizabeth; Yanfaunnas, Atika Mahira; Maidarti, Mila; Harzif, Achmad Kemal; Muharam, R.; Wiweko, Budi
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.174-180

Abstract

HIGHLIGHTS It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium. The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs.   ABSTRACT Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium. Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study was carried out in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) was performed if the endometrium reached adequate thickness (minimum 7 mm). Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%. Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer.
Prevalence, Severity, and Self-Medication for Dysmenorrhea among Female Adolescents in Indonesia Zulimartin, Handika; Harzif, Achmad Kemal; Shadrina, Amalia; Harahap, Juliana Sari; Tanjung, Anton; Muharam, R.
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Dysmenorrhea, commonly referred to as menstrual pain, is a prevalent condition affecting many reproductive-aged women, particularly female adolescents, with varying degrees of intensity. Dysmenorrhea affects 64.5% of female adolescents in Indonesia, with the highest prevalence rates found in West Java (98.8%) and Jakarta (87.5%). Over the years, various therapy modalities have been developed for treating this condition based on its pathophysiology. However, in Indonesia, a country renowned for its rich natural resources and medicinal herbs, there is a prevailing belief in the efficacy of traditional medicine. Female adolescents in Indonesia are often engaged in self-medication practices, combining traditional medicine with nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to analyze the prevalence, severity, and self- medication practices for dysmenorrhea among female adolescents in Indonesia. The study was conducted from January to December 2020 using an online survey that included questions about menstrual pain, family history, and the use of traditional medicine and NSAIDs. This study comprised 362 participants recruited through convenience sampling. Results showed that 92.5% of participants experienced dysmenorrhea with varying degrees of pain. A total of 216 (59.9%) female adolescents experienced frequent dysmenorrhea, while 118 (32.6%) reported experiencing this condition every menstrual cycle. Of all participants, 33.1% used traditional medicine as a treatment option, and 16.9% used NSAIDs. According to the self-reported visual analog scale (VAS), the use of natural remedies, such as traditional medicine, was associated with lower pain levels, suggesting their potential benefits in healthcare services for dysmenorrhea.
Co-Authors Achmad Kemal Harzif Agustina, Elizabeth Budi Wiweko Gita Pratama Harahap, Juliana Sari Mila Maidarti Shadrina, Amalia Tanjung, Anton Yanfaunnas, Atika Mahira Zulimartin, Handika