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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Cardiology Global Journal Basic Education
Muhammad Munawar
Faculty of Medicine, University of Indonesia/ Harapan Kita National Cardiovascular Center
Humanities Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Social Sciences

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Correlation between micro-RNA-21 expression and inflammation cytokine in rabbits implanted with bare metal stent with the incidence of neo intimal hyperplasia Hariawan, Hariadi; Soesatyo, Marsetyawan HNE; Munawar, Muhammad; Ghozali, Ahmad
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.065 KB) | DOI: 10.19106/JMedScie/005101201901

Abstract

In-stent restenosis after stenting in vascular occurs secondary to the accumulation of smooth muscle cell and extracellular matrix. This condition is a major complication caused by the occurrence of neointimal hyperplasia (NIH). The study aimed to prove the role of miRNA-21 as a risk predictor of the NIH event in aorta of rabbits animal model who underwent bare metal (BM) type stent implantation and to know the miRNA-21 role in IL-6 and IL-8 expressions. This study was quasi experimental, coducted in Catheterization Laboratory Dr. Sardjito General Hospital Yogyakarta. Stent implantation was observed intravascular ultrasonography. Blood vessel which was already deployed by stent taken as sample for pathologic examination. Rabbit blood samples were collected on day 0, 7, and 28. Quantification miRNA-21 expression has been done with qPCR and ELISA approach. These 10 rabbits divided into two groups in which one group as control (without stent deployment, 4 models) and another group as intervention (with BM type stent deployment, 6 models). The increase in expression of miRNA-21 on the day 7 and day 28 in the intervention group compared to the control group. Neointimal hyperplasia increased in intervention group on day 7, and 28 were from mild grade to moderate, and severe respectively. In addition, levels of IL-6 and IL-8 increased on day 28 compared with on day 7. This study showed increase of miRNA-21 expression on day 7 and NIH rise from the mild to moderate. Furthermore, on day 28, that increases of miRNA-21 expression and NIH rose from to moderate to severe. The increase of miRNA-21 was also shown on day 7 and 28 followed by the increase of IL-6 and IL-8 levels.
IMPLEMENTASI METODE THINK-PAIR-SHARE UNTUK MENINGKATKAN PROSES DAN HASIL BELAJAR BAHASA INDONESIA SISWA KELAS 3 SDN 4 NGARIP Ambarwati, Leri; Munawar, Muhammad
Global Journal Basic Education Vol 4 No 2 (2025): Mei
Publisher : Sains Global Institut, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35458/gjp.v4i2.4588

Abstract

Rendahnya hasil belajar dan terbatasnya keterlibatan siswa pada kegiatan belajar Bahasa Indonesia di kelas III SDN 4 Ngarip menjadi titik awal penelitian ini. Penerapan praktik kegiatan belajar yang mampu memperbaiki proses serta hasil belajar siswa amat diperlukan dalam situasi ini. Tujuan dari dilaksanakannya penelitian ini karena untuk mengetahui bagaimana pendekatan Think-Pair-Share mempengaruhi perkembangan proses pembelajaran dan hasilnya pada kegiatan belajar Bahasa Indonesia. Rancangan PTK yang diterapkan pada penelitian ini terdiri atas tahap prasiklus, siklus pertama dan siklus kedua. Tahapan perencanaan, pelaksanaan, observasi (pengamatan), dan refleksi semuanya tercakup dalam siklus. Sebanyak 10 siswa kelas III SDN 4 Ngarip menjadi subjek penelitian. Data diperoleh melalui tes untuk mengevaluasi hasil belajar, serta observasi untuk mengukur partisipasi siswa pada kegiatan pembelajaran. Dari hasil penelitian, penggunaan metode Think-Pair-Share mampu mempengaruhi peningkatan nilai akhir serta keterlibatan siswa dalam kegaiatan belajar. Berdasarkan hasil penelitian, pendekatan Think-Pair-Share terbukti sukses dalam peningkatan proses serta hasil belajar di tingkat Sekolah Dasar. Selain itu, pendekatan ini mendorong partisipasi siswa yang lebih dalam sepanjang pembelajaran.
Revisiting Subspecialty Training in Cardiology in Indonesia: Structural, Regulatory, and Global Perspectives Munawar, Muhammad; Lubis, Anggia Chairuddin; Setianto, Budi Yuli; Octaviono, Yudi Her; Munawar, Andina; Rifqi, Sodiqur; Widito, Sasmojo
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1971

Abstract

The rapid expansion of cardiology as a discipline has prompted the emergence of numerous subspecialties that require structured, competency-based training. In Indonesia, however, the development of subspecialty education remains inconsistent, divided between university-based programs known as Spesialis-2 (Sp-2) and hospital-based fellowships. The interchangeable use of the terms “fellowship” and “subspecialty” has generated conceptual ambiguity and regulatory uncertainty. Globally, subspecialty training in cardiology follows a hospital-based apprenticeship model, led by accredited teaching hospitals and closely regulated by professional boards such as ACGME, ACC, or ESC. Indonesia’s deviation from these international norms has implications not only for the quality of advanced cardiovascular training but also for the nation’s ability to attract international fellows—a marker of global academic recognition. This review examines the current landscape of cardiology subspecialty education in Indonesia, contrasting it with global frameworks, and discusses structural, academic, and legal challenges, including those concerning foreign trainees. The article concludes by proposing a policy framework to harmonize Indonesia’s subspecialty education with global standards, thereby strengthening both national capacity and international credibility.
Co-Authors Ambarwati, Leri Budhi Setianto Budi Nagawijaya Budi Yuli Setianto Cholid T. Tjahjono Dede Kusmana Dian L. Munawar Dicky A. Hanafy Erika Maharani Erwan Martanto Ghozali, Ahmad Hariadi Hariawan Harmani Kalim Hossain Moqaddas Ingrid Pardede Isman Firdaus Jimmy Pambudi Lubis, Anggia Chairuddin Marsetyawan HNE Soesatyo Munawar, Andina Octaviono, Yudi Her Otte J. Rachman Radityo Prakoso Robert E. Saragih Sodiqur Rifqi Surya Dharma Syarif Subiyakto Widito, Sasmojo Yoga Yuniadi Yoga Yuniadi