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All Journal JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Medical Sains : Jurnal Ilmiah Kefarmasian Journal Transformation of Mandalika Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Media, Sciences and Education
I Gusti Ayu Agung Septiari
Universitas Bali Internasional
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Economics, Econometrics & Finance Education Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Other

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PENGARUH VARIASI CARBOMER DAN GLISERIN TERHADAP KUALITAS HAND SANITIZER EKSTRAK ALOE VERA: THE EFFECT OF VARIATIONS OF CARBOMER AND GLISERIN ON THE QUALITY OF HAND SANITIZER ALOE VERA EXTRACT I Gusti Ngurah Agung Windra Wartana Putra; I Putu Gede Adi Purwa Hita; I Gusti Ayu Agung Septiari; Ida Ayu Manik Partha Sutema
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 6 No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.66 KB) | DOI: 10.37874/ms.v6i2.310

Abstract

Kondisi pandemi COVID-19 membuat penggunaan hand sanitizer dimasyarakat menjadi meningkat. Kepraktisan merupakan salah satu alasan masyarakat lebih mengunakan sediaan antiseptik hand sanitizer dibanding membersihkan tangan dengan sabun dan air mengalir. Tingginya penggunaan hand sanitizer membuat perlu adanya inovasi produk sehingga dapat memberikan kepuasan masyarakat yang lebih maksimal. Inovasi yang sering dilakukan oleh formulator adalah inovasi formula yang terkait pembaharuan bahan bahan dalam sediaan untuk meningkatkan kualitas dari suatu produk. Dalam melakukan inovasi, perlu melewati berbagai  tahapan tahapan pengujian untuk mengetahui sifat fisika dan kimia dari sediaan sehingga didapatkan sediaan  hand sanitizer yang berkualitas. Penelitian ini merupakan tahapan pendahuluan dalam inovasi yang bertujuan untuk mengetahui pengaruh yang dominan dari formula gelling agent carbomer dan humektan gliserin terhadap sifat fisika dan kimia dari hand sanitizer gel ekstrak lidah buaya. Penelitian ini termasuk penelitian eksperimental dimana dibuat 8 formula dengan variasi gelling agent carbomer dan humektan gliserin. Kemudian dilakukan pengukuran sifat fisika dan kimia seperti viskositas, daya sebar dan pH.  Data dari hasil sifat viskositas sediaan gel menghasilkan persamaan polinomial Y = 85148.37(A) + 109.16 (B) – 32936.27 (A)(B).  Dari sifat daya sebar sediaan gel menghasilkan persamaan polinomial Y = -17.63 (A) + 6.69 (B) + 4.60 (A)(B). Dari hasil uji pH ke 8 formula, rata rata nilai pH yang didapat yaitu 6.8. Dari hasil penelitian dapat diperoleh kesimpulan yaitu komponen carbomer memberikan pengaruh yang dominan dibanding komponen gliserin terhadap kenaikan viskositas gel dengan nilai koefisien pengaruh sebesar 85.148.37 dan memberikan pengaruh negatif terhadap nilai daya sebar gel dengan nilai koefisien pengaruh sebesar -17.63.
GAMBARAN PENGGUNAAN COMPLEMENTARY ALTERNATIVE MEDICINE (CAM) PADA PASIEN HIPERTENSI DI WILAYAH KERJA PUSKESMAS BLAHBATUH II Ni Nyoman Ayu Devi Suyeni; I Gusti Ayu Agung Septiari; Ni Made Maharianingsih
JOURNAL SCIENTIFIC OF MANDALIKA (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 4 No. 9 (2023): September
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol4iss9pp164-172

Abstract

Hypertension is an increase in a person's systolic blood pressure ≥ 140 mmHg and diastolic ≥ 90 mmHg. The importance of hypertension sufferers to control blood pressure to prevent cardiovascular risk, one of which is the non-pharmacological alternative of Complementary Alternative Medicine (CAM). This study aims to describe the use of CAM in hypertensive patients in the working area of ​​the Blahbatuh II Health Center. This research method is a non-experimental quantitative descriptive study with a cross-sectional method. The results of this study found that the most use of CAM for the treatment of hypertension in the working area of ​​the Blahbatuh II Health Center were women (59.6%), aged 56-65 years (51.4%), high school education (42.2%), most of them not working/household (33.9%), income ≤ Rp. 2,627,000 (39.4%), suffer from hypertension for 1-5 years (76.1%), have no family history of hypertension (56.9%), hypertension medication, namely amlodipine (52.3%), drinking schedule every day (45.9%). Respondents used CAM since diagnosis (66.1%), CAM was combined with conventional drugs (62.5%) and was recommended by the family (45.8%), the reason that using CAM was very trusting CAM (47.2%), and the reasons for not using CAM were the reasons doctors did not recommend (54.1%), felt a positive effect (94.4%) and were satisfied (94.4%) using CAM. The most common types of CAM were biological therapy in the form of herbs (56.9%), the frequency of using CAM once a day (45.8%), the types of plants used were celery and starfruit (19.5%), plant parts namely leaves (41.5%), the method of processing is boiled first (61%), with a dose of one glass (48.8%) and the use of herbal medicine is taken orally (80.5%). The conclusion of this study was that the sociodemographic characteristics of the use of CAM were mostly aged 56-65 years (51.4%), female sex (59.6%), last education SMK/SMA (42.2%), and the use of CAM was mostly used since suffering from hypertension as many (66.1%) of respondents with the most types of CAM namely biological therapy in the form of herbs (56.9%).
PENGARUH VARIASI CARBOMER DAN GLISERIN TERHADAP KUALITAS HAND SANITIZER EKSTRAK ALOE VERA: THE EFFECT OF VARIATIONS OF CARBOMER AND GLISERIN ON THE QUALITY OF HAND SANITIZER ALOE VERA EXTRACT I Gusti Ngurah Agung Windra Wartana Putra; I Putu Gede Adi Purwa Hita; I Gusti Ayu Agung Septiari; Ida Ayu Manik Partha Sutema
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 6 No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v6i2.310

Abstract

Kondisi pandemi COVID-19 membuat penggunaan hand sanitizer dimasyarakat menjadi meningkat. Kepraktisan merupakan salah satu alasan masyarakat lebih mengunakan sediaan antiseptik hand sanitizer dibanding membersihkan tangan dengan sabun dan air mengalir. Tingginya penggunaan hand sanitizer membuat perlu adanya inovasi produk sehingga dapat memberikan kepuasan masyarakat yang lebih maksimal. Inovasi yang sering dilakukan oleh formulator adalah inovasi formula yang terkait pembaharuan bahan bahan dalam sediaan untuk meningkatkan kualitas dari suatu produk. Dalam melakukan inovasi, perlu melewati berbagai  tahapan tahapan pengujian untuk mengetahui sifat fisika dan kimia dari sediaan sehingga didapatkan sediaan  hand sanitizer yang berkualitas. Penelitian ini merupakan tahapan pendahuluan dalam inovasi yang bertujuan untuk mengetahui pengaruh yang dominan dari formula gelling agent carbomer dan humektan gliserin terhadap sifat fisika dan kimia dari hand sanitizer gel ekstrak lidah buaya. Penelitian ini termasuk penelitian eksperimental dimana dibuat 8 formula dengan variasi gelling agent carbomer dan humektan gliserin. Kemudian dilakukan pengukuran sifat fisika dan kimia seperti viskositas, daya sebar dan pH.  Data dari hasil sifat viskositas sediaan gel menghasilkan persamaan polinomial Y = 85148.37(A) + 109.16 (B) – 32936.27 (A)(B).  Dari sifat daya sebar sediaan gel menghasilkan persamaan polinomial Y = -17.63 (A) + 6.69 (B) + 4.60 (A)(B). Dari hasil uji pH ke 8 formula, rata rata nilai pH yang didapat yaitu 6.8. Dari hasil penelitian dapat diperoleh kesimpulan yaitu komponen carbomer memberikan pengaruh yang dominan dibanding komponen gliserin terhadap kenaikan viskositas gel dengan nilai koefisien pengaruh sebesar 85.148.37 dan memberikan pengaruh negatif terhadap nilai daya sebar gel dengan nilai koefisien pengaruh sebesar -17.63.
Aktivitas antibakteri mucus siput darat (terestrial snails): review I Gusti Ayu Agung Septiari; Ni Putu Aryati Suryaningsih
Journal Transformation of Mandalika, e-ISSN: 2745-5882, p-ISSN: 2962-2956 Vol. 7 No. 5 (2026): Mei
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jtm.v7i5.1796

Abstract

Antibiotic resistance is one of the major health problems faced by many countries around the world. Due to the urgency of antibiotic resistance, efforts to identify new lead compounds from novel sources and analyses to determine their bioactivity are highly needed for antibiotic development. One of the invertebrate organisms studied for its potential to produce secondary metabolites with antibacterial properties is the class Gastropoda within the phylum Mollusca. Gastropods consist of more than 80 thousand species and differ from other classes in the phylum Mollusca due to their torsioned body. Gastropods have three subclasses, namely Prosobranchia, Opisthobranchia, and Pulmonata. One of the terrestrial gastropod species is snails, which include those with shells (snails) and shell-less snails (slugs), belonging to the subclass Pulmonata. Mucus from snails is utilized as traditional medicine and as an innovative natural product to treat various health problems. Since Gastropoda includes a large number of species distributed across various ecosystems, but research on the antibacterial potential of their secondary metabolites is still limited, this review aims to summarize studies exploring the antibacterial effects of secondary metabolites in the mucus produced by terrestrial gastropod species, particularly various species of terrestrial shelled snails (terrestrial snails). The preparation of this review article uses a literature study method with a systematic approach. The articles used are international articles discussing the antibacterial activity of secondary metabolites in the mucus produced by terrestrial shelled snails (snails). Articles were obtained from the PubMed database using the keywords snails AND antibacterial from the period 2000 to 2023; the period before 2000 was excluded due to the very limited number of articles. The results obtained from the journal review indicate the presence of bioactive components such as peptides, glycopeptides, and other secondary metabolites found in the mucus of several terrestrial snail species. These bioactive components exhibit antibacterial activity against both gram-positive and gram-negative bacteria.
Antibacterial Activity of Terrestrial Snail Mucus: A Review I Gusti Ayu Agung Septiari; Ni Putu Aryati Suryaningsih
Jurnal Pengetahuan dan Pendidikan Vol 3 No 2 (2024)
Publisher : Yayasan Baru Haji Samsudin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotic resistance is one of the major health problems faced by various countries in the world. Due to the urgency of the antibiotic resistance problem, efforts to identify new lead compounds from new sources and analysis to determine their bioactivity are urgently needed for antibiotic development. One of the invertebrate organisms studied in relation to its potential to produce secondary metabolites that have antibacterial properties is the Gastropoda class which is included in the Mollusca phylum. Gastropoda consists of more than 80 thousand species and differs from other classes in the Mollusca phylum because of its torso body. Gastropoda has 3 sub-classes, namely: Prosobranchia, Opistobranchia, and Pulmonata. One of the land Gastropod species is snails, both those with shells (snails) and naked snails (slugs) which are included in the Pulmonata sub-class. Snail mucus is used as a traditional medicine and also as an innovative natural product to treat various health problems. Since Gastropods include a large number of species that live in various ecosystems, but research on the antibacterial potential of their secondary metabolites is still limited, this review aims to summarize research that explores the antibacterial effects of secondary metabolites in mucus produced by species in the class of Gastropods that live on land (terrestrial gastropoda) especially various species of terrestrial snails. The preparation of this review article uses a literature study method with a systematic approach. The articles used are international articles that discuss the antibacterial activity of secondary metabolites in mucus produced by snails. Articles were obtained from the PubMed database using the keywords snails AND antibacterial from the period 2000 to 2023, the period before 2000 was excluded due to the very minimal number of articles. The results obtained from the journal review that has been carried out are the presence of bioactive components such as peptides, glycopeptides, and other secondary metabolites found in the mucus of several species of land snails. These bioactive components have antibacterial activity against gram-positive and gram-negative bacteria.
Co-Authors I Putu Gede Adi Purwa Hita Ni Made Maharianingsih Ni Nyoman Ayu Devi Suyeni Ni Putu Aryati Suryaningsih Sutema, Ida Ayu Manik Partha Wartana Putra, I Gusti Ngurah Agung Windra