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All Journal Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Jurnal Kesehatan Rajawali Asian Journal of Health and Applied Sciences Journal of Sustainability Science and Technology
Liah Kodariah
Institut Kesehatan Rajawali
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Energy Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengaruh Ekstrak Etanol Seledri (Apium Graveolens) Terhadap Profil Lipid Darah Dan Indeks Atherogenik Tikus Putih (Rattus Norvegicus) Yang Diinduksi Hiperlipidemia Liah Kodariah
Jurnal Kesehatan Rajawali Vol 9 No 1 (2019): Maret
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v9i1.5

Abstract

Latar Belakang. Prevalensi jumlah penderita jantung koroner yang dipicu oleh aterosklerosissemakin meningkat seiring dengan terus bertambahnya orang yang beresiko terkena penyakittersebut. Salah satunya disebabkan oleh kondisi hiperlipidemia. Hiperlipidemia merupakan suatukondisi dimana terdapat gangguan metabolisme lipid yang melibatkan peningkatan konsentrasilipoprotein plasma. Kondisi hiperlipidemia menyebabkan peningkatan konsentrasi lipid darahditandai dengan peningkatan kolesterol total, trigliserida, LDL dan penurunan HDL. Peningkatankonsentrasi LDL bersama dengan stress oksidatif menjadi pemicu utama terjadinyaaterosklerosis. Tujuan. untuk mengevaluasi pemberian sediaan ekstrak etanol seledri (Apiumgraveolens) terhadap tikus (Rattus norvegicus) galur wistar yang diinduksi hiperlipidemia.Metode. Sebanyak 25 ekor tikus jantan dikelompokkan menjadi 5 kelompok pelakuan, yaitu:kelompok I sebagai kontrol negatif hanya diberi pakan pellet dan akuades secara gavage,kelompok II sebagai kelompok hiperlipidemia diinduksi hiperlipidemia (pakan tinggi lemak +kristal kolesterol+ PTU), kelompok III sebagai kelompok kontrol positif diinduksi hiperlipidemia(pakan tinggi lemak + kristal kolesterol + PTU) dan diberi obat simvastatin dengan dosis 0.9 mg/kg BB. Kelompok IV dan V diinduksi hiperlipidemia (pakan tinggi lemak + kristal kolesterol +PTU), dan diberikan ekstrak seledri dengan dosis masing-masing 125 mg/kg BB tikus dan 250mg/kg BB tikus. Perlakuan diberikan secara oral gavage selama 4 minggu untuk induksihiperlipidemia dan 4 minggu untuk pemberian simvastatin dan ekstrak seledri. Hasil. Hasilanalisis data menunjukkan bahwa ekstrak etanol seledri dosis 125 mg/ kg BB dan dosis 250mg/kg BB efektif menurunkan kolesterol total serta efektif meningkatkan kadar HDL sehinggadapat menurunkan IA hewan uji yang diinduksi. Simpulan. Berdasarkan hasil yang diperolehdapat disimpulkan bahwa pemberian ekstrak seledri dapat menurunkan resiko aterosklerosis padatikus hiperlipidemia dengan memperbaiki profil lipid darah dan menurunkan status stressoksidatif.
PENGARUH EKSTRAK ETANOL SELEDRI TERHADAP KADAR MDA AORTA DAN PLASMA DARAH TIKUS PUTIH YANG DIINDUKSI HIPERLIPIDEMIA Liah Kodariah
Jurnal Kesehatan Rajawali Vol 9 No 2 (2019): September
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v9i2.34

Abstract

Latar Belakang. Tingginya kadar LDL memicu peningkatan peroksidasi lipid yang menghasilkan berbagai produk akhir yang bersifat radikal misalnya malondialdehid (MDA) dan dapat merusak makromolekul lain disekitarnya (Evans dan Cooke, 2006). Konsentrasi MDA dalam material biologi telah digunakan sebagai indikator kerusakan oksidatif pada lemak tak jenuh dan sebagai indikator keberadaan radikal bebasTujuan. untuk mengevaluasi pemberian sediaan ekstrak etanol seledri (Apium graveolens) terhadap kadar MDA aorta dan MDA plasma tikus (Rattus norvegicus) galur wistar yang diinduksi hiperlipidemia.Metode. Sebanyak 25 ekor tikus jantan dikelompokkan menjadi 5 kelompok pelakuan, yaitu: kelompok I sebagai kontrol negatif hanya diberi pakan pellet dan akuades secara gavage, kelompok II sebagai kelompok hiperlipidemia diinduksi hiperlipidemia (pakan tinggi lemak + kristal kolesterol+ PTU), kelompok III sebagai kelompok kontrol positif diinduksi hiperlipidemia (pakan tinggi lemak + kristal kolesterol + PTU) dan diberi obat simvastatin dengan dosis 0.9 mg /kg BB. Kelompok IV dan V diinduksi hiperlipidemia (pakan tinggi lemak + kristal kolesterol + PTU), dan diberikan ekstrak seledri dengan dosis masing-masing 125 mg/kg BB tikus dan 250 mg/kg BB tikus. Perlakuan diberikan secara oral gavage selama 4 minggu untuk induksi hiperlipidemia dan 4 minggu untuk pemberian simvastatin dan ekstrak seledriHasil. Hasil analisis data menunjukkan bahwa ekstrak etanol seledri dosis 125 mg/ kg BB dan dosis 250 mg/kg BB efektif menurunkan kadar MDA hewan uji yang diinduksiSimpulan. Berdasarkan hasil yang diperoleh dapat disimpulkan bahwa pemberian ekstrak seledri dapat menurunkan resiko aterosklerosis pada tikus hiperlipidemia dengan mengurangi kadar MDA pada aorta dan plasma darah tikus, serta dapat menurunkan status stress oksidatif.
IDENTIFICATION OF ASPERGILLUS SP GROWTH ON WHITE BREAD AGAINST STORAGE TEMPERATURE Fitri Rahmi Fadhilah; Liah Kodariah
Jurnal Kesehatan Rajawali Vol 10 No 2 (2020): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.188 KB)

Abstract

Bread is a kind of food consumed by the Indonesian people. the composition of in bread is one of the sources of nutrition microorganisms that are important in growth, especially the Aspergsillus sp. the objective of this study to identify the growth of Aspergillus sp. on bread to temperature storage at room temperature 25oC -37oC and cold temperature 4oC-10oC. The methodology used is a descriptive method. By using four samples of white bread sold in Burung Tungku market which is stored at room temperature and cold temperatures. the research was done in a Microbiologi laboratory of STIKes Rajawali Bandung. The result of this research showed that the growth of Aspergillus sp in white bread grew faster at room temperature than on cold temperatures. Room temperature of 25C- 37C Aspergillus sp began to grow on the 4th day. While at the cold temperature of 4C- 10C Aspergillus sp began to grow on the 10th day. From the result of the study, it can be concluded that the inhibition of fungal growth can be caused by several factors, namely temperature and humidity factors. which are less than optimal. The optimum temperature of Aspergillus is 25C- 37C with relative humidity (RH)
EFEKTIVITAS INFUSA KULIT NANAS SEBAGAI BIOLARVASIDA Aedes aegypti Liah Kodariah; ally Kafesa
Jurnal Kesehatan Rajawali Vol 11 No 1 (2021): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.514 KB)

Abstract

Dengue hemorrhagic fever is a disease caused by the dengue virus which is transmitted through the bite of the Aedes aegypti mosquito. Controls are generally carried out chemically which can cause negative impacts if used continuously. Pineapple peel is a plant that can be used as a biolarvicide which contains flavonoids, saponins, tannins, and bromelain enzymes which can cause the death of Aedes aegypti larvae.This study aims to determine the concentration of pineapple peel infusion which is effective in killing Aedes aegypti larvae seen from the LC50 value.This research uses experimental methods. The sample population was larvae of Aedes aegypti. Samples were taken in the captivity of the Bandung Health Polytechnic Laboratory as many as 140 instar III Aedes aegypti larvae with purposive sampling technique. The concentration of pineapple skin infusion used was 23%, 21%, 20%, 19%, and 17%. each treatment In this study, the percentage of larvae mortality was obtained, namely at a concentration of 23% there were 65% of larvae deaths, at a concentration of 21% there were 60% deaths, at a concentration of 20% there were 50% deaths, at a concentration of 19% there were 50% deaths, and at a concentration of 20% there were 50% deaths. and at concentration of 17% contained 35% of deaths.Based on the research, it can be concluded that pineapple skin infusion can be used as an effective biolarvicide seen from the LC50 value, which is at a concentration of 19%. contained 10 test larvae with two repetitions and observed after 24 hours.
Gambaran Kadar Rheumatoid Factor (Rf) Pada Wanita Menopause Liah Kodariah
Jurnal Kesehatan Rajawali Vol 12 No 1 (2022): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.833 KB) | DOI: 10.54350/jkr.v12i1.122

Abstract

Menopause occurs in women aged between 40-55 years. Decreased levels of the hormone estrogen at the time of menopause will interfere with calcium absorption so that bones become brittle. Cells that experience inflammation will cause the entry of antibodies into the space between the bones. In response to antigenic determinants, antibodies from IgG and IgM are formed which are called Rheumatoid Factor (RF). This study was to determine the RF levels in postmenopausal women qualitatively and then to quantitatively. Methods: This research is descriptive with RF examination using latex agglutination method. Sampling was done by purposive sampling of 30 samples. The results of this study were qualitatively 80% negative RF results and 20% positive RF results followed by a semi-quantitative test obtained 4 samples with a titer of 8 IU/mL and 2 samples with a titer of 16 IU/mL. Based on research on the description of RF levels in postmenopausal women, it can be concluded that the positive results of RF 20% and negative results of RF 80%.
Liver histology of Wistar rats (Rattus norvegicus) following oral administration of 50% ethanol Liah Kodariah; Rahmad Rezaldy; Suryanata Kesuma; Farhan Baehaki
Journal of Sustainability Science and Technology Vol. 2 No. 1 (2022): Journal of Sustainability Science and Technology (JOSST)
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/josst.v2i1.21

Abstract

Ethanol, also known as ethyl alcohol, pure alcohol, and alcohol, is a toxic, volatile, flammable, and colourless liquid. Alcohol is the most commonly consumed alcoholic beverage in everyday life. EtOH is a common abbreviation for ethanol, where "Et" stands for the ethyl group (C2H5). Sugar fermentation to ethanol is one of the earliest organic reactions ever performed by humans; ethanol consumption has also been known for a very long time. This study aims to determine the histology of the liver in Wistar rats (Rattus norvegicus) by orally administering ethanol at a concentration of 50 percent. The method used in this study was an experimental study by looking at the histology of rat liver. Rats were divided into two groups, with seven rats each. Group 1 was given 50% ethanol orally for seven days, and group 2, as a control, was only given orally with distilled water. After seven days, the rats were slaughtered, and their livers were extracted for further histological preparations. In the histology results of group 1, the histological images of the livers of the rats P1, P2, P3, P4, P5, P6 and P7 were abnormal or damaged. In the presence of necrotic cells, oral administration of 50 percent alcohol causes damage to hepatocyte cells, as determined by the study's findings. However, in general, hepatocyte cell damage in the liver produces a score of 1.7, which indicates a change leading to cell damage.
Pengaruh Induksi Timbal (Pb) Pada Mencit (Mus musculus) Terhadap Kadar Hemoglobin Liah Kodariah; Baiq Isti; Hasanah Sanusiyah Harahap; Reyna Synthia
Jurnal Kesehatan Rajawali Vol 13 No 1 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.154

Abstract

Hemoglobin is the oxygen-carrying compound in red blood cells. A low hemoglobin content indicates severe anemia this is due to pregnancy and the presence of heavy metals such as Lead (Pb). Lead Pb that enters through the respiratory tract and digestive tract will absorbed through the gastrointestinal tract and distributed to other tissues via blood. This study aims to determine Hb levels in the blood of mice (Mus Musculus) exposed to lead. This research method is experimental using 25 male mice which divided into 5 groups, namely the control group and the treatment group with the administration of Pb acetate by oral route for 1 week, 2 week, 3 weeks, and 4 weeks. The sample taken is the blood of mice obtained from heart to be checked for hemoglobin levels according to the time of exposure. The results of this study obtained hemoglobin levels in the P1 group of 11,2 g/dL and the P2 group of 10,078 g/dL, the Hb value includes into the category of very mild anemia. While the P3 group was 8,16 g/dL and the P4 group of 7,54 g/dL including the category of mild anemia. On the control group of 12,82 g/dL was included in the Normal Hemoglobin. Based on the result of the study, it can be concluded that giving exposure to Lead Pb to mice (Mus Musculus) has an effect on decreasing levels of Hb.
Efektivitas Ekstrak Daun Salam (Syzygium polyanthum) Dalam Mencegah Kenaikan Kadar Kolesterol LDL Tikus Putih (Rattus norvegicus) Diinduksi Kuning Telur Puyuh Baiq Isti Hijriani; Bustanul Atfal; Liah Kodariah; Nurul Hadiatun; Nurul Khatimah Ismatullah
Jurnal Kesehatan Rajawali Vol 13 No 2 (2023): Jurnal Kesehatan Rajawali
Publisher : Sekolah Tinggi Ilmu Kesehatan Rajawali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54350/jkr.v13i1.156

Abstract

Quail egg yolk contains high cholesterol which can trigger dyslipidemia. If Cholesterol is consumed in excess, will increase lipid profile, which can increase LDL cholesterol levels. Bay leaf extract contains several active compounds, like quercetin, a class of flavonoids with antioxidants that can prevent LDL oxidation. The aim of this study is to ensure the effectiveness of bay leaf extract on LDL cholesterol levels in white rats induced by quail egg yolk. The animal tested in this study were male white rats (Rattus norvegicus) with the Sprague Dawley strain. Samples were randomly selected and divided into five groups: three groups given quail egg yolk and bay leaf extract in various doses of 0.18 g/day, 0.36 g/day and 0.72 g/day, positive control given quail egg yolk, and negative control without treatment. The ANOVA test showed that there were significant results between the treatment groups, positive control and negative control (p<0.05). Next, the BNJ test showed that giving bay leaf extract (0.18 g/day, 0.36 g/day) had a significant effect on LDL cholesterol levels (p<0.05), while a dose of 0.72 g/day showed that not significant (p>0.05), so we can conclude that the dose of 0.72 g/day was the most effective in preventing an increase in LDL cholesterol levels.
The Effect of Garlic Decoction (Allium sativum L.) on The Histological Features of The Liver of Alloxan-induced Mice (Mus musculus) Kodariah, Liah; Karimah, Haniefatul; Purwaeni, Purwaeni; Fadilah, Tyas Ismi
Asian Journal of Health and Applied Sciences Vol. 2 No. 2 (2023): Asian Journal of Health and Applied Sciences (AJHAS)
Publisher : Lighthouse Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53402/ajhas.v2i2.280

Abstract

Giving alloxan can cause disruption of insulin production resulting in hyperglycemia. Hyperglycemia causes Reactive Oxygen Species (ROS) resulting in oxidative stress and liver cell damage. The use of natural ingredients, one of which is garlic (Allium sativum L) in the form of boiled water, because it contains flavonoid and organosulfur compounds. Therefore, the purpose of this study was to determine the histology of the liver of mice (Mus musculus) induced by alloxan after being given a decoction of garlic (Allium sativum L). This study used experimental research with a completely randomized design method on mice consisting of 6 groups with 4 replications each. The groups in this study consisted of a negative control group (without treatment), a positive control group (alloxan injection) a comparison control group (alloxan injection + glibenclamide) treatment groups at doses I, II and III (alloxan-induced + garlic boiled water (Allium sativum L) respectively 20 gr, 40 gr and 60 gr). Histology of the liver of mice (Mus musculus) was made by paraffin method with Hematoxylin Eosin (HE) staining. The result showed that there was a significant difference due to the value (p<0,05) but for a KP and P3 there was no significant difference with the value (p>0,05) on hydropic degeneration. Based on the results of the study, it can be concluded that the decoction of garlic (Allium sativum L) has an effect on the alloxan-induced liver histology of mice (Mus musculus).
Antibacterial activity of coriander seeds extract (Coriandrum sativum) against the growth of Streptococcus mutans Kodariah, Liah; Amaliah, Eka Yuliani; Fadhillah, Tyas Ismi
Journal of Indonesian Medical Laboratory and Science Vol 5 No 2 (2024): In Progress
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v5i2.149

Abstract

Background: Streptococcus mutans is the main cause of dental caries, previously known as part of the normal flora in the oral cavity which plays a role in the process of fermenting carbohydrates to produce acid, and causes tooth demineralization. Chemical-based medicinal products such as toothpaste and mouthwash. Continuous use of chemicals can cause side effects for users such as hypersensitivity, therefore an alternative treatment from natural ingredients such as coriander seeds which can inhibit bacterial growth is needed. Objective: This research aims to determine the lowest concentration of coriander seed extract in 0,75%, 1.5%, 3% inhibiting the growth of Streptococcus mutans. Methods: This study was conducted by soaking the test discs in coriander seed extract concentrations of 0.75%, 1.5% and 3%. each disc was inserted into the bacterial culture to be cultured, incubated and seen whether there was a clear zone or not. Result: Test results showed a clear zone at a concentration 1.5% with an average diameter of 1.5 mm, at concentration of 3% an average diameter of 3.7 mm and at concentration of 0.75% did not show clear zone. Conclusion: Based on the results of the study, the lowest concentration of coriander seed extract was obtained which was able to inhibit the growth of Streptococcus mutans bacteria, is at concentration of 1.5%, the diameter of the inhibition zone of coriander seed extract had weak antibacterial activity.
Co-Authors Ally Kafesa Amaliah, Eka Yuliani Anistia Fardila Baiq Isti BaiqIsti Hijriani Bustanul Atfal Fadhillah, Tyas Ismi Fadilah, Tyas Ismi Farhan Baehaki Fitri Rahmi Fadhilah Hasanah Sanusiyah Harahap Karimah, Haniefatul Kesuma, Suryanata Nurul Hadiatun Nurul Khatimah Ismatullah Purwaeni Purwaeni Rahmad Rezaldy Reyna Synthia Suyarta Efrida Pakpahan