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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Science Midwifery Current Research on Biosciences and Biotechnology eJournal Kedokteran Indonesia Makara Journal of Health Research Journal of Global Pharma Technology

Gita Pratama

Departemen Kebidanan Dan Penyakit Kandungan, Fakultas Kedokteran, Universitas Indonesia, Rumah Sakit Cipto Mangunkusumo, Jakarta; Human Reproductive, Infertility And Family Planning Research Center, Indonesia Medical Education And Research Institute

Author-ID : 345900

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Association between Menstrual Disorder and Work Disturbance among Employees Nuranna, Laila; Abdullah, Iftikar; Kayika, I. Putu G.; Pratama, Gita
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the association between menstrualdisorders including each menstrual cycle disorder, durationand volume of menstrual bleeding disorder, menstrual intervaldisorder, and another disorder that related to menstruationagainst disruption of work among employees.Methods: This study used a cross sectional design. Samplerandomization with winpepi® software for Windows 7®. Dataanalysis using SPSS 24® software for Windows 7®.Results: A total of 150 subjects were recruited in this study. Theprevalence of menstrual disorder was 87%, menstrual cycledisorder 3%. Menstrual volume disorder 31%, 15% menstrualabnormalities, 83% menstrual pain disorder and premenstrualsyndrome 71%. Prevalence of work disturbance was 49% formild disturbance, 47% for moderate disturbance and severework disturbance by 4%. There was a relationship betweenmenstrual volume disorder, hypermenorrhoea, and menstrual /dysmenorrhoea pain to occupational disruption among theemployee at RSCM (p <0.001). The submission of the proposedleaves due to menstrual disorder in the proposed permit for1 day by 73%.Conclusion: The prevalence of severe work disturbance due tomenstruation is not high but can lead to disruption in runningjobs and activities. However, it is important to be a concern so thatthe employees get good management and care.Keywords: employee, menstrual leave, menstrual disorder, prevalence,work disturbance

The Outcome on Conservative Surgical Treatment of Adenomyosis Wiweko, Budi; Legiantuko, Ario; Kemal, Achmad; Pratama, Gita; Situmorang, Herbert; Sumapraja, Kanadi; Natadisastra, Muharam; Hestiantoro, Andon
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To understand the outcome on conservative surgical treatment of adenomyosis. Methods: A retrospective cohort study followed for 2 years from 2010 to 2012 of women with adenomyosis were diagnosed by transvaginal sonography and confirmed histologically. Subjects divided into women who were treated by adenomyosis resection (with/without Osada’s technique) and who were underwent hysterectomy. Results: After the surgery, as many as 40 patients (81.63%) did not feel any pain (VAS 0), and 9 patients (18.37%) still felt pain. For the fertility outcome, we had 8 patients (20.51%) getting pregnant naturally without any fertility intervention. Two patients (5.13%) had successfully conceived by IVF. According to the type of surgery, from 8 natural pregnancy, 7 patients (87.50%) was underwent conventional resection of adenomyosis and 1 patients (12.50%) underwent Osada’s procedures. Two patients who were conceived by IVF, both of them were underwent Osada’s resection. Conclusion: Adenomyosis resection both conservative or Osada’s procedures actually has a better outcome for relieving pain; therefore, some patients can still have a child. Keywords: adenomyosis resection, conventional resection, infertility, Osada’s procedure

The Outcome on Conservative Surgical Treatment of Adenomyosis Budi Wiweko; Ario Legiantuko; Achmad Kemal; Gita Pratama; Herbert Situmorang; Kanadi Sumapraja; Muharam Natadisastra; Andon Hestiantoro
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To understand the outcome on conservative surgical treatment of adenomyosis. Methods: A retrospective cohort study followed for 2 years from 2010 to 2012 of women with adenomyosis were diagnosed by transvaginal sonography and confirmed histologically. Subjects divided into women who were treated by adenomyosis resection (with/without Osadaâ€™s technique) and who were underwent hysterectomy. Results: After the surgery, as many as 40 patients (81.63%) did not feel any pain (VAS 0), and 9 patients (18.37%) still felt pain. For the fertility outcome, we had 8 patients (20.51%) getting pregnant naturally without any fertility intervention. Two patients (5.13%) had successfully conceived by IVF. According to the type of surgery, from 8 natural pregnancy, 7 patients (87.50%) was underwent conventional resection of adenomyosis and 1 patients (12.50%) underwent Osadaâ€™s procedures. Two patients who were conceived by IVF, both of them were underwent Osadaâ€™s resection. Conclusion: Adenomyosis resection both conservative or Osadaâ€™s procedures actually has a better outcome for relieving pain; therefore, some patients can still have a child. Keywords: adenomyosis resection, conventional resection, infertility, Osadaâ€™s procedure

The Association between Menstrual Disorder and Work Disturbance among Employees Laila Nuranna; Iftikar Abdullah; I. Putu G. Kayika; Gita Pratama
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the association between menstrualdisorders including each menstrual cycle disorder, durationand volume of menstrual bleeding disorder, menstrual intervaldisorder, and another disorder that related to menstruationagainst disruption of work among employees.Methods: This study used a cross sectional design. Samplerandomization with winpepiÂ® software for Windows 7Â®. Dataanalysis using SPSS 24Â® software for Windows 7Â®.Results: A total of 150 subjects were recruited in this study. Theprevalence of menstrual disorder was 87%, menstrual cycledisorder 3%. Menstrual volume disorder 31%, 15% menstrualabnormalities, 83% menstrual pain disorder and premenstrualsyndrome 71%. Prevalence of work disturbance was 49% formild disturbance, 47% for moderate disturbance and severework disturbance by 4%. There was a relationship betweenmenstrual volume disorder, hypermenorrhoea, and menstrual /dysmenorrhoea pain to occupational disruption among theemployee at RSCM (p <0.001). The submission of the proposedleaves due to menstrual disorder in the proposed permit for1 day by 73%.Conclusion: The prevalence of severe work disturbance due tomenstruation is not high but can lead to disruption in runningjobs and activities. However, it is important to be a concern so thatthe employees get good management and care.Keywords: employee, menstrual leave, menstrual disorder, prevalence,work disturbance

The Role of Stem Cells in Obstetrics and Gynecology Gita Pratama
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 1 January 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Wharton’s Jelly Derived Mesenchymal Stem Cells: A Comparison Study in Preterm vs. Term Deliveries and in FBS vs. PRP vs Mesencult Culture Media Gita Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Use of human mesenchymal stem cells (MSCs) for therapy in the field of degenerative medicine has been extensively studied. One of the potential sources of MSC which is easily available is from the human umbilical cords Wharton’s jelly of the newborn baby. Wharton's jelly derived MSCs (WJ-MSCs) from full-term labor has been isolated and differentiated, but very limited data came from preterm labor. This study aimed to compare the proliferation and differentiation characteristics between human WJ-MSCs from preterm and term labor using xeno-free culture media, particularly platelet rich plasma (PRP). Methods: WJ-MSCs from preterm and term deliveries was cultured using culture medium supplemented with 10% PRP or MSC or FBS culture media. Cells were cultured until the fifth passages. Cumulative cell numbers and differentiation capacity of the MSCs was tested according to International Society for Cellular Therapy (ISCT) criteria. Results: The preterm WJ-MSCs grown in culture media is not significant differences with WJ-MSCs derived from full-term labor, but have higher number of cell populations. WJ-MSCs are able to differentiate into osteocyte, chondrocyte and adipocyte., and xeno-free media can be used to replace FBS. WJ J-MSCs from preterm labor can be used as a source for mesenchymal stem cells. Conclusion: WJ-MSCs collected from preterm samples to have a better proliferation rate compared to term samples, while possessing equal differentiation capacity. In addition, PRP can replace FBS as it a xeno-free material for WJ-MSCs production that required for regenerative medicine. Keywords: Mesenchymal stem cells, Wharton’s jelly, Preterm labor, Proliferation, Differentiation.

Comparison of the effect of Sumbawa honey and sucrose as extracellular cryoprotectants on viability, morphology, and phenotype stability of CD34+ hematopoietic stem cells from umbilical cord blood Samuel Febrian Wijaya; Retno Lestari; Inna Rahmawati; Imelda Rosalyn Sianipar; Robby Nuraditya; Iqbal Fasha; Gita Pratama; Radiana Dhewayani Antarianto
Current Research on Bioscences and Biotechnology Vol. 5 No. 1 (2023)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2023.5.1/CBWGKPBX

Cryopreservation is a common practice for the long-term storage and maintenance of the quality of Hematopoietic Stem Cells (HSC) from Umbilical Cord Blood (UCB). Cryomedium containing 10% DMSO is the standard intracellular cryoprotectant agent (CPA) in HSC cryopreservation. However, DMSO is toxic to both cells and patients during transplantation. Therefore, the concentration of DMSO needs to be reduced by adding extracellular CPAs, such as sucrose or Sumbawa honey. The objective of this study was to compare the ability of Sumbawa honey and sucrose as extracellular CPAs to protect HSC CD34+ during cryopreservation. This in vitro study was designed using cryomedium consisting of 10% DMSO as a control, 5% DMSO + 5% Sumbawa honey, and 5% DMSO + 5% sucrose. The results showed that the cryoprotectant containing 5% DMSO + 5% Sumbawa honey had a positive effect and a significant difference (p<0.05) compared with 5% DMSO + 5% sucrose on the viability and morphology of HSC. However, the mean reduction in phenotype stability as indicated by the decrease in percentage CD34+ in the 10% DMSO (6.90 Â± 8.60), 5% DMSO + 5% sucrose (10.60 Â± 9.20), and 5% DMSO + 5% Sumbawa honey (8.60 Â± 11.50) showed no significant difference (p>0.05). In conclusion, the combination of DMSO and Sumbawa honey was able to maintain the viability, morphology, and phenotype stability of HSC. Therefore, honey can be used as an alternative cryoprotectant for the cryopreservation of hematopoietic stem cells.

Anti-Müllerian Hormone Levels as Predictor of In Vitro Fertilization Outcomes Mila Maidarti; Prini Diandara Garinasih; Aprilia Asthasari Siregar; Gita Pratama; Achmad Kemal Harzif; Kanadi Sumapraja; Budi Wiweko
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

A decrease in serum anti-müllerian hormone (AMH) concentration suggests the reduction of antral follicle number. AMH serum level was correlated with ovarian stimulation outcomes, oocyte quantity and quality, embryo quality and in vitro fertilization (IVF) outcomes. However, the use of AMH to predict pregnancy rates in IVF is still debatable. This study aimed to determine the role of AMH in predicting ovarian response and pregnancy rates in IVF programs. This was a retrospective cohort study involving patients who underwent a short protocol of ovarian stimulation for IVF at the Yasmin clinic, dr Cipto Mangunkusumo General Hospital. from March 2013 to March 2021. A total of 1,527 out of 3,880 IVF cycles were included. Poor ovarian response was determined as a collection of fewer than four oocytes following ovarian stimulation. The data was then analyzed using the Mann Whitney test if the data distribution was not normal or the unpaired t-test if the data distribution was normal. Median AMH levels were higher in the normal (2.5(0.01-32)) compared to poor responder (0.68(0.01-6.86)) group (p<0.05; Mann Whitney). Serum AMH level and age had predictive value for pregnancy rate (p<0.05; Mann Whitney). Keywords: AMH, ovarian response, pregnancy rate, IVF. Kadar Hormon Anti-Müllerian sebagai Prediktor Luaran Fertilisasi in Vitro Abstrak Penurunan konsentrasi serum hormon anti-müllerian (HAM) menunjukkan penurunan jumlah folikel antral. HAM serum berkorelasi dengan luaran stimulasi ovarium kuantitas dan kualitas oosit serta kualitas embrio dan luaran fertilisasi in vitro (FIV). Namun, penggunaan HAM untuk memprediksi angka kehamilan dengan stimulasi ovarium pada FIV masih diperdebatkan. Tujuan penelitian ini untuk mengetahui peran serum HAM dalam memprediksi respons ovarium dan laju kehamilan pada program FIV. Penelitian ini adalah studi kohort retrospektif yang melibatkan pasien yang menjalani protokol singkat stimulasi ovarium pada program FIV di klinik Yasmin rumah sakit dr Cipto Mangunkusumo.dari bulan Maret 2013 sampai Maret 2021. Sebanyak 1.527 dari 3880 siklus IVF dimasukkan ke dalam penelitian. Dikatakan perespon buruk apabila diperoleh kurang dari empat oosit setelah stimulasi ovarium. Data kemudian dianalisis dengan menggunakan uji Mann Whitney bila sebaran data tidak normal atau uji t tidak berpasangan bila sebaran data normal. Median kadar HAM lebih tinggi pada kelompok perespons baik (2.5 (0.01-32)) dibandingkan perespons buruk (0.68 (0.01-6.86)) (p<0,05; Mann Whitney). Kadar HAM serum dan usia memiliki nilai prediktif terhadap angka kehamilan (p<0,05; Mann Whitney). Kata kunci: hormon anti-Müllerian, respons ovarium, angka kehamilan, FIV.

Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF Pratama, Gita; Agustina, Elizabeth; Yanfaunnas, Atika Mahira; Maidarti, Mila; Harzif, Achmad Kemal; Muharam, R.; Wiweko, Budi
Majalah Obstetri & Ginekologi Vol. 32 No. 3 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V32I32024.174-180

HIGHLIGHTS It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium. The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs. ABSTRACT Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium. Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study was carried out in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) was performed if the endometrium reached adequate thickness (minimum 7 mm). Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%. Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer.

Comparison of natural versus artificial cycles for endometrial preparation prior to frozen embryo transfer Tyagitha, Galuh Anindya; Nuryanto, Kartiwa Hadi; Pratama, Gita; Maidarti, Mila; Harzif, Achmad Kemal; Sumapraja, Kanadi; Lestari, Silvia Werdhy; Ampri, Irfan Arieqal Hatta; Talya, Natasha; Yanfaunas, Atika Mahira
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.304-312

BackgroundThe endometrial preparation phase preceding embryo transfer assumes pivotal significance in achieving optimal endometrial receptivity and ensuring the success of pregnancy. The natural cycle (NC) and artificial cycle (AC) are the preferred methods for many in vitro fertilization (IVF) specialists. The objective of this study was to compare the difference between NC and AC in women undergoing frozen-thawed embryo transfer (FET) after IVF. MethodsA cross-sectional study was conducted involving 150 adult women who underwent FET with a single autologous blastocyst stage embryo in a 5-year period (2014-2019). Bivariate analysis was conducted to discern implantation and pregnancy rates associated with NC and AC for endometrial preparation. Multiple logistic regression was used to assess the association between endometrial preparation and clinical outcomes while adjusting for potential confounders. ResultsOf the 150 subjects meeting study criteria, 19 underwent NC, while 131 underwent AC for endometrial preparation. Natural cycle exhibited a higher biochemical pregnancy rates compared to AC (89.5% vs. 53.4%; p=0.003). Artificial cycle is a significant determinant for biochemical pregnancy rates compared to NC (aOR: 0.132;95% CI: 0.028 – 0.623; p=0.010) ConclusionIn women undergoing FET, NC resulted in higher biochemical pregnancy rates compared to AC. However, clinical pregnancy rates and ongoing pregnancies rates did not exhibit significant disparities between NC and AC. Future studies will hopefully further illuminate which protocol is most suitable for the individual patient. Further multi-center randomized clinical trials are needed to confirm the relationship between biochemical pregnancy rates and NC.

Co-Authors Abdullah, Iftikar Achmad K. Harzif Achmad K. Harzif Achmad Kemal Achmad Kemal Harzif Ade Pryta Romanauli Simaremare Agustina, Elizabeth Aldri Frinaldi Ampri, Irfan Arieqal Hatta Andon Hestiantoro Angeline, Wiedya Kristianti Aprilia Asthasari Siregar Ario Legiantuko Asmarinah Bagastoro, Aswan Budi Wiweko Caroline G. Puspita Christine Verawaty Sibuea Christopher Yo, Edward Eva Zakiyah Faradina, Anindita Abigail Fasha, Iqbal Ferry Sandra Ginting, Kharnis Marsha Madora Hari Kurniawan, Riyan Hartanto Bayuaji Herbert Situmorang Herbert Situmorang I. Putu G. Kayika Iftikar Abdullah Imelda Rosalyn Sianipar Indah S. Widyahening Inna Rahmawati Iqbal Fasha Irzanti, Alisha Nurdya Kanadi Sumapradja Kartiwa Hadi Nuryanto Kayika, I. Putu G. Kemal, Achmad Kuara , Glenessa Laila Nuranna Laila Nuranna Legiantuko, Ario Lestari, Silvia Werdhy Mila Maidarti Muharam, R mutiara mutiara Nuraditya, Robby Nurdya Irzanti, Alisha Prasetya, David Eka Prini Diandara Garinasih R. Muharam Raden Muharam Natadisastra Radiana Dhewayani Antarianto Rahmawati, Inna Raymond R. Tjandrawinata Retno Lestari Retno Lestari Robby Nuraditya Samosir, Sarah Christina Samuel Febrian Wijaya Saraswati, Jaya Silaen, Rachel Teodora Silvana, Vita Silvia Werdhy Lestari Sitanggang, Ervina Julien Talya, Natasha Trinovita Andraini Tyagitha, Galuh Anindya Wijaya, Samuel Febrian Yana, Hiqmah Yusi Yanfaunas, Atika Mahira Yanfaunnas, Atika Mahira Yo, Edward Christopher

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