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PERBANDINGAN JUMLAH LEUKOSIT PADA PENDERITA TUBERKULOSIS SEBELUM DAN SESUDAH PENGOBATAN OBAT ANTI TUBERKULOSIS FASE INTENSIF Purwaeni Purwaeni
Jurnal Kesehatan Rajawali Vol 10 No 1 (2020): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

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Latar belakang: Tuberkulosis adalah penyakit menular disebabkan oleh bakteri Mycobacterium tuberculosis yang menyebar di udara melalui percikan air liur penderita tuberkulosis. Penderita tuberkulosis sebelum melakukan pengobatan terlihat adanya peningkatan jumlah leukosit yang menujukkan pembentukan leukosit yang banyak untuk melawan bakteri dalam proses fagositosis. Pemberian obat anti tuberkulosis pada pasien tuberkulsosis menunjukan penurunan jumlah leukosit. Obat anti tuberkulosis memiliki efek terhadap kerja sumsum tulang dalam memproduksi sel darah baru. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui perbandingan jumlah leukosit pada penderita TB sebelum dan sesudah pengobatan obat anti tuberkulosis fase intensif. Metode Penelitian: Metode Penelitian didapatkan dari data sekunder. Data sekunder kemudian dianalisa dengan melakukan uji normalitas dan uji wilcolxon. Hasil: Hasil penelitian ini menunjukan rerata leukosit penderita tuberkulosis sebelum pengobatan yaitu 11316,67 mg/dL sedangkan rerata leukosit penderita tuberkulosis sesudah pengobatan fase intensif yaitu 7158,97 mg/dL. Setelah dilakukan uji normalitas dan wilcolxon didapatkan nilai Asymp. Sig. (2-tailed) bernilai 0,000. Karena nilai 0,000 < 0,05 maka hipotesis diterima. Simpulan: Disimpulkan bahwa terdapat perbedaan jumlah leukosit penderita tuberkulosis sebelum mengonsumsi dan sesudah mengonsumsi obat anti tuberkulosis.

Review Artikel : Potensi Berbagai Bahan Alam Sebagai Insektisida Alami Kutu Rambut (Pediculus humanus capitis) Rifani Shalsadila; Mega Nuryanti; Purwaeni Purwaeni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

The head louse parasite (pediculus humanus capitis) is the cause of a common infection in tropical climates called pediculosis capitis. The food of head lice comes from the blood sucked on the human scalp. Various ways to deal with head lice are using lice combs and insect repellents (insecticides). Insecticidal liquid is a synthetic chemical containing permethrin, lindae, DDT malathion and carbaryl which can interfere with the human nervous system when used long-term. This study aimed to find various natural ingredients that have the potential as natural insecticides in overcoming pediculosis capitis. The method used was literature review through Google Scholar, ScienceDirect and ResearchGate websites. The results obtained are lime (Citrus hystrix), red betel (Piper ornatum), crimson (Annona squamosa), kirinyuh (Chromolaena adorate), pandan wangi (Pandanus amaryllifolius), bay leaves koja (Murraya koenigii L.), duku (Lansium domesticum corr), soursop (Annona muricata L.), eucalyptus (Melaleucalucalus L.), eucalyptus (Melaleuca cajuputi), garlic, shallots, coconut (Cocos nucifera), sembung rambat (Mikania micrantha), aloe vera (Aloe vera), jarak pagar (Jatropa curcas L.) and mengkudu (Morinda citrifolia) have the potential as natural insecticides in overcoming pediculosis capitis.

SKRINING DAN IDENTIFIKASI BAKTERI PENGHASIL SIKLODEKSTRIN GLUKOSIL TRANSFERASE (CGTASE) DARI TANAH CIHANJUANG RAHAYU Purwaeni; Raisya Amira Shabira; Feldha Fadhila
PROSIDING SIMPOSIUM KESEHATAN NASIONAL Vol. 1 No. 1 (2022): Simposium Kesehatan Nasional
Publisher : LPPM STIKES BULELENG

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Latar Belakang : Siklodekstrin digunakan dalam berbagai industri seperti industri farmasi, pangan, kesehatan, kosmetik dan kimia analisa. Penggunaan siklodekstrin dalam industri kesehatan dapat digunakan sebagai preparasi serum lipemik. Ketersediaan yang terbatas dan harga jual siklodekstrin yang tinggi membuat pemanfaatan siklodekstrin di berbagai bidang dibatasi. Tujuan Penelitian : Penelitian ini bertujuan untuk memperoleh isolat bakteri dan mengidentifikasi bakteri asal tanah Cihanjuang Rahayu yang mampu menghasilkan enzim CGTase. Metode Penelitian : Penelitian ini menggunakan metode simple random sampling untuk mengetahui adanya bakteri penghasil Enzim CGTase dari Tanah Cihanjuang Rahayu. Data yang digunakan dalam penelitian ini adalah secara deskriptif. Hasil : Hasil dari uji skrining pewarnaan Gram, pewarnaan Spora serta uji biokimia didapatkan bakteri gram positif, berbentuk basil, memiliki spora, motil, dapat memfermentasi karbohidrat, serta menghasilkan enzim katalase. Kesimpulan : Dari kelima sampel tanah didapatkan satu isolat bakteri yang berasal dari tanah perkebunan menunjukan hasil positif menghasilkan enzim CGTase yang teridentifikasi merupakan genus Bacillus sp

Identifikasi Cemaran Mikroba Pada Jamu Tradisional Yang Dijual Di Pasar Andir Kota Bandung Ni'matul Murtafi'ah; Purwaeni Purwaeni; Deti Kurnia
Jurnal Kesehatan Rajawali Vol 13 No 1 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.151

Pasar Andir, Bandung City, is one of the markets where herbal medicine sellers carry it. The use of water to wash used glasses that look cloudy. This is a source of microbial contamination. This research was to determine the presence of bacterial and mold/yeast contamination as well as the identification of gram staining and fungal staining. This study uses a descriptive observation method. The results of the calculation of Total Plate Number and Yeast Mold Number compared to KBPOM No. 12 of 2014 colonies â‰¤106 Colonies/g, while for Mold and Yeast: â‰¤104 Colonies/g. Testing the Plate Count The total bacteria did not exceed the contamination limit, while the calculation of the Fungal Number of the JGK, JGT samples exceeded the contamination limit. Results of gram staining of JGK gram-negative bacilli, JGJ and JGK gram-positive cocci. The result of the staining of the JGK sample was yeast, while the JGJ and JGT samples were mold.

Uji Pengaruh Ekstrak Daun Kirinyuh (Chromolaena odorata) Terhadap Waktu Pembekuan Darah Secara In Vitro Menggunakan Metode Lee-White Purwaeni Purwaeni; Hesti Yulia Ningsih; Cep Wahyu
Jurnal Kesehatan Rajawali Vol 13 No 1 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.165

The Kirinyuh plant comes from the Asteraceae family with the species name Chromolaena odorata. People use this plant as a traditional medicine for wound healing, an antimicrobial, anti-inflammatory, hemostatic, and coagulant. This kirinyuh plant contains flavonoids, saponins and tannins as metabolites that function to coagulate blood. This study aimed to determine the effect of adding kirinyuh (Chromolaena odorata) leaf extract on coagulant time in vitro in 16 respondents using the Lee-White method. The method used is experimental method with a total sample of 16 respondents and the sampling technique is purposive sampling. The statistical test used is the Paired Sample t-test. In examining the blood clotting time by giving kirinyuh leaf extract, the average value was 6 minutes 31 seconds, while the control obtained an average value of 7 minutes 12 seconds. The result of the Paired Sample tâ€“test statistical test is Sig. 0.001 (p <0.05) indicates a difference between the treatment and control groups.

Analysis of Caffeine Levels in Packaged Coffee in Indonesia Baehaki, Farhan; Nurhamidah, Yeni; Purwaeni, Purwaeni
Asian Journal of Health and Applied Sciences Vol. 2 No. 1 (2023): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v2i1.238

Coffee is a popular and much-loved drink in Indonesian society to relieve drowsiness or increase stamina when working. This is because in coffee, there is an active compound, namely caffeine. Although it has benefits, in fact, caffeine will have a negative impact on the body if consumed in excess. The Indonesian National Standard 01-3542-2004 has determined that the limit value of caffeine content in food and beverages is 0.45–2% w/w. This study aimed to determine the caffeine content of packaged coffee sold in the community using a UV-Vis Spectrophotometer. The results of the analysis showed that 16 of the 20 samples analyzed had caffeine levels in accordance with the provisions of the Indonesian National Standard, while the other 4 samples had caffeine levels above the specified value. Even sample Q has a caffeine content of 7.12% w/w, far above the threshold value. Based on the results of this study, it can be concluded that there are still packaged coffees containing caffeine above the specified threshold value. So, consumers should pay attention to the amount of caffeine consumed so as not to cause a negative impact on their health.

The Effect of Garlic Decoction (Allium sativum L.) on The Histological Features of The Liver of Alloxan-induced Mice (Mus musculus) Kodariah, Liah; Karimah, Haniefatul; Purwaeni, Purwaeni; Fadilah, Tyas Ismi
Asian Journal of Health and Applied Sciences Vol. 2 No. 2 (2023): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v2i2.280

Giving alloxan can cause disruption of insulin production resulting in hyperglycemia. Hyperglycemia causes Reactive Oxygen Species (ROS) resulting in oxidative stress and liver cell damage. The use of natural ingredients, one of which is garlic (Allium sativum L) in the form of boiled water, because it contains flavonoid and organosulfur compounds. Therefore, the purpose of this study was to determine the histology of the liver of mice (Mus musculus) induced by alloxan after being given a decoction of garlic (Allium sativum L). This study used experimental research with a completely randomized design method on mice consisting of 6 groups with 4 replications each. The groups in this study consisted of a negative control group (without treatment), a positive control group (alloxan injection) a comparison control group (alloxan injection + glibenclamide) treatment groups at doses I, II and III (alloxan-induced + garlic boiled water (Allium sativum L) respectively 20 gr, 40 gr and 60 gr). Histology of the liver of mice (Mus musculus) was made by paraffin method with Hematoxylin Eosin (HE) staining. The result showed that there was a significant difference due to the value (p<0,05) but for a KP and P3 there was no significant difference with the value (p>0,05) on hydropic degeneration. Based on the results of the study, it can be concluded that the decoction of garlic (Allium sativum L) has an effect on the alloxan-induced liver histology of mice (Mus musculus).

FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN FOOTSPRAY ANTI BAU KAKI EKSTRAK TEH HITAM (Camellia sinensis) DAN DAUN JAMBU BIJI (Psidium guajava L.) Shalsadila, Rifani; Nuryanti, Mega; Siahaan, Nurbaiti Fentiani; Nurkamal, Elsa; Farhan, Dicky; Purwaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.2939

Increased release of apocrine infected by bacteria during the decay process will result in foot odor or bromhidrosis. Foot odor is caused by skin microbes. Some of the bacteria that cause foot odor are Staphylococcus epidermidis and Staphylococcus aureus. Black tea and guava leaves are natural ingredients that contain antibacterial compounds, namely flavonoids, saponins, tannins and alkaloids. The purpose of this study was to formulate footspray preparations from extracts of black tea and guava leaves and to determine the antibacterial activity of each formulation. This study uses an experimental method. Extracts of black tea and guava leaves are produced from the maceration extraction process, then the resulting extract is formulated into footspray with various concentrations. Footspray preparations were tested for evaluation of physical preparations and tested for antibacterial activity of Staphylococcus epidermidis and Staphylococcus aureus by the paper disc method. The results showed that black tea and guava leaf extracts could be formulated as active substances in footspray preparations which had antibacterial activity which was indicated by the presence of clear zones in formulas 1, 2 and 3. However, in the control formula there was no antibacterial activity which was indicated by the absence of clear zone.

Formulasi dan Evaluasi Sediaan Harmoni Dada : Inovasi Minyak Perawatan Payudara Berkhasiat pada Ibu Menyusui dari Minyak Atsiri Daun Mint (Mentha piperita) Purwaeni, Purwaeni; Aliansy, Diani; Jaojah, Siti; Aulia, Reza Nurul; Meilasari, Rika Nur; Pertiwi, Dini Yulianti; Carla, Natasya Cintya
Generics: Journal of Research in Pharmacy Vol 5, No 1 (2025): Generics: Journal of Research in Pharmacy, Volume 5, Edisi 1, 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v5i1.25570

Daun mint (Mentha piperita) dikenal luas karena kandungan kimianya yang memiliki berbagai manfaat kesehatan. Daun mint mengandung senyawa aktif seperti mentol, menton, dan flavonoid yang dapat membantu mengurangi peradangan. Senyawa-senyawa ini berfungsi dengan menghambat pelepasan mediator inflamasi, seperti prostaglandin dan sitokin, yang berperan dalam proses peradangan. Selain itu, daun mint juga memiliki efek analgetik atau pereda nyeri. Kandungan mentol pada daun mint mampu memberikan sensasi dingin yang dapat meredakan nyeri dengan cara menghambat sinyal rasa sakit di saraf perifer. Penelitian ini bersifat eksperimental dan bertujuan untuk memformulasikan minyak atsiri dari daun mint. Produksi minyak atsiri dari daun mint dilakukan dengan metode destilasi. Minyak Harmoni Dada dibuat dalam 2 formulasi yakni F1 dengan konsentrasi minyak atsiri 3% dan F2 dengan konsentrasi 6%. Minyak Harmoni Dada dari minyak atsiri daun mint dievaluasi selama 4 minggu meliputi organoleptis, uji pH serta uji iritasi. Hasil penelitian menunjukkan bahwa ekstrak daun mint dapat diformulasikan menjadi produk minyak Harmoni Dada yang berfungsi sebagai perawatan payudara. Minyak dengan konsentrasi minyak atsiri 6% pada F2 merupakan sediaan yang paling baik. Bentuknya cair, warnanya kekuningan, wangi daun mint, homogen dengan pH 5, tidak menyebabkan iritasi pada kulit, disukai panelis dan memiliki efek menenangkan.

Formulasi dan Evaluasi Sediaan Harmoni Dada : Inovasi Minyak Perawatan Payudara Berkhasiat pada Ibu Menyusui dari Minyak Atsiri Daun Mint (Mentha piperita) Purwaeni, Purwaeni; Aliansy, Diani; Jaojah, Siti; Aulia, Reza Nurul; Meilasari, Rika Nur; Pertiwi, Dini Yulianti; Carla, Natasya Cintya
Generics: Journal of Research in Pharmacy Vol 5, No 1 (2025): Generics: Journal of Research in Pharmacy, Volume 5, Edisi 1, 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v5i1.25570

Daun mint (Mentha piperita) dikenal luas karena kandungan kimianya yang memiliki berbagai manfaat kesehatan. Daun mint mengandung senyawa aktif seperti mentol, menton, dan flavonoid yang dapat membantu mengurangi peradangan. Senyawa-senyawa ini berfungsi dengan menghambat pelepasan mediator inflamasi, seperti prostaglandin dan sitokin, yang berperan dalam proses peradangan. Selain itu, daun mint juga memiliki efek analgetik atau pereda nyeri. Kandungan mentol pada daun mint mampu memberikan sensasi dingin yang dapat meredakan nyeri dengan cara menghambat sinyal rasa sakit di saraf perifer. Penelitian ini bersifat eksperimental dan bertujuan untuk memformulasikan minyak atsiri dari daun mint. Produksi minyak atsiri dari daun mint dilakukan dengan metode destilasi. Minyak Harmoni Dada dibuat dalam 2 formulasi yakni F1 dengan konsentrasi minyak atsiri 3% dan F2 dengan konsentrasi 6%. Minyak Harmoni Dada dari minyak atsiri daun mint dievaluasi selama 4 minggu meliputi organoleptis, uji pH serta uji iritasi. Hasil penelitian menunjukkan bahwa ekstrak daun mint dapat diformulasikan menjadi produk minyak Harmoni Dada yang berfungsi sebagai perawatan payudara. Minyak dengan konsentrasi minyak atsiri 6% pada F2 merupakan sediaan yang paling baik. Bentuknya cair, warnanya kekuningan, wangi daun mint, homogen dengan pH 5, tidak menyebabkan iritasi pada kulit, disukai panelis dan memiliki efek menenangkan.

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